oxytetracycline--anhydrous and Candidiasis

Irrespective of the microbial agent, group III steroid solution cured external otitis efficiently in a rat model. The addition of antibiotic components to steroid solutions for the treatment of external otitis is of questionable validity.. External otitis, caused by infection with either Pseudomonas aeruginosa or Candida albicans, was established in a rat model and the treatment efficacy of a group III steroid solution was studied.. Three treatments were studied: (i) a group III steroid solution; (ii) a group I steroid combined with two antibiotic components; and (iii) a saline solution. A scoring scale was used to evaluate the characteristics of the ear canal skin. Bacteriological and fungal samples were collected for culturing and ear canal skin biopsies were taken for structural analyses.. It was possible to cause P. aeruginosa and C. albicans infections in an animal model. In the P. aeruginosa-infected animals, only the group III steroid treatment cured all the animals. In the C. albicans-infected animals, group III steroid treatment resolved external otitis faster than the other treatment modalities.

Topics: Administration, Topical; Animals; Anti-Bacterial Agents; Betamethasone; Candidiasis; Colony-Forming Units Assay; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ear Canal; Hydrocortisone; Male; Otitis Externa; Oxytetracycline; Polymyxin B; Pseudomonas Infections; Rats; Treatment Outcome

Topics: Abortion, Therapeutic; Anti-Bacterial Agents; Antibiotic Prophylaxis; Candidiasis; Chlamydia Infections; Female; Humans; Oxytetracycline; Pregnancy; Pregnancy Complications, Infectious

Topics: Amphotericin B; Animals; Candida albicans; Candidiasis; Endometritis; Female; Horse Diseases; Horses; Oxytetracycline

Topics: Candida albicans; Candidiasis; Chloramphenicol; Diarrhea; Diarrhea, Infantile; Dyspepsia; Enterotoxins; Erythromycin; Feces; Humans; Infant; Infant, Newborn; Nystatin; Oxacillin; Oxytetracycline; Staphylococcal Infections; Staphylococcus

Topics: Anti-Bacterial Agents; Bacteria; Candidiasis; Cross Infection; Enterobacter; Female; Haemophilus influenzae; Humans; Klebsiella pneumoniae; Male; Microbial Sensitivity Tests; Mutation; Mycoplasma Infections; Oxytetracycline; Penicillin Resistance; Penicillins; Pneumonia; Staphylococcal Infections; Staphylococcus; Streptococcus pneumoniae; Streptococcus pyogenes; Streptomycin; Tetracycline

Candida albicans, administered by gastric intubation, persisted in the gastrointestinal tract of gnotobiotic mice for long periods but was eliminated within a relatively short period of time in pathogen-free mice. Oxytetracycline administered by mouth had no reproducible effect on the persistence of C. albicans in the gastrointestinal tract of either germ-free or pathogen-free mice. Prolonged administration of streptomycin extended the time that C. albicans could be recovered from feces of pathogen-free mice when compared to mice not receiving the antibiotic or those receiving a single large dose. There was a brief interval of time during which C. albicans could not be recovered from the feces of gnotobiotic mice contaminated with certain intestinal bacteria, but eventually all mice began to shed the fungus again. C. albicans administered by mouth was not pathogenic for germ-free or pathogen-free mice. It can be concluded from these findings that mice do not possess an innate resistance to C. albicans but that pathogen-free mice do possess some ecological mechanism which prevents establishment of the fungus in their gastrointestinal tract. The reason for the difference in colonization of C. albicans in germ-free or gnotobiotic mice and pathogen-free mice was not determined.

Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bacteroides; Candida albicans; Candidiasis; Cecum; Disease Models, Animal; Enterococcus faecalis; Escherichia coli; Feces; Germ-Free Life; Lactobacillus; Lactococcus lactis; Male; Mice; Mice, Inbred ICR; Oxytetracycline; Streptomycin; Time Factors

Topics: Animals; Candida; Candidiasis; Chlortetracycline; Drug Resistance, Microbial; Mice; Oxytetracycline; Tetracycline; Virulence

Topics: Agranulocytosis; Bronchitis; Candidiasis; Drug Therapy; Oxytetracycline; Toxicology; Tuberculosis; Tuberculosis, Pulmonary

Topics: Adrenocorticotropic Hormone; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis; Child; Classification; Dexamethasone; Liver Diseases; Niacin; Nicotinic Acids; Oxytetracycline; Pathology; Prednisone; Spleen; Streptomycin; Toxicology; Tuberculosis

Topics: Acidosis; Alkalosis; Animals; Candida; Candidiasis; Humans; Hydrocortisone; Mice; Oxytetracycline

Forty cases of gonococcal urethritis were treated with oxytetracycline using various dosage schedules; there were 37 cures and three failures. The most convenient and most effective dosage was found to be 250 mg. oxytetracycline, given as a single intramuscular injection of 5 c.c.A series of 40 patients with non-gono-coccal urethritis was also collected. Two cases of urethritis due to Trichomonas vaginalis and two due to Candida albicans were removed from the series. Of the 36 cases which remained, cure was obtained with the use of oxytetracycline in different dosages in 30 cases; six cases were failures. The dosage which gave the best result in the therapy of non-gonococcal urethritis was 250 mg. oxytetracycline (5 c.c.), given as a single intramuscular injection, plus 250 mg. orally, four times a day for four days.The effectiveness of oxytetracycline in the treatment of urethritis has not decreased.

Topics: Candidiasis; Gonorrhea; Humans; Male; Oxytetracycline; Proteus Infections; Pseudomonas Infections; Staphylococcal Infections; Streptococcal Infections; Trichomonas Infections; Trichomonas vaginalis; Urethritis

Topics: Candida albicans; Candidiasis; Candidiasis, Oral; Deglutition Disorders; Esophagitis; Esophagoscopy; Humans; Lung Neoplasms; Nystatin; Oxytetracycline; Penicillins; Speech Disorders; Vocal Cord Paralysis

Topics: Candida albicans; Candidiasis; Colistin; Humans; Infections; Klebsiella; Oxytetracycline; Sepsis; Streptomycin

Topics: Animals; Candidiasis; Cornea; Corneal Ulcer; Cortisone; Eye Infections, Fungal; Lagomorpha; Oxytetracycline; Rabbits; Research; Toxicology

Topics: Burns; Candidiasis; Chloramphenicol; Chlortetracycline; Escherichia coli Infections; Humans; Influenza, Human; Klebsiella; Oximetry; Oxygen Inhalation Therapy; Oxytetracycline; Penicillins; Pneumococcal Infections; Pneumonia; Proteus Infections; Pseudomonas Infections; Staphylococcal Infections; Statistics as Topic; Streptococcal Infections; Streptomycin; Sulfanilamide; Sulfanilamides

Topics: Acetazolamide; Adult; Antifungal Agents; Candida albicans; Candidiasis; Corneal Ulcer; Drug Therapy, Combination; Eye Infections, Fungal; Humans; Iodine Compounds; Male; Middle Aged; Nystatin; Oxytetracycline; Tinea; Trichophyton

Topics: Candida; Candidiasis; Diethylstilbestrol; Granuloma; Humans; Oxytetracycline; Phenols

Topics: Candida; Candidiasis; Chlortetracycline; Disease; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Larynx; Oxytetracycline; Paralysis; Trichomonas Infections; Vagina; Vaginal Diseases

Topics: Anti-Bacterial Agents; Candidiasis; Face; Mouth Diseases; Oxytetracycline; Penicillins; Tongue Diseases