oxytetracycline--anhydrous and Acute-Disease

Postparturient endometritis in cattle is discussed in this review paper, considerable attention being paid to diagnosis and treatment. Clinical examination is stressed in the discussion of diagnosis. The diagnosis of endometritis may be established by rectal and vaginoscopical examination in nearly every case. Cytological and bacteriological examinations supply only little information. In view of the method of treatment, it is essential to determine whether or not the cow is affected with pyometra. Treatment of acute postparturient endometritis consists in intra-uterine administration of oxytetracycline (for a period of from one to three days). Pyometra should be treated by injection of prostaglandins (PG). When it is doubted whether pyometra is developing and a corpus luteum is present, treatment is nevertheless advisable. All other cases of chronic endometritis do not require therapy. The tendency to spontaneous recovery is so considerable in cattle that treatment cannot add anything to the results.

Topics: Acute Disease; Animals; Cattle; Cattle Diseases; Chronic Disease; Endometritis; Female; Instillation, Drug; Oxytetracycline; Pregnancy; Puerperal Infection; Uterus

The objective of the present study was to evaluate the effectiveness of enrofloxacin (ERFX) as a second-line antibiotic for treatment of acute Escherichia coli (E. coli) mastitis. Forty-two cows with naturally occurring acute E. coli mastitis were enrolled. On the first day of treatment (day 0), empirically selected antibiotics (oxytetracycline: n = 32, kanamycin: n = 10) were administered. Although systemic signs improved in 10 cows (first-line group), the signs remained unchanged or worsened in 32 cows on day 1, including two cows that were found dead. The 30 surviving cows were randomly assigned to second-line groups constituting an ERFX group (n = 19) or a control group (n = 11) that was treated with other antibiotics. Response to each treatment was evaluated by measuring clinical signs from day 0 to day 3, subsequent quarter milk recovery, and the 60-day survival rate. Appetite on day 3 was significantly better in the ERFX group compared to the control group. No significant differences were observed in the 60-day survival rate or the subsequent milk recovery between the ERFX group and the control group. Thus, the use of ERFX as a second-line antibiotic for the treatment of acute E. coli mastitis could induce a rapid appetite recovery.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Appetite; Cattle; Cattle Diseases; Disease Progression; Drug Therapy, Combination; Enrofloxacin; Escherichia coli Infections; Female; Fluoroquinolones; Kanamycin; Mastitis; Oxytetracycline; Retreatment; Time Factors; Treatment Failure; Treatment Outcome

No clinical trials have been conducted in India on the efficacy of parenteral antibacterials to treat footrot in sheep. In addition, there are no studies worldwide on the efficacy of parenteral antibacterials to treat chronic footrot. Sixty two sheep with acute footrot and 30 sheep with chronic footrot from 7 villages in Kashmir, India were recruited into two separate trials. Sheep with acute footrot were allocated to one of three treatments using stratified random sampling: long acting parenteral oxytetracycline, long acting parenteral enrofloxacin and topical application of potassium permanganate solution (a traditional treatment used by sheep farmers in India). In a quasi pre-post intervention design, sheep with chronic footrot that had not responded to treatment with potassium permanaganate were randomly allocated to treatment with one of the two parenteral antibacterials mentioned above. Sheep with acute footrot were treated on day 0 and those with chronic footrot on days 0, 3, 6 and 9. Sheep were monitored for up to 28 days after treatment. Time to recovery from lameness and initial healing of lesions was assessed using Kaplan-Meier survival curves, nonparametric log-rank and Wilcoxon sign-rank tests.. There was significant correlation in recovery from lameness and presence of healing lesions in sheep with acute (r = 0.94) or chronic (r = 0.98) footrot. Sheep with acute footrot which were treated with parenteral antibacterials had a significantly more rapid recovery from lameness and had healing lesions (median = 7 days) compared with those treated with topical potassium permanganate solution (less than 50% recovered in 28 days). The median time to recovery in sheep with chronic footrot treated with either antibacterial was 17 days; this was significantly lower than the median of 75 days lame before treatment with antibacterials. The median time to recovery for both acute and chronic footrot increased as the severity of lesions increased. There was no difference in time to recovery by age, body condition score, duration lame, or presence of pus in the foot within acute and chronically affected sheep.. We conclude that use of parenteral antibacterials to treat sheep lame with either acute or chronic footrot in India is highly effective. This is likely to improve welfare and give economic benefits to the farmers.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bacterial Infections; Chronic Disease; Delayed-Action Preparations; Enrofloxacin; Female; Fluoroquinolones; Foot Diseases; India; Lameness, Animal; Male; Oxytetracycline; Potassium Permanganate; Sheep; Sheep Diseases

