Page last updated: 2024-11-02

oxymetazoline and Sinusitis

oxymetazoline has been researched along with Sinusitis in 12 studies

Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.

Sinusitis: Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.

Research Excerpts

ExcerptRelevanceReference
"The aim was to study changes in sales and prescribing of nasal decongestants containing oxymetazoline or xylometazoline, changes in number of physician visits for rhinitis and sinusitis, and changes in public expenditures for physician visits due to the switch of these drugs from prescription to over-the-counter status in Sweden in 1989."3.70The impact of over-the-counter availability of nasal sprays on sales, prescribing, and physician visits. ( Isacson, D; Lundberg, L, 1999)
"The aim of this study was to evaluate the incidence of paranasal sinusitis and the histologic changes in the sinus mucosa after long-term administration of topical nasal decongestants, phenylephrine and oxymetazoline."3.69Paranasal sinusitis after long-term use of topical nasal decongestants. ( Jeon, SY; Kim, HS; Min, YG; Son, YI; Suh, SH; Yoon, S, 1996)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's5 (41.67)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schechtman, SA1
Wertz, AP1
Shanks, A1
Thompson, A1
Tremper, K1
Pynnonen, MA1
Healy, DW1
Song, XH1
Zhang, L1
Han, DM1
Wang, KJ1
Wang, H1
Zhang, W1
Bende, M1
Fukami, M1
Arfors, KE1
Mark, J1
Stierna, P1
Intaglietta, M1
Min, YG1
Kim, HS1
Suh, SH1
Jeon, SY1
Son, YI1
Yoon, S1
Lundberg, L1
Isacson, D1
Negley, JE1
Krause, H1
Pawar, S1
Reeves-Hoché, MK1
Inanli, S1
Oztürk, O1
Korkmaz, M1
Tutkun, A1
Batman, C1
Riegle, EV1
Gunter, JB1
Lusk, RP1
Muntz, HR1
Weiss, KL1
Maes, JJ1
Clement, PA1
Ten Eyck, TG1
Schleuning, A1
Tanaka, M1
Neffson, AH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Hot Saline Irrigation vs Room Temperature Saline Irrigation in the Control of Intraoperative Bleeding During Functional Endoscopic Sinus Surgery (FESS)[NCT01717274]60 participants (Actual)Interventional2012-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

4 trials available for oxymetazoline and Sinusitis

ArticleYear
RinoFlow nasal wash and sinus system as a mechanism to deliver medications to the paranasal sinuses: results of a radiolabeled pilot study.
    Ear, nose, & throat journal, 1999, Volume: 78, Issue:8

    Topics: Administration, Inhalation; Adolescent; Adult; Drug Delivery Systems; Equipment Design; Female; Huma

1999
The effects of topical agents of fluticasone propionate, oxymetazoline, and 3% and 0.9% sodium chloride solutions on mucociliary clearance in the therapy of acute bacterial rhinosinusitis in vivo.
    The Laryngoscope, 2002, Volume: 112, Issue:2

    Topics: Acute Disease; Administration, Topical; Adolescent; Adult; Aged; Analysis of Variance; Androstadiene

2002
Comparison of vasoconstrictors for functional endoscopic sinus surgery in children.
    The Laryngoscope, 1992, Volume: 102, Issue:7

    Topics: Blood Pressure; Child; Child, Preschool; Chronic Disease; Cocaine; Double-Blind Method; Heart Rate;

1992
The usefulness of irrigation of the maxillary sinus in children with maxillary sinusitis on the basis of the Water's X-ray.
    Rhinology, 1987, Volume: 25, Issue:4

    Topics: Anti-Bacterial Agents; Child; Child, Preschool; Combined Modality Therapy; Humans; Imidazoles; Maxil

1987

Other Studies

8 other studies available for oxymetazoline and Sinusitis

ArticleYear
Preoperative β-blockade and hypertension in the first hour of functional endoscopic sinus surgery.
    The Laryngoscope, 2017, Volume: 127, Issue:7

    Topics: Administration, Topical; Adrenergic beta-Antagonists; Adult; Anesthetics, Local; Chronic Disease; Dr

2017
[Effects of oxymetazoline hydrochloride on ex vivo human nasal cilia movement measured with high-speed digital microscopy].
    Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2008, Volume: 43, Issue:4

    Topics: Cells, Cultured; Cilia; Humans; Microscopy; Mucociliary Clearance; Nasal Mucosa; Oxymetazoline; Sinu

2008
Effect of oxymetazoline nose drops on acute sinusitis in the rabbit.
    The Annals of otology, rhinology, and laryngology, 1996, Volume: 105, Issue:3

    Topics: Acute Disease; Administration, Intranasal; Animals; Drug Evaluation; Maxillary Sinus; Nasal Deconges

1996
Paranasal sinusitis after long-term use of topical nasal decongestants.
    Acta oto-laryngologica, 1996, Volume: 116, Issue:3

    Topics: Administration, Topical; Animals; Nasal Decongestants; Nasal Mucosa; Nerve Degeneration; Oxymetazoli

1996
The impact of over-the-counter availability of nasal sprays on sales, prescribing, and physician visits.
    Scandinavian journal of primary health care, 1999, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Prescriptions; Female; Health Expenditures; H

1999
Nasal decongestants in otorhinolaryngology.
    Western medicine; the medical journal of the west, 1966, Volume: 7, Issue:6

    Topics: Adolescent; Adult; Aged; Female; Humans; Male; Middle Aged; Nasal Decongestants; Oxymetazoline; Resp

1966
[Clinical use of Nasibin for chronic sinusitis].
    Jibi inkoka Otolaryngology, 1966, Volume: 38, Issue:11

    Topics: Adolescent; Adult; Child; Female; Humans; Male; Nasal Decongestants; Oxymetazoline; Sinusitis

1966
A topical nasal decongestant for children.
    Eye, ear, nose & throat monthly, 1968, Volume: 47, Issue:3

    Topics: Child, Preschool; Cresols; Female; Foreign Bodies; Fractures, Bone; Humans; Imidazoles; Infant; Male

1968