oxyquinoline has been researched along with Melanoma in 5 studies
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the transition metal chelator, 8-hydroxyquinoline (8-HQ), was examined on the growth and phenotype expression of B16 mouse melanoma cells." | 7.68 | Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines. ( Beery, E; Nordenberg, J; Novogrodsky, A; Patia, M; Warshawsky, A; Wasserman, L, 1990) |
| " With the aim of improving the disappointingly low activity of inorganic gallium salts, we have developed the orally bioavailable gallium complex KP46 [tris(8-quinolinolato)gallium(III)] that had already been successfully studied in a phase I clinical trial." | 5.35 | The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. ( Berger, W; Heffeter, P; Jakupec, MA; Keppler, BK; Marculescu, R; Rappersberger, K; Valiahdi, SM, 2009) |
| "The effect of the transition metal chelator, 8-hydroxyquinoline (8-HQ), was examined on the growth and phenotype expression of B16 mouse melanoma cells." | 3.68 | Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines. ( Beery, E; Nordenberg, J; Novogrodsky, A; Patia, M; Warshawsky, A; Wasserman, L, 1990) |
| " With the aim of improving the disappointingly low activity of inorganic gallium salts, we have developed the orally bioavailable gallium complex KP46 [tris(8-quinolinolato)gallium(III)] that had already been successfully studied in a phase I clinical trial." | 1.35 | The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. ( Berger, W; Heffeter, P; Jakupec, MA; Keppler, BK; Marculescu, R; Rappersberger, K; Valiahdi, SM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valiahdi, SM | 1 |
| Heffeter, P | 1 |
| Jakupec, MA | 1 |
| Marculescu, R | 1 |
| Berger, W | 1 |
| Rappersberger, K | 1 |
| Keppler, BK | 1 |
| Pletz, N | 1 |
| Schön, M | 1 |
| Ziegelbauer, K | 1 |
| Emmert, S | 1 |
| Liu, N | 1 |
| Dobbelstein, M | 1 |
| Schön, MP | 1 |
| Aarntzen, EH | 1 |
| Srinivas, M | 1 |
| Bonetto, F | 1 |
| Cruz, LJ | 1 |
| Verdijk, P | 1 |
| Schreibelt, G | 1 |
| van de Rakt, M | 1 |
| Lesterhuis, WJ | 1 |
| van Riel, M | 1 |
| Punt, CJ | 1 |
| Adema, GJ | 1 |
| Heerschap, A | 1 |
| Figdor, CG | 1 |
| Oyen, WJ | 1 |
| de Vries, IJ | 1 |
| Lockshin, A | 1 |
| Giovanella, BC | 1 |
| Kozielski, T | 1 |
| Stehlin, JS | 1 |
| Nordenberg, J | 1 |
| Novogrodsky, A | 1 |
| Beery, E | 1 |
| Patia, M | 1 |
| Wasserman, L | 1 |
| Warshawsky, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Active Immunization of Patients With Stage III and IV Melanoma in Whom a Regional Lymph Node Dissection is Planned, With Peptide-Pulsed Dendritic Cells: Evaluation of in Vivo Immune and Clinical Response and Migration[NCT00243594] | Phase 1/Phase 2 | 40 participants (Anticipated) | Interventional | 1999-09-30 | Completed | ||
| An Exploratory Study: Dendritic Cells for Immunotherapy of Metastatic Endometrial Cancer Patients[NCT04212377] | Phase 2 | 8 participants (Actual) | Interventional | 2019-04-08 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for oxyquinoline and Melanoma
| Article | Year |
|---|---|
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
4 other studies available for oxyquinoline and Melanoma
| Article | Year |
|---|---|
The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Gallium; Humans; Inhibitory Concentration 50; Melanoma; Org | 2009 |
Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Doxorubicin; Gene Expression; Humans; I-kappa B | 2012 |
Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.
Topics: Animals; Cell Line; Cell Survival; Diphtheria Toxin; Edetic Acid; Humans; Hydroxyquinolines; Indium; | 1984 |
Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines.
Topics: Animals; Cell Division; Cell Line; Humans; Melanoma; Melanoma, Experimental; Mice; Oxyquinoline | 1990 |