To determine whether ceftiofur sodium would be useful for treatment of acute interdigital phlegmon (foot rot) in cattle.. Randomized controlled trial.. 308 cross-bred yearling steers with clinical signs of acute interdigital phlegmon (i.e., lameness with interdigital swelling, interdigital lesions, or both).. Steers were randomly assigned to 1 of 3 treatment groups: ceftiofur at a dosage of 0.1 mg/kg (0.045 mg/lb) of body weight, IM, every 24 hours; ceftiofur at a dosage of 1.0 mg/kg (0.45 mg/lb), IM, every 24 hours, and oxytetracycline at a dosage of 6.6 mg/kg (3 mg/lb), IM, every 24 hours. All animals were treated for 3 days; treatment was considered successful if animals were no longer lame on day 4. Biopsy specimens were collected prior to treatment from 5 animals in each group and submitted for anaerobic bacterial culture and histologic examination.. Success rates for the high-dosage ceftiofur (94/129; 73%) and oxytetracycline (87/128; 68%) groups were significantly higher than that for the low-dosage ceftiofur group (5/50; 10%), but there were no significant differences between the high-dosage ceftiofur and oxytetracycline groups. Anaerobic bacteria most frequently isolated from biopsy specimens were Porphyromonas levii and Provetella intermedia.. Use of ceftiofur at a dosage of 1.0 mg/kg for treatment of cattle with acute interdigital phlegmon was as effective as use of oxytetracycline at a dosage of 6.6 mg/kg. However, ceftiofur has a negligible withdrawal time and, therefore, may be a better choice for treatment of near-market weight animals.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Bacteroidaceae Infections; Biopsy; Cattle; Cattle Diseases; Cephalosporins; Dose-Response Relationship, Drug; Foot; Foot Rot; Lameness, Animal; Oxytetracycline; Porphyromonas; Time Factors

In a single blind, randomized study, 46 patients with acute external otitis were treated with either oxytetracycline/hydrocortisone with polymyxin B (TPB) or hydrocortisone-17-alpha-butyrate eardrops for 7 days. Pseudomonas pyocyanea, Staphylococcus epidermidis and Staph. aureus were the microorganisms most frequently found in the ear canal. Fungi were not found in any culture. The overall cure rate was 80%. No significant difference in therapeutic efficacy was noted between the preparations except regarding Staph. aureus, which was cultured from 17% of the patients. Although the butyrate solution did not contain any antibiotic supplement, it seemed to be more effective than TPB in treating the staphylococcal infections. These findings suggest that such other factors as the hydrogen ion concentration, the steroid potency or the vehicle per se are of importance for the successful treatment of acute external otitis.

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Aged; Anti-Inflammatory Agents; Bacterial Infections; Child; Drug Combinations; Female; Humans; Hydrocortisone; Male; Middle Aged; Otitis Externa; Oxytetracycline; Polymyxin B; Polymyxins; Randomized Controlled Trials as Topic; Single-Blind Method

Topics: Acute Disease; Adolescent; Adult; Aged; Ampicillin; Anti-Bacterial Agents; Bronchial Diseases; Clinical Trials as Topic; Doxycycline; Drug Combinations; Female; Humans; Male; Middle Aged; Oxytetracycline; Random Allocation; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Topics: Acute Disease; Bronchitis; Cephalosporins; Chronic Disease; Clinical Trials as Topic; Humans; Oxytetracycline

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Bronchitis; Cephalexin; Chronic Disease; Clinical Trials as Topic; Family Practice; Female; Humans; Male; Middle Aged; Oxytetracycline; Smoking; Sputum; Surveys and Questionnaires; Time Factors

Topics: Acute Disease; Adolescent; Adult; Aged; Bromhexine; Bronchitis; Chronic Disease; Clinical Trials as Topic; Humans; Middle Aged; Oxytetracycline

Topics: Acute Disease; Adolescent; Adult; Brucellosis; Child; Child, Preschool; Doxycycline; Drug Therapy, Combination; Female; Humans; Infant; Male; Middle Aged; Oxytetracycline; Streptomycin

Topics: Acute Disease; Adult; Aniline Compounds; Clinical Trials as Topic; Expectorants; Female; Humans; Male; Oxytetracycline; Sinusitis; Toluene

