oxymetazoline has been researched along with Blood Pressure, High in 10 studies
Oxymetazoline: A direct acting sympathomimetic used as a vasoconstrictor to relieve nasal congestion. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1251)
oxymetazoline : A member of the class of phenols that is 2,4-dimethylphenol which is substituted at positions 3 and 6 by 4,5-dihydro-1H-imidazol-2-ylmethyl and tert-butyl groups, respectively. A direct-acting sympathomimetic with marked alpha-adrenergic activity, it is a vasoconstrictor that is used (generally as the hydrochloride salt) to relieve nasal congestion.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the first 3 h after administration of PPA, there was a dose-response increase in the systolic and diastolic blood pressures, which then returned to baseline." | 2.69 | Effects of sustained-release oral phenylpropanolamine on the nasal mucosa of healthy subjects. ( Graf, P; Hallén, H; Palm, J; Toll, K, 1999) |
| " Given its vasoconstrictive properties, it can have cardiovascular adverse effects when systemically absorbed." | 1.62 | Topical Nasal Decongestant Oxymetazoline: Safety Considerations for Perioperative Pediatric Use. ( Cartabuke, R; Jatana, KR; Tobias, JD, 2021) |
| "Oxymetazoline nasal spray is a potent alpha 1-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa." | 1.29 | Cardiac arrest after oxymetazoline nasal spray. ( Thrush, DN, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cartabuke, R | 1 |
| Tobias, JD | 1 |
| Jatana, KR | 1 |
| Bellew, SD | 1 |
| Johnson, KL | 1 |
| Nichols, MD | 1 |
| Kummer, T | 1 |
| Latham, GJ | 1 |
| Jardine, DS | 1 |
| Schechtman, SA | 1 |
| Wertz, AP | 1 |
| Shanks, A | 1 |
| Thompson, A | 1 |
| Tremper, K | 1 |
| Pynnonen, MA | 1 |
| Healy, DW | 1 |
| Thrush, DN | 1 |
| Le Jossec, M | 1 |
| Cloix, JF | 1 |
| Dausse, JP | 1 |
| Sprung, J | 1 |
| Alhaddad, ST | 1 |
| Graf, P | 1 |
| Toll, K | 1 |
| Palm, J | 1 |
| Hallén, H | 1 |
| Remie, R | 1 |
| Van Rossum, JX | 1 |
| Coppes, RP | 1 |
| Zaagsma, J | 1 |
| Schmitt, H | 1 |
| Fénard, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.[NCT02285634] | 68 participants (Actual) | Interventional | 2014-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change from baseline in diastolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Oxymetazoline 0.05% | 5.7 |
| Phenylephrine 0.25% | 7.9 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 6.2 |
| Bacteriostatic 0.9% NaCL | 9.3 |
Change from baseline in heart rate. (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | beats/min (Mean) |
|---|---|
| Oxymetazoline 0.05% | 2.8 |
| Phenylephrine 0.25% | 5.2 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 7.5 |
| Bacteriostatic 0.9% NaCL | 6.8 |
Change in mean arterial blood pressure from the baseline measurement (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Oxymetazoline 0.05% | 5.1 |
| Phenylephrine 0.25% | 6.4 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 4.6 |
| Bacteriostatic 0.9% NaCL | 6.5 |
Change from baseline in systolic blood pressure. (NCT02285634)
Timeframe: baseline, 30 minutes
| Intervention | mmHg (Mean) |
|---|---|
| Oxymetazoline 0.05% | 7.5 |
| Phenylephrine 0.25% | 8.2 |
| Lidocaine 1% Plus Epinephrine 1:100,000 | 3.5 |
| Bacteriostatic 0.9% NaCL | 8.9 |
2 trials available for oxymetazoline and Blood Pressure, High
| Article | Year |
|---|---|
Effect of Intranasal Vasoconstrictors on Blood Pressure: A Randomized, Double-Blind, Placebo-Controlled Trial.
Topics: Administration, Intranasal; Anesthetics, Local; Blood Pressure; Double-Blind Method; Emergency Servi | 2018 |
Effects of sustained-release oral phenylpropanolamine on the nasal mucosa of healthy subjects.
Topics: Administration, Intranasal; Administration, Oral; Adult; Aerosols; Blood Pressure; Cross-Over Studie | 1999 |
8 other studies available for oxymetazoline and Blood Pressure, High
| Article | Year |
|---|---|
Topical Nasal Decongestant Oxymetazoline: Safety Considerations for Perioperative Pediatric Use.
Topics: Age Factors; Child; Child, Preschool; Female; Heart Rate; Humans; Hypertension; Intraoperative Compl | 2021 |
Oxymetazoline and hypertensive crisis in a child: can we prevent it?
Topics: Administration, Inhalation; Administration, Intranasal; Blood Pressure; Child; Child, Preschool; Dru | 2013 |
Preoperative β-blockade and hypertension in the first hour of functional endoscopic sinus surgery.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Adult; Anesthetics, Local; Chronic Disease; Dr | 2017 |
Cardiac arrest after oxymetazoline nasal spray.
Topics: Anti-Arrhythmia Agents; Atropine; Bradycardia; Cardiopulmonary Resuscitation; Child, Preschool; Endo | 1995 |
[Evidence for two alpha 2B-adrenoreceptor isoforms in the renal cortex of salt-sensitive and salt resistant Sabra rats. Effect of salt loading].
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Guanabenz; Hyp | 1995 |
Use of anticholinergics to treat bradycardia caused by alpha1-adrenergic agonist overdose is not safe.
Topics: Administration, Inhalation; Adrenergic alpha-Agonists; Bradycardia; Child, Preschool; Cholinergic An | 1996 |
Dysfunctional presynaptic alpha 2-adrenoceptors expose facilitatory beta 2-adrenoceptors in the vasculature of spontaneously hypertensive rats.
Topics: Animals; Cocaine; Fenoterol; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nore | 1992 |
[Effect of sympathomimetics on the vasomotor centers].
Topics: Animals; Blood Pressure; Bradycardia; Cats; Hemodynamics; Hypertension; Hypotension; Isoproterenol; | 1971 |