oxytetracycline--anhydrous and Abscess

To determine oxytetracycline concentrations in plasma and in fluid from. 10 clinically normal female sheep.. Sterile tissue chambers were surgically implanted in both paralumbar fossae of each sheep; ≥ 2 weeks later (day -6), 1 randomly selected chamber was inoculated with CPT, and the opposite chamber was injected with sterile growth medium. Sheep received oxytetracycline IM (n = 5) or by percutaneous injection into CPT-inoculated (4) or uninoculated (1) chambers on day 0. Tissue fluid from each chamber and venous blood samples for plasma collection were obtained at predetermined times over 6 days for bacterial counts (tissue chambers) and analysis of oxytetracycline concentrations (tissue chambers and plasma). Sheep were euthanized on day 6. Regional lymph nodes were collected bilaterally from each sheep for culture.. Measurable concentrations of oxytetracycline were present in each chamber throughout the study, regardless of administration route or presence of CPT. No CPT growth was detected after the 48-hour time point in inoculated chambers injected with oxytetracycline; however, CPT was isolated from all inoculated chambers throughout the study after IM drug administration. One regional lymph node (ipsilateral to a CPT-inoculated, oxytetracycline-injected chamber with no CPT growth after 48 hours) was culture positive for CPT.. Intralesional administration of oxytetracycline may eliminate growth of CPT locally, but complete elimination of the organism remains difficult.

Topics: Abscess; Animals; Anti-Bacterial Agents; Corynebacterium Infections; Corynebacterium pseudotuberculosis; Disease Models, Animal; Extracellular Fluid; Female; Injections, Intralesional; Injections, Intramuscular; Lymphadenitis; Oxytetracycline; Random Allocation; Sheep; Sheep Diseases

Topics: Abscess; Analgesics; Animals; Anti-Infective Agents; Blood Cell Count; Blood Chemical Analysis; Butorphanol; Cerebrospinal Fluid; Clostridium; Clostridium Infections; Dimethyl Sulfoxide; Female; Horse Diseases; Horses; Metronidazole; Myositis; Oxytetracycline; Prognosis; Serum; Ultrasonography; Urinalysis

Using broth conjugation, we found that 19 of 29 (66%) oxytetracycline (OT)-resistant isolates of Aeromonas salmonicida transferred the OT resistance phenotype to Escherichia coli. The OT resistance phenotype was encoded by high-molecular-weight R-plasmids that were capable of transferring OT resistance to both environmental and clinical isolates of Aeromonas spp. The molecular basis for antibiotic resistance in OT-resistant isolates of A. salmonicida was determined. The OT resistance determinant from one plasmid (pASOT) of A. salmonicida was cloned and used in Southern blotting and hybridization experiments as a probe. The determinant was identified on a 5.4-kb EcoRI fragment on R-plasmids from the 19 OT-resistant isolates of A. salmonicida. Hybridization with plasmids encoding the five classes (classes A to E) of OT resistance determinants demonstrated that the OT resistance plasmids of the 19 A. salmonicida isolates carried the class A resistance determinant. Analysis of data generated from restriction enzyme digests showed that the OT resistance plasmids were not identical; three profiles were characterized, two of which showed a high degree of homology.

Topics: Abscess; Aeromonas; Aeromonas hydrophila; Animals; Conjugation, Genetic; Guinea Pigs; Humans; Molecular Weight; Oxytetracycline; R Factors; Restriction Mapping; Salmonidae; Species Specificity; Tetracycline Resistance

Factors associated with foot abscess were evaluated in a cohort of 3,322 suckling pigs reared on a woven-wire floor (wire diameter, 0.5 cm; size of openings, 1 x 3.8 cm). In bivariate analysis, foot abscess was significantly (P < 0.05) associated with postpartum sow illness, number of pigs born alive, and parity, but not with birthweight (P = 0.31) or time spent on wire flooring (P = 0.89). One oxytetracycline treatment (100 mg, IM) at birth or 1 treatment at birth and a second 5 to 7 days later reduced (P < 0.05) the risk of lesions by about half. Multivariate analyses indicated that pigs in large litters (> 10 pigs at birth) born to sows with postpartum illnesses had an increased risk (relative risk [RR], 3.77) of developing foot abscess, compared with pigs in small litters (< or = 10 pigs) born to unaffected sows. For sows without evidence of postpartum illness, pigs in large litters had a slightly increased risk (RR, 1.32) of developing foot abscess, compared with pigs in small litters. Pigs born to multiparous sows also had an increased risk (RR, 1.69) of developing foot abscess, compared with pigs born to primiparous sows. Similar risk estimates were obtained when logistic regression models included location farrowed (crate number) as a fixed effect, and when litter was a random effect in a logistic-binomial regression.

