oxyfedrine and Coronary-Disease

Topics: Amiodarone; Angina Pectoris; Chronic Disease; Coronary Disease; Digitalis Glycosides; Humans; Lidoflazine; Oxyfedrine; Perhexiline; Practolol; Prenylamine; Verapamil

Observations are presented about the effects of four kinds of coronary vasodilators (dipyridamole, oxyfedrine, prenylamine and trimetazidine) on coronary circulation in the heart with coronary sclerosis which has been induced by intravenous injection of allylamine in the dog. Following results are obtained: 1) All of the drugs examined increase coronary blood flow and decrease coronary vascular resistance in the dogs with coronary sclerosis as well as in normal dogs. 2) An amplitude of response of coronary circulation to the coronary vasodilators is significantly less in the dogs with coronary sclerosis than in the normal dogs. 3) The clinical value of coronary vasodilator has been discussed.

Topics: Allylamine; Animals; Coronary Angiography; Coronary Circulation; Coronary Disease; Dipyridamole; Dogs; Female; Hemodynamics; Male; Oxyfedrine; Prenylamine; Trimetazidine; Vascular Resistance; Vasodilator Agents

Composite preparation refracterin administered in a dose of 300 mg/day for 3 days in addition to routine therapy significantly improved the results of treatment of severe cardiac insufficiency of ischemic genesis compared to placebo. Improvement of clinical status of patients is determined by positive dynamics of systolic and diastolic functions of the left ventricle.

Topics: Acetyldigoxins; Aged; Cardiac Output, Low; Cardiotonic Agents; Chronic Disease; Coronary Disease; Cytochromes c; Drug Combinations; Echocardiography; Female; Humans; Inosine; Male; Middle Aged; NAD; Oxyfedrine; Systole; Treatment Outcome; Ventricular Function, Left

In an open multicentre trial, the clinical efficacy and tolerance of Oxyfedrine, (Ildamen forte) was evaluated in 123 patients with angina pectoris. After three months of treatment the frequency of anginal attacks and nitroglycerin consumption were markedly reduced in 80 percent, after 12 months in 88% of patients; 37 percent were totally angina-free and 50% were without need for sublingual nitroglycerin. Side-effects were reported by 23.6% of patients during the first months of treatment with a total of eight symptoms being reported in 40 instances; after one year, the incidence of side-effects was substantially reduced to 8 instances in 6 percent of patients. Laboratory investigation were not significantly affected: in 11 patients minor deviations from the reference range were noted without clinical relevance. Dropouts due do drug intolerance were not observed.

Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Female; Humans; Long-Term Care; Male; Middle Aged; Oxyfedrine; Propiophenones

Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Female; Follow-Up Studies; Humans; Male; Middle Aged; Oxyfedrine; Propiophenones

Topics: Blood Pressure; Bupranolol; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Drug Evaluation; Heart; Heart Rate; Hemodynamics; Humans; Isosorbide Dinitrate; Myocardial Contraction; Oxyfedrine; Propanolamines; Propiophenones; Radionuclide Imaging; Xenon Radioisotopes

Topics: Blood Pressure; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Drug Evaluation; Heart Rate; Humans; Oxyfedrine; Propiophenones; Pulse; Respiration

The influence of Dipyridamol and Oxyfedrin on regional myocardial precapillary microperfusion patterns was investigated in groups of 15 and 13 patients by means of selective double lable perfusion scintigraphy. Automatic impulse rate integration allows the comparison of different perfusion areas in the same scintigram as well as the comparison of different identical regions in different scintigrams. The scans were taken in two positions (frontal and l.a.o.). Microperfusion patterns were measured before and after the intravenous application of the drug. We found a typical shift of the microperfusion patterns with both medicaments. Under the influence of Oxyfedrin and Dipyridamol there was an increase of the relative microperfusion intensity in the vicinity of the major arteries but there were great differences as to the degree of their reaction maximum. Besides the results of the groups some typical cases are demonstrated. The method allows a satisfactory measurement of differences in the regional precapillary myocardial perfusion under the influence of coronary active drugs. We believe that statements on physiologic and pathologic functions are possible.

