oxytetracycline--anhydrous and Colitis

Eighteen ponies were inoculated IV with Ehrlichia risticii-infected P388D1 mouse monocyte cells. Twenty-four hours after onset of fever (rectal temperature > 38.8 C), 9 ponies were treated with oxytetracycline (6.6 mg/kg of body weight, IV, q 24 h) for 5 days. The remaining 9 ponies served as infected nontreated controls. Mean scores of the following variables were not significantly different between groups on the day treatment was begun: rectal temperature, diarrhea, borborygmal sounds, feed intake, mental attitude, and evidence of a hyperresonant area in the abdomen. All ponies were observed for progression of clinical signs typical of ehrlichial colitis. Within 12 hours of initiation of treatment, only 1 treated pony had a rectal temperature > 38.8 C and most rectal temperatures were < 38.3 C. In contrast, only 2 control ponies had rectal temperatures < 38.8 C (mean rectal temperature values were significantly, P = 0.01, different between groups). In the treatment group, 4 ponies had no signs of depression after the first day of treatment, and only 1 had signs of depression after the second day of treatment (mean scores between groups were significantly different, P = 0.01). Feed intake remained normal in 4 treated ponies and improved in 4 of the remaining 5 after treatment began. Most of the control ponies had a progressive decrease in their feed intake during the observation period (mean scores between groups were significantly, P = 0.01, different). Three ponies in the control group and 2 ponies in the treatment group developed diarrhea before the treatment observation period began.(ABSTRACT TRUNCATED AT 250 WORDS)

Topics: Animals; Colitis; Ehrlichiosis; Horse Diseases; Horses; Injections, Intravenous; Oxytetracycline

Equine ehrlichial colitis was experimentally induced in 18 ponies, using Ehrlichia risticii-infected blood. Four ponies (group 1) were treated with oxytetracycline (6.6 mg/kg of body weight, IV, q 12 h), beginning 14 hours before inoculation and continuing for 5 days after inoculation. Four additional ponies (group 2) were treated similarly for 10 days after inoculation. The remaining 10 ponies were used as nontreated, infected controls. Clinical disease was delayed in 3 group-1 ponies and in 4 group-2 ponies. Protective immunity developed in the remaining pony that did not develop clinical disease and in 1 group-1 pony and 2 group-2 ponies that developed mild, transient clinical signs.

Topics: Animals; Colitis; Ehrlichia; Horse Diseases; Horses; Oxytetracycline; Rickettsiaceae Infections

Topics: Animals; Colitis; Horse Diseases; Horses; Oxytetracycline

The course run by the disease is described in a horse which showed the symptom complex of colitis X following treatment with oxytetracycline. Disseminated intravascular coagulation was also observed in this horse. The possibility of disseminated intravascular coagulation being part of colitis X is discussed.

Topics: Animals; Colitis; Disseminated Intravascular Coagulation; Horse Diseases; Horses; Male; Oxytetracycline

Topics: Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Child; Colitis; Emulsions; Enema; Female; Humans; Hydrocortisone; Male; Middle Aged; Oxytetracycline

Topics: Colitis; Dysentery, Amebic; Humans; Oxytetracycline

Topics: Adolescent; Anti-Bacterial Agents; Child; Colistin; Colitis; Drug Therapy; Enterocolitis; Erythromycin; Escherichia coli Infections; Gastroenteritis; Oxytetracycline; Staphylococcal Infections

Topics: Amebiasis; Anti-Bacterial Agents; Colitis; Dysentery, Amebic; Entamoebiasis; Oleandomycin; Oxytetracycline; Protein Synthesis Inhibitors; Tetracycline

Topics: Chlortetracycline; Colitis; Oxytetracycline

Topics: Bacteriology; Bronchitis; Colitis; Enteritis; Enterocolitis, Pseudomembranous; Oxytetracycline

Topics: Chloramphenicol; Colitis; Colitis, Ulcerative; Intestinal Diseases; Oxytetracycline; Staphylococcal Infections

Topics: Bacteriology; Colitis; Micrococcus; Oxytetracycline; Staphylococcus

Topics: Chloramphenicol; Colitis; Gastroenteritis; Oxytetracycline

Topics: Colitis; Enteritis; Enterocolitis; Oxytetracycline

Topics: Administration, Oral; Chlortetracycline; Colitis; Oxytetracycline

Topics: Chlortetracycline; Colitis; Irritable Bowel Syndrome; Mucus; Oxytetracycline

Topics: Brucellosis; Colitis; Irritable Bowel Syndrome; Oxytetracycline; Typhoid Fever; Whooping Cough