oxymetazoline has been researched along with Muscle Contraction in 51 studies
Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " 3 X 10(-8) -- 10(6) M yohimbine enhanced the overflow of tritium and the smooth muscle contraction induced by transmural sympathetic nerve stimulation." | 3.65 | Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine. ( Borowski, E; Endo, T; Starke, K, 1975) |
| " At higher concentrations, 3 x 10(-5) and 10(-4) m, of the antagonist, the agonist dose-response curve was shifted to the right with a decrease in the maximum effect." | 1.33 | Antagonism by imidazoline-type drugs of muscarinic and other receptors in the guinea-pig ileum. ( Miller, DD; Patil, PN; Salazar-Bookaman, MM, 2006) |
| "Oxymetazoline was less effective, indanidine and clonidine were ineffective." | 1.32 | Contractile actions of imidazoline alpha-adrenoceptor agonists and effects of noncompetitive alpha1-adrenoceptor antagonists in human vas deferens. ( Amobi, N; Guillebaud, J; Kaisary, A; Lloyd-Davies, RW; Smith, IC; Turner, E, 2003) |
| " Pretreatment of CCSM strips with selective alpha2-adrenoceptor antagonists, rauwolscine and RS-15385, produced rightward shifts in the dose-response curves to UK 14,304 (pA2 values 7." | 1.30 | The expression of functional postsynaptic alpha2-adrenoceptors in the corpus cavernosum smooth muscle. ( Gallant, CM; Goldstein, I; Gupta, S; Moreland, RB; Traish, A; Yang, S, 1998) |
| "When oxymetazoline was used as an agonist and in the presence of CEC, prazosin was unexpectedly weak in urethra with an affinity value of 6." | 1.29 | Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit. ( Deplanne, V; Galzin, AM, 1996) |
| " The dose-response curves generated by the model for partial agonists were similar to the curves obtained experimentally in vitro." | 1.27 | Relationship between alpha-adrenoceptor occupancy and contractile response in rat vas deferens. Experimental and theoretical analysis. ( Díaz-Toledo, A; Martí, MC, 1988) |
| "4 X 10(-6) M) produced parallel shifts to the right of the dose-response curves to noradrenaline and oxymetazoline in isolated strips of cat splenic capsule." | 1.26 | The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen. ( Blakeley, AG; Summers, RJ, 1977) |
| " 2 In the absence of morphine the inhibitory effects of the presynaptic alpha-adrenoceptor agonists, clonidine and oxymetazoline were much reduced and the dose-response curve was flat." | 1.26 | The inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro. ( Gillan, MG; Kosterlitz, HW; Robson, LE; Waterfield, AA, 1979) |
| " Cocaine (2 x 10(-6) M and 10(-5) M) produced 2 and 7 fold shifts to the left of the dose-response curve to (-)-noradrenaline recorded isotonically in isolated splenic capsular strips of the cat." | 1.26 | Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips. ( Summers, RJ; Tillman, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (37.25) | 18.7374 |
| 1990's | 18 (35.29) | 18.2507 |
| 2000's | 13 (25.49) | 29.6817 |
| 2010's | 1 (1.96) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Akinaga, J | 2 |
| Lima, V | 2 |
| Kiguti, LR | 1 |
| Hebeler-Barbosa, F | 1 |
| Alcántara-Hernández, R | 1 |
| García-Sáinz, JA | 1 |
| Pupo, AS | 3 |
| Gil-Gastelum, O | 2 |
| Valencia, I | 2 |
| Larios, FJ | 1 |
| Castillo, EF | 2 |
| Castillo, C | 3 |
| López, O | 1 |
| Medina, R | 1 |
| Amobi, N | 1 |
| Guillebaud, J | 1 |
| Kaisary, A | 1 |
| Lloyd-Davies, RW | 1 |
| Turner, E | 1 |
| Smith, IC | 1 |
| Arévalo-León, LE | 1 |
| Gallardo-Ortíz, IA | 1 |
| Urquiza-Marín, H | 1 |
| Villalobos-Molina, R | 1 |
| Campos, M | 1 |
| de Lucena Morais, P | 1 |
| Fülöp, K | 2 |
| Zádori, Z | 1 |
| Rónai, AZ | 1 |
| Gyires, K | 2 |
| Salazar-Bookaman, MM | 1 |
| Miller, DD | 3 |
| Patil, PN | 3 |
| Zádori, ZS | 1 |
| Shujaa, N | 1 |
| Dunkel, P | 1 |
| Kamikihara, SY | 1 |
| Mueller, A | 1 |
| Nojimoto, FD | 1 |
