oxytetracycline--anhydrous and Granuloma

The effect of acute inflammation on oxytetracycline (OTC) distribution was studied in a tissue cage model in calves. An acute inflammatory reaction was induced in tissue cages by injecting lipopolysaccharide (LPS) from Salmonella typhimurium. The distribution of OTC to tissue cage fluid (TCF) was also compared with distribution to fluid from granuloma pouches (GPF). Tissue from LPS-injected cages showed histological changes indicating an acute inflammatory reaction. Concentrations of OTC were higher in LPS cages than in controls; at 1, 2, 4 and 10 h the difference was statistically significant (P less than 0.05). Numerically the overall elimination rate constant (kel) was larger, elimination half-life (t1/2) shorter, peak concentration (Cmax) higher, and time of peak concentration (Tmax) shorter in LPS cages than in controls. The area under the curve (AUC) of OTC was greater and the ratio AUCTCF/AUCserum was higher in LPS cages than in controls. Although statistically significant differences were not found for all the pharmacokinetic parameters, it was concluded that distribution to and elimination from LPS cages were both faster than in controls. Concentration-time profiles of OTC were similar in TCF and GPF in that concentrations were lower and elimination was more prolonged than in serum. Levels were higher in GPF than in TCF up to 3 h after injection; thereafter the relationship was reversed. Distribution to and elimination processes from GPF appeared to be faster than from TCF as numerically kel was higher, t1/2 shorter and Tmax shorter in GPF than in TCF. It was concluded that the granuloma pouch model and the tissue cage model have similarities in distribution and elimination patterns and that differences are most probably due to differences in the ratio of the surface area to the volume.

Topics: Acute Disease; Animals; Cattle; Cattle Diseases; Diffusion Chambers, Culture; Granuloma; Inflammation; Injections, Intravenous; Lipopolysaccharides; Oxytetracycline; Tissue Distribution

The results of the oxytetracycline therapy given orally to 26 patients with severe papulopustular rosacea are presented. The biopsies were taken at the most typical sites. In 19 out of 26 patients the pathological changes characteristic of papulopustular rosacea were found. In 7 out of 26 patients epitheloid granulomas without central caseation were histologically observed. In these 7 patients tuberculosis was excluded (the absence of other tuberculous stigmata, normal laboratory data). Tetracycline (oxytetracycline) was given orally to 26 patients. One month later, a remarkable clinical improvement could be seen, i.e. the papules and pustules disappeared in all 26 patients and the recurrence of the disease could not be noticed in any patient during a 2.5-year-observation period. As no signs of tuberculosis could be detected in these patients, the authors believe that rosaceiform changes with epitheloid granulomas should be systematized in rosacea as "rosacea-like eruptions". A good therapeutic response of "rosacea-like eruptions" to tetracyclines could possibly confirm the authors' hypothesis.

Topics: Adult; Aged; Facial Dermatoses; Granuloma; Humans; Middle Aged; Oxytetracycline; Rosacea

Topics: Adolescent; Adult; Aged; Diagnosis, Differential; Female; Granuloma; Humans; Middle Aged; Oxytetracycline; Rosacea; Sarcoidosis; Skin Diseases

Topics: Adult; Dermatitis; Female; Granuloma; Humans; Orbital Diseases; Oxytetracycline; Sarcoidosis

Topics: Catheterization; Edema; Eyelid Neoplasms; Female; Granuloma; Humans; Hydrocortisone; Lacrimal Duct Obstruction; Oils; Oxytetracycline

Topics: Granuloma; Humans; Laryngoscopy; Oxytetracycline; Postoperative Complications; Pseudomonas Infections; Staphylococcal Infections; Surgical Wound Infection; Tomography; Tomography, X-Ray Computed; Tracheal Stenosis; Tracheotomy

Topics: Candida; Candidiasis; Diethylstilbestrol; Granuloma; Humans; Oxytetracycline; Phenols