Topics: Angiocardiography; Coronary Angiography; Coronary Circulation; Coronary Disease; Humans; Injections, Intravenous; Oxyfedrine; Propiophenones; Radionuclide Imaging

In 17 patients with coronary heart disease the effects of the beta-active agent L-3-(beta-hydroxy-alpha-methyl-phenethyl-amino)-3'-methoxy-propiophenone (oxyfedrine, Ildamen) were proved at rest and during atrial pacing by measurements of coronary venous O2-saturation, myocardial lactate extraction, angina threshold and ST-segment depression. In 88% oxyfedrine had antianginal effectivity with rise in angina threshold (+11%), reduction of ST-segment depression (--48%) and reduction of lactate production(--63%). The rise in coronary venous O2-saturation ("35%) and the electrocardiographic and metabolic reduction of hypoxic reaction indicate the improvement of nutritional coronary flow. Therefore improvement of myocardial O2-balance is derived from the reduced energy requirement by decrease of heart size and ventricular wall tension and the rise of myocardial O2-supply by coronary dilation in spite of the increased energy requirement by ascending contractility. Conclusively the application of oxyfedrine is preferred in coronary heart disease with simultaneous congestive heart failure.

Topics: Adult; Aged; Clinical Trials as Topic; Coronary Disease; Electrocardiography; Energy Metabolism; Female; Heart Atria; Humans; Male; Middle Aged; Myocardium; Oxyfedrine; Oxygen Consumption; Propiophenones

Medical treatment of angina pectoris is largely based on the use of beta-blocking agents, calcium antagonists, and nitrates. Oxyfedrine, an amino ketone derivative and partial agonist at beta receptors, has been shown to have potent antianginal properties and to increase coronary blood flow in normal and ischemic myocardial regions in experimental studies. We assessed the effects of intravenous oxyfedrine on regional myocardial blood flow, using positron emission tomography (15-oxygen water), in six patients with chronic stable angina, positive exercise tests, and documented coronary artery disease. Myocardial blood flow was measured in all patients before (baseline) and 10 minutes after the intravenous administration of a single bolus (0.11-0.13 mg/kg) of oxyfedrine. Compared to baseline, heart rate and systolic blood pressure remained almost unchanged after the administration of oxyfedrine. Mean baseline myocardial blood flow was 0.90 +/- 0.15 ml/g/min in areas supplied by arteries with significant coronary stenosis and 1.08 +/- 0.19 ml/g/min in areas supplied by nonstenotic coronary vessels (p less than 0.05). After the administration of oxyfedrine, myocardial blood flow increased significantly in both the regions supplied by stenotic vessels (by 25%; from 0.90 +/- 0.15 to 1.20 +/- 0.31 ml/g/min; p = 0.002) and in areas supplied by angiographically normal coronary vessels (by 22%; from 1.08 +/- 0.19 to 1.38 +/- 0.49 ml/g/min; p less than 0.05). The results of this study indicate that in patients with coronary artery disease, intravenous oxyfedrine significantly increases regional myocardial blood flow, both in areas supplied by critically obstructed vessels and in areas supplied by normal or less severely narrowed coronary arteries.

Topics: Aged; Angina Pectoris; Coronary Circulation; Coronary Disease; Female; Humans; Male; Middle Aged; Oxyfedrine; Regional Blood Flow; Tomography, Emission-Computed

Out of oxyfedrine++ side effects known up to the present (mild agitation, stupor, heat sensation, pains in the epigastrium++, skin allergy) 24 cases of ageusia appearing usually after 4 weeks of treatment with oxyfedrine++ were presented. Disturbances of taste are found to be unpleasant for patients, and result in remarkable exacerbation of their general feeling. The complaints subside completely after finishing treatment, and the time of taste disorder withdrawal is prolonged according to the time of oxyfedrine++ treatment.

