oxyfedrine and Myocardial-Infarction

Refracterin therapy of patients with chronic heart failure caused by coronary heart disease and postinfarction cardiosclerosis markedly promoted improvement in the pulmonary and systemic circulation in comparison with patients receiving traditional therapy. The mean functional class of chronic cardiac failure decreased by 43% under the effect of refracterin vs. 27% decrease in the group receiving traditional therapy. After 1-month refracterin course the end-systolic and end-diastolic sizes of the left ventricle decreased by 12 and 7%, respectively, ejection fraction increased by 7.2% in comparison with the initial level, total oxidant activity and MDA content in the plasma decreased significantly, while total antioxidant activity, catalase and SOD activities, cytochrome C, NADH, and NADPH levels increased. The prooxidant-antioxidant system was shifted towards antioxidants, which attests to activation of the defense and adaptive mechanisms after administration of refracterin, which is especially important in elderly patients with initially decreased reserve potentialities of the antioxidant defense system.

Topics: Acetyldigoxins; Aged; Aged, 80 and over; Antioxidants; Cardiotonic Agents; Cytochromes c; Drug Combinations; Heart Failure; Humans; Inosine; Myocardial Infarction; NAD; Oxidative Stress; Oxyfedrine; Sclerosis

Left ventricular (LV) function was investigated by left heart catheterization at rest and during exercise in 15 men 3--5 months after acute myocardial infarction. The effect of 8 mg oxyfedrine i.v. in 10 patients was compared to placebo in 5. The administration of oxyfedrine led to a significant decrease of LV end-diastolic pressure; an increase of LV dp/dt max, heart rate, LV ejection fraction and LV stroke work; and a shift of LV function curve indicating its improvement. These results give evidence for a positive inotropic effect of this drug which could have therapeutic implications in patients with impaired LV function after myocardial infarction.

Topics: Adult; Aged; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Heart; Heart Rate; Heart Ventricles; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Physical Exertion; Placebos; Propiophenones

Topics: Adult; Aged; Electrocardiography; Heart Rate; Humans; Middle Aged; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Phonocardiography; Propiophenones; Time Factors

Acute high blood viscosity (HBV) and myocardial necrosis was established by epinephrine (Epi) and ice water stress in rats. Effects of iv oxyfedrine (Oxy) on HBV, plasma viscosity (PV), hematocrit, erythrocyte electrophoretic time (EET), and fibrinogenic viscosity (FV) were studied in model. Results showed that Oxy 1 mg.kg-1 iv markedly decreased the arterial and venous blood HBV at shear rates of 700 s-1 and 70 s-1, respectively (P < 0.01). There were significant differences in the alleviation of HBV among 3 groups (Oxy 0.01, 0.1, and 1 mg.kg-1 iv). The above doses markedly decreased the HBV, PV, and FV, and shortened the EET. Effects of iv Oxy on the myocardial necrosis rat model were scrutinized under the light and electron microscopes. Oxy iv 1 mg.kg-1.d-1 x 1, 3, and 5 d prevented or mitigated the occurrence and development of myocardial necrosis. The structure of heart mitochondria and myofibrils were clearly discernible. This action may be related to the alleviation of HBV by Oxy.

Topics: Animals; Blood Viscosity; Cold Temperature; Epinephrine; Female; Male; Myocardial Infarction; Oxyfedrine; Rats; Rats, Wistar; Stress, Physiological

Topics: Adult; Echocardiography; Female; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Oxyfedrine; Propiophenones

Topics: Animals; Atenolol; Blood Pressure; Heart Rate; Macaca mulatta; Myocardial Infarction; Nifedipine; Oxyfedrine; Propiophenones

The findings on computer tomography after ligation of the coronary artery of a dogs heart are described. The ischaemic area can be differentiated from normal myocardium by its hypo-dense appearance. The localisation and size of the ischaemic area correlates with the scintigraphic findings. The known morphological and functional changes after intravenous oxyfedrin (positively inotropic, increased myocardial blood-flow) can also be seen on the computer tomogram (after oxyfedrin: myocardial thickening, reduction in cross-sectional area of the left ventricle, improved contraction, increased density of the ischaemic area). This confirms the possible diagnostic role of CT in the elucidation of changes in the left ventricle in the course of coronary disease.

