oxytetracycline--anhydrous and Liver-Diseases

Topics: Administration, Oral; Anesthesia, General; Animals; Anti-Bacterial Agents; Cats; Cattle; Cattle Diseases; Chloramphenicol; Drug Interactions; Escherichia coli Infections; Horse Diseases; Horses; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Liver Diseases; Oxytetracycline; Penicillin G; Penicillin Resistance; Postoperative Complications; Salmonella Infections, Animal; Streptococcus; Substance-Related Disorders; Sulfonamides; Urinary Tract Infections

Topics: Ampicillin; Antitubercular Agents; Asparaginase; Chemical and Drug Induced Liver Injury; Chloramphenicol; Chlortetracycline; Erythromycin; Griseofulvin; Humans; Liver Diseases; Methicillin; Oleandomycin; Oxytetracycline; Penicillins; Rifampin; Tetracycline

Topics: Anti-Bacterial Agents; Bone and Bones; Chlortetracycline; Demeclocycline; Gastroenterology; Liver Diseases; Metabolism; Nitrogen; Oxytetracycline; Photosensitivity Disorders; Protein Synthesis Inhibitors; Tetracycline; Tooth; Toxicology

Naringenin is a naturally occurring citrus flavanone, which has been reported to have a wide range of pharmacological properties. The present work was carried out to evaluate the effect of naringenin on antioxidant and lipid peroxidation status in liver of oxytetracycline-intoxicated rats. Intraperitonial administration of oxytetracycline 200 mg/kg for 15 days resulted a significant elevation in serum hepatospecific markers such as aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, and bilirubin and the levels of lipid peroxidation markers (thiobarbituric acid reactive substances (TBARS) and lipid hydroperoxides) in liver. Oxytetracycline also caused a significant reduction in the activities of superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione (GSH), vitamin C and vitamin E in liver. Oral administration of naringenin (50 mg/kg b.w.t.) with oxytetracycline significantly decreased the activities of serum aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and the levels of bilirubin along with significant decrease in the levels of lipid peroxidation markers in the liver. In addition, naringenin significantly increased the activities of superoxide dismutase, catalase and GSH peroxidase as well as the level of GSH, vitamin C and vitamin E in liver of the oxytetracycline-treated rats. Our results demonstrate that naringenin exhibited antioxidant property and decrease the lipid peroxidation against oxytetracycline-induced oxidative stress in liver.

Topics: Animals; Anti-Bacterial Agents; Antioxidants; Catalase; Chemical and Drug Induced Liver Injury; Flavanones; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Liver; Liver Diseases; Male; Oxidative Stress; Oxytetracycline; Rats; Rats, Wistar; Superoxide Dismutase

Topics: Aflatoxin B1; Aflatoxins; Ampicillin; Animals; Anti-Bacterial Agents; Carcinogens; Ditiocarb; Drug Therapy, Combination; Goats; Liver Diseases; Male; Oxytetracycline; Premedication; Stanozolol; Sulfadimethoxine; Thiocarbamates

Topics: Aflatoxin B1; Aflatoxins; Animals; Carcinogens; Charcoal; Drug Therapy, Combination; Goats; Liver Diseases; Male; Oxytetracycline; Stanozolol

Turkeys were given oxytetracycline (OTC) as a feed supplement at levels of 0 g, 50 g, and 200 g OTC per ton of feed. After 8, 16, and 18 weeks the birds were sacrificed and bacteria were isolated from heart blood and liver tissue. When these isolates were tested for resistance against eight antibiotics, a direct correlation was observed between the level of supplement and the level of antibiotic resistance in the bacterial isolates. In postmortem studies on the livers from birds consuming both levels of OTC, an increase in the occurrence of lesions was observed. The livers from control birds appeared to have more granulomas.

Topics: Animal Feed; Animals; Drug Resistance, Microbial; Food, Fortified; Liver; Liver Diseases; Male; Oxytetracycline; Poultry; Poultry Diseases; Turkeys

Topics: Biotransformation; Coumarins; Creatinine; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseases; Oxytetracycline; Phenylbutazone; Pyrimidines; Sulfonic Acids

Topics: Bacteriological Techniques; Brucellosis; Child; Chloramphenicol; Complement Fixation Tests; Diagnosis; Epidemiology; Europe; Humans; Joint Diseases; Liver Diseases; Meningitis; Neuritis; Oxytetracycline; Serologic Tests

Topics: Adrenocorticotropic Hormone; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis; Child; Classification; Dexamethasone; Liver Diseases; Niacin; Nicotinic Acids; Oxytetracycline; Pathology; Prednisone; Spleen; Streptomycin; Toxicology; Tuberculosis

Topics: Acidosis; Cesarean Section; Fatty Liver; Female; Hematemesis; Humans; Hypoproteinemia; Hypotension; Hysterectomy; Jaundice; Liver Diseases; Melena; Oxytetracycline; Pathology; Placenta Previa; Pneumonia; Postpartum Hemorrhage; Postpartum Period; Pregnancy; Pregnancy Complications; Tetracycline; Toxicology

Topics: Blood; gamma-Globulins; Glycoproteins; Hepatectomy; Hyperplasia; Hypertrophy; Kidney Diseases; Liver Diseases; Necrosis; Neoplasms; Neoplasms, Experimental; Oxytetracycline; Rats; Research; Wounds and Injuries

Topics: Biliary Tract; Disease; Gallbladder Diseases; Hepatic Duct, Common; Humans; Liver Diseases; Oxytetracycline

Topics: Biochemical Phenomena; Chloramphenicol; Liver Diseases; Metabolism; Nitrogen; Oxytetracycline

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Chlortetracycline; Liver Diseases; Oxytetracycline; Penicillins

Topics: Hepatic Insufficiency; Humans; Liver Diseases; Oxytetracycline; Postoperative Period

Topics: Chemical and Drug Induced Liver Injury; Chlortetracycline; Chronic Disease; Fatty Liver; Liver Diseases; Oxytetracycline