oxymatrine has been researched along with Disease Models, Animal in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (14.89) | 29.6817 |
| 2010's | 32 (68.09) | 24.3611 |
| 2020's | 8 (17.02) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cao, Z; Chen, L; Liu, Y; Peng, T | 1 |
| Liu, C; Liu, Y; Meng, C; Wu, F | 1 |
| Du, J; Hao, YJ; Li, YX; Ma, L; Sun, T; Wang, HB; Wang, J; Wang, SJ; Wang, YS; Yu, JQ; Zhao, P; Zhou, R | 1 |
| Luo, Y; Malewicz, N; Nie, H; Pan, J; Rong, J; Situ, Y; Tang, D; Verkhratsky, A; Wang, Y; Ye, K; Zhang, Z; Zhao, J; Zhu, T | 1 |
| Li, Y; Liu, D; Liu, F; Liu, M; Pan, Y; Xiong, Y; Zeng, X; Zhao, H; Zheng, L | 1 |
| Chen, F; Fan, Q; Liu, Y; Long, L; Nie, H; Verkhratsky, A; Wu, Y; Zeng, H; Zhang, X; Zhang, Z; Zhao, J; Zhou, D; Zhu, T | 1 |
| Huang, X; Li, Q; Mei, Z; Tu, C; Wang, W; Xiang, X; Xiong, H; Zhao, Z | 1 |
| Jiao-Yan, Y; Mei, Z; Na, H; Peng, Y; Qi, Y; Qing-Qing, L; Rui-Tao, Z; Ting, S; Wei, J; Xi, L | 1 |
| Chen, L; Guo, Y; Li, D; Li, Y; Qi, X; Yang, G; Zhang, J; Zhang, X; Zhang, Y | 1 |
| Hu, YH; Kong, DJ; Lan, X; Li, X; Qin, YF; Wang, H | 1 |
| Ma, A; Wang, Q; Wang, Y; Wen, J; Yang, Y; Zhang, Y | 1 |
| Jiang, DR; Jiang, W; Zhang, X; Zhao, M; Zhou, AL | 1 |
| Chen, Q; Deng, S; Dong, Y; Duan, X; Fan, H; Liu, X; Liu, Y; Nan, Z; Shou, Z; Tang, Q; Wu, H; Xu, M; Yang, J; Zhang, L; Zuo, D | 1 |
| Jin, B; Jin, H | 1 |
| Dong, P; Han, H; Han, W; Ji, X | 1 |
| Chen, Y; Hao, Y; Li, H; Lv, Z; Qi, Z; Qiao, B | 1 |
| Chen, Q; Deng, S; Fan, H; Liu, X; Liu, Y; Shou, Z; Tang, Q; Wang, Y; Wu, H; Xu, M; Yu, T; Zhang, M | 1 |
| Ahn, KS; Arfuso, F; Bailey Vitarbo, J; Fan, L; Halim, CE; Kumar, AP; Narula, AS; Sethi, G; Tan, CH; Xinjing, SL | 1 |
| Chen, Q; Gu, SL; Li, M; Zhou, W; Zi, XH | 1 |
| Goldsmith, JR; Guzman, JR; Jobin, C; Koo, JS; Mühlbauer, M; Narula, A | 1 |
| Du, J; Dun, L; He, X; Jin, S; Li, J; Li, Y; Ma, L; Sun, T; Wang, H; Xu, Y; Yu, J; Zhou, R | 1 |
| Hu, Z; Shi, L; Song, G; Wang, C; Zhang, D; Zhang, H | 1 |
| Dai, G; Liu, J; Liu, YK; Wang, X; Wang, Y; Xu, Q; Xu, X; Zhang, J; Zhang, W | 1 |
| Chen, T; Fu, Q; Ma, SP; Zhang, TZ | 1 |
| Chen, H; Chen, Z; Jiang, G; Liu, X; Qiu, T; Wang, M | 1 |
| Deng, YO; Liu, YG; Lu, XQ; Wu, SX; Yang, L | 1 |
| Qin, XY; Shi, L; Wang, HW; Wang, QZ; Xu, YP | 1 |
| Bai, B; Li, Y; Wang, X; Wang, Y; Zhang, M; Zhang, R | 1 |
| Fan, L; Feng, H; Jia, B; Lan, F; Li, L; Liu, Q; Wang, T; Wang, Y; Xiao, W; Xing, G; Ye, W; Yue, X; Zhao, L; Zhou, C | 1 |
| Jiang, Y; Luo, H; Mu, Q; Shen, X; Zhi, Y; Zhu, Y | 1 |
| Li, Y; Pan, Z; Sun, H; Xie, G; Xing, Y; Yue, H | 1 |