Topics: Acute Disease; Ampicillin; Bacteria; Child; Child, Preschool; Clinical Trials as Topic; Diaper Rash; Diarrhea; Erythema; Haemophilus influenzae; Humans; Mitosporic Fungi; Otitis Media; Oxytetracycline; Penicillin G Benzathine; Penicillin G Procaine; Penicillin V; Streptococcus; Streptococcus pneumoniae; Sulfisoxazole; Urticaria; Vomiting

Signs of ocular infections like discharge and conjunctivitis occur commonly in cats in shelters and feline herpesvirus 1 (FHV-1), Chlamydia felis, Mycoplasma spp, and feline calicivirus (FCV) are thought to be the most common causes. While molecular assays are available to amplify nucleic acids of each of these agents as single tests or in panels, additional information is needed concerning whether the assay results can be used to predict response to treatment. The objectives of this study were to report results for conventional polymerase chain reaction (PCR) assays that amplify nucleic acids of FHV-1, Mycoplasma spp., C. felis, and FCV from cats with signs of acute ocular and upper respiratory infections in an animal shelter and to determine whether the results are associated with treatment responses to topical administration of cidofovir (anti-FHV-1) or oxytetracycline (anti-Mycoplasma spp. and C. felis). Conjunctival samples were collected from both eyes of 60 cats with ocular signs of disease. Total deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) were extracted from each sample and assayed for DNA of FHV-1, Mycoplasma spp., and C. felis and RNA of FCV by conventional PCR assays. Cats were randomized to be administered either oxytetracycline ointment or cidofovir drops in both eyes and a standardized ocular disease score system was used to determine a total ocular score for each cat prior to treatment on Day 0 and on Day 7. Nucleic acids of one or more agents were amplified from one or both eyes from 39 of 60 cats (65%). FHV-1 DNA (21 cats), Mycoplasma spp. DNA (25 cats) or FCV RNA (2 cats) were amplified most commonly. After treatment for 7 days, 32 of 60 cats (53.3%) were considered improved with 27 of 32 cats (84.4%) having ocular scores of 0 (21 cats) or 1 (6 cats). When the results of the FHV-1 PCR assay were compared to cidofovir treatment responses, the positive and negative predictive values of the assay were shown to be 29.4% and 60%, respectively. When the results of the Mycoplasma spp. PCR assay were compared to oxytetracycline treatment responses, the positive and negative predictive values of the assay were shown to be 40% and 38.5%, respectively. The predictive value of conventional PCR assay results for FHV-1 or Mycoplasma spp. DNA was low, suggesting that performing these tests to formulate a treatment protocol has minimal clinical utility in cats with suspected acute ocular infections.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Antiviral Agents; Cat Diseases; Cats; Cidofovir; Conjunctiva; Cytosine; DNA, Bacterial; DNA, Viral; Eye Infections, Bacterial; Eye Infections, Viral; Herpesviridae Infections; Mycoplasma; Mycoplasma Infections; Ointments; Ophthalmic Solutions; Organophosphonates; Oxytetracycline; Polymerase Chain Reaction; Varicellovirus

An 11-year-old Hanoverian-cross gelding was evaluated because of acute onset of ataxia, recumbency, and fever. At the stable, this and other horses had recently been infested with ticks. Results of analysis of a sample of CSF were within reference limits, but hematologic abnormalities included lymphopenia, thrombocytopenia, mild anemia, and intracytoplasmic inclusion bodies in neutrophils that were consistent with Anaplasma phagocytophilum (previously Ehrlichia equi). Results of serum biochemical analyses were characteristic of infection and included high, unconjugated bilirubin concentration. Other common causes of recumbency in horses, such as equine protozoal myeloencephalitis, infection with eastern or western equine encephalitis viruses and equine herpesvirus-1, West Nile viral encephalitis, trauma, and metabolic disease, were ruled out. The horse responded quickly to i.v. administration of oxytetracycline and recovered fully within 6 days.

