oxytetracycline--anhydrous and Dental-Caries

The effect of early weaning on caries progression, dentin formation, and dentin mineralization was examined in four groups of rats. Two groups received a normal diet and were weaned on day 18 or 21, and another two received a sucrose-rich diet and were weaned on day 18 or 21. At age 35 days the lower molars were sectioned sagittally, and the areas of dentin formation and of the dentinal caries were quantified. The width of the predentin zone was measured from histologically stained sections of maxillary molars. Early weaning reduced dentin formation in the group on the high-sucrose diet only the first days; later this effect was partially caught up with. A high-sucrose diet significantly increased caries frequency and extension of caries lesions compared with a normal diet in both early weaned and normally weaned groups. The effect of early weaning on caries frequency and extension in the high-sucrose group was insignificant compared with the normally weaned group on a high-sucrose diet. The predentin zone was wider in the sucrose groups than in the control groups at the end of the experiment. These results indicate that the effect of sucrose on dentin formation was dependent on the stage of physiologic dentin formation, but early weaning as such did not affect this.

Topics: Analysis of Variance; Animals; Anti-Bacterial Agents; Coloring Agents; Dental Caries; Dental Enamel; Dentin; Dentinogenesis; Diet; Diet, Cariogenic; Dietary Sucrose; Disease Progression; Female; Fluoresceins; Fluorescent Dyes; Male; Molar; Oxytetracycline; Rats; Rats, Sprague-Dawley; Tooth Calcification; Weaning

Female Wistar rats were weaned at the age of 3 weeks and fed for 7 weeks either a high-sucrose diet, a non-cariogenic raw potato-starch diet, a high-sucrose diet with 5% xylitol supplement, a raw potato-starch diet with 5% xylitol supplement or a non-cariogenic, commercial, powdered rat food (Ewos R3) for reference. A low xylitol concentration reduced the progression and severity of carious lesions but did not affect dentine apposition or the width of predentine in rats fed high-carbohydrate diets. Widening of the predentine zone in rats fed a high-sucrose diet might reflect disturbed mineralization, which could not be explained by serum ionized calcium or phosphate ion levels and which could not be corrected by low xylitol concentrations. It is concluded that the reduced area of dentinal carious lesions after low xylitol supplementation is not dependent on dentine formation or mineralization, but rather on direct effects in the mouth.

Topics: Animals; Calcium; Coloring Agents; Dental Caries; Dentin; Dentinogenesis; Diet, Cariogenic; Dietary Carbohydrates; Disease Progression; Female; Oxytetracycline; Phosphates; Phosphorus; Rats; Rats, Wistar; Solanum tuberosum; Starch; Sucrose; Tooth Calcification; Xylitol

Topics: Adolescent; Adult; Calcium Hydroxide; Dental Caries; Dental Pulp; Dental Pulp Capping; Humans; Middle Aged; Oxytetracycline; Zinc Oxide-Eugenol Cement

Topics: Age Factors; Child, Preschool; Dental Caries; Female; Gestational Age; Humans; Infant; Male; Minerals; Oxytetracycline; Pregnancy; Rolitetracycline; Tetracycline; Tooth Abnormalities; Tooth Calcification; Tooth Discoloration; Tooth, Deciduous

Topics: Adolescent; Age Factors; Child; Child, Preschool; Chlortetracycline; Dental Caries; Germany, West; Humans; Infant; Oxytetracycline; Tetracycline; Tooth; Tooth Abnormalities; Tooth Discoloration; Tooth, Deciduous

Topics: Adolescent; Child; Child, Preschool; Chlortetracycline; Cystic Fibrosis; Dental Caries; Female; Fluorescence; Humans; Incisor; Male; Oxytetracycline; Tetracycline; Tooth Calcification; Tooth Discoloration

Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Child; Demeclocycline; Dental Calculus; Dental Caries; Erythromycin; Female; Fluorescence; Humans; Infant; Oxytetracycline; Pregnancy; Tetracycline; Tetracyclines; Tooth, Deciduous; Toxicology

Topics: Animals; Bacteriology; Dental Caries; Face; Mouth; Oxytetracycline; Penicillins; Rats