| Cui, L; Du, W; Li, M; Liu, L; Wang, L; Yang, R; Zhang, X | 1 |
| Chen, Y; Fang, YN; Guo, CY; Li, Q; Wang, Y | 1 |
| Guo, D; Jiangbo, Y; Runtao, G; Shusen, Y; Xu, W | 1 |
| Ding, CB; Jiang, JD; Peng, ZG; Song, DQ; Zhang, JP; Zhao, Y | 1 |
| Hu, Z; Liu, Z; Miao, N; Sun, S; Sun, Y; Wang, Y; Xu, M; Yuan, J; Yuan, X | 1 |
| Du, D; Hu, Z; Liu, Z; Wang, Y; Xu, M; Yuan, X | 1 |
| Cai, CH; Chai, NL; Fu, Q; Shi, H; Wan, J; Wu, BY; Xu, SP | 1 |
| Dai, XY; Hao, YJ; Li, YX; Liu, HY; Sun, T; Wang, HY; Yu, JQ | 1 |
| Chen, CW; Fan, Z; Jia, Y; Lu, L; Mao, Y; Peng, YS; Song, Y; Yang, W; Zeng, M; Zhu, HY | 1 |
| Song, J; Wang, LL; Yao, P; Zhong, HM; Zhu, L | 1 |
| Jin, YR; Li, CH; Piao, DM; Piao, XX; Wu, CS | 1 |
| Li, Q; Shi, GF | 1 |
| Gong, ZN; Rao, SY; Xu, GL; Yao, L; Yu, SQ; Zhang, SQ | 1 |
| Liu, WZ; Lu, LG; Niu, FL; Shi, Y; Zheng, P | 1 |
| Bao-Feng, Y; Dan, Z; De-Li, D; Guo-Fen, Q; Hong-Li, S; Lei, L; Lei, S; Wen-Feng, C; Yan, L | 1 |
1 review(s) available for oxymatrine and Disease Models, Animal
| Article | Year |
|---|---|
Anti-cancer effects of oxymatrine are mediated through multiple molecular mechanism(s) in tumor models.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Humans; Neoplasms; Quinolizines | 2019 |
46 other study(ies) available for oxymatrine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Oxysophoridine rescues spinal cord injury via anti‑inflammatory, anti‑oxidative stress and anti‑apoptosis effects.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blood-Brain Barrier; Dinoprostone; Disease Models, Animal; Female; Gene Expression; Genes, bcl-2; Inflammation Mediators; NF-kappa B; Oxidative Stress; Rats; Spinal Cord Injuries | 2018 |
Oxysophoridine attenuates the injury caused by acute myocardial infarction in rats through anti-oxidative, anti-inflammatory and anti-apoptotic pathways.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Caspase 3; Creatine Kinase; Disease Models, Animal; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Oxidation-Reduction; Oxidative Stress; Rats; Signal Transduction; Troponin C | 2015 |
Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; Cyclooxygenase 2; Cytokines; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Intercellular Adhesion Molecule-1; Male; Mice, Inbred ICR; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Reperfusion Injury; Signal Transduction; Time Factors; Transcription Factor RelA | 2015 |
Oxymatrine screened from Sophora flavescens by cell membrane immobilized chromatography relieves histamine-independent itch.