Topics: Acute Disease; Anaplasma phagocytophilum; Animals; Anti-Bacterial Agents; Diagnosis, Differential; Ehrlichiosis; Granulocytes; Hematologic Diseases; Horse Diseases; Horses; Inclusion Bodies; Injections, Intravenous; Male; Oxytetracycline

Investigation of the effects of prostaglandin E1, melatonin, and oxytetracycline on lipid peroxidation, antioxidant and paraoxonase activities, and homocysteine levels in an experimental model of spinal cord injury.. To determine the antioxidant efficacy of prostaglandin E1, melatonin, and oxytetracycline and whether paraoxonase and homocysteine can be used as monitoring parameters in the acute oxidative stress of spinal cord injury.. Melatonin has been found useful in spinal cord injury in previous studies. No study exists investigating the effects of melatonin, prostaglandin E1, and oxytetracycline as well as the response type of paraoxonase enzyme and homocysteine levels in the acute oxidative stress of spinal cord injury.. Sixty-three male albino Wistar rats were anesthetized with 400 mg/kg chloral hydrate and divided into 5 groups. The G1 (n = 7) control group provided the baseline levels. G2-G5 underwent T3-T6 total laminectomies and spinal cord injuries by clip compression at the T4-T5 levels. Medications were applied to G3-G5 right after clip compression. Hence, G2 constituted laminectomy + injury, G3 laminectomy + injury + prostaglandin E1; G4 laminectomy + injury + melatonin, and G5 laminectomy + injury + oxytetracycline groups. Animals were decapitated either the first or fourth hour after injury. Spinal cord tissue and blood malonyldialdehyde and plasma homocysteine levels, plasma glutathione peroxidase, superoxide dismutase, paraoxonase activities were assayed. The SPSS 9.0 program was used for statistical analysis and graphics. Intergroup comparisons were made by Bonferroni corrected Mann Whitney U test (P < 0.025) and intragroups comparisons by Wilcoxon Rank test (P < 0.03).. In injury groups, plasma homocysteine levels decreased and paraoxonase activities increased as erythrocyte superoxide dismutase levels and plasma glutathione peroxidase activities decreased in parallel to increases of tissue and blood malonyldialdehyde levels. These alterations were relatively suppressed by prostaglandin E1, melatonin, and oxytetracycline administrations in varying degrees. Melatonin was the most powerful agent, particularly at the fourth hour. Oxytetracycline was also effective, both at the first and fourth hour. Prostaglandin E1 was effective in comparison to injury group, but not as much as melatonin and oxytetracycline.. Melatonin and oxytetracycline are effective in preventing lipid peroxidation in spinal cord injury. Paraoxonase and homocysteine can be used in monitoring the antioxidant defense system as well as superoxide dismutase and plasma glutathione peroxidase, both in injury and medicated groups.

Topics: Acute Disease; Alprostadil; Animals; Antioxidants; Aryldialkylphosphatase; Biomarkers; Disease Models, Animal; Double-Blind Method; Free Radical Scavengers; Homocysteine; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Oxidative Stress; Oxytetracycline; Prospective Studies; Random Allocation; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries; Treatment Outcome

The article analyses the immediate and late-term results of treatment of patients suffering from thromboangiitis of the lower limbs with acute forms of thromboses of the main arteries and shunts (13 persons) and chronic arterial insufficiency (60 patients). The treatment consisted in intraarterial drug infusion with the use of fibrinolysis activators (celiasa, awelysin) as well as other pathogenetically aimed agents in the form of microcrystal suspensions (hydrocortisone, oxytetracycline, zinc insulin). Regional thrombolysis in acute thrombosis allowed authentic lysis of fresh thrombi in the main arteries in two patients (15%). Local thrombolysis with subsequent course of arterial infusion made possible effective arrest of the local ischemic syndrome in patients with III-IV degree arterial insufficiency and affection of the distal arterial bed and allowed the limb to be preserved during a follow-up period of 2 years in 92.5% of patients.

Topics: Acute Disease; Adult; Chronic Disease; Femoral Artery; Fibrinolytic Agents; Follow-Up Studies; Humans; Hydrocortisone; Infusions, Intra-Arterial; Ischemia; Leg; Male; Middle Aged; Oxytetracycline; Streptokinase; Thromboangiitis Obliterans; Thrombolytic Therapy; Thrombosis; Zinc

