oxytetracycline--anhydrous and Drug-Hypersensitivity

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bacterial Infections; Cattle; Child; Chlortetracycline; Cross Infection; Drug Hypersensitivity; Drug Resistance, Microbial; Female; Food Preservation; Germ-Free Life; Growth; Humans; Male; Meat; Oxytetracycline; Public Health; Rats; Sulfonamides; Time Factors

Topics: Administration, Oral; Adolescent; Adult; Demeclocycline; Doxycycline; Drug Hypersensitivity; Gonorrhea; Humans; Injections, Intramuscular; Male; Middle Aged; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G Procaine; Penicillin Resistance; Tetracycline

Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Hypersensitivity; Female; Humans; Injections, Intravenous; Male; Middle Aged; Oxytetracycline; Peritonitis; Staphylococcal Infections; Streptococcal Infections; Surgical Wound Infection

Toxicity of tetracyclines was studied experimentally on different species of laboratory animals. It was shown that tetracycline, oxytetracycline and chlortetracycline were close by their chemical structure and physico-chemical properties, as well as by the main toxicity parameters, i.e. acute toxicity, cumulative activity, skin-irritating and sensitizing effect. Under the conditions of subacute experiments the above 3 antibiotics induced evenly pronounced one direction changes in animals. The data obtained during the experiments provided recommendation of the level of 0.1 mg/m3 as the maximum allowable concentration (MAC) of oxytetracycline and chlortetracycline, i.e. the same level as the previously recommended for tetracycline.

Topics: Administration, Oral; Animals; Chlortetracycline; Drug Hypersensitivity; Guinea Pigs; Lethal Dose 50; Maximum Allowable Concentration; Mice; Oxytetracycline; Rats; Species Specificity; Tetracycline; Tetracyclines; Time Factors

Topics: Aminopyrine; Cells, Cultured; Drug Hypersensitivity; Fluorescent Antibody Technique; gamma-Globulins; Lectins; Lymphocyte Activation; Lymphocytes; Oxytetracycline; Penicillins; Phenylbutazone; Sulfamethoxypyridazine

Topics: Agranulocytosis; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Hypersensitivity; Female; Humans; Lymphocyte Activation; Middle Aged; Oxytetracycline; Prednisolone

Topics: Administration, Oral; Anemia, Hemolytic; Blood-Brain Barrier; Chlortetracycline; Demeclocycline; Doxycycline; Drug Hypersensitivity; Female; Glucosephosphate Dehydrogenase Deficiency; Gonorrhea; Humans; Injections, Intramuscular; Intestinal Absorption; Male; Methacycline; Minocycline; Oxytetracycline; Penicillins; Tetracycline; Urethritis

Topics: Drug Hypersensitivity; Humans; Lymphocyte Activation; Oxytetracycline; Penicillins; Phenobarbital; Skin Tests; Streptomycin; Sulfadiazine

Topics: Drug Hypersensitivity; Female; Humans; Middle Aged; Oxytetracycline

Topics: Adult; Aminosalicylic Acids; Antitubercular Agents; Cycloserine; Drug Hypersensitivity; Drug Resistance, Microbial; Ethambutol; Ethionamide; Female; Humans; Isoniazid; Kanamycin; Male; Middle Aged; Neomycin; Oxytetracycline; Rifampin; Streptomycin; Thiosemicarbazones; Viomycin

Topics: Allergens; Anti-Bacterial Agents; Antimetabolites; Cells, Cultured; Contrast Media; Drug Hypersensitivity; Humans; Lymphocyte Activation; Lymphocytes; Macrophages; Oxytetracycline; Vasodilator Agents

Topics: Adult; Chloramphenicol; Drug Hypersensitivity; Evaluation Studies as Topic; Female; Humans; Leukocytes; Male; Methods; Oxytetracycline; Penicillins

Topics: Drug Hypersensitivity; Humans; Oral Manifestations; Oxytetracycline; Skin Manifestations

Topics: Child, Preschool; Drug Hypersensitivity; Follow-Up Studies; Glucocorticoids; Humans; Infant; Male; Otitis Media; Oxytetracycline; Skin Tests; Wissler's Syndrome

Topics: Child; Child, Preschool; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Male; Oxytetracycline

Topics: Animal Feed; Animals; Anti-Bacterial Agents; Bacitracin; Cattle; Chlortetracycline; Drug Hypersensitivity; Escherichia coli; Fish Products; Food Additives; Humans; Oleandomycin; Oxytetracycline; Penicillin Resistance; Penicillins; Poultry; Preservation, Biological; Salmonella typhimurium; Swine; Tetracycline

Topics: Administration, Topical; Anti-Inflammatory Agents; Dental Pulp Capping; Dental Pulp Necrosis; Drug Hypersensitivity; Dry Socket; Humans; Hydrocortisone; Oxytetracycline

Topics: Animals; Cecum; Chlortetracycline; Colon, Sigmoid; Cricetinae; Diarrhea; Drug Hypersensitivity; Epithelium; Intestine, Large; Necrosis; Oxytetracycline; Tetracycline; Vascular Diseases

Topics: Child, Preschool; Drug Hypersensitivity; Female; Humans; Male; Oxytetracycline

Topics: Bronchopneumonia; Chloramphenicol; Drug Hypersensitivity; Erythromycin; Geriatrics; Methicillin; Oxytetracycline; Penicillins; Pulmonary Emphysema; Purpura; Pyelonephritis; Streptomycin; Sulfonamides; Toxicology

Topics: Anti-Bacterial Agents; Bacitracin; Chloramphenicol; Chlortetracycline; Dihydrostreptomycin Sulfate; Drug Hypersensitivity; Framycetin; Kanamycin; Neomycin; Oxytetracycline; Penicillins; Skin Tests; Streptomycin; Toxicology; Virginiamycin

Topics: Aminosalicylic Acid; Aminosalicylic Acids; Biopsy; Chemical and Drug Induced Liver Injury; Cycloserine; Drug Hypersensitivity; Ethionamide; France; Hepatitis; Isoniazid; Japan; Kanamycin; Liver Function Tests; Oxytetracycline; Pathology; Prednisone; Streptomycin; Sulfisoxazole; Toxicology; Tuberculosis

Topics: Anti-Bacterial Agents; Chlortetracycline; Drug Hypersensitivity; Oxytetracycline; Penicillins; Polymyxins; Streptomycin