oxytetracycline--anhydrous and Colonic-Neoplasms

A prospective randomized study on the effects of Enterobiotic (oxytetracycline + neomycin) given per os to patients operated upon electively and curatively for carcinoma coli and recti is presented. 75 patients were treated and 66 were controls. A highly significant reduction of peroperative total and Gram-negative bacterial growth from the bowel was registered and a probably significant reduction of anaerobic bacterial growth. In the whole material a highly significant lower incidence of wound sepsis and intra-abdominal infectious complications occurred in the treated group, compared with the control group. This applies also to the resection material, while the difference is of probable significance in the excision group. 13 of 66 patients died, 8 of septic complications, all in the non-treated group. There was no mortality in the pretreated group. The difference between the noninfected and the infected patient groups was significant as regards the preoperative intraluminal total growth of bacteria and the growth of Gram-negative bacteria. The subsequent non-infected patients show a significantly increased number of cultures not showing any growth of bacteria. No negative side effects of Enterobiotic therapy were noted.

Topics: Adenocarcinoma; Aged; Bacterial Infections; Bacteriological Techniques; Colonic Neoplasms; Drug Combinations; Feces; Female; Humans; Intestines; Intraoperative Care; Male; Neomycin; Oxytetracycline; Postoperative Care; Prospective Studies; Random Allocation; Rectal Neoplasms; Surgical Wound Infection

In the available literature some evidence has been shown, implying that antibiotic prophylaxis in connection with colorectal surgery might increase the frequency of local recurrences of the carcinoma. 134 patients undergoing elective curative surgery of the large bowel have been followed for 20-52 months. 66 patients had been pretreated with Enterobiotic; 68 patients were controls. In our study, we found no difference between the pretreated and non-pretreated group concerning the frequency of anastomotic suture line recurrences or other types of local recurrences in the operation field.

Topics: Adenocarcinoma; Aged; Bacterial Infections; Clinical Trials as Topic; Colon; Colonic Neoplasms; Follow-Up Studies; Humans; Middle Aged; Neomycin; Neoplasm Recurrence, Local; Neoplasm Seeding; Oxytetracycline; Preoperative Care; Random Allocation; Rectal Neoplasms; Risk; Surgical Wound Infection; Tablets

Topics: Adolescent; Adult; Age Factors; Aged; Child; Colectomy; Colon; Colonic Diseases; Colonic Neoplasms; Female; Humans; Male; Middle Aged; Morbidity; Neomycin; Oxytetracycline; Postoperative Care; Postoperative Complications; Preoperative Care; Statistics as Topic; Sulfathiazoles