oxytetracycline--anhydrous and Genital-Diseases--Male

Rams shedding Brucella ovis in semen but without palpable abnormalities of the epididymides were treated with long-acting oxytetracycline for 15 days and dihydrostreptomycin for 7 days (n = 9) or conventional oxytetracycline and dihydrostreptomycin (n = 9) for 7 days. Nine rams were not treated. More treated rams were considered to have satisfactory breeding soundness examination results at posttreatment weeks 3, 7, 12, and 19. Nontreated rams continued to shed B ovis in semen. After treatment, B ovis was not recovered from 78% of rams given long-acting oxytetracycline and dihydrostreptomycin or from 89% of rams given conventional oxytetracycline and dihydrostreptomycin. At week 21, all rams were euthanatized, and specimens of the testes and epididymides were bacteriologically cultured for B ovis. Brucella ovis was not recovered from the testes of rams or from the epididymides from rams not shedding the organism in the semen. In one treated ram, B ovis was recovered from the semen but not from other tissues. All rams remained ELISA-positive, with the exception of 2 treated rams that ceased shedding B ovis in semen immediately after treatment was started; both these rams became ELISA-negative on the last examination at week 19.

Topics: Animals; Antibodies, Bacterial; Breeding; Brucella; Brucellosis; Delayed-Action Preparations; Dihydrostreptomycin Sulfate; Epididymis; Genital Diseases, Male; Genitalia, Male; Leukocyte Count; Male; Oxytetracycline; Random Allocation; Semen; Sheep; Sheep Diseases; Sperm Motility; Testis

Topics: Adolescent; Adult; Chlamydia Infections; Drug Combinations; Drug Therapy, Combination; Erythromycin; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Middle Aged; Mycoplasma Infections; Oxytetracycline; Sulfones; Uracil; Ureaplasma; Urinary Tract Infections

Topics: Animals; Anti-Bacterial Agents; Diterpenes; Drug Therapy, Combination; Female; Genital Diseases, Female; Genital Diseases, Male; Injections, Intramuscular; Male; Mycoplasmatales Infections; Oxytetracycline; Sheep; Sheep Diseases; Ureaplasma; Urologic Diseases

Topics: Disease; Genital Diseases, Male; Humans; Male; Oxytetracycline; Prostatitis; Seminal Vesicles