oxytetracycline--anhydrous and Leg-Length-Inequality

In this study, the changes in longitudinal bone growth and metaphyseal modeling induced by middiaphyseal periosteal stripping in the rat femur were analyzed by means of histomorphometrical techniques. One hundred forty-four male 30-day-old Sprague-Dawley albino rats distributed in 4 groups of 36 were studied: a control group, a sham group, a group with middiaphyseal right femoral periosteal stripping, and a group with a polyethylene ring wrapped around the stripped zone. The animals were euthanized at 1, 2, or 4 weeks from the start of the experiment, after double tetracycline labeling. A statistically significant, albeit small, longitudinal overgrowth of stripped femurs was observed after a latency period of 2 to 4 weeks. The metaphyseal diameters were greater in stripped femurs than nonstripped femurs. This finding was associated with a lower osteoclastic index in the external metaphyseal surface and with a lower bone formation rate in the internal surface of the metaphyseal cortex. These latter findings have not been reported previously in the literature and may support the role of the periosteum in controlling metaphyseal modeling.

Topics: Animals; Bone Remodeling; Diaphyses; Femur; Leg Length Inequality; Male; Oxytetracycline; Periosteum; Rats; Rats, Sprague-Dawley

Topics: Altitude; Animals; Body Temperature; Bone Development; Carbon Dioxide; Cartilage; Child; Hindlimb; Humans; Hyperbaric Oxygenation; Leg Length Inequality; Nitrogen; Oxygen; Oxytetracycline; Partial Pressure; Rabbits; Regional Blood Flow; Statistics as Topic; Time Factors