oxyfedrine and Headache

oxyfedrine has been researched along with Headache* in 1 studies

Trials

1 trial(s) available for oxyfedrine and Headache

Article	Year
A controlled comparison of oxyfedrine, isosorbide dinitrate and placebo in the treatment of patients suffering attacks of angina pectoris. British journal of clinical pharmacology, 1980, Volume: 10, Issue:3 1 In a group of 23 patients with documented ischaemic heart disease who experienced angina pectoris, oral oxyfedrine (24 mg three times daily) was compared with isosorbide dinitrate (10 mg three times daily) and placebo in a double-blind double-crossover clinical trial. 2 Isosorbide dinitrate appeared no better than placebo, either in terms of symptomatic relief or ECG responses to exercise. Thirty eight per cent of patients complained of headaches and 28% had to cease taking the drug for this reason. 3 Oxyfedrine produced statistically significant improvements in both symptom level (P < 0.01) and ECG ST-segment responses to exercise (P < 0.01). The only side effect noted was a reversible loss of taste sensation by one patient. 4 Neither drug produced any adverse changes in any haematological or biochemical parameters. 5 Oxyfedrine is, therefore, to be preferred to isosorbide dinitrate, being both much better tolerated and more efficacious. Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Exercise Test; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Oxyfedrine; Placebos; Propiophenones	1980

Article

Year

A controlled comparison of oxyfedrine, isosorbide dinitrate and placebo in the treatment of patients suffering attacks of angina pectoris.

British journal of clinical pharmacology, 1980, Volume: 10, Issue:3

1 In a group of 23 patients with documented ischaemic heart disease who experienced angina pectoris, oral oxyfedrine (24 mg three times daily) was compared with isosorbide dinitrate (10 mg three times daily) and placebo in a double-blind double-crossover clinical trial. 2 Isosorbide dinitrate appeared no better than placebo, either in terms of symptomatic relief or ECG responses to exercise. Thirty eight per cent of patients complained of headaches and 28% had to cease taking the drug for this reason. 3 Oxyfedrine produced statistically significant improvements in both symptom level (P < 0.01) and ECG ST-segment responses to exercise (P < 0.01). The only side effect noted was a reversible loss of taste sensation by one patient. 4 Neither drug produced any adverse changes in any haematological or biochemical parameters. 5 Oxyfedrine is, therefore, to be preferred to isosorbide dinitrate, being both much better tolerated and more efficacious.

Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Exercise Test; Female; Headache; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Oxyfedrine; Placebos; Propiophenones

1980