| Castilho, A | 1 |
| Buratini, J | 1 |
| Corboz, MR | 1 |
| Rivelli, MA | 1 |
| Mingo, GG | 1 |
| McLeod, RL | 1 |
| Varty, L | 1 |
| Jia, Y | 1 |
| Hey, JA | 1 |
| Wang, HW | 1 |
| Wu, CC | 1 |
| Steen, S | 1 |
| Skärby, TV | 1 |
| Norgren, L | 1 |
| Andersson, KE | 1 |
| MacDonald, A | 1 |
| McGrath, JC | 1 |
| Malta, E | 1 |
| Raper, C | 1 |
| Tawa, PE | 1 |
| Fuder, H | 1 |
| Selbach, M | 1 |
| Duarte, J | 1 |
| Pérez-Vizcaíno, F | 1 |
| Zarzuelo, A | 1 |
| Jiménez, J | 1 |
| Tamargo, J | 1 |
| Malone, ED | 1 |
| Brown, DR | 1 |
| Trent, AM | 1 |
| Turner, TA | 1 |
| Colucci, R | 1 |
| Blandizzi, C | 1 |
| Carignani, D | 1 |
| Lazzeri, G | 1 |
| Natale, G | 1 |
| Crema, F | 1 |
| Del Tacca, M | 1 |
| Deplanne, V | 1 |
| Galzin, AM | 1 |
| Liu, L | 1 |
| Coupar, IM | 1 |
| Gupta, S | 1 |
| Moreland, RB | 1 |
| Yang, S | 1 |
| Gallant, CM | 1 |
| Goldstein, I | 1 |
| Traish, A | 1 |
| Muramatsu, I | 3 |
| Murata, S | 1 |
| Isaka, M | 1 |
| Piao, HL | 1 |
| Zhu, J | 1 |
| Suzuki, F | 2 |
| Miyamoto, S | 1 |
| Oshita, M | 2 |
| Watanabe, Y | 2 |
| Taniguchi, T | 3 |
| Arimitsu, M | 1 |
| Mitsui-Saito, M | 1 |
| Sato, K | 1 |
| Ozaki, H | 1 |
| Koga, Y | 1 |
| Karaki, H | 1 |
| Thorin, E | 1 |
| Hiraoka, Y | 1 |
| Ohmura, T | 1 |
| Morikawa, K | 1 |
| Nagata, O | 1 |
| Kato, H | 1 |
| Nakamura, S | 1 |
| Akagi, Y | 1 |
| Jing, L | 1 |
| Jagadeesh, JM | 1 |
| De Los Angeles, J | 1 |
| Kontani, H | 1 |
| Tsuji, T | 1 |
| Kimura, S | 1 |
| Rajamani, K | 1 |
| Leong, S | 1 |
| Lavelle, A | 1 |
| Docherty, JR | 1 |
| Blakeley, AG | 1 |
| Summers, RJ | 2 |
| Gillan, MG | 1 |
| Kosterlitz, HW | 1 |
| Robson, LE | 1 |
| Waterfield, AA | 1 |
| Bevan, JA | 1 |
| Johansson, P | 1 |
| Starke, K | 3 |
| Borowski, E | 1 |
| Endo, T | 2 |
| Taube, HD | 1 |
| Sanders, J | 1 |
| Tillman, J | 1 |
| Rajkumar, K | 1 |
| Sharma, PL | 1 |
| Ratnasooriya, WD | 1 |
| Wadsworth, RM | 1 |
| Gilmore, DP | 1 |
| Weitzell, R | 1 |
| Wikberg, J | 1 |
| Zhang, L | 1 |
| Keef, KD | 1 |
| Bradley, ME | 1 |
| Buxton, IL | 1 |
| Sperlágh, B | 1 |
| Vizi, ES | 1 |
| Yoshida, M | 1 |
| Latifpour, J | 1 |
| Nishimoto, T | 1 |
| Weiss, RM | 1 |
| Hong, E | 1 |
| Christ, GJ | 1 |
| Díaz-Toledo, A | 1 |
| Martí, MC | 1 |
| Törnebrandt, K | 1 |
| Nobin, A | 1 |
| Owman, C | 1 |
| Gibson, A | 1 |
| Pollock, D | 1 |
| Amer, MS | 1 |
51 other studies available for oxymetazoline and Muscle Contraction
| Article | Year |
|---|---|
Differential phosphorylation, desensitization, and internalization of α1A-adrenoceptors activated by norepinephrine and oxymetazoline.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; HEK293 Cells; Humans; Male; Muscle Contraction; Norep | 2013 |
Endothelial inhibitory modulation on the contractile responses to alpha 2-adrenergic agonists.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidi | 2002 |
Vasocontractile effects of alpha 2-adrenergic agonists associated with intracellular calcium release.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidi | 2002 |
Contractile actions of imidazoline alpha-adrenoceptor agonists and effects of noncompetitive alpha1-adrenoceptor antagonists in human vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Dibenzylchlorethamine; Dose-Response Relati | 2003 |
Evidence for the role of alpha1D- and alpha1A-adrenoceptors in contraction of the rat mesenteric artery.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; In Vitro Techniques; Ma | 2003 |
Functional characterisation of alpha(1)-adrenoceptors in denervated rat vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Male; Muscle Cont | 2003 |
Characterisation of alpha2-adrenoceptor subtypes involved in gastric emptying, gastric motility and gastric mucosal defence.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Disease Models, Animal; | 2005 |
Antagonism by imidazoline-type drugs of muscarinic and other receptors in the guinea-pig ileum.