Topics: Adult; Aged; Ageusia; Coronary Disease; Female; Humans; Male; Middle Aged; Oxyfedrine; Remission, Spontaneous

Acute ischemic left ventricular failure was induced in dogs by coronary embolization with plastic microspheres, resulting in reduced cardiac output (CO), increased left ventricular end-diastolic pressure (LVEDP), pulmonary capillary pressure (PCP), and total peripheral resistance (TPR). Intravenous (i.v.) administration of alifedrine, a beta-adrenergic partial agonist (0.3 mg/kg as bolus and 0.3 mg/kg/h as infusion), significantly improved performance of the failing heart. Left ventricular contractility was increased up to 50%, heart rate (HR) up to 28%, and CO up to 30%. LVEDP, PCP, and TPR were markedly decreased. Myocardial oxygen consumption was increased only to a minor degree despite the positive inotropic effect; coronary flow was augmented up to 26%. Thus, alifedrine in this model markedly improved left ventricular function by balanced stimulation of the myocardium and reduction of pre- and afterload.

Topics: Acute Disease; Adrenergic beta-Antagonists; Anesthesia; Animals; Blood Pressure; Coronary Disease; Dogs; Female; Heart; Heart Failure; Heart Rate; Hemodynamics; Male; Microspheres; Oxyfedrine; Propiophenones

Cardiac tissue from different parts of hearts from guinea pigs and rabbits have the capacity to rapidly synthesize prostacyclin (PGI2). Auricles show a higher PGI2-formation than ventricles. Addition of the endoperoxide PGH2 markedly enhanced the myocardial PGI2-biosynthesis. Furthermore many cardiotonic drugs induced a significant rise, but eicosanoids or cyclooxygenase inhibitors a marked reduction of the cardiac PGI2-formation. Acute pressure overload by graduated aortic stenosis, ischemia by coronary ligation or pacing with high frequency reduced the cardiac contractility. After aortic stenosis the myocardial PGI2-biosynthesis is lowered, but increased after coronary ligation or pacing. Under these conditions indomethacin, PGE1, iloprost, verapamil and trapidil markedly reduced the PGI2-biosynthesis and exert a protective effect in regard to cardiac damage. The results indicate that pathophysiological changes significantly influence the PGI2-biosynthesis of the heart. The drug induced inhibition of the myocardial PGI2-formation parallels a cardioprotective effect of these substances.

Topics: Animals; Aortic Valve Stenosis; Caffeine; Coronary Disease; Epoprostenol; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Isoproterenol; Myocardium; Ouabain; Oxyfedrine; Rabbits; Reference Values; Trapidil

The effects of alifedrine, a positive inotropic agent, were examined in greyhounds anaesthetised with chloralose. An intravenous dose of 0.3 mg kg-1 resulted in a substantial increase in myocardial contractility (increased dP/dtmax, cardiac output and stroke volume) without significantly affecting heart rate. The effects of alifedrine on the severity of arrhythmias resulting from both coronary artery occlusion and reperfusion were also determined. A mild antiarrhythmic effect was observed during early ischaemia when the incidence of ventricular tachycardia was reduced from 90% in controls to 50% in treated dogs. There was also a significant reduction in the number of extrasystoles appearing as ventricular tachycardia (from 511 +/- 138 to 151 +/- 84). The total number of extrasystoles during the first 30 min of ischaemia was also reduced, although not significantly, from 846 +/- 193 to 527 +/- 86. Following release of a 40 min coronary artery occlusion there was a marked reduction in reperfusion-induced ventricular fibrillation from 75% in controls, to 37% in the alifedrine-treated dogs. The overall survival from the combined occlusion-reperfusion insult was increased from 20% in controls to 50%. These results suggest that alifedrine has an unusual and useful spectrum of pharmacological activity in that it combines antiarrhythmic activity with an ability to improve cardiac function.

Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Coronary Circulation; Coronary Disease; Dogs; Female; Hemodynamics; Male; Oxyfedrine; Propiophenones

Experience in the treatment of over 500 chronic coronary patients with various anti-anginal drugs or their combinations is summarized. Controlled (double blind) and open studies and acute pharmacologic tests demonstrated comparative efficacy of depot-nitrates, beta-blockers, oxyfedrine, cordaron, lidoflazinum, molsidamine (corvaton). The effects on exercise tolerance (bicycle ergometry) with isolated and combined use of the drugs are described. Indications for surgery are discussed.

Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Adult; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Drug Evaluation; Drug Therapy, Combination; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Molsidomine; Nitroglycerin; Oxyfedrine; Propranolol; Sydnones; Vasodilator Agents

Experiments were made on 56 white noninbred male rats with transitory coronary insufficiency (duration of myocardial ischemia 10, 40 and 120 min, the length of subsequent reperfusion 10 and 40 min). It was discovered that there were changes in the ultrastructure of cardiocytes and vessels of the microcirculatory bed both in the area of ischemia and reperfusion and in the distant heart regions, an increase in myocardial cell and microvessel lesions during postischemic reperfusion not only in the area of ischemia but also in distant zones. In addition, a reduction was noted in the degree of ischemic and reperfusion myocardial injury during the prophylactic use of myophedrine. The mechanisms of the protective action of myophedrine in acute transitory coronary insufficiency are discussed.

Topics: Animals; Cardiovascular Agents; Coronary Circulation; Coronary Disease; Drug Evaluation, Preclinical; Heart; Male; Microcirculation; Microscopy, Electron; Myocardium; Oxyfedrine; Propiophenones; Rats; Time Factors

Topics: Adult; Coronary Disease; Female; Heart Ventricles; Humans; Male; Middle Aged; Oxyfedrine; Propiophenones

This work was done on 116 white random-bred male rats using the experimental model of transient coronary insufficiency of varying duration and showed that activation of free-radical peroxidation of myocardial lipids is one of the main pathogenetic factors in the mechanism of development of the ischaemia and reperfusion damage of the heart in transient coronary insufficiency. Inhibition of lipid peroxidation after preliminary administration to the animals of sodium selenite and myophedrine significantly enhanced the heart's resistance to reversible ischaemia. It is suggested that the use of antioxidants is an effective method of pathogenetic therapy and prevention of transient coronary insufficiency.

Topics: Animals; Coronary Disease; Drug Evaluation, Preclinical; Lipid Peroxides; Male; Myocardial Contraction; Oxidation-Reduction; Oxyfedrine; Rats; Selenious Acid; Selenium

Topics: Coronary Circulation; Coronary Disease; Heart; Heart Ventricles; Humans; Oxyfedrine; Propiophenones

The experiments on dogs showed that in chronic myocardial ischaemia nonachlasine raising the retrograde arterial pressure and increasing the retrograde blood inflow to the ischaemic focus exerts a positive influence on the collateral cardiac haemodynamics. Raising the tonus of the coronary vessels in the intact regions of the myocardium to a greater extent than in the ischaemic region, nonachlasine redistributes the bloodflow to the advantage of the ischaemic zone. Oxyphedrin, decreasing of the ischaemic zone. Oxyphedrin, decreasing the tonus of the coronaries, especially in the intact areas of the myocardium, elicits the syndrome of "stealing" the zone of ischaemia.

Topics: Adrenergic beta-Agonists; Angina Pectoris; Animals; Chronic Disease; Collateral Circulation; Coronary Circulation; Coronary Disease; Dogs; Nonachlazine; Oxyfedrine; Regional Blood Flow; Vasodilator Agents

