oxytetracycline--anhydrous and Neoplasms

MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression at the post-transcriptional level. It is now well established that the overexpression of some miRNAs (oncogenic miRNAs) is responsible for initiation and progression of human cancers and the discovery of new molecules able to interfere with their production and/or function represents one of the most important challenges of current medicinal chemistry of RNA ligands. In this work, we studied the ability of 18 different antibiotics, known as prokaryotic ribosomal RNA, to bind to oncogenic miRNA precursors (stem-loop structured pre-miRNAs) in order to inhibit miRNAs production. In vitro inhibition, binding constants, thermodynamic parameters and binding sites were investigated and highlighted that aminoglycosides and tetracyclines represent interesting pre-miRNA ligands with the ability to inhibit Dicer processing.

Topics: Aminoglycosides; Anti-Bacterial Agents; Base Sequence; DEAD-box RNA Helicases; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Models, Molecular; Molecular Sequence Data; Neoplasms; Ribonuclease III; Ribosomes; Tetracyclines

Topics: 4-Butyrolactone; Bacteria; Butylene Glycols; Clostridium; Depression, Chemical; Female; Humans; Intestines; Lignans; Male; Menstruation; Metronidazole; Neoplasms; Oxytetracycline; Plant Extracts; Pregnancy

Topics: Animals; Antibiotics, Antineoplastic; Azaserine; Bleomycin; Chlortetracycline; Cycloheximide; Dactinomycin; Dog Diseases; Dogs; Fatty Acids, Unsaturated; Leucomycins; Mitomycins; Neoplasms; Oleandomycin; Olivomycins; Oxytetracycline; Streptozocin

Topics: Animals; Cell-Free System; Hypoglycemia; Male; Microscopy, Electron; Neoplasms; Neoplasms, Experimental; Oncogenic Viruses; Oxytetracycline; Rats; Viruses

Topics: Acridines; Anti-Bacterial Agents; Bacteria; Bacteriophage Typing; Chloramphenicol; Chlortetracycline; Coloring Agents; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Humans; Neomycin; Neoplasms; Oxacillin; Oxytetracycline; Penicillin Resistance; Pseudomonas aeruginosa; Staphylococcus; Streptococcus; Streptomycin; Sulfathiazoles

Topics: Carcinoma; Carcinoma, Bronchogenic; Clinical Laboratory Techniques; Cytodiagnosis; Fluorescence; Gastric Juice; Gastric Lavage; Humans; Neoplasms; Oxytetracycline; Sputum

Topics: Fluorescence; Humans; Neoplasms; Oxytetracycline; Ultraviolet Rays

Topics: Biomedical Research; Female; Humans; Infections; Neoplasms; Oxytetracycline; Radium; Uterine Neoplasms; Vaginitis

Three strains of Past. septica were isolated in Hong Kong. The clinical histories and the detailed bacteriological and serological studies are presented.

Topics: Abscess; Animals; Appendix; China; Chloramphenicol; Cobalt Isotopes; Epidemiology; Female; Hemagglutination; Hong Kong; Humans; Neoplasms; Oxytetracycline; Pasteurella; Pasteurella Infections; Penicillins; Peptic Ulcer Perforation; Peritoneal Cavity; Streptomycin; Uterine Cervical Neoplasms; Zoonoses

Topics: Blood; gamma-Globulins; Glycoproteins; Hepatectomy; Hyperplasia; Hypertrophy; Kidney Diseases; Liver Diseases; Necrosis; Neoplasms; Neoplasms, Experimental; Oxytetracycline; Rats; Research; Wounds and Injuries

Topics: Animals; Anti-Bacterial Agents; Carcinoma; Carcinoma, Ehrlich Tumor; Fluorescence; Fluorescent Dyes; Humans; Mice; Microscopy; Microscopy, Fluorescence; Neoplasms; Neoplasms, Experimental; Oxytetracycline; Rats; Research; Tetracycline

Topics: Bronchiectasis; Bronchitis; Carcinoma, Bronchogenic; Fluorescence; Humans; Lung Diseases; Neoplasms; Oxytetracycline; Pulmonary Emphysema; Tetracycline

Topics: Bronchi; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Diagnosis, Differential; Humans; Neoplasms; Oxytetracycline; Pneumonia

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Chlortetracycline; Dermatologic Agents; Neoplasms; Oncogenic Viruses; Oxytetracycline; Viruses

Topics: Anti-Bacterial Agents; Neoplasms; Oxytetracycline; Penicillins