oxyphenbutazone has been researched along with Agranulocytosis in 16 studies
Oxyphenbutazone: A non-steroidal anti-inflammatory drug. Oxyphenbutazone eyedrops have been used abroad in the management of postoperative ocular inflammation, superficial eye injuries, and episcleritis. (From AMA, Drug Evaluations Annual, 1994, p2000) It had been used by mouth in rheumatic disorders such as ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis but such use is no longer considered justified owing to the risk of severe hematological adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p27)
oxyphenbutazone : A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following association with blood dyscrasis and Stevens-Johnson syndrome.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " She subsequently developed agranulocytosis and cholestatic hepatitis as an adverse reaction to these drugs, later identified as oxyphenbutazone and diazepam." | 3.67 | Agranulocytosis and hepatitis as a result of Mexican drug therapy. ( Jacknowitz, AI; Walker, BK, 1984) |
| "Thirteen out of 17 deaths from agranulocytosis were attributed to co-trimoxazole treatment." | 1.26 | Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone. ( Inman, WH, 1977) |
| "Cases of drug-induced aplastic anaemia, haemolytic anaemia, thrombocytopenia, and agranulocytosis reported to the Swedish Adverse Drug Reaction Committee during the five-year period 1966-70 have been analysed and compared with cases of the same cytopenias from "all" causes." | 1.25 | Drug-induced blood dyscrasias in Sweden. ( Böttiger, LE; Westerholm, B, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HAUGEN, J | 1 |
| SKARSTEN, KW | 1 |
| JOHANSEN, PE | 1 |
| TOJNER, H | 1 |
| SVANTESSON, H | 1 |
| Offerhaus, L | 1 |
| Jacknowitz, AI | 1 |
| Walker, BK | 1 |
| Keränen, N | 1 |
| Kauko, M | 1 |
| Talvensaari, T | 1 |
| Veikkolin, T | 1 |
| Tiililä, M | 1 |
| Smith, CS | 1 |
| Chinn, S | 1 |
| Watts, RW | 1 |
| Inman, WH | 1 |
| Chaplin, S | 1 |
| Lagarde, B | 1 |
| Varieras, B | 1 |
| Böttiger, LE | 1 |
| Westerholm, B | 1 |
| Brownlie, BE | 1 |
| Strang, PJ | 1 |
| Segagni, E | 1 |
| Mina, G | 1 |
| Varaldo, G | 1 |
1 review available for oxyphenbutazone and Agranulocytosis
| Article | Year |
|---|---|
Bone marrow depression due to mianserin, phenylbutazone, oxyphenbutazone, and chloramphenicol--Part I.
Topics: Agranulocytosis; Anemia, Aplastic; Bone Marrow; Cell Membrane; Chloramphenicol; Dibenzazepines; DNA | 1986 |
15 other studies available for oxyphenbutazone and Agranulocytosis
| Article | Year |
|---|---|
[Granulocytopenia following oxyphenbutazone treatment].
Topics: Agranulocytosis; Humans; Oxyphenbutazone; Phenylbutazone | 1962 |
[A case of agranulocytosis during Tanderil treatment].
Topics: Agranulocytosis; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Arthritis; Arthritis, Rheumatoi | 1962 |
[AGRANULOCYTOSIS IN TANDERIL TREATMENT. CASE WITH ASSOCIATED ALLERGIC MANIFESTATIONS].
Topics: Agranulocytosis; Immunoelectrophoresis; Oxyphenbutazone; Penicillins; Prednisolone; Tendinopathy; Th | 1963 |
[2 CASES OF TANDERIL SIDE-EFFECTS IN CHILDREN].
Topics: Agranulocytosis; Arthritis; Arthritis, Rheumatoid; Blood Cell Count; Child; Humans; Leukopenia; Oxyp | 1964 |
Phenylbutazone, oxyphenbutazone labeling revised.
Topics: Agranulocytosis; Anemia, Aplastic; Drug Labeling; Humans; Oxyphenbutazone; Phenylbutazone | 1984 |
[Russian roulette with pyrazolones].
Topics: Agranulocytosis; Aminopyrine; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Female; Humans; Mal | 1983 |
Agranulocytosis and hepatitis as a result of Mexican drug therapy.
Topics: Adult; Agranulocytosis; Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Diazepam; Dru | 1984 |
[Drug induced agranulocytosis].
Topics: Agranulocytosis; Dipyrone; Humans; Male; Middle Aged; Oxyphenbutazone; Sulfamethoxazole; Trimethopri | 1981 |
The sensitivity of human bone marrow granulocyte/monocyte precursor cells to phenylbutazone, oxyphenbutazone and gamma-hydroxyphenylbutazone in vitro, with observations on the bone marrow colony formation in phenylbutazone-induced granulocytopoenia.
Topics: Adult; Aged; Agranulocytosis; Bone Marrow; Bone Marrow Cells; Bone Marrow Diseases; Depression, Chem | 1977 |
Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone.
Topics: Adolescent; Adult; Age Factors; Aged; Agranulocytosis; Anemia, Aplastic; Child; Death Certificates; | 1977 |
[Agranulocytosis caused by medication].
Topics: Agranulocytosis; Antithyroid Agents; Female; Humans; Male; Oxyphenbutazone; Phenylbutazone; Sex Fact | 1971 |
[Transitory agranulocytosis of toxic origin in a child (during treatment with oxyphenylbutazone and sulfamethoxazole-trimethoprim)].
Topics: Agranulocytosis; Child, Preschool; Drug Therapy, Combination; Erythromycin; Fever; Humans; Male; Oxy | 1974 |
Drug-induced blood dyscrasias in Sweden.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Agranulocytosis; Anemia, Aplastic; Anemi | 1973 |
Oxyphenbutazone (Tanderil) and blood dyscrasia.
Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Bone Marrow; Female; Hematologic Diseases; Hematopoi | 1969 |
[On a case of partial aplastic myelosis during rheumatic disease].
Topics: Agranulocytosis; Analgesics; Anemia, Aplastic; Antihypertensive Agents; Child; Female; Humans; Oxyph | 1969 |