oxypurinol and Carotid-Stenosis

oxypurinol has been researched along with Carotid-Stenosis* in 1 studies

Other Studies

1 other study(ies) available for oxypurinol and Carotid-Stenosis

ArticleYear
Purine catabolism in advanced carotid artery plaque.
    Nucleosides, nucleotides & nucleic acids, 2006, Volume: 25, Issue:9-11

    This study was carried out on carotid artery plaque and plasma of 50 patients. We analyzed uric acid, hypoxanthine, xanthine, and allantoin levels to verify if enzymatic purine degradation occurs in advanced carotid plaque; we also determined free radicals and sulphydryl groups to check if there is a correlation between oxidant status and purine catabolism. Comparing plaque and plasma we found higher levels of free radicals, hypoxanthine, xanthine, and a decrease of some oxidant protectors, such as sulphydryl groups and uric acid, in plaque. We also observed a very important phenomenon in plaque, the presence of allantoin due to chemical oxidation of uric acid, since humans do not have the enzyme uricase. The hypothetical elevated activity of xanthine oxidase in atherosclerosis could be reduced by specific therapies using its inhibitors, such as oxypurinol or allopurinol.

    Topics: Aged; Aged, 80 and over; Allantoin; Allopurinol; Carotid Stenosis; Chemistry, Clinical; Female; Free Radicals; Humans; Hypoxanthine; Male; Middle Aged; Oxidants; Oxypurinol; Purines; Uric Acid; Xanthine

2006