oxytetracycline--anhydrous and Anemia

Topics: Anaplasma marginale; Anaplasmosis; Anemia; Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Erythrocytes; Female; Oxytetracycline

Topics: Anemia; Animals; Anti-Bacterial Agents; Chronic Disease; Female; Immunohistochemistry; Lymph Nodes; Mycoplasma Infections; Oxytetracycline; Sheep; Sheep Diseases; Treatment Outcome

Eperythrozoon suis infection was identified in a pig herd during an investigation into anaemia and low viability in newborn piglets and severe regenerative macrocytic anaemia in older piglets. The organisms were identified in the erythrocytes of piglets a few days old. Extensive investigations failed to detect other causes of the anaemia and low viability. There was no response to parenteral iron administration alone but the piglets' viability and anaemia responded to the administration of tetracyclines. This is the first report of E suis infection in Northern Ireland.

Topics: Anemia; Animals; Animals, Newborn; Anti-Bacterial Agents; Chlortetracycline; Female; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Swine; Swine Diseases

The concentration of hemoglobin, hematocrit, number of erythrocytes and content of iron in the bloodserum of 35 sheep or lambs from five herds in which Eperythrozoon ovis was demonstrated in summer 1994 in bloodsmears by staining with acridinorange are compared with the findings in 70 animals of the same farms which did not suffer from eperythrozoonosis or which were already treated. Sick animals showed significantly lower levels than clinically healthy sheep except for iron. Eperythrozoonosis is characterised by anaemia, poor weight gains or weight reduction. The mortality in lambs reaches up to 28%. Oxytetracyclin was injected subcutaneously for therapy in a single dose of 20 mg/kg bodyweight. Two weeks after treatment the lambs had less clinical symptoms, the ewes needed up to four weeks. Also eggs of trichostronglylids, coccidia, and once of tapeworms were demonstrated and specifically treated. The transmission of the disease and the economic impact are discussed.

Topics: Anemia; Animals; Anti-Bacterial Agents; Blood; Erythrocyte Count; Hematocrit; Hemoglobins; Iron; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Parasite Egg Count; Reference Values; Sheep; Sheep Diseases

Previous studies revealed that inhibition of mitochondrial protein synthesis by tetracyclines during a number of cell divisions results in proliferation arrest, in vitro as well as in in vivo. The tetracyclines may, therefore, be considered as cytostatics. In this context it is of interest to know the effect of the tetracyclines on rapidly dividing normal cell types, such as erythroid and lymphoid cells. To investigate the influence of the tetracyclines on the proliferation of these cells, we studied immunological responses to sheep red blood cells and recovery from severe anaemia in rats in the presence or absence of oxytetracycline (OTC). Under the experimental conditions used, effects of OTC on the immune responses were only found for events directly or indirectly related to T cell proliferation. The results presented thus strongly suggest that OTC inhibits the division of T lymphoid cells only. The proliferation of other haemopoietic cells is not influenced, most likely because these cells are not permeable to OTC.

Topics: Anemia; Animals; Antibody Formation; Cell Differentiation; Cell Division; Erythrocytes; Hypersensitivity, Delayed; Immunity, Cellular; Immunologic Memory; Lymphocytes; Male; Oxytetracycline; Rats; Rats, Inbred Strains

Eperythrozoonosis was diagnosed in 23 herds of swine. Icterus and anemia were the major diagnostic criteria, with low packed cell volumes confirming the clinical impression of anemia. Indirect hemagglutination titers provided an indirect measure of infection rates and appeared to correlate positively with severity of signs. Treatment with oxytetracycline and arsanilic acid controlled the disease, but only when combined with efforts to limit transmission of the causative organism through control of lice.

Topics: Anaplasmataceae Infections; Anemia; Animals; Arsanilic Acid; Female; Insect Control; Jaundice; Mycoplasma Infections; Oxytetracycline; Phthiraptera; Pregnancy; Pregnancy Complications, Infectious; Swine; Swine Diseases

Topics: Anaplasma; Anaplasmosis; Anemia; Animals; Babesia; Babesiosis; Carbanilides; Cattle; Cattle Diseases; Complement Fixation Tests; Glyoxal; Hematocrit; Imidazoles; Injections, Intramuscular; Male; Oxytetracycline; Thiosemicarbazones; Ticks; Vaccination

Topics: Anemia; Biopsy; Cholecystectomy; Cholelithiasis; Diarrhea; Edema; Humans; Intestinal Mucosa; Jejunum; Laparotomy; Male; Microscopy, Electron; Middle Aged; Oxytetracycline; Prednisone; Skin Manifestations; Whipple Disease

Topics: Anemia; Animals; Bartonella Infections; Cat Diseases; Cats; Chloramphenicol; Conjunctivitis; Feeding and Eating Disorders; Female; Humans; Mucous Membrane; Oxytetracycline; Rickettsia Infections; Vitamin B 12

Topics: Anemia; Chloramphenicol; Chlorpromazine; Eye; Glutethimide; Herpes Zoster; Herpes Zoster Ophthalmicus; Hodgkin Disease; Lung Abscess; Mechlorethamine; Meprobamate; Nitrofurantoin; Novobiocin; Ophthalmology; Oxytetracycline; Pentobarbital; Polymyxins; Pseudomonas Infections; Quinine; Retina; Sepsis; Streptomycin; Toxicology

Topics: Anemia; Anti-Bacterial Agents; Bone Marrow Diseases; Bone Marrow Examination; Chlortetracycline; Dogs; Eosinophils; Erythromycin; Leukopenia; Oxytetracycline; Research; Tetracyclines; Toxicology

Topics: Anemia; Anemia, Hemolytic; Child; Enteritis; Gastroenteritis; Humans; Infant; Oxytetracycline; Tracheophyta

Topics: Anaplasmosis; Anemia; Animals; Chlortetracycline; Jaundice; Louisiana; Oxytetracycline

Topics: Anemia; Anemia, Megaloblastic; Chlortetracycline; Intestines; Oxytetracycline; Tracheophyta

Topics: Anemia; Anemia, Pernicious; Humans; Myelitis; Nervous System Diseases; Oxytetracycline

Topics: Anemia; beta-Thalassemia; Erythroblasts; Humans; Oxytetracycline; Thalassemia