oxytetracycline--anhydrous and Infertility--Female

The occurrence of Chlamydophila abortus in female camels affected with ovarian hydrobursitis and a trial for medical treatment were studied. A total of 111 cases were included in two experiments. In Experiment 1, sera from 51 affected cases were tested for C. abortus antibody using enzyme-linked immunosorbent assay (ELISA). In Experiment 2, 60 female camels affected with bilateral ovarian hydrobursitis were divided into treated and control groups (n = 30 each). Based on the bursal diameter, females of both groups were subdivided into those having small (< 5 cm), medium (5-7 cm) or large (> 7 cm) bursae. Treated group received 20 mg/kg body weight oxytetracycline intramuscular, 4% lotagen intrauterine, and 500 μg cloprostenol intramuscular. Controls did not receive any treatment. All females were observed for 90 days non-return rate (NRR) and calving rate (CR). Antibodies against C. abortus were observed in 44/51 (86.3%) of the affected females. The 90 days NRR of the treated and control groups were 13/30 (43.3%) and 0/30 (0.0%), respectively, (P = 0.001), while the CR were 10/30 (33.3%) and 0/30 (0.0%), respectively, (P = 0.01). Based on bursal size, the 90 days NRR were 11/15 (73.3%), 2/7 (28.6%) and 0/8 (0.0%) for treated females having small, medium and large bursa, while the CR were 9/15 (60%), 1/7 (14.3%), and 0/8 (0.0%), respectively, (P = 0.01). In conclusion, it seems that C. abortus may be responsible for the spreading of the ovarian hydrobursitis syndrome in dromedaries. Small sized bursa could be medically treated.

Topics: Animals; Anti-Bacterial Agents; Antibodies, Bacterial; Camelus; Chlamydophila; Chlamydophila Infections; Cloprostenol; Cresols; Drug Combinations; Female; Formaldehyde; Infertility, Female; Luteolytic Agents; Ovarian Diseases; Oxytetracycline

A prospective clinical trial was conducted on 2 large dairies in the San Joaquin Valley of California to determine whether a single intrauterine infusion with procaine penicillin G or oxytetracycline reduced the calving-to-conception interval in cows with endometritis. Cows with endometritis were randomly assigned to a treatment or a control group. The uterus of treated cows on 1 dairy was infused with 0.8 to 1.0 million U of procaine penicillin G in 40 ml of sterile water, and the uterus of treated cows on the other dairy was infused with 500 mg of oxytetracycline in 20 ml of sterile water, both of which were typical doses used on dairies in the area. A difference was not observed in the cumulative proportion of cows remaining nonpregnant between 87 penicillin-treated and 77 control cows on the 1 dairy (P = 0.356), or between 74 oxytetracycline-treated and 62 control cows on the other dairy (P = 0.174). Results suggest that routine infusion of antibiotics to treat endometritis, as commonly practiced, may not be efficacious.

Topics: Animals; Cattle; Cattle Diseases; Endometritis; Female; Infertility, Female; Infusions, Parenteral; Oxytetracycline; Penicillin G Procaine; Pregnancy; Time Factors; Uterus

The efficacy of oxytetracycline (OTC) alone or combined with streptomycin in the treatment of 118 Najdi ewes believed to have been naturally infected with Brucella melitensis, was evaluated by culture of selected tissues and organs at slaughter. Groups of sheep were given 250, 500 or 1,000 mg of OTC intraperitoneally (i/p) daily for six weeks and in the respective groups at necropsy 52, 69 and 100% of sheep were found to be Brucella-free. Treatment with 250 mg OTC (daily for six weeks i/p) combined with 1,000 mg streptomycin (daily for three weeks intramuscularly) increased the percentage of Brucella-free sheep to 82%. When a group of sheep were each inoculated i/p with 1,000 mg of long-acting OTC every three days over a period of six weeks, 75% of them were Brucella-free at necropsy. B. melitensis was isolated from all (24) non-treated (control) sheep. The results showed that long-term treatment with a high dose of OTC alone had succeeded in eliminating B. melitensis from a group of 16 naturally infected sheep.

Topics: Abortion, Veterinary; Animals; Brucellosis; Drug Therapy, Combination; Female; Infertility, Female; Oxytetracycline; Pregnancy; Pregnancy Complications, Infectious; Random Allocation; Sheep; Sheep Diseases; Streptomycin

Topics: Animals; Anti-Infective Agents, Local; Colistin; Dihydrostreptomycin Sulfate; Female; Genital Diseases, Female; Gentamicins; Horse Diseases; Horses; Hydrocortisone; Infertility, Female; Nitrofurantoin; Novobiocin; Oxytetracycline; Penicillin G; Penicillin G Procaine; Penicillins; Polymyxins; Povidone; Pregnancy; Pregnancy, Animal; Pseudomonas Infections

Topics: Animals; Anti-Bacterial Agents; Aspergillus; Breeding; Cattle; Cattle Diseases; Cervix Mucus; Female; Fertility; Humans; Infections; Infertility; Infertility, Female; Microbiology; Oxytetracycline; Staphylococcus; Statistics as Topic; Streptococcus; Uterus; Vibrio

Topics: Female; Health Services; Humans; Infertility; Infertility, Female; Oxytetracycline; Research; Suppositories