The effect exerted on the partially ischaemic heart when administering 0.9 mg/kg L-3-(beta-hydroxy-alpha-methylphenethylamino)-3'-methoxypropiophenone (oxyfedrine, ildamen) approx. 10 min after i.v. application of 0.05 mg/kg digoxin was tested on 20 dogs previously anaesthetized with propiomazine-pentobarbital. The following parameters were studied and subsequently compound with the results of former trials of ours' without digoxin premedication: aortic pressure (ASP, ADP), left-ventricular pressure (LVSP, LVEDP), heart rate (HR), cardiac output (HMV), stroke volume (SV), dp/dtmax, dp/dtmax/IP, t-dp/dtmax, blood flow in the normal and partially ischaemic myocardium, the latter being measured with heat conductance probes and labelled microspheres. ASP and ADP show the same reduction--as compared with the control value--both after the administration of oxyfedrine with and without digoxin premedication. After digoxin premedication oxyfedrine led to a somewhat less marked reduction of LVSP; on premedication with digoxin LVEDP was slightly increased whereas it was reduced after additional administration of oxyfedrine as was also the case without digoxin pretreatment. The increase in HR after oxyfedrine is almost the same as without digoxin pretreatment. Also the increase in HMV and the SV lowering are not influenced by digoxin. By administration of oxyfedrine dp/dtmax is always increased by the same amount, starting from the already increased value after digoxin premedication, which is probably an additive effect. The same applies to the quotient dp/dtmax/IP. After oxyfedrine the time t-dp/dtmax is lowered by the same amount, irrespective of a digoxin premedication. Oxyfedrine does not produce a further increase in the heat conductance values after previous application of digoxin; when measuring the blood flow with labelled microspheres the same result was found, which means that by previous administration of digoxin the circulatory effect of oxyfedrine is obviously inhibited. Summing up one can say that by combining the active principles digoxin and oxyfedrine the function parameters of the heart can be influenced only positively.

Topics: Anesthesia; Animals; Coronary Circulation; Coronary Disease; Digoxin; Dogs; Female; Hemodynamics; Male; Myocardial Contraction; Oxyfedrine; Propiophenones; Time Factors

Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Coronary Disease; Hemodynamics; In Vitro Techniques; Lactates; Myocardium; Oxyfedrine; Propiophenones; Swine

In order to assess the effects of oxyfedrine in ischaemic heart disease, echocardiographic evaluation of left ventricular function was performed 2,5,10,15 and 20 minutes after the intravenous administration of 12 mg oxyfedrine in 15 patients with coronary artery disease without angiographic abnormalities of left ventricular wall motion. The following parameters were measured: heart rate, mean arterial blood pressure, internal dimension in diastole (LVIDd) and in systole (LVIDs) of the left ventricule and the percentage shortening of the LVID (%LVID). There was a significant increase in %LVID (peak 10 minutes after drug administration; p less than 0.001) indicating improved left ventricular function, associated with slight changes in pre-load (LVIDd) and in heart rate, and no variation in mean blood pressure. No abnormalities of contraction were observed after the administration of oxyfedrine. These results suggest that oxyfedrine exerts a direct positive inotropic effect of the myocardium in patients with significant coronary artery stenoses.

Topics: Aged; Coronary Circulation; Coronary Disease; Echocardiography; Hemodynamics; Humans; Middle Aged; Oxyfedrine; Propiophenones; Time Factors

Topics: Animals; Coronary Disease; Disease Models, Animal; Female; Glycolysis; Heart; Isoproterenol; Male; Myocardium; Oxyfedrine; Propiophenones; Rats

Topics: Animals; Coronary Disease; Guinea Pigs; Humans; Oxyfedrine; Propiophenones

Topics: Cardiac Volume; Coronary Disease; Humans; Lactates; Myocardium; Oxyfedrine; Oxygen Consumption; Propiophenones

Topics: Cardiotonic Agents; Coronary Circulation; Coronary Disease; Heart Ventricles; Humans; Myocardial Contraction; Oxyfedrine; Propiophenones; Radionuclide Imaging

Topics: Animals; Coronary Circulation; Coronary Disease; Heart; Hemodynamics; Myocardial Contraction; Oxyfedrine; Propiophenones; Swine

Topics: Adult; Aged; Coronary Disease; Heart Failure; Humans; Middle Aged; Myocardial Contraction; Myocardial Infarction; Myocardium; Oxyfedrine; Propiophenones

In experimental angina pectoris of dogs developed by Sze-keres et al, 1976, and modified by the authors it was shown that nonachlazine in doses of 3 and 5 mg/kg decreased or even completely prevented the ST segment elevation on the epicardial electrogram from the focus of myocardial ischemia. Oxyphedrine in doses of 0.05, 0.1, and 0,3 mg/kg had no such effect. In doses of 0.1 and 0.3 mg/kg the drug aggravated the epicardial electrogram.

Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Electrocardiography; Nonachlazine; Oxyfedrine; Phenothiazines; Propiophenones

Topics: Adrenergic beta-Antagonists; Bradycardia; Chronic Disease; Coronary Disease; Humans; Nitroglycerin; Oxyfedrine

Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Anticoagulants; Calcium; Cardiac Glycosides; Chromonar; Coronary Disease; Coronary Vessels; Humans; Middle Aged; Nitrates; Oxyfedrine; Vasodilator Agents

Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium; Coronary Disease; Digitalis Glycosides; Exercise Therapy; Humans; Middle Aged; Oxyfedrine; Postoperative Care; Vasodilator Agents

Topics: Adrenergic beta-Agonists; Adult; Aged; Coronary Circulation; Coronary Disease; Humans; Male; Middle Aged; Myocardial Contraction; Oxyfedrine; Propiophenones; Propranolol

In 10 patients with coronary heart disease, local ventricular wall motion, local poststenotic flow, and distribution of myocardial perfusion were determined in the underperfused myocardium before and after 8 mg of Oxyfedrin intravenously. In 8 of the 10 patients there was a uniform reaction consisting of an improvement of wall motion, increase in flow, and homogeneity of flow distribution. These parallel changes of local wall movement and local blood flow in a poststenotic underperfused part of the myocardium can most probably be explained by the positively inotropic action of Oxyfedrin with a consecutive increase in blood flow. The results show that a therapeutic affect in patients with a coronary stenosis less than 60% in the left descending artery can be obtained with a positively inotropic substance.

Topics: Adult; Blood Pressure; Constriction, Pathologic; Coronary Disease; Coronary Vessels; Female; Heart Rate; Heart Ventricles; Humans; Male; Middle Aged; Myocardial Contraction; Oxyfedrine; Regional Blood Flow

Topics: Adult; Blood Pressure; Coronary Disease; Drug Evaluation; Exercise Test; Heart Rate; Humans; Injections, Intravenous; Middle Aged; Oxyfedrine; Physical Exertion; Propiophenones

Topics: Adult; Aged; Coronary Disease; Fatty Acids, Nonesterified; Humans; Middle Aged; Oxyfedrine; Propiophenones

In feline experiments and 65 clinical cases of ischaemic heart disease the efficacy of a new beta-stimulating agetn -- Ildamen -- was studied, the obtained effect was compared to that of Euphillin. Ildamen was found to be highly effective in patients with a moderately decreased coronary reserve and without atherosclerotic lesions in the coronary vessels.

Topics: Adrenergic beta-Agonists; Adult; Aged; Aminophylline; Animals; Blood Pressure; Cats; Chronic Disease; Coronary Circulation; Coronary Disease; Drug Evaluation; Female; Humans; Male; Middle Aged; Oxyfedrine; Propiophenones; Vasodilator Agents

Topics: Aged; Coronary Disease; Digoxin; Exercise Therapy; Female; Humans; Male; Middle Aged; Myocardial Infarction; Oxyfedrine

Topics: Coronary Disease; Coronary Vessels; Dipyridamole; Humans; Myocardium; Oxyfedrine; Perfusion; Propiophenones; Radiometry

Topics: Adrenergic beta-Antagonists; Ambulatory Care; Analgesics; Angina Pectoris; Anticoagulants; Coronary Disease; Humans; Hypnotics and Sedatives; Myocardial Infarction; Nitrites; Oxyfedrine; Time Factors

Topics: Acetyldigoxins; Adult; Aged; Blood Pressure; Coronary Disease; Digoxin; Drug Combinations; Female; Heart Rate; Humans; Male; Middle Aged; Oxyfedrine; Propiophenones; Time Factors