oxymetazoline has been researched along with Epistaxis in 10 studies
Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.
Epistaxis: Bleeding from the nose.
| Excerpt | Relevance | Reference |
|---|---|---|
| " the vasoconstrictor oxymetazoline applied topically in achieving hemostasis in patients presenting to the emergency department with anterior epistaxis." | 7.96 | Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis. ( Johnson, J; Schrader, M; Whitworth, K; Wisniewski, S, 2020) |
| "In this retrospective study, 36 patients were given oxymetazoline as a first step in treatment for posterior epistaxis." | 7.70 | Oxymetazoline in the treatment of posterior epistaxis. ( Doo, G; Johnson, DS, 1999) |
| "The purpose of this study was to determine if use of an intranasal vasoconstrictor (oxymetazoline) could be used to effectively treat epistaxis, avoiding nasal packing." | 7.69 | Use of oxymetazoline in the management of epistaxis. ( Krempl, GA; Noorily, AD, 1995) |
| "The study aimed to determine the effect of oxymetazoline nasal spray on the patency of the fistula created after dacryocystorhinostomy, specifically: to compare the success of fistula formation with oxymetazoline versus placebo, and to compare the incidence of post-operative congestion, pain and bleeding with oxymetazoline versus placebo." | 5.34 | A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients. ( Lagunzad, JKD; Ranche, FKT; Sosuan, GMN, 2020) |
| " the vasoconstrictor oxymetazoline applied topically in achieving hemostasis in patients presenting to the emergency department with anterior epistaxis." | 3.96 | Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis. ( Johnson, J; Schrader, M; Whitworth, K; Wisniewski, S, 2020) |
| "In this retrospective study, 36 patients were given oxymetazoline as a first step in treatment for posterior epistaxis." | 3.70 | Oxymetazoline in the treatment of posterior epistaxis. ( Doo, G; Johnson, DS, 1999) |
| "The purpose of this study was to determine if use of an intranasal vasoconstrictor (oxymetazoline) could be used to effectively treat epistaxis, avoiding nasal packing." | 3.69 | Use of oxymetazoline in the management of epistaxis. ( Krempl, GA; Noorily, AD, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Whitworth, K | 1 |
| Johnson, J | 1 |
| Wisniewski, S | 1 |
| Schrader, M | 1 |
| Sosuan, GMN | 1 |
| Ranche, FKT | 1 |
| Lagunzad, JKD | 1 |
| Drake, AE | 1 |
| Packer, CD | 1 |
| Poetker, DM | 1 |
| Brown, CS | 1 |
| Abi-Hachem, R | 1 |
| Jang, DW | 1 |
| Bellew, SD | 1 |
| Johnson, KL | 1 |
| Nichols, MD | 1 |
| Kummer, T | 1 |
| Wolfe, TR | 1 |
| Bernstone, T | 1 |
| Krempl, GA | 1 |
| Noorily, AD | 1 |
| Doo, G | 1 |
| Johnson, DS | 1 |
| Rector, FT | 1 |
| DeNuccio, DJ | 1 |
| Alden, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.[NCT02285634] | 68 participants (Actual) | Interventional | 2014-11-30 | Completed | |||
| Feasibility Study of a Nasal Compression Device in Comparison to Digital Nasal Compression for Stopping Epistaxis[NCT05789264] | 40 participants (Anticipated) | Interventional | 2023-09-26 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change from baseline in diastolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Oxymetazoline 0.05% | 5.7 |
| Phenylephrine 0.25% | 7.9 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 6.2 |
| Bacteriostatic 0.9% NaCL | 9.3 |
Change from baseline in heart rate. (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | beats/min (Mean) |
|---|---|
| Oxymetazoline 0.05% | 2.8 |
| Phenylephrine 0.25% | 5.2 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 7.5 |
| Bacteriostatic 0.9% NaCL | 6.8 |
Change in mean arterial blood pressure from the baseline measurement (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Oxymetazoline 0.05% | 5.1 |
| Phenylephrine 0.25% | 6.4 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 4.6 |
| Bacteriostatic 0.9% NaCL | 6.5 |
Change from baseline in systolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Oxymetazoline 0.05% | 7.5 |
| Phenylephrine 0.25% | 8.2 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 3.5 |
| Bacteriostatic 0.9% NaCL | 8.9 |
1 review available for oxymetazoline and Epistaxis
| Article | Year |
|---|---|
Intranasal drug delivery: an alternative to intravenous administration in selected emergency cases.
Topics: Absorption; Administration, Intranasal; Analgesics, Opioid; Anesthetics, Local; Benzodiazepines; Bio | 2004 |
3 trials available for oxymetazoline and Epistaxis
| Article | Year |
|---|---|
A randomized controlled trial on the effects of oxymetazoline nasal spray after dacryocystorhinostomy among adult patients.
Topics: Adult; Aged; Dacryocystorhinostomy; Double-Blind Method; Epistaxis; Female; Fistula; Humans; Male; M | 2020 |
Effect of Intranasal Vasoconstrictors on Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intranasal; Anesthetics, Local; Blood Pressure; Double-Blind Method; Emergency Servi | 2018 |
A comparison of cocaine, oxymetazoline, and saline for nasotracheal intubation.
Topics: Clinical Trials as Topic; Cocaine; Double-Blind Method; Epistaxis; Humans; Imidazoles; Intubation, I | 1987 |
6 other studies available for oxymetazoline and Epistaxis
| Article | Year |
|---|---|
Comparative Effectiveness of Topically Administered Tranexamic Acid Versus Topical Oxymetazoline Spray for Achieving Hemostasis in Epistaxis.
Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Emergency Service, Hospital; Epistaxis; Fema | 2020 |
Epistaxis Complicated by Hemolacria: A Case Report.
Topics: Administration, Intranasal; Aged, 80 and over; Epistaxis; Humans; Kidney Failure, Chronic; Male; Oxy | 2020 |
Endoscopic-guided coblation treatment of nasal telangiectasias in hereditary hemorrhagic telangiectasia: "How I do it".
Topics: Anesthesia, Local; Bevacizumab; Cautery; Electrosurgery; Endoscopy; Epistaxis; Humans; Nose; Oxymeta | 2017 |
Management of epistaxis in patients with ventricular assist device: a retrospective review.
Topics: Anticoagulants; Epistaxis; Female; Heart-Assist Devices; Hemostatic Techniques; Humans; Male; Oxymet | 2018 |
Use of oxymetazoline in the management of epistaxis.
Topics: Adult; Cautery; Drug Administration Schedule; Epistaxis; Female; Humans; Male; Middle Aged; Oxymetaz | 1995 |
Oxymetazoline in the treatment of posterior epistaxis.
Topics: Adult; Aged; Epistaxis; Female; Humans; Male; Middle Aged; Nasal Decongestants; Oxymetazoline; Recur | 1999 |