oxybutynin has been researched along with Muscle Contraction in 70 studies
oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of two drugs: the anticholinergic agent oxybutynin (Ditropan) and the calcium channel blocker verapamil (Isoptin) in the management of nocturnal enuresis in patients with orthotopic ileal reservoirs." | 9.13 | Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study. ( El-Bahnasawy, MS; Gomha, MA; Nabeeh, A; Shaaban, H, 2008) |
| "Sixty-three children with persistent nocturnal enuresis were urodynamically assessed and subsequently treated with oxybutynin chloride." | 7.68 | Comparison of urodynamic findings and response to oxybutynin in nocturnal enuresis. ( Alken, P; Jünemann, KP; Köhrmann, KU; Persson-Jünemann, C; Seemann, O, 1993) |
| "To compare the results of the standard urotherapy alone and associated with pelvic floor muscle training alone, and in combination with oxybutynin in treatment of nonmonosymptomatic nocturnal enuresis." | 5.30 | Pelvic floor muscle training alone or in combination with oxybutynin in treatment of nonmonosymptomatic enuresis. A randomized controlled trial with 2-year follow up. ( Campos, RM; D'Ancona, CAL; Glazer, HI; Hacad, CR; Lopes, MHBM; Lúcio, AC; Perissinotto, MCR, 2019) |
| "To evaluate the efficacy of two drugs: the anticholinergic agent oxybutynin (Ditropan) and the calcium channel blocker verapamil (Isoptin) in the management of nocturnal enuresis in patients with orthotopic ileal reservoirs." | 5.13 | Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study. ( El-Bahnasawy, MS; Gomha, MA; Nabeeh, A; Shaaban, H, 2008) |
| "Byakko-ka-ninjin-to (BN) is a Kampo medicine (traditional Japanese medicine) that is frequently used to treat xerostomia, which is also a side effect of anticholinergic agents such as oxybutynin and propiverine widely used for the treatment of patients with urinary incontinence or frequency." | 3.73 | Effects of Byakko-ka-ninjin-to on salivary secretion and bladder function in rats. ( Aburada, M; Goto, K; Hattori, N; Ichiki, H; Iizuka, A; Ishige, A; Sakaguchi, M; Takeda, S; Yamamoto, M; Yamamoto, T; Yasuda, M, 2005) |
| "Sixty-three children with persistent nocturnal enuresis were urodynamically assessed and subsequently treated with oxybutynin chloride." | 3.68 | Comparison of urodynamic findings and response to oxybutynin in nocturnal enuresis. ( Alken, P; Jünemann, KP; Köhrmann, KU; Persson-Jünemann, C; Seemann, O, 1993) |
| "The antispasmodic effects of the flavone compounds flavoxate hydrochloride, 3-methylflavone carboxylic acid (MFCA), and REC 15/2053 (and in the case of the detrusor, oxybutynin), on the human detrusor, prostatic adenoma, prostatic capsule, and bladder neck, were studied by the in vitro isometric method." | 3.68 | Antispasmodic effects of flavoxate, MFCA, and REC 15/2053 on smooth muscle of human prostate and urinary bladder. ( Caine, M; Gin, S; Pietra, C; Ruffmann, R, 1991) |