Topics: Alkaloids; Animals; Antipruritics; Cell Membrane; Chloroquine; Chromatography; Disease Models, Animal; Drug Discovery; Ganglia, Spinal; Histamine; Humans; Isothiocyanates; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Oligopeptides; Phytotherapy; Plant Extracts; Pruritus; Quinolizines; RNA, Messenger; Sophora; TRPA1 Cation Channel | 2021 |
Oxymatrine ameliorated experimental colitis via mechanisms involving inflammatory DCs, gut microbiota and TLR/NF-κB pathway.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Microbiome; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; NF-kappa B | 2023 |
Analgesic and antipruritic effects of oxymatrine sustained-release microgel cream in a mouse model of inflammatory itch and pain.
Topics: Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Antipruritics; Behavior, Animal; Cytokines; Delayed-Action Preparations; Dermatitis, Allergic Contact; Disease Models, Animal; Gels; Male; Mice, Inbred C57BL; Pain; Pruritus; Quinolizines; Rabbits; Skin; Skin Cream | 2020 |
Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Chaperonin 60; Disease Models, Animal; Down-Regulation; HaCaT Cells; HSP90 Heat-Shock Proteins; Humans; Imiquimod; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Protein Binding; Pruritus; Psoriasis; Quinolizines | 2020 |
Oxymatrine improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury by downregulating CAV1 and MMP9 expression.
Topics: Alkaloids; Animals; Blood-Brain Barrier; Brain Ischemia; Caveolin 1; Disease Models, Animal; Down-Regulation; Matrix Metalloproteinase 9; Mice, Inbred C57BL; Neuroprotective Agents; Permeability; Quinolizines; Reperfusion Injury; Sophora | 2021 |
Oxymatrine Extends Survival by Attenuating Neuroinflammation in a Mouse Model of Amyotrophic Lateral Sclerosis.
Topics: Alkaloids; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Mice; Mice, Transgenic; Motor Neurons; Quinolizines; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1 | 2021 |
Oxymatrine protects cardiac allografts by regulating immunotolerant cells.
Topics: Alkaloids; Allografts; Animals; B-Lymphocytes, Regulatory; Dendritic Cells; Disease Models, Animal; Graft Rejection; Graft Survival; Heart Transplantation; Humans; Immune Tolerance; Male; Mice; Quinolizines; T-Lymphocytes, Regulatory | 2021 |
Anti‑inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Biomarkers; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Gene Expression; Inflammation Mediators; Lymphocyte Count; Male; Nuclear Receptor Subfamily 1, Group F, Member 3; Quinolizines; Rats; Spleen; T-Lymphocytes, Regulatory; Th17 Cells | 2017 |
Inhibitory effect of oxymatrine on hepatocyte apoptosis
Topics: Alanine Transaminase; Alkaloids; Animals; Apoptosis; Aspartate Aminotransferases; Caspase 3; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Galactosamine; Glycogen Synthase Kinase 3 beta; Hepatocytes; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Liver Failure, Acute; Male; Microscopy, Electron, Transmission; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinolizines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2017 |
Oxymatrine protects against DSS-induced colitis via inhibiting the PI3K/AKT signaling pathway.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cells, Cultured; Chromones; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred BALB C; Morpholines; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Quinolizines; Signal Transduction; Sophora; Th1 Cells; Th17 Cells | 2017 |
Oxymatrine attenuates lipopolysaccharide-induced acute lung injury by activating the epithelial sodium channel and suppressing the JNK signaling pathway.
Topics: Acute Lung Injury; Alkaloids; Animals; Disease Models, Animal; Epithelial Sodium Channels; Injections, Spinal; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Molecular Targeted Therapy; Quinolizines | 2018 |
Oxymatrine attenuates amyloid beta 42 (Aβ
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Male; Maze Learning; Memory; Neurons; Oxidative Stress; Peptide Fragments; Primary Cell Culture; Quinolizines; Rats; Rats, Sprague-Dawley | 2019 |
Oxymatrine can attenuate pathological deficits of Alzheimer's disease mice through regulation of neuroinflammation.