The effect of acute inflammation on oxytetracycline (OTC) distribution was studied in a tissue cage model in calves. An acute inflammatory reaction was induced in tissue cages by injecting lipopolysaccharide (LPS) from Salmonella typhimurium. The distribution of OTC to tissue cage fluid (TCF) was also compared with distribution to fluid from granuloma pouches (GPF). Tissue from LPS-injected cages showed histological changes indicating an acute inflammatory reaction. Concentrations of OTC were higher in LPS cages than in controls; at 1, 2, 4 and 10 h the difference was statistically significant (P less than 0.05). Numerically the overall elimination rate constant (kel) was larger, elimination half-life (t1/2) shorter, peak concentration (Cmax) higher, and time of peak concentration (Tmax) shorter in LPS cages than in controls. The area under the curve (AUC) of OTC was greater and the ratio AUCTCF/AUCserum was higher in LPS cages than in controls. Although statistically significant differences were not found for all the pharmacokinetic parameters, it was concluded that distribution to and elimination from LPS cages were both faster than in controls. Concentration-time profiles of OTC were similar in TCF and GPF in that concentrations were lower and elimination was more prolonged than in serum. Levels were higher in GPF than in TCF up to 3 h after injection; thereafter the relationship was reversed. Distribution to and elimination processes from GPF appeared to be faster than from TCF as numerically kel was higher, t1/2 shorter and Tmax shorter in GPF than in TCF. It was concluded that the granuloma pouch model and the tissue cage model have similarities in distribution and elimination patterns and that differences are most probably due to differences in the ratio of the surface area to the volume.

Topics: Acute Disease; Animals; Cattle; Cattle Diseases; Diffusion Chambers, Culture; Granuloma; Inflammation; Injections, Intravenous; Lipopolysaccharides; Oxytetracycline; Tissue Distribution

The treatment of an outbreak of acute pneumonia in 50 four- to eight-month-old Friesian and Friesian cross calves is described. At the first visit (day 0) 16 calves received 20 mg/kg bodyweight of oxytetracycline dihydrate intramuscularly and 15 received 10 mg/kg of the macrolide tilmicosin subcutaneously. The remaining 19 in-contact animals were not considered ill enough to be included in the trial and received 20 mg/kg of oxytetracycline dihydrate. The rectal temperature, demeanour, respiratory rate and respiratory effort of each calf was assessed on days 1, 2, 3, 9, 14, 21 and 28, and calves which had not responded were given repeat injections of the same antibiotic. All the calves recovered from the outbreak and of the 19 calves treated strategically, three required a second injection. Among the calves with clinical pneumonia, fewer treatments (P less than 0.01) were required by those treated with tilmicosin. The rectal temperatures of both groups decreased (P less than 0.05) after the first injection, but on day 3 the decrease was greater (P less than 0.05) in the group treated with tilmicosin. Respiratory rates varied widely but respiratory effort was less (P less than 0.05) on day 2 in the calves treated with tilmicosin. When long-acting antibiotic injections are used to treat enzootic pneumonia it is suggested that a second visit should be made on day 3 to assess the animals' response to treatment.

Topics: Acute Disease; Animals; Anti-Bacterial Agents; Cattle; Cattle Diseases; Delayed-Action Preparations; Disease Outbreaks; Injections, Intramuscular; Injections, Subcutaneous; Macrolides; Oxytetracycline; Pneumonia; Respiration; Tylosin

Danofloxacin, a novel fluoroquinolone antimicrobial drug was evaluated in the treatment of acute bacterial pneumonia in recently housed beef cattle of approximately 300 kg liveweight. The clinical responses of 67 pneumonic cattle treated with danofloxacin were compared with those of 65 cattle treated with oxytetracycline, both treatments being given by intramuscular injection for either three or five days, depending on clinical response. Both treatments resulted in a rapid fall in group mean rectal temperature and improved the clinical condition of the majority of cases. However, in comparison with oxytetracycline, danofloxacin therapy was characterised by significantly fewer treatment days, a higher response rate, significantly better reduction of pyrexia and fewer cattle requiring re-treatment.

Topics: 4-Quinolones; Acute Disease; Animals; Anti-Infective Agents; Bacterial Infections; Body Temperature; Cattle; Cattle Diseases; Drug Evaluation; Fever; Fluoroquinolones; Housing, Animal; Oxytetracycline; Pneumonia

Topics: Acute Disease; Administration, Oral; Animals; Dose-Response Relationship, Drug; Hot Temperature; In Vitro Techniques; Injections, Subcutaneous; Male; Mice; Oxytetracycline; Penicillin G

A method to produce bovine pneumonic pasteurellosis for experimental purposes was studied and the clinical response of experimentally infected calves to selected antimicrobials was characterized. Male Holstein calves stressed with multiple hot and cold water applications followed by intratracheal inoculation of broth cultures of Pasteurella multocida serotype B developed acute clinical illness consistent with pneumonia. Infected, untreated calves consistently developed classic pneumonic pasteurellosis, infected calves treated with either oxytetracycline or sulfadimethoxine recovered from acute clinical disease, and the uninfected controls remained healthy. This disease model offers potential for use in pharmacokinetic and target tissue drug concentration studies and for dosage titration of drugs intended for treatment of bacterial pneumonias.