Topics: Animals; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; | 2006 |
Pre- and postsynaptic mechanisms in the clonidine- and oxymetazoline-induced inhibition of gastric motility in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbachol; Clonidine; Gastrointest | 2007 |
alpha1-Adrenoceptors in proximal segments of tail arteries from control and reserpinised rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Arteries; Bu | 2007 |
Mechanism of decongestant activity of alpha 2-adrenoceptor agonists.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; A | 2008 |
Effects of oxymetazoline on isolated rat's tracheal smooth muscle.
Topics: Animals; Dose-Response Relationship, Drug; Muscle Contraction; Muscle, Smooth; Oxymetazoline; Rats; | 2008 |
Pharmacological characterization of postjunctional alpha-adrenoceptors in isolated human omental arteries and veins.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Arteries; Clonidin | 1984 |
Post-natal development of functional neurotransmission in rat vas deferens.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Cocaine; Electric Stimulation; In Vitro Techniques; Male; | 1984 |
Pre- and postjunctional effects of clonidine- and oxymetazoline-like compounds in guinea-pig ileal preparations.
Topics: Acetylcholine; Animals; Clonidine; Electric Stimulation; Guinea Pigs; Ileum; Imidazoles; In Vitro Te | 1981 |
Characterization of sensory neurotransmission and its inhibition via alpha 2B-adrenoceptors and via non-alpha 2-receptors in rabbit iris.
Topics: Animals; Cholinergic Fibers; Electric Stimulation; In Vitro Techniques; Iris; Kinins; Muscle Contrac | 1993 |
Aminophylline preferentially inhibits chloroethylclonidine-insensitive alpha-adrenoceptor-mediated contractions in rat aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aminophylline; Animals; Aorta, Thoracic; Ca | 1993 |
Influence of adrenergic and cholinergic mediators on the equine jejunum in vitro.
Topics: Acetylcholine; Adrenergic Agonists; Adrenergic Antagonists; Animals; Atropine; Brimonidine Tartrate; | 1996 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 1996 |
Functional characterization of alpha-1-adrenoceptor subtypes in the prostatic urethra and trigone of male rabbit.
Topics: Adrenergic Agonists; Animals; Dose-Response Relationship, Drug; Male; Muscle Contraction; Norepineph | 1996 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrat | 1997 |
The expression of functional postsynaptic alpha2-adrenoceptors in the corpus cavernosum smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Cyc | 1998 |
Alpha1-adrenoceptor subtypes and two receptor systems in vascular tissues.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; COS Cells; In Vit | 1998 |
Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cattle; Clonidine; Cyclic | 1998 |
Functional cross-talk between endothelial muscarinic and alpha2-adrenergic receptors in rabbit cerebral arteries.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Cerebral Arteries; Endothelin-1; Endothelium, Vas | 1998 |
Binding and functional characterization of alpha1-adrenoceptor subtypes in the rat prostate.
Topics: Acetonitriles; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha- | 1999 |
Evaluation of alpha1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; D | 1999 |
Depolarization of membrane potential and the smooth muscle contraction by isothiocyanatobenzyl imidazoline in guinea-pig stomach circular muscle.