Topics: Alkaloids; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Inflammation Mediators; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinolizines | 2019 |
Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway.
Topics: Alkaloids; Amides; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cell Proliferation; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Interleukins; Male; Mice; Mice, Inbred BALB C; Oxidative Stress; Pyridines; Quinolizines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Treatment Outcome | 2019 |
[The effect of oxymatrine on aging mice caused by D+ -galactose].
Topics: Aging; Alkaloids; Animals; Antioxidants; Disease Models, Animal; Female; Galactose; Learning; Male; Malondialdehyde; Maze Learning; Memory; Mice; Quinolizines; Random Allocation; Sophora; Superoxide Dismutase; Treatment Outcome | 2012 |
Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation.
Topics: Alkaloids; Animals; Cell Line; Cell Nucleus; Colitis; Cytokines; Dendritic Cells; Dextran Sulfate; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme Activation; I-kappa B Proteins; Inflammation Mediators; Lipopolysaccharides; Mice; Mice, Transgenic; NF-kappa B; Phosphorylation; Protein Transport; Quinolizines; Rats; Transcription Factor RelA | 2013 |
Antinociceptive effects of oxymatrine from Sophora flavescens, through regulation of NR2B-containing NMDA receptor-ERK/CREB signaling in a mice model of neuropathic pain.
Topics: Alkaloids; Analgesics; Animals; Chronic Pain; Constriction; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Neuralgia; Phytotherapy; Plant Extracts; Quinolizines; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve; Signal Transduction; Sophora | 2013 |
Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-α activation.
Topics: Alkaloids; Animals; Body Weight; Disease Models, Animal; Fatty Liver; Insulin Resistance; Intra-Abdominal Fat; Lipid Metabolism; Lipids; Liver; Male; Non-alcoholic Fatty Liver Disease; Organ Size; PPAR alpha; Quinolizines; Rats | 2013 |
Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regulation of DDAH/ADMA metabolism pathway in rats.
Topics: Alkaloids; Amidohydrolases; Animals; Arginine; Cardiotonic Agents; Disease Models, Animal; Female; Heart Failure; Hemodynamics; Isoproterenol; Male; Metabolic Networks and Pathways; Myocardium; Natriuretic Peptide, Brain; Organ Size; Protein-Arginine N-Methyltransferases; Quinolizines; Rats; Rats, Sprague-Dawley; Troponin I | 2014 |
Anti-asthmatic effects of oxymatrine in a mouse model of allergic asthma through regulating CD40 signaling.
Topics: Alkaloids; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Bronchoalveolar Lavage Fluid; CD40 Antigens; Dexamethasone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin E; Interleukins; Irritants; Mice, Inbred BALB C; Ovalbumin; Pulmonary Eosinophilia; Quinolizines; Random Allocation; Signal Transduction | 2015 |
Oxymatrine ameliorates renal ischemia-reperfusion injury from oxidative stress through Nrf2/HO-1 pathway.
Topics: Alkaloids; Animals; Antioxidants; Apoptosis; Blotting, Western; Disease Models, Animal; Heme Oxygenase-1; Immunohistochemistry; In Situ Nick-End Labeling; Kidney; Male; NF-E2-Related Factor 2; Oxidative Stress; Quinolizines; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Reproducibility of Results; Time Factors; Treatment Outcome | 2015 |
[The Analgesia of Oxymatrine Affecting Calcium Channel and GABA Release].
Topics: Alkaloids; Analgesia; Animals; Calcium; Calcium Channels; Disease Models, Animal; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Neuralgia; Pain Management; Quinolizines; Spinal Cord | 2015 |
Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-β1-Smad3 pathway.
