oxytetracycline--anhydrous and Femoral-Fractures

Osteotomies of distal femur were fixed by intraosseous self-reinforced poly-L-lactic acid (SR-PLLA) plates in 29 adult rabbits. The follow-up times were from 3 to 24 weeks. After sacrifice, radiological, histological, microradiographic, and oxytetracycline fluorescence studies were performed. Although radiographically no redisplacements were found, in 12 weeks two fixations were broken and a fibrotic nonunion was observed in one case. At 24 weeks full bone consolidation was seen in all except one osteotomy. No foreign-body reactions were observed. The present article is the first report on successful application of absorbable plates for intraosseous fixation of weight-bearing bone osteotomies. The present investigation demonstrated that the SR-PLLA plates were suitable for the fixation of cancellous bone osteotomies in rabbits.

Topics: Animals; Anti-Bacterial Agents; Female; Femoral Fractures; Femur; Fracture Fixation; Male; Materials Testing; Osteotomy; Oxytetracycline; Polyesters; Prostheses and Implants; Rabbits

The absorption, biocompatibility, and fixation properties of self-reinforced (SR) poly-L-lactic acid (PLLA) and poly-DL-lactic acid (PDLLA) were investigated in cancellous bone in 56 rats. Osteotomies of the distal femur were operatively fixed with cylindrical implants made of SR-PLLA and SR-PDLLA/PLLA (40 PDLLA:60 PLLA). The follow-up times were one, three, six, 12, 24, 36, and 48 weeks. Roentgenographic, microradiographic, histologic, histomorphometric, and oxytetracycline-labeling studies were done. Histologically, there was no evidence of inflammation or foreign-body reaction in the bony tissues. Histomorphometric analysis showed that absorption in the SR-PDLLA/PLLA implant was faster than in the SR-PLLA implant. Absorption started peripherally in the implants and continued with subsequent replacement by new bone. At 48 weeks the implant was completely surrounded by a layer of new bone. The SR-PLLA and SR-PDLLA/PLLA implants were visible in all specimens during the 48-week follow-up period. Ninety-five percent of the osteotomies were consolidated. Implants made of SR polylactic acid in rats proved to be biocompatible and slowly absorbable, and they possessed sufficient mechanical properties for fixation of osteotomies.

Topics: Absorption; Animals; Biocompatible Materials; Drug Implants; Femoral Fractures; Femur; Lactates; Lactic Acid; Microradiography; Osteotomy; Oxytetracycline; Polyesters; Polymers; Prostheses and Implants; Rats

Topics: Adult; Aged; Arthritis, Rheumatoid; Bone Matrix; Cadaver; Cartilage, Articular; Female; Femoral Fractures; Femoral Neck Fractures; Femur Head; Fractures, Spontaneous; Humans; Male; Microscopy, Fluorescence; Middle Aged; Osteoarthritis; Oxytetracycline

Topics: Acrylic Resins; Animals; Bone Regeneration; Dogs; Femoral Fractures; Humans; Microscopy, Fluorescence; Oxytetracycline

Topics: Femoral Fractures; Fistula; Fracture Fixation; Humans; Osteomyelitis; Oxytetracycline; Pharmacology; Pseudarthrosis; Radiography; Solubility; Staphylococcal Infections; Toxicology