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oxybutynin and Nocturnal Enuresis

oxybutynin has been researched along with Nocturnal Enuresis in 21 studies

oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.

Nocturnal Enuresis: Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.

Research Excerpts

ExcerptRelevanceReference
"To assess the efficacy of desmopressin plus oxybutynin and compare two starting dosages of desmopressin (120 and 240 µg) in a randomized, double-blinded, placebo-controlled trial for children with monosymptomatic nocturnal enuresis (MNE) resistant to desmopressin."9.16Desmopressin and oxybutynin in monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial and an assessment of predictive factors. ( Del Gado, R; Iossa, AC; Montaldo, P; Narciso, V; Rea, M; Tafuro, L, 2012)
"To evaluate the efficacy of two drugs: the anticholinergic agent oxybutynin (Ditropan) and the calcium channel blocker verapamil (Isoptin) in the management of nocturnal enuresis in patients with orthotopic ileal reservoirs."9.13Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study. ( El-Bahnasawy, MS; Gomha, MA; Nabeeh, A; Shaaban, H, 2008)
"Combination therapy (CT) (desmopressin plus oxybutynin) has been considered for the treatment of monosymptomatic nocturnal enuresis (MNE)."8.31Combination therapy (desmopressin plus oxybutynin) improves the response rate compared with desmopressin alone in patients with monosymptomatic nocturnal enuresis and nocturnal polyuria and absence of constipation predict the response to this treatment. ( Capalbo, D; Di Sessa, A; Esposito, C; Grella, C; Guarino, S; Marzuillo, P; Miraglia Del Giudice, E; Papparella, A, 2023)
"Enuresis is identified as voluntary or involuntary leakage of urine for at least three consecutive months in the daytime and/or nighttime on clothes for children older than five."5.62Desmopressin versus desmopressin + oxybutynin in the treatment of children with nocturnal enuresis. ( Çakıroğlu, B; Gözüküçük, A; Kılıç, M, 2021)
" Desmopressin in combination with a fixed dose anticholinergic has been shown to be useful in individuals who fail desmopressin monotherapy, but still fails to achieve success rates greater than 60%."5.43Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis. ( Berkenwald, A; Ellsworth, P; Pires, J, 2016)
"To compare the results of the standard urotherapy alone and associated with pelvic floor muscle training alone, and in combination with oxybutynin in treatment of nonmonosymptomatic nocturnal enuresis."5.30Pelvic floor muscle training alone or in combination with oxybutynin in treatment of nonmonosymptomatic enuresis. A randomized controlled trial with 2-year follow up. ( Campos, RM; D'Ancona, CAL; Glazer, HI; Hacad, CR; Lopes, MHBM; Lúcio, AC; Perissinotto, MCR, 2019)
"To assess the efficacy of desmopressin plus oxybutynin and compare two starting dosages of desmopressin (120 and 240 µg) in a randomized, double-blinded, placebo-controlled trial for children with monosymptomatic nocturnal enuresis (MNE) resistant to desmopressin."5.16Desmopressin and oxybutynin in monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial and an assessment of predictive factors. ( Del Gado, R; Iossa, AC; Montaldo, P; Narciso, V; Rea, M; Tafuro, L, 2012)
"To evaluate the efficacy of two drugs: the anticholinergic agent oxybutynin (Ditropan) and the calcium channel blocker verapamil (Isoptin) in the management of nocturnal enuresis in patients with orthotopic ileal reservoirs."5.13Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study. ( El-Bahnasawy, MS; Gomha, MA; Nabeeh, A; Shaaban, H, 2008)
"We assessed prospectively the efficacy of holding exercises and/or antimuscarinics (oxybutynin chloride and placebo) for increasing maximum voided volume in prepubertal children with monosymptomatic nocturnal enuresis."5.12Do holding exercises or antimuscarinics increase maximum voided volume in monosymptomatic nocturnal enuresis? A randomized controlled trial in children. ( Bael, A; Bernaerts, K; Hirche, H; Lax, H; Van Dessel, E; van Gool, JD; Van Hoeck, KJ; Van Renthergem, D; Vandermaelen, V, 2007)
"Combination therapy (CT) (desmopressin plus oxybutynin) has been considered for the treatment of monosymptomatic nocturnal enuresis (MNE)."4.31Combination therapy (desmopressin plus oxybutynin) improves the response rate compared with desmopressin alone in patients with monosymptomatic nocturnal enuresis and nocturnal polyuria and absence of constipation predict the response to this treatment. ( Capalbo, D; Di Sessa, A; Esposito, C; Grella, C; Guarino, S; Marzuillo, P; Miraglia Del Giudice, E; Papparella, A, 2023)
"The patients who had lower urinary tract symptoms (LUTS) were classified as nonmonosymptomatic NE (NMNE)."2.87The Relationship Between Nocturnal Enuresis and Spina Bifida Occulta: A Prospective Controlled Trial. ( Bayar, G; Kilinc, MF; Sariogullari, U; Yavuz, A, 2018)
"Bedwetting (nocturnal enuresis) is not uncommon in childhood but it can have a profound effect on children and their families."2.44Nocturnal enuresis in children. ( Dobson, P; Weaver, A, 2007)
"Enuresis is identified as voluntary or involuntary leakage of urine for at least three consecutive months in the daytime and/or nighttime on clothes for children older than five."1.62Desmopressin versus desmopressin + oxybutynin in the treatment of children with nocturnal enuresis. ( Çakıroğlu, B; Gözüküçük, A; Kılıç, M, 2021)
" Desmopressin in combination with a fixed dose anticholinergic has been shown to be useful in individuals who fail desmopressin monotherapy, but still fails to achieve success rates greater than 60%."1.43Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis. ( Berkenwald, A; Ellsworth, P; Pires, J, 2016)
" Taking domestic usage by age group into account, there is a disproportionately higher number of CNS adverse event cases reported in pediatric patients as compared with adult patients."1.35Spectrum of central anticholinergic adverse effects associated with oxybutynin: comparison of pediatric and adult cases. ( Gish, P; Johann-Liang, R; Mosholder, AD; Truffa, M, 2009)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (33.33)29.6817
2010's11 (52.38)24.3611
2020's3 (14.29)2.80