Topics: Acute Disease; Animals; Animals, Newborn; Cattle; Cattle Diseases; Lung; Male; Oxytetracycline; Pasteurella Infections; Pneumonia; Sulfadimethoxine

It was shown in experiments with albino rats that intoxication with tetracyclines and especially with chlortetracycline and tetracycline lowered the levels of sulfhydryl groups in the blood and liver homogenates of the animals, while the levels of the --S--S-groups increased. Tetracycline is characterized by a lower hepatotoxic action and did not affect the levels of sulfhydryl groups. It is suggested that impairment of lipid metabolism, inhibition of bile production and suppression of tissue respiration and oxidative phosphorylation due to oxidation or binding of SH-groups of enzymes and low molecular substances were the main links in the pathogenesis of liver fatty degeneration induced by tetracycline antibiotics.

Topics: Acute Disease; Animals; Chlortetracycline; Erythrocytes; Liver; Male; Oxytetracycline; Rats; Sulfhydryl Compounds; Tetracyclines; Time Factors

Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Conjunctivitis; Female; Humans; Klebsiella Infections; Male; Microbial Sensitivity Tests; Middle Aged; Ointments; Oxytetracycline; Staphylococcal Infections; Streptococcal Infections

Topics: Acute Disease; Anaplasmosis; Animals; Cattle; Cattle Diseases; Female; Injections, Intramuscular; Oxytetracycline

The efficacy of 3 antibiotic formulations was measured in the treatment of artificially induced anaplasmosis in the early stages of an ascending parasitemia (1% to 4%) in 23 splenectomized calves. Group 1, consisting of 5 calves, served as nontreated controls. Four calves (group 2) were treated 1 time with 10 mg of oxytetracycline (T-50)/kg of body weight IM; 5 calves (group 3) were treated 3 times with 10 mg of T-50/kg IM; 5 calves (group 4) were treated 1 time with 20 mg of an experimental oxytetracycline (T-200)/kg IM; and 4 calves (group 5) were treated 1 time with 10 mg of a synthetically derived antibacterial agent, doxycycline (D-100)/kg IM. All control calves died and 1 of 4 calves died that was treated 1 time with T-50. Other deaths did not occur. All treatments were effective in moderating the infective process, but T-50 given 3 times and T-200 given 1 time were markedly more effective than T-50 and D-100 given 1 time. There appeared to be little or no difference in therapeutic efficacy between T-50 and D-100 given 1 time and between T-50 given 3 times and T-200 given 1 time.

Topics: Acute Disease; Anaplasmosis; Animals; Blood; Cattle; Cattle Diseases; Doxycycline; Injections, Intramuscular; Oxytetracycline; Splenectomy

An open comparative study was carried out to assess the effectiveness of 4 antibiotic regimens in eradicating acute bacterial infections of the upper respiratory tract. Patients in each treatment group had similar physical parameters, severity of disease and bacterial pathogens, and were treated for 10 days with either erythromycin estolate, erythromycin stearate, ampicillin or oxytetracycline in the recommended dosage. Each patient was reviewed daily by physical examination and the bacteriological findings from throat swab and salivary washings. The results showed that erythromycin stearate produced more rapid bacterial eradication and clinical resolution of symptoms and fever than with the other antibiotic preparations, and was well tolerated by most patients.

Topics: Acute Disease; Ampicillin; Bacterial Infections; Erythromycin; Erythromycin Estolate; Escherichia coli Infections; Humans; Oxytetracycline; Penicillin Resistance; Respiratory Tract Infections; Stearates

Topics: Acute Disease; Anemia, Hemolytic, Autoimmune; Child, Preschool; Female; Humans; Laryngitis; Oxytetracycline

Sensitivity of Shigella, pathogenic Escherichia, Proteus and Staphylococcus isolated from children with acute intestinal diseases was studied with respect to antibiotics widely used in medical practice: streptomycin, levomycetin, tetracycline, chlortetracycline, oxytetracycline and neomycin. The antibiotic sensitivity was determined with the method of indicator discs. It was found that sensitivity of shigella was: 44 percent to streptomycin, 69.5 per cent to levomycetin, 18.5 per cent to tetracycline, 18.5 per cent to chlortetracycline, 23 per cent to oxytetracycline and 94 per cent to neomycin. Sensitivity of pathogenic Eschericia was 28, 33, 14, 14, 25 and 74 per cent, sensitivity of staphylococci was 46, 56.5, 21, 21, 31.5 and 89.5 per cent, sensitivity of Proteus was 15, 31.5, 3.5, 3.5, 7.5 and 52.5 per cent respectively. Cross resistance with respect to tetracyclines was found in all the microbes studie. Intragenera differences in the antibiotic sensitivity were observed among Shigella and pathogenic Escherichia.

