oxytetracycline--anhydrous and Anaplasmataceae-Infections

A three-year-old, male neutered domestic shorthair cat was presented with dysphagia and regurgitation following treatment with oral doxycycline and oxytetracycline for Haemobartonella felis infection. Fluoroscopy confirmed the presence of multiple strictures along the entire length of the oesophagus. Balloon dilatation was performed successfully on two occasions and the symptoms resolved. To the authors' knowledge, this is the first report of oesophageal strictures associated with oral administration of tetracyclines in a cat in the UK.

Topics: Administration, Oral; Anaplasmataceae; Anaplasmataceae Infections; Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Doxycycline; Esophageal Stenosis; Male; Oxytetracycline

Splenectomised Saimiri sciureus squirrel monkeys are being used increasingly as an experimental host for human malarial studies, notably for the assessment of candidate vaccines against Plasmodium falciparum blood-stage infection. Recently, we have reported that colony-reared S. sciureus monkeys are asymptomatic carriers of Haemobartonella sp. and that patent Haemobartonella infection, activated following splenectomy, may interfere with the course of P. falciparum parasitaemia in these animals. For several years, splenectomised S. sciureus monkeys were routinely submitted to oxytetracycline therapy before their use in malarial studies in order to prevent a possible spontaneous Heamobartonella infection. However, we report here that such antibiotic therapy is often ineffective and that neoarsphenamine chemotherapy may be considered as an alternative to cure both latent and patent haemobartonellosis in S. sciureus monkeys.

Topics: Anaplasmataceae; Anaplasmataceae Infections; Animals; Animals, Laboratory; Arsenicals; Arsphenamine; Carrier State; Disease Models, Animal; Female; Humans; Male; Oxytetracycline; Primate Diseases; Saimiri; Splenectomy

Topics: Anaplasmataceae Infections; Animals; Anti-Bacterial Agents; Cat Diseases; Cats; Chloramphenicol; Oxytetracycline; Treatment Outcome

Topics: Anaplasmataceae Infections; Animals; Erythrocytes; Female; Leukocytes; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Swine; Swine Diseases

The apparent suppression of Anaplasma marginale infection by Eperythrozoon teganodes in a splenectomized calf has been reported. A splenectomized calf, inoculated with 500 ml of blood having 23% erythrocytes infected with A. marginale, developed eperythrozoonosis on the fourth day post inoculation. A. marginale parasitaemia remained very low during the patent eperythrozoonosis. A. marginale parasites started to increase in number only after E. teganodes infection had been controlled with neoarsphenamine. A splenectomized calf treated identically, but not showing E. teganodes parasites in the peripheral blood, developed clinical anaplasmosis and fulminant parasitaemia within 3-4 days post inoculation.

Topics: Anaplasmataceae Infections; Anaplasmosis; Animals; Antibiosis; Arsenicals; Cattle; Cattle Diseases; Erythrocytes; Mycoplasma Infections; Oxytetracycline; Splenectomy

Topics: Anaplasmataceae Infections; Animals; Dog Diseases; Dogs; Male; Oxytetracycline; Prednisolone; Splenectomy

On two occasions an anaplasm was isolated from sheep on the Dutch island of Ameland. The organism proved to be highly pathogenic for splenectomised sheep; a non-splenectomised animal recovered spontaneously after the packed cell volume had decreased by 40%. Treatment with oxytetracycline was effective. Its pathogenicity for goats appeared to be low, and the organism was apparently not infective to splenectomised cattle. This anaplasm differs from Anaplasma ovis in that less than 30% of the organisms are marginally situated in the red cell, as against over 70% in A. ovis; cross-immunity with A. ovis was incomplete and the latter appeared to be far more pathogenic to goats than the Dutch anaplasm, for which the name Anaplasma mesaeterum sp.n. is proposed. Its ultrastructure is similar to that of A. marginale and A. ovis. The vector is either Ixodes ricinus or Haemaphysalis punctata. Its practical importance remains to be ascertained.

Topics: Anaplasma; Anaplasmataceae Infections; Animals; Arachnid Vectors; Blood; Netherlands; Oxytetracycline; Sheep; Sheep Diseases; Splenectomy; Ticks

Eperythrozoonosis was diagnosed in 23 herds of swine. Icterus and anemia were the major diagnostic criteria, with low packed cell volumes confirming the clinical impression of anemia. Indirect hemagglutination titers provided an indirect measure of infection rates and appeared to correlate positively with severity of signs. Treatment with oxytetracycline and arsanilic acid controlled the disease, but only when combined with efforts to limit transmission of the causative organism through control of lice.

Topics: Anaplasmataceae Infections; Anemia; Animals; Arsanilic Acid; Female; Insect Control; Jaundice; Mycoplasma Infections; Oxytetracycline; Phthiraptera; Pregnancy; Pregnancy Complications, Infectious; Swine; Swine Diseases