oxytetracycline--anhydrous and Pain--Postoperative

Oral surgical procedures produce side effects such as pain and inflammation, the magnitude of which depends on the degree of tissue damage produced.. To explore the effectiveness and safety of the topical application of 1% oxytetracycline hydrochloride after biopsy of the oral mucosa.. A randomized, double-blind, placebo- and no treatment-controlled study was conducted in 90 patients with lesions needing histopathologic analysis. The patients were divided into three groups. Group I (control) received no treatment; in group II, the site of surgical intervention was treated topically with 1% oxytetracycline hydrochloride three times a day for 1 week; and in group III, the patients were treated in the same way but with placebo. Using a visual analog scale, we determined the time of maximum postoperative pain.. Maximum pain intensity was recorded in the placebo group, with peak pain occurring 24 hours after surgery. The pain subsequently tended to decrease gradually over the 1-week period of the study. The maximum level of pain was significantly lower in group II than in the controls. No adverse effects were recorded.. Topical 1% oxytetracycline hydrochloride decreases pain symptoms after oral mucosa biopsy.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Biopsy; Double-Blind Method; Female; Humans; Male; Middle Aged; Mouth Mucosa; Oxytetracycline; Pain, Postoperative; Statistics, Nonparametric; Surgical Wound Infection; Time Factors; Young Adult

Dry socket and post-extraction pain are typical discomforts experienced by patients after tooth extraction. In this study, we inserted gauze coated with oxytetracycline-hydrocortisone ointment into the extraction socket immediately after lower third molar extraction and then evaluated the occurrence of dry socket and post-extraction pain compared with gauze non-insertion.. This retrospective study was carried out on patients undergoing lower third molar extraction in the Department of Oral Surgery at Shizuoka Prefectural General Hospital in Shizuoka, Japan from November 2018 to October 2019. A comparison was carried out between a gauze-insertion group and a non-insertion group. The occurrence versus non-occurrence of dry socket was determined, and degree of pain was assessed based on a visual analogue scale (VAS) and on patients reporting the number of loxoprofen sodium oral analgesic tablets (60mg/tablet) that they had taken. Dry socket was defined as patient-reported spontaneous pain that did not subside 1 to 3 days postoperatively. Spontaneous post-extraction pain was recorded four times: on the operative day, on the first postoperative day (POD1), on POD3, and during suture removal (POD7).. The occurrence of dry socket was lower in the gauze-insertion group than in the non-insertion group (0.9%, 2/215 vs. 19.6%, 9/46, p<0.001). The results also showed that both VAS-defined pain level and the number of analgesic tablets taken were lower in the gauze-insertion group than in the non-insertion group on POD3 and POD7.. Inserting gauze coated with oxytetracycline-hydrocortisone ointment into the extraction socket immediately after third molar extraction reduces the occurrence of both dry socket and post-extraction pain.

Topics: Adult; Anti-Bacterial Agents; Dental Care; Drug Combinations; Dry Socket; Female; Humans; Hydrocortisone; Japan; Male; Mandible; Molar, Third; Ointments; Oxytetracycline; Pain, Postoperative; Retrospective Studies; Tooth Extraction; Tooth, Impacted

Adequate post-operative management of equine abdominal patients is as necessary to patient survival as the most heroic corrective surgery. Post-operative management must begin during the anaesthesia recovery phase to insure adequate oxygen supply, ventilation, and minimize any abdominal discomfort. The animal's physiological status must be constantly monitored to detect and determine the degree of abnormalities concerning serum electrolytes, fluid balance, and acid-base abnormalities. The most commonly observed serum electrolyte imbalance is hypokalaemia. Replacement potassium is usually supplied intravenously. If the dificit is slight, oral replacement may be possible. Fluid balance is usually maintained via intravenous fluid therapy as determined by monitoring PCV and plasma protein. Metabolic acidosis is treated with 5 percent sodium bicarbonate administered intravenously. Broad spectrum antibiotics are usually given intravenously but may be administered intra-peritoneally. To facilitate the intravenous therapy, an indwelling silastic catheter is often employed to minimize jugular thrombosis.

Topics: Abdomen; Animals; Bicarbonates; Blood Proteins; Drainage; Gastrointestinal Motility; Hematocrit; Horse Diseases; Horses; Hypocalcemia; Infusions, Parenteral; Intestinal Obstruction; Meperidine; Neomycin; Oxygen; Oxytetracycline; Pain, Postoperative; Peritonitis; Physical Exertion; Postoperative Care; Postoperative Complications; Water