Compounds > oxymetazoline
Page last updated: 2024-11-02

oxymetazoline and Cerebrospinal Fluid Otorrhea

oxymetazoline has been researched along with Cerebrospinal Fluid Otorrhea in 2 studies

Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.

Cerebrospinal Fluid Otorrhea: Discharge of cerebrospinal fluid through the external auditory meatus or through the eustachian tube into the nasopharynx. This is usually associated with CRANIOCEREBRAL TRAUMA (e.g., SKULL FRACTURE involving the TEMPORAL BONE;), NEUROSURGICAL PROCEDURES; or other conditions, but may rarely occur spontaneously. (From Am J Otol 1995 Nov;16(6):765-71)

Research Excerpts

ExcerptRelevanceReference
"Oxymetazoline did not cause ototoxicity in a chinchilla animal model 2 months after a single application via a tympanostomy tube."1.38Oxymetazoline ototoxicity in a chinchilla animal model. ( Akache, F; Akinpelu, OV; Daniel, SJ; Funnell, WR; Sahmkow, S, 2012)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Daniel, SJ1
Akinpelu, OV1
Sahmkow, S1
Funnell, WR1
Akache, F1
Isaacson, G1

Other Studies

2 other studies available for oxymetazoline and Cerebrospinal Fluid Otorrhea

ArticleYear
Oxymetazoline ototoxicity in a chinchilla animal model.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2012, Volume: 146, Issue:1

    Topics: Administration, Topical; Animals; Cerebrospinal Fluid Otorrhea; Chinchilla; Disease Models, Animal;

2012
Further evidence of oxymetazoline's safety in otologic surgery.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2012, Volume: 147, Issue:1

    Topics: Animals; Cerebrospinal Fluid Otorrhea; Female; Middle Ear Ventilation; Otoacoustic Emissions, Sponta

2012