| "Oxybutynin has statistically significant effects on subjective symptoms and objective urodynamic parameters in patients with detrusor hyperactivity compared to propantheline." | 2.67 | Randomized, double-blind, multicenter trial on treatment of frequency, urgency and incontinence related to detrusor hyperactivity: oxybutynin versus propantheline versus placebo. ( Bunke, B; de Geeter, P; Ebner, A; Faber, P; Hannappel, J; Heidler, H; Madersbacher, H; Melchior, H; Schäfer, W; Thüroff, JW, 1991) |
| "Forty six patients with symptoms of overactive bladder, i." | 1.36 | In women with urinary incontinence how necessary is cystometry? ( Saleem, A, 2010) |
| " Our results suggest that the association between an antimuscarinic drug and an antagonist of P2X purinoceptors such as suramin might be helpful to reduce the therapeutic dosage of the antimuscarinic drug, along with its side effects." | 1.33 | Altered neurogenic and mechanical responses to acetylcholine, ATP and substance P in detrusor from rat with outlet obstruction. ( Pinna, C; Puglisi, L; Sanvito, P, 2006) |
| "Oxybutynin was administered at 15 mg/animal, and the plasma concentrations of oxybutynin and N-desethyloxybutynin were measured by high-performance liquid chromatography to clarify the effective concentration." | 1.33 | Comparison of the effects of percutaneous and intraduodenal administration of oxybutynin on bladder contraction and salivation in rabbits. ( Hamamoto, T; Kontani, H; Nomura, Y; Saito, H; Sawanishi, H; Takeuchi, S, 2006) |
| "Treatment with oxybutynin decreased isovolumetric detrusor pressure in all 3 stop tests by up to 6 cm." | 1.32 | Which stop test is best? Measuring detrusor contractility in older females. ( Bergmann, MA; Griffiths, D; Resnick, NM; Tan, TL, 2003) |
| "Oxybutynin has been used for treatment of urge urinary incontinence for more than 20 years." | 1.32 | Effectiveness of vaginally administered oxybutynin on rabbit bladder function. ( Borow, A; Burden, O; Leggett, RE; Levin, RM; Whitbeck, C, 2003) |
| "Oxybutynin has been used for neurogenic bladder disorders and is known to have anti-cholinergic and antispasmodic properties." | 1.32 | Effects of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl)glycolate hydrochloride, a metabolite of oxybutynin, on bladder specimens and rhythmic bladder contraction in rats in comparison with oxybutynin. ( Koganei, M; Murata, N; Uchida, M; Yamaji, T, 2004) |
| "Oxybutynin has been used for neurogenic bladder disorders in clinic and known to have anti-cholinergic and spasmolytic properties." | 1.32 | [Effect of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl) glycolate, metabolite of oxybutynin, on intra-artery administered acetylcholine-induced urinary bladder contraction in anesthetized dogs]. ( Koganei, M; Nakajima, M; Uchida, M; Yamaji, T, 2004) |
| "To evaluate type of neurogenic bladder and to observe changes of autonomous detrusor contraction (ADC) after the normalization of the compliance and capacity of the bladder in cauda equina injury." | 1.31 | Significance of low compliance bladder in cauda equina injury. ( Kim, HJ; Lee, IY; Park, CI; Shin, JC, 2002) |
