Page last updated: 2024-11-02

oxymetazoline and Epistaxis

oxymetazoline has been researched along with Epistaxis in 10 studies

Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.

Epistaxis: Bleeding from the nose.

Research Excerpts

ExcerptRelevanceReference
" the vasoconstrictor oxymetazoline applied topically in achieving hemostasis in patients presenting to the emergency department with anterior epistaxis."7.96Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis. ( Johnson, J; Schrader, M; Whitworth, K; Wisniewski, S, 2020)
"In this retrospective study, 36 patients were given oxymetazoline as a first step in treatment for posterior epistaxis."7.70Oxymetazoline in the treatment of posterior epistaxis. ( Doo, G; Johnson, DS, 1999)
"The purpose of this study was to determine if use of an intranasal vasoconstrictor (oxymetazoline) could be used to effectively treat epistaxis, avoiding nasal packing."7.69Use of oxymetazoline in the management of epistaxis. ( Krempl, GA; Noorily, AD, 1995)
"The study aimed to determine the effect of oxymetazoline nasal spray on the patency of the fistula created after dacryocystorhinostomy, specifically: to compare the success of fistula formation with oxymetazoline versus placebo, and to compare the incidence of post-operative congestion, pain and bleeding with oxymetazoline versus placebo."5.34A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients. ( Lagunzad, JKD; Ranche, FKT; Sosuan, GMN, 2020)
" the vasoconstrictor oxymetazoline applied topically in achieving hemostasis in patients presenting to the emergency department with anterior epistaxis."3.96Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis. ( Johnson, J; Schrader, M; Whitworth, K; Wisniewski, S, 2020)
"In this retrospective study, 36 patients were given oxymetazoline as a first step in treatment for posterior epistaxis."3.70Oxymetazoline in the treatment of posterior epistaxis. ( Doo, G; Johnson, DS, 1999)
"The purpose of this study was to determine if use of an intranasal vasoconstrictor (oxymetazoline) could be used to effectively treat epistaxis, avoiding nasal packing."3.69Use of oxymetazoline in the management of epistaxis. ( Krempl, GA; Noorily, AD, 1995)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's2 (20.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Whitworth, K1
Johnson, J1
Wisniewski, S1
Schrader, M1
Sosuan, GMN1
Ranche, FKT1
Lagunzad, JKD1
Drake, AE1
Packer, CD1
Poetker, DM1
Brown, CS1
Abi-Hachem, R1
Jang, DW1
Bellew, SD1
Johnson, KL1
Nichols, MD1
Kummer, T1
Wolfe, TR1
Bernstone, T1
Krempl, GA1
Noorily, AD1
Doo, G1
Johnson, DS1
Rector, FT1
DeNuccio, DJ1
Alden, MA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.[NCT02285634]68 participants (Actual)Interventional2014-11-30Completed
Feasibility Study of a Nasal Compression Device in Comparison to Digital Nasal Compression for Stopping Epistaxis[NCT05789264]40 participants (Anticipated)Interventional2023-09-26Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Diastolic Blood Pressure

Change from baseline in diastolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes

InterventionmmHg (Mean)
Oxymetazoline 0.05%5.7
Phenylephrine 0.25%7.9
Lidocaine 1% Plus Epinephrine 1:100,0006.2
Bacteriostatic 0.9% NaCL9.3

Change in Heart Rate

Change from baseline in heart rate. (NCT02285634)
Timeframe: baseline, 30 minutes

Interventionbeats/min (Mean)
Oxymetazoline 0.05%2.8
Phenylephrine 0.25%5.2
Lidocaine 1% Plus Epinephrine 1:100,0007.5
Bacteriostatic 0.9% NaCL6.8

Change in Mean Arterial Blood Pressure

Change in mean arterial blood pressure from the baseline measurement (NCT02285634)
Timeframe: baseline, 30 minutes

InterventionmmHg (Mean)
Oxymetazoline 0.05%5.1
Phenylephrine 0.25%6.4
Lidocaine 1% Plus Epinephrine 1:100,0004.6
Bacteriostatic 0.9% NaCL6.5

Change in Systolic Blood Pressure

Change from baseline in systolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes

InterventionmmHg (Mean)
Oxymetazoline 0.05%7.5
Phenylephrine 0.25%8.2
Lidocaine 1% Plus Epinephrine 1:100,0003.5
Bacteriostatic 0.9% NaCL8.9

Reviews

1 review available for oxymetazoline and Epistaxis

ArticleYear
Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases.
    Journal of emergency nursing, 2004, Volume: 30, Issue:2

    Topics: Absorption; Administration, Intranasal; Analgesics, Opioid; Anesthetics, Local; Benzodiazepines; Bio

2004

Trials

3 trials available for oxymetazoline and Epistaxis

ArticleYear
A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients.
    BMC research notes, 2020, May-01, Volume: 13, Issue:1

    Topics: Adult; Aged; Dacryocystorhinostomy; Double-Blind Method; Epistaxis; Female; Fistula; Humans; Male; M

2020
Effect of Intranasal Vasoconstrictors on Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The Journal of emergency medicine, 2018, Volume: 55, Issue:4

    Topics: Administration, Intranasal; Anesthetics, Local; Blood Pressure; Double-Blind Method; Emergency Servi

2018
A comparison of cocaine, oxymetazoline, and saline for nasotracheal intubation.
    AANA journal, 1987, Volume: 55, Issue:1

    Topics: Clinical Trials as Topic; Cocaine; Double-Blind Method; Epistaxis; Humans; Imidazoles; Intubation, I

1987

Other Studies

6 other studies available for oxymetazoline and Epistaxis

ArticleYear
Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis.
    The Journal of emergency medicine, 2020, Volume: 58, Issue:2

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Emergency Service, Hospital; Epistaxis; Fema

2020
Epistaxis Complicated by Hemolacria: A Case Report.
    Clinical medicine & research, 2020, Volume: 18, Issue:2-3

    Topics: Administration, Intranasal; Aged, 80 and over; Epistaxis; Humans; Kidney Failure, Chronic; Male; Oxy

2020
Endoscopic-guided coblation treatment of nasal telangiectasias in hereditary hemorrhagic telangiectasia: "How I do it".
    American journal of rhinology & allergy, 2017, May-01, Volume: 31, Issue:3

    Topics: Anesthesia, Local; Bevacizumab; Cautery; Electrosurgery; Endoscopy; Epistaxis; Humans; Nose; Oxymeta

2017
Management of epistaxis in patients with ventricular assist device: a retrospective review.
    Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2018, Aug-02, Volume: 47, Issue:1

    Topics: Anticoagulants; Epistaxis; Female; Heart-Assist Devices; Hemostatic Techniques; Humans; Male; Oxymet

2018
Use of oxymetazoline in the management of epistaxis.
    The Annals of otology, rhinology, and laryngology, 1995, Volume: 104, Issue:9 Pt 1

    Topics: Adult; Cautery; Drug Administration Schedule; Epistaxis; Female; Humans; Male; Middle Aged; Oxymetaz

1995
Oxymetazoline in the treatment of posterior epistaxis.
    Hawaii medical journal, 1999, Volume: 58, Issue:8

    Topics: Adult; Aged; Epistaxis; Female; Humans; Male; Middle Aged; Nasal Decongestants; Oxymetazoline; Recur

1999