oxysophocarpine and Hand--Foot-and-Mouth-Disease

oxysophocarpine has been researched along with Hand--Foot-and-Mouth-Disease* in 1 studies

Other Studies

1 other study(ies) available for oxysophocarpine and Hand--Foot-and-Mouth-Disease

Article	Year
Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells. Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17 Recent outbreak of hand, foot and mouse disease caused by enterovirus 71 is a serious threat to infants and children in Asia-Pacific countries. No vaccines or antiviral therapies are available against this infection. In this study, we found that quinolizidine alkaloids could improve the levels of T cells in mice. The structure-activity relationships demonstrated that the oxidation and double bonds are important for the excellent potency. Oxysophocarpine, the most effective compound of six quinolizidine alkaloids, could also relieve symptoms and reduce mortality in lethal enterovirus 71-infected mice through compensating for the decreased levels of T cells. This work suggested that quinolizidine alkaloids have the potential against enterovirus 71 for further development of novel antiviral drugs. Topics: Alkaloids; Animals; Antiviral Agents; Enterovirus A, Human; Hand, Foot and Mouth Disease; Humans; Mice, Inbred BALB C; Quinolizidines; Structure-Activity Relationship; T-Lymphocytes	2015

Article

Year

Quinolizidine alkaloids reduced mortality in EV71-infected mice by compensating for the levels of T cells.

Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17

Recent outbreak of hand, foot and mouse disease caused by enterovirus 71 is a serious threat to infants and children in Asia-Pacific countries. No vaccines or antiviral therapies are available against this infection. In this study, we found that quinolizidine alkaloids could improve the levels of T cells in mice. The structure-activity relationships demonstrated that the oxidation and double bonds are important for the excellent potency. Oxysophocarpine, the most effective compound of six quinolizidine alkaloids, could also relieve symptoms and reduce mortality in lethal enterovirus 71-infected mice through compensating for the decreased levels of T cells. This work suggested that quinolizidine alkaloids have the potential against enterovirus 71 for further development of novel antiviral drugs.

Topics: Alkaloids; Animals; Antiviral Agents; Enterovirus A, Human; Hand, Foot and Mouth Disease; Humans; Mice, Inbred BALB C; Quinolizidines; Structure-Activity Relationship; T-Lymphocytes

2015