| "Temiverine (p-INN) is a newly synthesized drug that is expected to have anticholinergic action." | 1.30 | Pharmacologic actions of temiverine (p-INN) and its active metabolite, RCC-36, on isolated human urinary bladder muscle. ( Kikukawa, H; Nishi, K; Ueda, S; Wada, Y; Yoshida, M, 1998) |
| "Propiverine is a drug for the treatment of incontinence and pollakiuria." | 1.30 | [Effects of propiverine hydrochloride (propiverine) on isolated rat and dog urinary bladder]. ( Kaneko, S; Nakano, D; Nishimori, T; Ohara, M, 1999) |
| "Oxybutynin has a proved role in correcting uninhibited detrusor contractions in the intact and the bowel augmented bladder." | 1.29 | Oxybutynin administration diminishes the high gastric muscular tone associated with bladder reconstruction. ( Lewis, AG; Reeves, D; Sheldon, CA, 1995) |
| "3." | 1.28 | Pharmacological properties of tiropramide, an antispasmodic drug. ( Hisayama, T; Iwase, M; Nagai, H; Sakuma, N; Takayanagi, I, 1989) |
| "Thiphenamil at lower doses (10(-4) M to 5 X 10(-4) M) showed a biphasic effect--an increase of the bladder tissue activity followed by a relaxation phase--that oxybutynin and verapamil failed to produce." | 1.27 | Analysis of the in vitro pharmacologic response of renal pelvis and detrusor smooth muscle to thiphenamil, oxybutynin and verapamil. ( Constantinou, CE; Levounis, P, 1988) |
| " Terodiline (10(-6) M) parallelly shifted the dose-response curve for carbachol in rabbit detrusor to the right, and high doses of terodiline (3 X 10(-6)-3 X 10(-5) M) inhibited the maximal contraction." | 1.27 | [Effect of terodiline hydrochloride in isolated rabbit detrusor]. ( Abe, M; Ikeda, S; Ono, Y; Ujiie, A; Yamazaki, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (14.29) | 18.7374 |
| 1990's | 23 (32.86) | 18.2507 |
| 2000's | 26 (37.14) | 29.6817 |
| 2010's | 10 (14.29) | 24.3611 |
| 2020's | 1 (1.43) | 2.80 |
| Authors | Studies |
|---|---|
| Kaiser, C | 2 |
| Spagnuolo, CJ | 2 |
| Adams, TC | 1 |
| Audia, VH | 2 |
| Dupont, AC | 2 |
| Hatoum, H | 1 |
| Lowe, VC | 1 |
| Prosser, JC | 1 |
| Sturm, BL | 1 |
| Noronha-Blob, L | 4 |
| Ikeda, K | 2 |
| Kobayashi, S | 1 |
| Suzuki, M | 2 |
| Miyata, K | 2 |
| Takeuchi, M | 2 |
| Yamada, T | 1 |
| Honda, K | 1 |
| Naito, R | 1 |
| Yonetoku, Y | 1 |
| Okamoto, Y | 1 |
| Toyoshima, A | 1 |
| Del Bello, F | 1 |
| Barocelli, E | 1 |
| Bertoni, S | 1 |
| Bonifazi, A | 1 |
| Camalli, M | 1 |
| Campi, G | 1 |
| Giannella, M | 1 |
| Matucci, R | 1 |
| Nesi, M | 1 |
| Pigini, M | 1 |
| Quaglia, W | 1 |
| Piergentili, A | 1 |
| Ness, TJ | 1 |
| McNaught, J | 1 |
| Clodfelder-Miller, B | 1 |
| Su, X | 2 |
| Campos, RM | 1 |
| Lúcio, AC | 1 |
| Lopes, MHBM | 1 |
| Hacad, CR | 1 |
| Perissinotto, MCR | 1 |
| Glazer, HI | 1 |
| D'Ancona, CAL | 1 |
| Uvin, P | 1 |
| Boudes, M | 1 |
| Menigoz, A | 1 |
| Franken, J | 1 |
| Pinto, S | 1 |
| Gevaert, T | 1 |
| Verplaetse, R | 1 |
| Tytgat, J | 1 |
| Vennekens, R | 1 |
| Voets, T | 1 |
| De Ridder, D | 1 |
| Babaoglu, M | 1 |
| Zumrutbas, AE | 1 |
| Acar, IC | 1 |
| Hatip, FB | 1 |
| Kucukatay, V | 1 |
| Eskicorapci, S | 1 |
