oxyquinoline has been researched along with Malignant Melanoma in 5 studies
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.
quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the transition metal chelator, 8-hydroxyquinoline (8-HQ), was examined on the growth and phenotype expression of B16 mouse melanoma cells." | 7.68 | Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines. ( Beery, E; Nordenberg, J; Novogrodsky, A; Patia, M; Warshawsky, A; Wasserman, L, 1990) |
| " With the aim of improving the disappointingly low activity of inorganic gallium salts, we have developed the orally bioavailable gallium complex KP46 [tris(8-quinolinolato)gallium(III)] that had already been successfully studied in a phase I clinical trial." | 5.35 | The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. ( Berger, W; Heffeter, P; Jakupec, MA; Keppler, BK; Marculescu, R; Rappersberger, K; Valiahdi, SM, 2009) |
| "The effect of the transition metal chelator, 8-hydroxyquinoline (8-HQ), was examined on the growth and phenotype expression of B16 mouse melanoma cells." | 3.68 | Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines. ( Beery, E; Nordenberg, J; Novogrodsky, A; Patia, M; Warshawsky, A; Wasserman, L, 1990) |
| " With the aim of improving the disappointingly low activity of inorganic gallium salts, we have developed the orally bioavailable gallium complex KP46 [tris(8-quinolinolato)gallium(III)] that had already been successfully studied in a phase I clinical trial." | 1.35 | The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines. ( Berger, W; Heffeter, P; Jakupec, MA; Keppler, BK; Marculescu, R; Rappersberger, K; Valiahdi, SM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valiahdi, SM | 1 |
| Heffeter, P | 1 |
| Jakupec, MA | 1 |
| Marculescu, R | 1 |
| Berger, W | 1 |
| Rappersberger, K | 1 |
| Keppler, BK | 1 |
| Pletz, N | 1 |
| Schön, M | 1 |
| Ziegelbauer, K | 1 |
| Emmert, S | 1 |
| Liu, N | 1 |
| Dobbelstein, M | 1 |
| Schön, MP | 1 |
| Aarntzen, EH | 1 |
| Srinivas, M | 1 |
| Bonetto, F | 1 |
| Cruz, LJ | 1 |
| Verdijk, P | 1 |
| Schreibelt, G | 1 |
| van de Rakt, M | 1 |
| Lesterhuis, WJ | 1 |
| van Riel, M | 1 |
| Punt, CJ | 1 |
| Adema, GJ | 1 |
| Heerschap, A | 1 |
| Figdor, CG | 1 |
| Oyen, WJ | 1 |
| de Vries, IJ | 1 |
| Lockshin, A | 1 |
| Giovanella, BC | 1 |
| Kozielski, T | 1 |
| Stehlin, JS | 1 |
| Nordenberg, J | 1 |
| Novogrodsky, A | 1 |
| Beery, E | 1 |
| Patia, M | 1 |
| Wasserman, L | 1 |
| Warshawsky, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Active Immunization of Patients With Stage III and IV Melanoma in Whom a Regional Lymph Node Dissection is Planned, With Peptide-Pulsed Dendritic Cells: Evaluation of in Vivo Immune and Clinical Response and Migration[NCT00243594] | Phase 1/Phase 2 | 40 participants (Anticipated) | Interventional | 1999-09-30 | Completed | ||
| An Exploratory Study: Dendritic Cells for Immunotherapy of Metastatic Endometrial Cancer Patients[NCT04212377] | Phase 2 | 8 participants (Actual) | Interventional | 2019-04-08 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for oxyquinoline and Malignant Melanoma
| Article | Year |
|---|---|
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
Targeting of 111In-labeled dendritic cell human vaccines improved by reducing number of cells.
Topics: Adolescent; Adult; Aged; Cancer Vaccines; Cell Movement; Dendritic Cells; Female; Granulocyte-Macrop | 2013 |
4 other studies available for oxyquinoline and Malignant Melanoma
| Article | Year |
|---|---|
The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Gallium; Humans; Inhibitory Concentration 50; Melanoma; Org | 2009 |
Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Doxorubicin; Gene Expression; Humans; I-kappa B | 2012 |
Determination of cytotoxicity in vivo using 111indium-labeled human tumor cells.
Topics: Animals; Cell Line; Cell Survival; Diphtheria Toxin; Edetic Acid; Humans; Hydroxyquinolines; Indium; | 1984 |
Anti-proliferative effects and phenotypic alterations induced by 8-hydroxyquinoline in melanoma cell lines.
Topics: Animals; Cell Division; Cell Line; Humans; Melanoma; Melanoma, Experimental; Mice; Oxyquinoline | 1990 |