Authors

AuthorsStudies
Moretti, E1
Barbosa, L1
da Silva, IB1
de Lima, AMJ1
Lemos, A1
Capalbo, D1
Guarino, S1
Di Sessa, A1
Esposito, C1
Grella, C1
Papparella, A1
Miraglia Del Giudice, E1
Marzuillo, P1
Gözüküçük, A1
Kılıç, M1
Çakıroğlu, B1
Yavuz, A1
Bayar, G1
Kilinc, MF1
Sariogullari, U1
Campos, RM1
Lúcio, AC1
Lopes, MHBM1
Hacad, CR1
Perissinotto, MCR1
Glazer, HI1
D'Ancona, CAL1
Rittig, N1
Hagstroem, S1
Mahler, B1
Kamperis, K1
Siggaard, C1
Mikkelsen, MM1
Bower, WF1
Djurhuus, JC1
Rittig, S1
Ellsworth, PI1
Berkenwald, A1
Pires, J1
Ellsworth, P1
Saldano, DD1
Chaviano, AH1
Maizels, M1
Azhir, A1
Gheissari, A1
Fragzadegan, Z1
Adebi, A1
El-Bahnasawy, MS1
Shaaban, H1
Gomha, MA1
Nabeeh, A1
Gish, P1
Mosholder, AD1
Truffa, M1
Johann-Liang, R1
Boetzkes, S1
Van Hoeck, K1
Verbrugghe, W1
Ramet, J1
Wojciechowski, M1
Jorens, PG1
Yucel, S1
Kol, A1
Guntekin, E1
Baykara, M1
Wiener, JS1
Friedman, BC1
Friedman, B1
Goldman, RD1
Deshpande, AV1
Caldwell, PH1
Montaldo, P1
Tafuro, L1
Rea, M1
Narciso, V1
Iossa, AC1
Del Gado, R1
Zaffanello, M1
Giacomello, L1
Brugnara, M1
Fanos, V1
Van Hoeck, KJ1
Bael, A1
Van Dessel, E1
Van Renthergem, D1
Bernaerts, K1
Vandermaelen, V1
Lax, H1
Hirche, H1
van Gool, JD1
Weaver, A1
Dobson, P1

Reviews

4 reviews available for oxybutynin and Nocturnal Enuresis

ArticleYear
What do cochrane systematic reviews say about interventions for enuresis in children and adolescents? An overview of systematic reviews.
    Journal of pediatric urology, 2022, Volume: 18, Issue:4

    Topics: Adolescent; Child; Deamino Arginine Vasopressin; Enuresis; Humans; Imipramine; Nocturnal Enuresis; S

2022
Medical management of nocturnal enuresis.
    Paediatric drugs, 2012, Apr-01, Volume: 14, Issue:2

    Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Antidiuretic

2012
Therapeutic options in childhood nocturnal enuresis.
    Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 2007, Volume: 59, Issue:2

    Topics: Antidiuretic Agents; Arginine Vasopressin; Behavior Therapy; Child; Child, Preschool; Deamino Argini

2007
Nocturnal enuresis in children.
    The journal of family health care, 2007, Volume: 17, Issue:5

    Topics: Antidiuretic Agents; Causality; Child; Deamino Arginine Vasopressin; Health Education; Humans; Mande

2007

Trials

7 trials available for oxybutynin and Nocturnal Enuresis

ArticleYear
The Relationship Between Nocturnal Enuresis and Spina Bifida Occulta: A Prospective Controlled Trial.
    Urology, 2018, Volume: 120

    Topics: Antidiuretic Agents; Child; Deamino Arginine Vasopressin; Female; Humans; Lower Urinary Tract Sympto

