oxytetracycline--anhydrous and Nausea

Augmentin and oxytetracycline were compared in the treatment of chest infections in general practice in an investigator-blind study of 748 patients randomly allocated to 7 days' treatment with standard doses of either Augmentin or oxytetracycline. Significantly more patients treated with Augmentin had a good overall response to therapy both at day 7 (P less than 0.001) and at day 14 (P less than 0.01). The differences between treatments were less marked for individual signs and symptoms of lower respiratory tract infections, due to smaller numbers of patients with any particular symptom. Augmentin, however, was significantly more effective than oxytetracycline in the resolution of chest pain at day 7 (P less than 0.025) and cough at day 14 (P less than 0.005). Sputum purulence was also cleared more effectively by Augmentin by day 14 (P less than 0.001). Both treatments were well tolerated, with no significant difference between treatments in the small number of adverse events. Augmentin has been shown to be an effective, well tolerated treatment for chest infections, superior to oxytetracycline in efficacy and possibly in speed of resolution of clinical symptoms.

Topics: Adolescent; Adult; Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Clavulanic Acids; Clinical Trials as Topic; Diarrhea; Drug Combinations; Humans; Middle Aged; Nausea; Oxytetracycline; Random Allocation; Respiratory Tract Infections; Sputum

Topics: Administration, Oral; Adult; Amines; Clinical Trials as Topic; Doxycycline; Follow-Up Studies; Gonorrhea; Humans; Male; Microbial Sensitivity Tests; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Penicillins; Time Factors; Urethra; Urethritis; Vomiting

Seven cases are reported in which drugs of the tetracycline group produced a fall in the glomerular filtration rate. In six patients there was a primary underlying renal disease and renal impairment. All seven patients were made seriously ill by the antibiotic. Two patients required immediate haemodialysis; one died and the other continued on dialysis until transplanted. Another patient initially responded to intravenous fluids and protein restriction but his renal function deteriorated and four months later he began maintenance haemodialysis. Three patients required peritoneal dialysis. The seventh patient responded satisfactorily to conservative management. The medical and medicolegal complications arising from the use of tetracycline in patients with renal disease are discussed. Yet another plea is made that drugs of the tetracycline group other than doxycycline should not be given to patients with chronic renal failure.

Topics: Adult; Aged; Body Weight; Creatinine; Diarrhea; Dietary Proteins; Female; Glomerular Filtration Rate; Humans; Infusions, Parenteral; Kidney Failure, Chronic; Male; Middle Aged; Nausea; Oxytetracycline; Peritoneal Dialysis; Renal Dialysis; Tetracycline; Urea; Vomiting

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Doxycycline; Drug Resistance, Microbial; Follow-Up Studies; Gonorrhea; Humans; Male; Middle Aged; Milk; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Recurrence; Streptomycin; Sulfisoxazole; Urethritis; Vomiting

Topics: Administration, Oral; Adolescent; Adult; Animals; Doxycycline; Drug Resistance, Microbial; Female; Gonorrhea; Humans; Middle Aged; Milk; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Streptomycin; Sulfonamides; Treponema pallidum; Vomiting

Topics: Antacids; Humans; Nausea; Oxytetracycline; Vomiting