Topics: Acute Disease; Anti-Bacterial Agents; Child; Chloramphenicol; Chlortetracycline; Drug Resistance, Microbial; Escherichia; Georgia (Republic); Humans; Intestinal Diseases; Microbial Sensitivity Tests; Neomycin; Oxytetracycline; Proteus; Shigella; Species Specificity; Staphylococcus; Streptomycin; Tetracycline

Topics: Acute Disease; Aged; Amebiasis; Anti-Bacterial Agents; Bacterial Infections; Clostridium Infections; Diarrhea; Dysentery, Bacillary; Enterotoxins; Escherichia coli Infections; Feces; Humans; Iodoquinol; Metronidazole; Oxytetracycline; Salmonella Infections; Serotyping; Staphylococcal Infections; Vibrio Infections; Water-Electrolyte Balance

Topics: Acute Disease; Adult; Aged; Female; Humans; Male; Middle Aged; Oxytetracycline; Respiratory Therapy; Respiratory Tract Infections

Topics: Acute Disease; Ampicillin; Anti-Bacterial Agents; Child; Child, Preschool; Chloramphenicol; Clioquinol; Enterococcus faecalis; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Feces; Furazolidone; Gastroenteritis; Humans; Methicillin; Nalidixic Acid; Neomycin; Oleandomycin; Oxytetracycline; Penicillin G; Phenanthrenes; Polymyxins; Proteus; Staphylococcus; Streptomycin; Tetracycline; Tetracyclines

Topics: Acute Disease; Adult; Ascorbic Acid; Ascorbic Acid Deficiency; Humans; Oxytetracycline; Penicillins; Pneumonia; Streptomycin

Topics: Acute Disease; Adult; Bromhexine; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Oxytetracycline; Sinusitis; Time Factors

Topics: Acute Disease; Adult; Chlortetracycline; Czechoslovakia; Drug Evaluation; Gonorrhea; Humans; Male; Military Medicine; Oxytetracycline

Topics: Acute Disease; Animals; Cattle; Dairying; Female; Neomycin; Oxytetracycline; Skin Absorption; Streptomycin

Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Animals; Doxycycline; Drug Resistance, Microbial; Follow-Up Studies; Gonorrhea; Humans; Male; Middle Aged; Milk; Nausea; Neisseria gonorrhoeae; Oxytetracycline; Recurrence; Streptomycin; Sulfisoxazole; Urethritis; Vomiting

Topics: Acute Disease; Adult; Chloramphenicol; Humans; Middle Aged; Nephrectomy; Oxytetracycline; Pyelonephritis; Sepsis; Shock, Septic; Suppuration; Time Factors; Uremia

Topics: Acute Disease; Adolescent; Adult; Child; Doxycycline; Gonorrhea; Humans; Male; Middle Aged; Oxytetracycline

Topics: Acute Disease; Blood Sedimentation; Bronchial Diseases; Chronic Disease; Doxycycline; Humans; Lung Diseases; Oxytetracycline; Radiography

Topics: Acute Disease; Administration, Oral; Bacteriological Techniques; Doxycycline; Follow-Up Studies; Gonorrhea; Humans; Injections, Intramuscular; Male; Microbial Sensitivity Tests; Military Medicine; Neisseria gonorrhoeae; Oxytetracycline; Penicillin G Procaine; Penicillin Resistance; Texas; United States; Urethritis

Topics: Acute Disease; Adolescent; Adult; Aged; Female; Humans; Hydrocortisone; Middle Aged; Oxytetracycline; Time Factors; Vaginitis

Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Chlortetracycline; Depression, Chemical; Enterococcus faecalis; Erythromycin; Erythromycin Ethylsuccinate; Female; Furazolidone; Humans; Male; Middle Aged; Neomycin; Nitrofurantoin; Oleandomycin; Oxytetracycline; Penicillin G; Penicillin Resistance; Penicillins; Pneumonia; Polymyxins; Ristocetin; Staphylococcus; Streptococcus; Streptomycin; Tetracycline; Urine