2018
Pelvic floor muscle training alone or in combination with oxybutynin in treatment of nonmonosymptomatic enuresis. A randomized controlled trial with 2-year follow up.
    Einstein (Sao Paulo, Brazil), 2019, Jun-27, Volume: 17, Issue:3

    Topics: Brazil; Child; Child, Preschool; Combined Modality Therapy; Exercise Therapy; Female; Humans; Male;

2019
New treatment protocol for primary nocturnal enuresis in children according to ultrasound bladder measurements.
    Saudi medical journal, 2008, Volume: 29, Issue:10

    Topics: Antidiuretic Agents; Child; Clinical Protocols; Combined Modality Therapy; Deamino Arginine Vasopres

2008
Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study.
    Scandinavian journal of urology and nephrology, 2008, Volume: 42, Issue:4

    Topics: Adult; Calcium Channel Blockers; Cholinergic Antagonists; Colonic Pouches; Cross-Over Studies; Cyste

2008
Anticholinergics do not improve cure rate of alarm treatment of monosymptomatic nocturnal enuresis.
    Urology, 2011, Volume: 77, Issue:3

    Topics: Adolescent; Child; Cholinergic Antagonists; Clinical Alarms; Combined Modality Therapy; Female; Huma

2011
Desmopressin and oxybutynin in monosymptomatic nocturnal enuresis: a randomized, double-blind, placebo-controlled trial and an assessment of predictive factors.
    BJU international, 2012, Volume: 110, Issue:8 Pt B

    Topics: Adolescent; Antidiuretic Agents; Child; Deamino Arginine Vasopressin; Double-Blind Method; Female; H

2012
Do holding exercises or antimuscarinics increase maximum voided volume in monosymptomatic nocturnal enuresis? A randomized controlled trial in children.
    The Journal of urology, 2007, Volume: 178, Issue:5

    Topics: Behavior Therapy; Child; Child, Preschool; Conditioning, Classical; Female; Follow-Up Studies; Human

2007

Other Studies

10 other studies available for oxybutynin and Nocturnal Enuresis

ArticleYear
Combination therapy (desmopressin plus oxybutynin) improves the response rate compared with desmopressin alone in patients with monosymptomatic nocturnal enuresis and nocturnal polyuria and absence of constipation predict the response to this treatment.
    European journal of pediatrics, 2023, Volume: 182, Issue:4

    Topics: Child; Constipation; Deamino Arginine Vasopressin; Female; Humans; Male; Nocturnal Enuresis; Polyuri

2023
Desmopressin versus desmopressin + oxybutynin in the treatment of children with nocturnal enuresis.
    Journal of pediatric urology, 2021, Volume: 17, Issue:4

    Topics: Antidiuretic Agents; Child; Deamino Arginine Vasopressin; Enuresis; Female; Humans; Male; Mandelic A

2021
Outcome of a standardized approach to childhood urinary symptoms-long-term follow-up of 720 patients.
    Neurourology and urodynamics, 2014, Volume: 33, Issue:5

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Antidiuretic Agents; Biofeedback, Psychology; Child; Child

2014
Response to Commentary re 'Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis'.
    Journal of pediatric urology, 2016, Volume: 12, Issue:4

    Topics: Antidiuretic Agents; Deamino Arginine Vasopressin; Enuresis; Humans; Mandelic Acids; Nocturnal Enure

2016
Evaluating use of higher dose oxybutynin in combination with desmopressin for refractory nocturnal enuresis.
    Journal of pediatric urology, 2016, Volume: 12, Issue:4

    Topics: Adolescent; Antidiuretic Agents; Attention Deficit Disorder with Hyperactivity; Child; Deamino Argin

2016
Sustainability of remission of pediatric primary nocturnal enuresis--comparison of remission using Try for Dry vs. non-Try for Dry treatment plans.
    Urologic nursing, 2008, Volume: 28, Issue:4

    Topics: Adolescent; Algorithms; Antidiuretic Agents; Child; Combined Modality Therapy; Constipation; Deamino

2008
Spectrum of central anticholinergic adverse effects associated with oxybutynin: comparison of pediatric and adult cases.
    The Journal of pediatrics, 2009, Volume: 155, Issue:3

    Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Central Nervous System; Chi

2009
Two unusual pediatric cases of dilutional hyponatremia.
    Pediatric emergency care, 2010, Volume: 26, Issue:7

    Topics: Antidiuretic Agents; Child; Cholinergic Antagonists; Deamino Arginine Vasopressin; Drug Therapy, Com

2010
Editorial comment. Anticholinergics do not improve cure rate of alarm treatment of monosymptomatic nocturnal enuresis.
    Urology, 2011, Volume: 77, Issue:3

    Topics: Adolescent; Child; Cholinergic Antagonists; Clinical Alarms; Combined Modality Therapy; Humans; Mand

2011
Oxybutynin for treatment of nocturnal enuresis in children.
    Canadian family physician Medecin de famille canadien, 2011, Volume: 57, Issue:5

    Topics: Child; Humans; Mandelic Acids; Muscarinic Antagonists; Nocturnal Enuresis

2011