| Aybek, Z | 1 |
| Aizawa, N | 2 |
| Homma, Y | 2 |
| Igawa, Y | 2 |
| Fujimura, M | 1 |
| Izumimoto, N | 1 |
| Kanie, S | 1 |
| Kobayashi, R | 1 |
| Yoshikawa, S | 1 |
| Momen, S | 1 |
| Hirakata, M | 1 |
| Komagata, T | 1 |
| Okanishi, S | 3 |
| Iwata, M | 1 |
| Hashimoto, T | 1 |
| Doi, T | 3 |
| Yoshimura, N | 2 |
| Kawai, K | 1 |
| El-Bahnasawy, MS | 1 |
| Shaaban, H | 1 |
| Gomha, MA | 1 |
| Nabeeh, A | 1 |
| Saleem, A | 1 |
| Moro, C | 1 |
| Uchiyama, J | 1 |
| Chess-Williams, R | 1 |
| Schuler, V | 1 |
| Suter, K | 1 |
| Fürer, K | 1 |
| Eberli, D | 1 |
| Horst, M | 1 |
| Betschart, C | 1 |
| Brenneisen, R | 1 |
| Hamburger, M | 1 |
| Mennet, M | 1 |
| Schnelle, M | 1 |
| Simões-Wüst, AP | 1 |
| von Mandach, U | 1 |
| Wüst, M | 1 |
| Averbeck, B | 1 |
| Reif, S | 1 |
| Bräter, M | 1 |
| Ravens, U | 1 |
| Shin, JC | 1 |
| Park, CI | 1 |
| Kim, HJ | 1 |
| Lee, IY | 1 |
| Tan, TL | 1 |
| Bergmann, MA | 1 |
| Griffiths, D | 1 |
| Resnick, NM | 1 |
| Shimizu, I | 2 |
| Kawashima, K | 2 |
| Ishii, D | 2 |
| Oka, M | 2 |
| Levin, RM | 2 |
| Whitbeck, C | 1 |
| Borow, A | 1 |
| Burden, O | 1 |
| Leggett, RE | 1 |
| Uchida, M | 2 |
| Koganei, M | 2 |
| Murata, N | 1 |
| Yamaji, T | 2 |
| Nakajima, M | 1 |
| Hui, CS | 1 |
| Besch, HR | 1 |
| Bidasee, KR | 1 |
| Kim, Y | 1 |
| Masuda, H | 1 |
| de Miguel, F | 1 |
| Chancellor, MB | 1 |
| Nuhoğlu, B | 1 |
| Fidan, V | 1 |
| Ayyildiz, A | 1 |
| Ersoy, E | 1 |
| Germiyanoğlu, C | 1 |
| Sakaguchi, M | 1 |
| Goto, K | 1 |
| Ichiki, H | 1 |
| Hattori, N | 1 |
| Iizuka, A | 1 |
| Yamamoto, M | 1 |
| Takeda, S | 1 |
| Ishige, A | 1 |
| Aburada, M | 1 |
| Yasuda, M | 1 |
| Yamamoto, T | 1 |
| Mokry, J | 1 |
| Nosalova, G | 1 |
| Jakubesova, M | 1 |
| Dmochowski, RR | 1 |
| Pinna, C | 1 |
| Sanvito, P | 1 |
| Puglisi, L | 1 |
| Kontani, H | 1 |
| Hamamoto, T | 1 |
| Takeuchi, S | 1 |
| Nomura, Y | 1 |
| Sawanishi, H | 1 |
| Saito, H | 1 |
| Ohtake, A | 1 |
| Saitoh, C | 1 |
| Yuyama, H | 1 |
| Ukai, M | 1 |
| Okutsu, H | 1 |
| Noguchi, Y | 1 |
| Hatanaka, T | 1 |
| Sato, S | 1 |
| Sasamata, M | 1 |
| Mizushima, H | 2 |
| Kinoshita, K | 1 |
| Abe, K | 1 |
| Ishizuka, H | 1 |
| Yamada, Y | 2 |
| Riedel, ES | 1 |
| Leon, LA | 1 |
| Laping, NJ | 1 |
| Takayanagi, R | 1 |
| Ozeki, T | 1 |
| Yokoyama, H | 1 |
| Iga, T | 1 |
| McGuire, EJ | 1 |
| Savastano, JA | 1 |
| Koff, SA | 1 |
| Murtagh, D | 1 |
| Sheldon, CA | 1 |
| Reeves, D | 1 |
| Lewis, AG | 1 |
| Taniguchi, K | 1 |
| Tsubaki, K | 1 |
| Mizuno, H | 1 |
| Take, K | 1 |
| Okumura, K | 1 |
| Terai, T | 2 |
| Shiokawa, Y | 1 |
| Hohenfellner, M | 1 |
| Bürger, R | 1 |
| Schad, H | 1 |
| Heimisch, W | 1 |
| Riedmiller, H | 1 |
| Lampel, A | 1 |
| Thüroff, JW | 2 |
| Hohenfellner, R | 1 |
| Persson-Jünemann, C | 1 |
| Seemann, O | 1 |
| Köhrmann, KU | 1 |
| Jünemann, KP | 1 |
| Alken, P | 1 |
| Tillig, B | 1 |
| Constantinou, CE | 3 |
| Waldeck, K | 1 |
| Larsson, B | 1 |
| Andersson, KE | 2 |
| Nilvebrant, L | 1 |
| Gillberg, PG | 1 |
| Stahl, M | 1 |
| Sparf, B | 1 |
| Watanabe, T | 1 |
| Omata, S | 1 |
| Lee, JZ | 1 |
| Kikukawa, H | 2 |