Topics: Animals; Atropine; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Te | 1999 |
Effects of adrenergic alpha2-receptor agonists on urinary bladder contraction in conscious rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Clonidine; Male; Muscle Co | 2000 |
Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Desipramine; Do | 2001 |
The effects of labetalol (AH 5158) on adrenergic transmission in the cat spleen.
Topics: Animals; Cats; Drug Interactions; Electric Stimulation; Ethanolamines; In Vitro Techniques; Labetalo | 1977 |
The inhibitory effects of presynaptic alpha-adrenoceptor agonists on contractions of guinea-pig ileum and mouse vas deferens in the morphine-dependent and withdrawn states produced in vitro.
Topics: Adenosine Diphosphate; Adrenergic alpha-Agonists; Animals; Clonidine; Drug Implants; Drug Interactio | 1979 |
Transient responses of rabbit cerebral blood vessels to norepinephrine: correlation with intrinsic myogenic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Basilar Artery; Carotid Artery, Internal; Cerebral Arteries; | 1979 |
Antagonistic effects of synthetic alpha adrenoceptor agonists on isolated artery strips from the cod, Gadus morhua.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Therapy, Combi | 1979 |
Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Muscle Contrac | 1975 |
Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Clonidine; Cocaine; Corticosterone; In Vitro | 1975 |
Alpha adrenergic and histaminergic effects of tolazoline-like imidazolines.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Chlorpheniramine; Guinea Pigs; Heart Atria; His | 1975 |
Investigation of the role of calcium in the supersensitivity produced by cocaine in cat spleen strips.
Topics: Angiotensin II; Animals; Calcium; Cats; Chlorpheniramine; Cocaine; Desipramine; Drug Interactions; F | 1979 |
Effect of estradiol and progesterone on the isometric tension developed by longitudinal and circular isthmus of rabbit fallopian tube.
Topics: Animals; Barium; Epinephrine; Estradiol; Fallopian Tubes; Female; In Vitro Techniques; Muscle Contra | 1979 |
The effect of sympathomimetic drugs on contractility of the vas deferens in vitro and in vivo.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Fertility; Guinea Pigs; Humans; I | 1979 |
Is histamine involved in the sympathomimetic effect of nicotine?
Topics: Animals; Arteries; Chlorpheniramine; Histamine; Hydroxydopamines; In Vitro Techniques; Muscle Contra | 1978 |
Differentiation between pre- and postjunctional alpha-receptors in guinea pig ileum and rabbit aorta.
Topics: Animals; Aorta, Thoracic; Cimetidine; Clonidine; Dibenzylchlorethamine; Dose-Response Relationship, | 1978 |
Action of alpha 2A-adrenergic receptors in circular smooth muscle of canine proximal colon.
Topics: Adenylate Cyclase Toxin; Animals; Binding, Competitive; Cell Membrane; Clonidine; Colforsin; Colon; | 1992 |
Is the neuronal ATP release from guinea-pig vas deferens subject to alpha 2-adrenoceptor-mediated modulation?
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Berberine; | 1992 |
Pharmacological characterization of alpha adrenergic receptors in the young and old female rabbit urethra.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Calcium; Clonidine; Female; | 1991 |
Contractile and relaxant effects of alpha-adrenergic agonists on rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Clonidine; Endothelium, Vascular; In Vitro Tech | 1991 |
Determination of agonist dissociation constants in isolated vasculature: equivalence of estimates obtained by the method of partial irreversible receptor inactivation and a novel application of the operational model of pharmacological agonism.
Topics: Animals; Aorta; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxymetazoline; Pharmacology; Phe | 1990 |
Relationship between alpha-adrenoceptor occupancy and contractile response in rat vas deferens. Experimental and theoretical analysis.
Topics: Animals; Dibenzylchlorethamine; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Mal | 1988 |
Pharmacological characterization of alpha-adrenergic receptor subtypes mediating contraction in human mesenteric arteries and veins.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Clonidine; Drug Interactions; Female; Humans; Male; Mesenter | 1985 |
The absence of cocaine- and 6-hydroxydopamine-induced supersensitivity to oxymetazoline in the rat anococcygeus muscle.
Topics: Animals; Cocaine; Drug Interactions; Hydroxydopamines; Imidazoles; In Vitro Techniques; Male; Muscle | 1973 |
Cyclic guanosine 3',5'-monophosphate and gallbladder contraction.
Topics: Acetylcholine; Animals; Cholecystokinin; Cyclic GMP; Dogs; Gallbladder; Male; Muscle Contraction; Ox | 1974 |