Topics: Abscess; Analysis of Variance; Animals; Animals, Newborn; Animals, Suckling; Cohort Studies; Female; Foot Diseases; Housing, Animal; Incidence; Litter Size; Male; Oxytetracycline; Parity; Puerperal Disorders; Regression Analysis; Risk Factors; Swine; Swine Diseases

Prophylactic efficacy of 100 mg of long-acting oxytetracycline (OTC) given IM to neonatal pigs within 12 hours of birth was evaluated in a swine herd. The herd had a history of increased neonatal mortality, diarrhea, foot abscess, and arthritis in nursing pigs. Two trials were conducted in which liters and individual pigs were the treatment groups of interest. In both trials, OTC treatment failed to reduce mortality, diarrhea, or arthritis or the need for subsequent antimicrobial therapy (P greater than 0.05). Preweaning weight gains were not increased (P greater than 0.05) in treated pigs. However, in the individual pig trial, foot abscess rates were significantly (P = 0.01) lower in treated pigs (3.7%) than in nontreated pigs (8%). Aerobic bacteria isolated from pigs with diarrhea, arthritis, or foot abscess had minimum inhibitory concentrations for OTC greater than or equal to 64 micrograms/ml or were classed as resistant on the basis of disk-diffusion tests.

Topics: Abscess; Animals; Animals, Newborn; Arthritis, Infectious; Bacterial Infections; Diarrhea; Female; Foot Diseases; Male; Oxytetracycline; Prognosis; Random Allocation; Swine; Swine Diseases; Weight Gain

Topics: Abscess; Adult; Chronic Disease; Drug Combinations; Drug Therapy, Combination; Erythromycin; Female; Folliculitis; Furunculosis; Humans; Male; Middle Aged; Oxytetracycline; Pyoderma; Skin Ulcer; Staphylococcal Infections; Streptococcal Infections

Topics: Abscess; Ampicillin; Animals; Leucomycins; Mice; Mice, Nude; Oxytetracycline; Pasteurella Infections; Rodent Diseases

The clinically used topical antibiotic ointments, gentamicin 0.1%, oxytetracycline 3% w/polymyxin 0.1% and chloramphenicol 2% and an experimental preparation, 10-undecen-1-yl thiopseudourea iodide (AHR-1911) were studied for anti-infective action applied externally on the skin of mice inoculated subcutaneously with S. aureus and E. coli. In both infections statistically significant difference was encountered between curative and "clinical" healing rate in the case of the less effective preparations and/or dosages. The method appears suitable to establish and to compare the in vivo activity of ointments. This is not directly related to that of the aqueous drug solutions. AHR-1911, a powerful inhibitor of nucleic acid and protein synthesis, showed a bimodal action, with maximal effectiveness at 0.12-0.25% concentration, due presumably to the anti-inflammatory effect of higher concentrations. Direct evidence for the absorption of the drug from the application site was obtained using 14C labeled AHR-1911.

Topics: Abscess; Administration, Topical; Animals; Drug Combinations; Drug Evaluation; Escherichia coli Infections; Gentamicins; Isothiuronium; Mice; Ointments; Oxytetracycline; Polymyxins; Skin Ulcer; Staphylococcal Infections; Thiourea

Topics: Abscess; Administration, Oral; Animal Feed; Animals; Anti-Bacterial Agents; Bacterial Vaccines; Chlortetracycline; Germ-Free Life; Lymphadenitis; Oxytetracycline; Penicillin G Benzathine; Streptococcal Infections; Streptococcus; Swine; Swine Diseases; Vaccination

Topics: Abscess; Adult; Aged; Biopsy; Chloramphenicol; Drug Eruptions; Eosinophils; Erythema; Female; Humans; Leg Dermatoses; Leukocytes; Male; Middle Aged; Oxytetracycline; Purpura; Skin; Skin Diseases; Thigh

Topics: Abscess; Anti-Bacterial Agents; Bacteria; Chloramphenicol; Humans; Neomycin; Oxytetracycline; Penicillin Resistance; Penicillins; Salivary Gland Diseases; Staphylococcus; Streptococcus; Streptomycin; Submandibular Gland

Topics: Abdominal Muscles; Abscess; Bronchitis; Bursitis; Cellulitis; Chemical Phenomena; Chemistry; Hematoma; Infections; Leg Ulcer; Oxytetracycline; Paraplegia; Parotitis; Pressure Ulcer; Suppuration; Surgical Wound Infection; Tracheitis

