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oxyphenbutazone and Stevens-Johnson Syndrome

oxyphenbutazone has been researched along with Stevens-Johnson Syndrome in 7 studies

Oxyphenbutazone: A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)
oxyphenbutazone : A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.

Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.

Research Excerpts

ExcerptRelevanceReference
"The authors report 18 children with toxic epidermal necrolysis (T."1.27[Toxic epidermal necrolysis in children (Lyell's syndrome). Apropos of 18 cases]. ( Cloup, M; De Frost, Y; Hubert, P; Marsol, P; Richard, P; Roujeau, JC; Teillac, D, 1987)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zeile, G1
Wandel, E1
Bork, K1
Krönig, B1
Neetens, A1
Zelencova, L1
Teillac, D1
Marsol, P1
Richard, P1
Hubert, P1
Roujeau, JC2
Cloup, M1
De Frost, Y1
Albengres, E1
Moritz, S1
Piacentino, A1
Cuny, M1
Revuz, J1
Touraine, R1
Kimmig, J1
Bruinsma, W1
Ritland, S1

Other Studies

7 other studies available for oxyphenbutazone and Stevens-Johnson Syndrome

ArticleYear
[Lyell's syndrome with transient bone marrow depression caused by oxyphenebutazone].
    MMW, Munchener medizinische Wochenschrift, 1979, Jul-13, Volume: 121, Issue:28

    Topics: Adult; Anemia; Blood Cell Count; Bone Marrow Cells; Bone Marrow Diseases; Humans; Male; Oxyphenbutaz

1979
Toxic epidermal bullous necrolysis. A case of lyell-syndrome with fatal issue.
    Bulletin de la Societe belge d'ophtalmologie, 1977, Sep-17, Volume: 178

    Topics: Aged; Eye; Female; Humans; Oxyphenbutazone; Skin; Stevens-Johnson Syndrome; Uveitis

1977
[Toxic epidermal necrolysis in children (Lyell's syndrome). Apropos of 18 cases].
    Archives francaises de pediatrie, 1987, Volume: 44, Issue:8

    Topics: Child; Child, Preschool; Combined Modality Therapy; Critical Care; Female; Humans; Infant; Male; Oxy

1987
Lymphocyte transformation test in drug-induced toxic epidermal necrolysis.
    International archives of allergy and applied immunology, 1985, Volume: 78, Issue:1

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dipyrone; Drug Combinations; Female; Flurbiprofen; Hu

1985
[Allergy and surgery].
    Langenbecks Archiv fur Chirurgie, 1966, Volume: 316

    Topics: Adult; Aged; Anti-Bacterial Agents; Ascorbic Acid; Drug Hypersensitivity; Erythema Multiforme; Femal

1966
Adverse reaction profiles of drug eruptions.
    Dermatologica, 1972, Volume: 145, Issue:6

    Topics: Ampicillin; Analgesics; Aspirin; Chlorpromazine; Drug-Related Side Effects and Adverse Reactions; Er

1972
[Stevens-Johnson syndrome after treatment with Tanderil].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1968, Nov-01, Volume: 88, Issue:21

    Topics: Adolescent; Female; Humans; Oxyphenbutazone; Stevens-Johnson Syndrome

1968