Topics: Acute Kidney Injury; Alkaloids; Animals; Cytokines; Disease Models, Animal; Down-Regulation; Fibrosis; Inflammation; Kidney; Mice; Mice, Inbred C57BL; Quinolizines; Random Allocation; Signal Transduction; Smad3 Protein; Transcription Factor RelA; Transforming Growth Factor beta1; Ureteral Obstruction | 2016 |
Oxymatrine protects against sepsis-induced myocardial injury via inhibition of the TNF-α/p38-MAPK/caspase-3 signaling pathway.
Topics: Alkaloids; Animals; Apoptosis; Biomarkers; Caspase 3; Disease Models, Animal; Gene Expression Regulation; Heart Diseases; Heart Function Tests; Male; Myocardium; p38 Mitogen-Activated Protein Kinases; Quinolizines; Rats; Sepsis; Signal Transduction; Tumor Necrosis Factor-alpha | 2016 |
Protective effects of oxymatrine against arsenic trioxide-induced liver injury.
Topics: Alkaloids; Animals; Antioxidants; Arsenic Trioxide; Arsenicals; Blotting, Western; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Heme Oxygenase-1; Male; NF-E2-Related Factor 2; Oxidative Stress; Oxides; Quinolizines; Rats; Rats, Wistar; Signal Transduction | 2017 |
Oxymatrine provides protection against Coxsackievirus B3-induced myocarditis in BALB/c mice.
Topics: Alkaloids; Animals; Antiviral Agents; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Enterovirus B, Human; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Muscle Cells; Myocarditis; Quinolizines; Tumor Necrosis Factor-alpha; Viral Load | 2017 |
Oxymatrine inhibits development of morphine-induced tolerance associated with decreased expression of P-glycoprotein in rats.
Topics: Alkaloids; Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Gene Expression Regulation; Male; Morphine; Pain; Quinolizines; Rats; Rats, Wistar | 2010 |
Neuroprotection and underlying mechanisms of oxymatrine in cerebral ischemia of rats.
Topics: Alkaloids; Analysis of Variance; Animals; Arachidonate 15-Lipoxygenase; Brain Edema; Brain Infarction; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phospholipases A2, Cytosolic; Quinolizines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2011 |
[Antifibrotic effects of oxymatrine in mice with chronic viral myocarditis].
Topics: Alkaloids; Animals; Antiviral Agents; Captopril; Chronic Disease; Disease Models, Animal; Down-Regulation; Enterovirus B, Human; Fibrosis; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Quinolizines; Transforming Growth Factor beta1; Virus Diseases | 2010 |
Oxymatrine, the main alkaloid component of Sophora roots, protects heart against arrhythmias in rats.
Topics: Aconitine; Alkaloids; Animals; Arrhythmias, Cardiac; Calcium; Cardiovascular Agents; Coronary Vessels; Disease Models, Animal; Dose-Response Relationship, Drug; Myocytes, Cardiac; Phytotherapy; Plant Extracts; Plant Roots; Quinolizines; Rats; Rats, Wistar; Sodium; Sodium Channels; Sophora | 2011 |
Zebrafish as a potential model organism for drug test against hepatitis C virus.
Topics: Alkaloids; Animals; Antiviral Agents; Blotting, Western; Disease Models, Animal; Drug Evaluation, Preclinical; Fish Diseases; Gene Amplification; Gene Expression Regulation, Viral; Genetic Vectors; Green Fluorescent Proteins; Hepacivirus; Hepatitis C; Hepatocytes; Humans; In Situ Hybridization; Larva; Microinjections; Microscopy, Fluorescence; Quinolizines; Replicon; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Untranslated Regions; Viral Nonstructural Proteins; Zebrafish | 2011 |
The synergistic anti-inflammatory effect of the combination of sodium ferulate and oxymatrine and its modulation on inflammation-associated mediators in RAW 264.7 cells.
