oxytetracycline--anhydrous and Kidney-Diseases

Topics: Administration, Oral; Anesthesia, General; Animals; Anti-Bacterial Agents; Cats; Cattle; Cattle Diseases; Chloramphenicol; Drug Interactions; Escherichia coli Infections; Horse Diseases; Horses; Humans; Hydrogen-Ion Concentration; Kidney Diseases; Liver Diseases; Oxytetracycline; Penicillin G; Penicillin Resistance; Postoperative Complications; Salmonella Infections, Animal; Streptococcus; Substance-Related Disorders; Sulfonamides; Urinary Tract Infections

Topics: Absorption; Acne Vulgaris; Bacteria; Bacteriuria; Bronchial Diseases; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemistry; Chlortetracycline; Demeclocycline; Drug Eruptions; Humans; Infections; Kidney Diseases; Methacycline; Oxytetracycline; Protein Binding; Tetracycline; Tooth Discoloration

Tetracyclines have been used as in vivo indicators of new bone formation because they form complexes with mineral at bone-forming surfaces. Four of 12 dogs in a bone-labeling study developed clinical signs of renal disease (vomiting, diarrhea, dehydration, and azotemia) within 1 to 2 days of receiving oxytetracycline at a bone-labeling dose of 25 mg/kg of body weight, once daily for 2 consecutive days. To delineate the relationship between oxytetracycline administration and renal damage, six dogs were given the bone-labeling dose intravenously and were subsequently evaluated by determination of clinical signs, serum biochemical analysis, urinalysis, and histologic examination (experiment 1). Drug administration was modified in the five dogs remaining in the bone-labeling orthopedic study. These dogs received the oxytetracycline dose as a slow intravenous infusion diluted with 250 ml of lactated Ringer's solution (experiment 2). All six dogs of experiment 1 developed persistent isosthenuria within 2 days of receiving the bone-labeling dose of oxytetracycline. Clinical illness (three of six dogs) was associated with azotemia, creatinemia, and hyperphosphatemia. All dogs had multifocal, mild to moderate flattening of renal tubular epithelium, characteristic of nephrosis. None of the dogs of experiment 2 developed any clinical indications of renal disease, and the only biochemical abnormality was isosthenuria in two of the five dogs. Thus the development of clinical signs and biochemical abnormalities associated with the intravenous administration of oxytetracycline was obviated by the slow administration of a dilution of the calculated bone-labeling dose of the antibiotic.

Topics: Animals; Anti-Bacterial Agents; Blood Urea Nitrogen; Bone and Bones; Creatinine; Dogs; Injections, Intravenous; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Nephrosis; Oxytetracycline; Phosphorus; Specific Gravity

Topics: Animals; Dog Diseases; Dogs; Kidney Diseases; Oxytetracycline

Topics: Biotransformation; Coumarins; Creatinine; Humans; Hypoglycemic Agents; Kidney Diseases; Liver Diseases; Oxytetracycline; Phenylbutazone; Pyrimidines; Sulfonic Acids

Topics: Anti-Bacterial Agents; Humans; Infant; Infant, Newborn; Kidney; Kidney Diseases; Methicillin; Oxytetracycline

Topics: Alanine Transaminase; Aspartate Aminotransferases; Blood Urea Nitrogen; Creatinine; Humans; Kidney Diseases; Kidney Failure, Chronic; Kidney Function Tests; Liver; Oxytetracycline

Topics: Adolescent; Adult; Aged; Bacteria; Chronic Disease; Female; Humans; Kidney Diseases; Male; Middle Aged; Oxytetracycline; Urinary Tract Infections

Topics: Bacteriuria; Carcinoma, Squamous Cell; Female; Genital Diseases, Female; Humans; Hysterectomy; Kidney Diseases; Kidney Function Tests; Neomycin; Oxytetracycline; Postoperative Complications; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Infectious; Pyelonephritis; Uterine Cervical Neoplasms

Topics: Acute Kidney Injury; Adult; Aged; Anuria; Creatinine; Drug Therapy; Female; Glomerular Filtration Rate; Humans; Kidney Diseases; Kidney Failure, Chronic; Male; Middle Aged; Oxytetracycline; Renal Dialysis

Topics: Glomerular Filtration Rate; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Oxytetracycline; Uremia

Topics: Adolescent; Adult; Animals; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Demeclocycline; Dogs; Female; Humans; Kidney Diseases; Male; Methacycline; Oxytetracycline; Photosensitivity Disorders; Pregnancy; Tetracycline; Tooth Calcification; Tooth Discoloration

Topics: Alkaline Phosphatase; Animals; Histocytochemistry; Kidney; Kidney Diseases; Oxytetracycline; Penicillins; Rabbits; Rats; Streptomycin

Topics: Child; Cystoscopy; Humans; Infant; Kanamycin; Kidney Diseases; Methenamine; Nitrofurantoin; Oxytetracycline; Pyelonephritis; Sulfisoxazole; Surgical Procedures, Operative; Urinary Bladder Neck Obstruction; Urography; Vesico-Ureteral Reflux

Topics: Anti-Bacterial Agents; Black People; Chemical and Drug Induced Liver Injury; Chlortetracycline; Demeclocycline; Female; Hepatitis; Hepatitis A; Humans; Kidney Diseases; Liver; Maternal-Fetal Exchange; Oxytetracycline; Pharmacology; Pregnancy; Pregnancy Complications; Tetracycline; Tetracyclines; Tooth; Toxicology; Urine

Topics: Blood; gamma-Globulins; Glycoproteins; Hepatectomy; Hyperplasia; Hypertrophy; Kidney Diseases; Liver Diseases; Necrosis; Neoplasms; Neoplasms, Experimental; Oxytetracycline; Rats; Research; Wounds and Injuries

A strain of Leptospira zanoni was used to produce chronic renal infections in young white mice. A variant of this strain produced an acute disease with over 50% mortality. The responses of both forms of disease to chemotherapy were studied. When treatment of the acute disease was initiated before jaundice occurred, suitable single doses of streptomycin, chlortetracycline, tetracycline, erythromycin, oxytetracycline and oxytetracycline (in oil) prevented death and chronic renal infection in a high percentage of mice. Bicillin, a long-acting penicillin preparation, was more effective than other penicillins, but it prevented the development of chronic renal infection in only half the treated mice. Streptomycin was the only antibiotic of which a single administration regularly cured the chronic renal infections: chlortetracycline, tetracycline and oxytetracycline (in oil) were partially effective. Oxytetracycline, chloramphenicol, Bicillin, fortified penicillin, procaine penicillin and potassium penicillin had no permanent action. The suitability of mice as laboratory animals in the study of experimental leptospirosis and the need for complete cure of carriers of chronic renal infection are emphasized. The above findings indicate that streptomycin is the drug of choice for the treatment of leptospirosis in animals, and that it is worthy of further trial in man.

Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chloramphenicol; Chlortetracycline; Erythromycin; Kidney Diseases; Leptospira; Leptospirosis; Mice; Oxytetracycline; Penicillin G Benzathine; Penicillins; Streptomycin; Tetracycline