Topics: Animals; Coronary Circulation; Disease Models, Animal; Dogs; Female; Male; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Tomography, X-Ray Computed

Topics: Adrenergic beta-Agonists; Animals; Collateral Circulation; Creatine Kinase; Heart Ventricles; Myocardial Infarction; Myocardium; Necrosis; Oxyfedrine; Propiophenones; Rats

Topics: Adult; Aged; Coronary Disease; Heart Failure; Humans; Middle Aged; Myocardial Contraction; Myocardial Infarction; Myocardium; Oxyfedrine; Propiophenones

Topics: Acute Disease; Adult; Aged; Heart; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Nitroglycerin; Oxyfedrine; Propiophenones

In 16 patients with acute transmural myocardial infarction the effect of 8 mg of intravenous oxyfedrine followed by an infusion of 0.3 mg/kg body weight per hour on haemodynamics of the pulmonary and systemic circulation and dynamic cardiac indices was investigated. Cardiac rate, systemic arterial blood pressure, minute volume, cardiac output, and tension-time index remained unchanged on the whole. On the other hand oxyfedrine produced a persistant significant decrease of the mean and diastolic pulmonary artery pressure, pulmonary capillary pressure, and of the contraction and pressure-increase time. These effects were also demonstrable in patients previously treated with digitalis. No cardiac arrhythmias were observed. The positive inotropic effect of oxyfedrine is suggested as reason for these changes.

Topics: Aged; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Propiophenones; Pulmonary Artery; Stimulation, Chemical

Regional left ventricular blood flow and the extent of myocardial ischaemia were studied after acute coronary artery occlusion in open-chest dogs before and after infusion of oxyfedrin, a beta-adrenergic stimulant. Regional blood flow was measured with radioactive tracer microspheres and local tissue injury was estimated by the S-T segment elevation in epicardial electrocardiograms. Animals receiving oxyfedrin were divided into two groups: 1 and 2. Oxyfedrin was infused intravenously in a dose of 0.80 to 0.94 mg.kg-1 in dogs of group 1 and 1.45 to 1.60 mg.kg-1 in dogs of group 2. The rate of infusion in the animals of both groups was 0.61 mg.min-1. Oxyfedrin caused further S-T segment elevation over ischaemic myocardium and increased the extent of ischaemic injury in group 1 dogs. Conversely, in this same group of dogs, the blood flow was unchanged in low flow regions ( less than 0.3 cm3.g-1.min-1) and increased in higher flow areas, inside the ischaemic region. In the animals of group 2, oxyfedrin caused further S-T segment elevation over ischaemic myocardium and increased the extent of ischaemic injury. Concomitantly, blood flow was significantly reduced both inside and outside the ischaemic region. These observations in dogs of group 1 (ie increased blood flow inside the ischaemic region by infusion of oxyfedrin, in flow zones higher than 0.3 cm3.g-1.min-1, with a further S-T segment elevation over ischaemic myocardium, and an increase in the extent of ischaemic injury) may be explained by a primary effect of oxyfedrin on oxygen demands with secondary changes in blood flow.

Topics: Animals; Coronary Circulation; Dogs; Electrocardiography; Heart; Myocardial Infarction; Oxyfedrine; Oxygen Consumption; Propiophenones

In 16 patients with acute transmural myocardial infarction the effect of 8 mg of intravenous oxyfedrine followed by an infusion of 0.3 mg/kg body weight per hour on haemodynamics of the pulmonary and systemic circulation and dynamic cardiac indices was investigated. Cardiac rate, systemic arterial blood pressure, minute volume, cardiac output, and tension-time index remained unchanged on the whole. On the other hand oxyfedrine produced a persistant significant decrease of the mean and diastolic pulmonary artery pressure, pulmonary capillary pressure, and of the contraction and pressure-increase time. These effects were also demonstrable in patients previously treated with digitalis. No cardiac arrhythmias were observed. The positive inotropic effect of oxyfedrine is suggested as reason for these changes.

Topics: Aged; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Oxyfedrine; Propiophenones; Pulmonary Circulation; Vascular Resistance

Topics: Adult; Aged; Angina Pectoris; Cardiac Output; Cineangiography; Female; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Propiophenones

Topics: Adult; Aged; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Infarction; Oxyfedrine; Propiophenones; Time Factors

Topics: Coronary Circulation; Humans; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Propiophenones; Regional Blood Flow; Stimulation, Chemical

Topics: Aged; Coronary Disease; Digoxin; Exercise Therapy; Female; Humans; Male; Middle Aged; Myocardial Infarction; Oxyfedrine

Topics: Cardiac Output; Heart; Heart Rate; Humans; Myocardial Contraction; Myocardial Infarction; Oxyfedrine; Propiophenones

Topics: Adrenergic beta-Antagonists; Ambulatory Care; Analgesics; Angina Pectoris; Anticoagulants; Coronary Disease; Humans; Hypnotics and Sedatives; Myocardial Infarction; Nitrites; Oxyfedrine; Time Factors