Topics: Abscess; Adult; Aged; Alcoholism; Amylases; Atropine; Cholelithiasis; Duodenal Obstruction; Edema; Female; Gastrectomy; Heme; Hemorrhage; Humans; Hyperglycemia; Hypocalcemia; Immunization, Passive; Intestinal Fistula; Jejunum; Leukocytosis; Lipase; Male; Middle Aged; Oxytetracycline; Pancreatectomy; Pancreatic Cyst; Pancreatitis; Pepsin A; Serum Albumin

Topics: Abscess; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Erysipelothrix Infections; Female; Folliculitis; Humans; Impetigo; Infections; Leg Ulcer; Lymphangitis; Male; Middle Aged; Oxytetracycline; Skin Diseases

Topics: Abscess; Anti-Bacterial Agents; Bacteroides; Bacteroides Infections; Brain; Brain Abscess; Cerebral Angiography; Child; Chlortetracycline; Drainage; Hemiplegia; Humans; Hydrocephalus; Oxytetracycline; Radiography; Tetracycline

Topics: Abscess; Adrenocorticotropic Hormone; Asphyxia Neonatorum; Blood Transfusion; Cesarean Section; Communicable Diseases; Cortisone; Dexamethasone; Erythromycin; Female; Genital Diseases, Female; Gynecology; Humans; Infant, Newborn; Neomycin; Obstetrics; Ovary; Oxytetracycline; Pelvic Inflammatory Disease; Peritonitis; Pneumococcal Infections; Pre-Eclampsia; Pregnancy; Puerperal Infection

Topics: Abscess; Adolescent; Aerosols; Child; Eczema; Herpes Zoster; Humans; Hydrocortisone; Infant; Nebulizers and Vaporizers; Ointments; Oxytetracycline; Pharyngitis; Pyoderma; Varicose Ulcer

Three strains of Past. septica were isolated in Hong Kong. The clinical histories and the detailed bacteriological and serological studies are presented.

Topics: Abscess; Animals; Appendix; China; Chloramphenicol; Cobalt Isotopes; Epidemiology; Female; Hemagglutination; Hong Kong; Humans; Neoplasms; Oxytetracycline; Pasteurella; Pasteurella Infections; Penicillins; Peptic Ulcer Perforation; Peritoneal Cavity; Streptomycin; Uterine Cervical Neoplasms; Zoonoses

Topics: Abscess; Diathermy; Drug Therapy; Eyelids; Gangrene; Humans; Oxytetracycline; Penicillins; Postoperative Complications; Postoperative Period; Staphylococcal Infections; Streptococcal Infections; Sulfonamides; Surgical Wound Infection

Topics: Abscess; Albumins; Amylases; Bacillus; Chloramphenicol; Drainage; Globulins; Humans; Liver Function Tests; Oxytetracycline; Pancreas; Pancreatitis; Urine

Topics: Abscess; Arthritis; Child; Chloramphenicol; Diagnosis, Differential; Drainage; Erythromycin; Humans; Infant; Joint Diseases; Novobiocin; Osteomyelitis; Oxytetracycline; Penicillins; Sepsis; Staphylococcal Infections; Streptococcal Infections; Suppuration; Surgical Procedures, Operative; Tetracycline

Topics: Abdominal Injuries; Abscess; Bacterial Infections; Humans; Oxytetracycline; Pathology; Spleen; Splenectomy; Splenic Diseases; Splenic Vein; Thrombosis

Topics: Abscess; Anti-Bacterial Agents; Chlortetracycline; Drug Resistance; Drug Resistance, Microbial; Erythromycin; Escherichia coli Infections; Female; Humans; Mastitis; Oxytetracycline; Penicillins; Pregnancy; Puerperal Infection; Punctures; Staphylococcal Infections

Topics: Abscess; Cornea; Corneal Diseases; Disease; Oxytetracycline; Sulfanilamide; Sulfanilamides; Sulfonamides

Topics: Abscess; Blood Transfusion; Humans; Infant; Oxytetracycline; Skin; Skin Diseases

Topics: Abscess; Anti-Bacterial Agents; Chloramphenicol; Dura Mater; Epidural Abscess; Erythromycin; Humans; Oxytetracycline; Spinal Canal

Topics: Abscess; Embolism; Escherichia coli; Escherichia coli Infections; Lung; Lung Abscess; Oxytetracycline; Pulmonary Embolism

Topics: Abdomen; Abdominal Abscess; Abscess; Oxytetracycline; Subphrenic Abscess

Topics: Abscess; Lung; Lung Abscess; Oxytetracycline

Topics: Abscess; Humans; Lung; Lung Abscess; Oxytetracycline

Topics: Abscess; Anti-Bacterial Agents; Lung; Lung Abscess; Oxytetracycline; Penicillins