oxytetracycline--anhydrous and Hemorrhagic-Disorders

A 10-month-old ram with fever, inappetence and haemorrhagic diathesis had petechiae and ecchymoses at various body sites and was infested by ticks. Haematological examination revealed pancytopenia, while serum biochemistry indicated hepatic dysfunction. Blood smears were negative for Ehrlichia spp. and other haemoparasites. Paired sera revealed infection by Anaplasma phagocytophilum, but testing by polymerase chain reaction was negative. Treatment with oxytetracycline was effective. This is the first reported clinical case of ovine anaplasmosis in Greece caused by A. phagocytophilum.

Topics: Anaplasma phagocytophilum; Animals; Anti-Bacterial Agents; Ehrlichiosis; Hemorrhagic Disorders; Male; Oxytetracycline; Sheep; Sheep Diseases; Tick Infestations; Ticks; Treatment Outcome

Based on literature and on the results of this open clinical trial we conclude, that there is no connection between application of the above named group of drugs and the change in parameters of haemostasis function, which might lead to a manifest haemorrhagic diathesis. Within the period surveyed of 14 days no case of induced coagulopathy and particularly no thrombocytopenia was seen. The substances under consideration themselves did not exert any anticoagulatory effect nor did they potentiate or inhibit the effect of a concurrently given cumarin derivative.

Topics: Ambroxol; Blood Coagulation; Bromhexine; Drug Combinations; Hemorrhagic Disorders; Humans; Oxytetracycline; Thrombocytopenia

Topics: Female; Hemorrhagic Disorders; Humans; Middle Aged; Oxytetracycline; Pneumonia