Topics: Acute Disease; Adult; Chloramphenicol; Chlortetracycline; Chronic Disease; Depression, Chemical; Female; Gonorrhea; Humans; Microbial Sensitivity Tests; Neisseria gonorrhoeae; Oxytetracycline; Penicillin Resistance; Penicillins; Streptomycin; Tetracycline

Topics: Acute Disease; Adolescent; Appendicitis; Child; Child, Preschool; Humans; Injections, Intraperitoneal; Oxytetracycline; Peritonitis

Topics: Acute Disease; Chronic Disease; Gels; Humans; Hydrocortisone; Maxillary Sinus; Oroantral Fistula; Oxytetracycline; Polymyxins; Postoperative Complications; Sinusitis

Topics: Acute Disease; Child; Chloramphenicol; Chlortetracycline; Drug Resistance, Microbial; Dysentery, Bacillary; Humans; Microbial Sensitivity Tests; Oxytetracycline; Shigella; Shigella dysenteriae; Shigella sonnei; Streptomycin; USSR

Topics: Acute Disease; Adolescent; Adult; Aged; Child; Cholecystectomy; Cholecystitis; Cholelithiasis; Female; Humans; Male; Middle Aged; Oxytetracycline

Topics: Acute Disease; Adult; Bronchi; Bronchitis; Chronic Disease; Expectorants; Humans; Male; Oxytetracycline; Sulfadiazine

Topics: Acute Disease; Bronchitis; Capillary Permeability; DNA; Expectorants; Fibrinogen; Humans; L-Lactate Dehydrogenase; Microscopy, Fluorescence; Oxytetracycline; Photometry; Protein Binding; Quaternary Ammonium Compounds; Spectrophotometry; Sputum

Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Female; Gingivitis; Gingivitis, Necrotizing Ulcerative; Humans; Hydrocortisone; Male; Oxytetracycline; Stomatitis; Stomatitis, Aphthous

Topics: Acute Disease; Child; Female; Fever; Humans; Oxytetracycline; Q Fever; Urinary Tract Infections

Topics: Acute Disease; Adolescent; Adult; Chlortetracycline; Dysentery; Feces; Female; Humans; Injections, Intramuscular; Male; Methods; Middle Aged; Oxytetracycline; Protein Binding; Tetracycline

Topics: Acute Disease; Agglutination Tests; Antibody Formation; Complement Fixation Tests; Dysentery, Bacillary; Humans; Injections, Intramuscular; Mouth; Oxytetracycline; Phagocytosis; Tetracycline

Topics: Acute Disease; Communicable Diseases; Oxytetracycline; Respiratory System; Respiratory Tract Infections

Topics: Acute Disease; Drug Combinations; Gingivitis; Humans; Hydrocortisone; Oxytetracycline

Topics: Acute Disease; Alanine Transaminase; Intestinal Obstruction; Oxytetracycline; Transaminases

Topics: Acute Disease; Appendectomy; Appendicitis; Biomedical Research; Humans; Oxytetracycline; Peritonitis

Topics: Acute Disease; Humans; Intestinal Obstruction; Oxytetracycline

Topics: Acute Disease; Child; Chlortetracycline; Infant; Injections, Intramuscular; Otitis Media; Otitis Media, Suppurative; Oxytetracycline; Penicillin G; Penicillins

Topics: Acute Disease; Gonorrhea; Humans; Injections, Intramuscular; Male; Oxytetracycline; Urethritis

Topics: Acute Disease; Intestinal Obstruction; Oxytetracycline

Topics: Acute Disease; Humans; Osteomyelitis; Oxytetracycline

Topics: Acute Disease; Communicable Diseases; Injections, Intramuscular; Otolaryngology; Oxytetracycline

Topics: Acute Disease; Humans; Infant; Infant, Newborn; Oxytetracycline; Respiration Disorders; Respiratory System; Respiratory Tract Diseases

Topics: Acute Disease; Animals; Intestinal Obstruction; Lagomorpha; Oxytetracycline; Rabbits

Topics: Acute Disease; Child; Humans; Otitis Media; Oxytetracycline

Topics: Acute Disease; Intestinal Obstruction; Oxytetracycline; Portal Vein

Topics: Acute Disease; Amebiasis; Chlortetracycline; Dysentery; Dysentery, Amebic; Entamoebiasis; Oxytetracycline