Topics: Alkaloids; Angelica sinensis; Animals; Anti-Inflammatory Agents; C-Reactive Protein; Carrageenan; Coumaric Acids; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Edema; Enzyme-Linked Immunosorbent Assay; Female; Inflammation Mediators; Interferon-gamma; Interleukin-11; Lipopolysaccharides; Macrophages; Male; Mice; Plants, Medicinal; Quinolizines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Sophora; Xylenes | 2011 |
The effects of the combination of sodium ferulate and oxymatrine on lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Coumaric Acids; Disease Models, Animal; Drug Combinations; Edema; Inflammation; Lipopolysaccharides; Lung; Mice; Peroxidase; Quinolizines; Random Allocation; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2012 |
Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells.
Topics: Alkaline Phosphatase; Alkaloids; Animals; Apoptosis; Carbon Tetrachloride; Cell Survival; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; In Vitro Techniques; Liposomes; Liver Cirrhosis; Male; Matrix Metalloproteinase 2; Quinolizines; Rats; Rats, Sprague-Dawley; Tissue Inhibitor of Metalloproteinase-1 | 2012 |
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
Topics: Alkaloids; Animals; Chronic Disease; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Antagonists; GABA Plasma Membrane Transport Proteins; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Mice; Mice, Inbred ICR; Muscimol; Neuralgia; Neuroprotective Agents; Nipecotic Acids; Oximes; Pain Measurement; Pain Threshold; Quinolizines; Receptors, GABA-A; Spinal Cord | 2012 |
[Prophylactic and therapeutic effect of oxymatrine on D-galactosamine-induced rat liver fibrosis].
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Calcium Hydroxide; Chemoprevention; Disease Models, Animal; Galactosamine; Liver Cirrhosis; Liver Function Tests; Male; Quinolizines; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Transforming Growth Factor beta | 2002 |
[Effects of oxymatrine on procollagen metabolism and its gene expression in experimental fibrotic rats].
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Collagen Type III; Disease Models, Animal; Female; Gene Expression; Liver Cirrhosis; Liver Cirrhosis, Experimental; Procollagen; Quinolizines; Rats; Rats, Sprague-Dawley | 2003 |
Treatment of pig serum-induced rat liver fibrosis with Boschniakia rossica, oxymatrine and interferon-alpha.
Topics: Alkaloids; Animals; Antiviral Agents; Biomarkers; Blood Proteins; Disease Models, Animal; Drugs, Chinese Herbal; Immunohistochemistry; Interferon-alpha; Liver Cirrhosis; Male; Organ Size; Orobanchaceae; Quinolizines; Rats; Rats, Wistar; RNA, Messenger; Swine; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Effects of oxymatrine on experimental hepatic fibrosis and its mechanism in vivo.
Topics: Alkaloids; Animals; Carbon Tetrachloride Poisoning; Collagen; Disease Models, Animal; Drugs, Chinese Herbal; Liver Cirrhosis; Male; Quinolizines; Rats; Rats, Sprague-Dawley | 2005 |
Attenuation of acute lung injury in mice by oxymatrine is associated with inhibition of phosphorylated p38 mitogen-activated protein kinase.
Topics: Alkaloids; Animals; Dexamethasone; Disease Models, Animal; Drug Administration Schedule; Drug Antagonism; Drug Evaluation, Preclinical; Injections, Intraperitoneal; Injections, Intravenous; Lung; Male; Medicine, Chinese Traditional; Mice; Microscopy, Electron, Scanning; Oleic Acid; Organ Size; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinolizines; Respiratory Distress Syndrome; Sophora; Tumor Necrosis Factor-alpha | 2005 |
Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Dextran Sulfate; Disease Models, Animal; Interleukin-6; Male; NF-kappa B; Quinolizines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2005 |
Cardioprotective effects and underlying mechanisms of oxymatrine against Ischemic myocardial injuries of rats.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Direct; Heart Ventricles; Lipid Peroxidation; Male; Malondialdehyde; Myocardial Infarction; Myocytes, Cardiac; Phytotherapy; Quinolizines; Rats; Rats, Wistar; Superoxide Dismutase | 2008 |