oxytetracycline--anhydrous and Carcinoma-256--Walker

oxytetracycline--anhydrous has been researched along with Carcinoma-256--Walker* in 1 studies

Other Studies

1 other study(ies) available for oxytetracycline--anhydrous and Carcinoma-256--Walker

Article	Year
Inhibition of mitochondrial protein synthesis leads to proliferation arrest in the G1-phase of the cell cycle. Cancer letters, 1986, Volume: 32, Issue:1 Mitochondrial protein synthesis is specifically inhibited by low concentrations of tetracyclines. Prolonged inhibition of mitochondrial protein synthesis leads to a lack of oxidative ATP generating capacity, which results in proliferation arrest of normal and malignant cells of epithelial origin, as has been shown previously. The present study indicates that this holds true also for fibroblasts and sarcoma cells. It is shown that this proliferation arrest leads to accumulation of the growth-arrested cells in the G1-phase of the cell cycle. This offers several interesting possibilities to use tetracyclines in anticancer combination therapies. Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma 256, Walker; Cell Division; Cells, Cultured; DNA; Doxycycline; Electron Transport Complex IV; Flow Cytometry; Interphase; Male; Mitochondria; Oxytetracycline; Protein Biosynthesis; Rats; Rats, Inbred Strains; Tetracyclines	1986

Article

Year

Inhibition of mitochondrial protein synthesis leads to proliferation arrest in the G1-phase of the cell cycle.

Cancer letters, 1986, Volume: 32, Issue:1

Mitochondrial protein synthesis is specifically inhibited by low concentrations of tetracyclines. Prolonged inhibition of mitochondrial protein synthesis leads to a lack of oxidative ATP generating capacity, which results in proliferation arrest of normal and malignant cells of epithelial origin, as has been shown previously. The present study indicates that this holds true also for fibroblasts and sarcoma cells. It is shown that this proliferation arrest leads to accumulation of the growth-arrested cells in the G1-phase of the cell cycle. This offers several interesting possibilities to use tetracyclines in anticancer combination therapies.

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma 256, Walker; Cell Division; Cells, Cultured; DNA; Doxycycline; Electron Transport Complex IV; Flow Cytometry; Interphase; Male; Mitochondria; Oxytetracycline; Protein Biosynthesis; Rats; Rats, Inbred Strains; Tetracyclines

1986