| Yoshida, M | 2 |
| Wada, Y | 2 |
| Nishi, K | 1 |
| Ueda, S | 2 |
| Yono, M | 1 |
| Takahashi, W | 1 |
| Inadome, A | 1 |
| Seshita, H | 1 |
| Kaneko, S | 1 |
| Nakano, D | 1 |
| Ohara, M | 1 |
| Nishimori, T | 1 |
| Hashimoto, K | 1 |
| Ohnishi, N | 1 |
| Esa, A | 1 |
| Sugiyama, T | 1 |
| Park, Y | 1 |
| Kurita, T | 1 |
| Kamo, I | 2 |
| Imai, S | 2 |
| Ikeura, Y | 1 |
| Natsugari, H | 1 |
| Oku, S | 1 |
| Kohayakawa, H | 1 |
| Rovner, ES | 1 |
| Wein, AJ | 2 |
| Finkbeiner, AE | 1 |
| Bissada, NK | 1 |
| Welch, LT | 1 |
| Uruno, T | 1 |
| Murakami, F | 1 |
| Wada, K | 1 |
| Hizukuri, M | 1 |
| Igarashi, M | 1 |
| Yoshida, K | 1 |
| Matsuoka, Y | 1 |
| Sunagane, N | 1 |
| Kubota, K | 1 |
| Morikawa, K | 1 |
| Hashimoto, S | 1 |
| Yamauchi, T | 1 |
| Kato, H | 1 |
| Ito, Y | 1 |
| Gomi, Y | 1 |
| Deguchi, Y | 1 |
| Ohtsuka, M | 1 |
| Kumada, S | 1 |
| Scholtmeijer, RJ | 1 |
| van Mastrigt, R | 1 |
| Carter, JP | 2 |
| McPherson, DW | 1 |
| Natalie, KJ | 1 |
| Rzeszotarski, WJ | 2 |
| Waid, PP | 1 |
| Kachur, JF | 2 |
| Bunke, B | 1 |
| Ebner, A | 1 |
| Faber, P | 1 |
| de Geeter, P | 1 |
| Hannappel, J | 1 |
| Heidler, H | 1 |
| Madersbacher, H | 1 |
| Melchior, H | 1 |
| Schäfer, W | 1 |
| Caine, M | 1 |
| Gin, S | 1 |
| Pietra, C | 1 |
| Ruffmann, R | 1 |
| Koonings, PP | 1 |
| Bergman, A | 1 |
| van Waalwijk van Doorn, ES | 1 |
| Zwiers, W | 1 |
| Kato, K | 1 |
| Kitada, S | 1 |
| Chun, A | 1 |
| Takayanagi, I | 1 |
| Hisayama, T | 1 |
| Iwase, M | 1 |
| Sakuma, N | 1 |
| Nagai, H | 1 |
| Peterson, JS | 1 |
| Hanson, RC | 1 |
| Tonini, M | 1 |
| Rizzi, CA | 1 |
| Perucca, E | 1 |
| De Ponti, F | 1 |
| D'Angelo, L | 1 |
| Del Vecchio, A | 1 |
| Crema, A | 1 |
| Levounis, P | 1 |
| Abe, M | 1 |
| Ono, Y | 1 |
| Yamazaki, Y | 1 |
| Ujiie, A | 1 |
| Ikeda, S | 1 |
| Aida, Y | 1 |
| Kaneko, Y | 1 |
| Kasama, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study to Assess the Safety and Efficacy of Solifenacin (VESIcare) for Improving Urinary and Bladder Functions in Patients Undergoing Radiation Therapy of the Prostate[NCT01777217] | Phase 4 | 8 participants (Actual) | Interventional | 2013-02-28 | Terminated (stopped due to Terminated) | ||
| To Explore the Effect of beta3-adrenoceptor Agonist on Patients With Overactive Bladder and Develop Its Urinary Biomarker[NCT04693897] | 400 participants (Anticipated) | Observational [Patient Registry] | 2021-03-01 | Not yet recruiting | |||
| Pilot Study: Mirabegron for the Treatment of Pain Motivated Urinary Frequency and Urgency in Women, an Open Label Study With Dose Escalation[NCT02981459] | Phase 4 | 0 participants (Actual) | Interventional | 2017-12-08 | Withdrawn (stopped due to Withdrawn by Sponsor) | ||
| A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive Bladder[NCT01640002] | Phase 1 | 42 participants (Anticipated) | Interventional | 2012-05-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The AUASS score range is 1-7 (mild), 8-19 (moderate) and 20-35 (severe). The AUASS asks 7 questions scored 0-5, the scores are summed for the total score. (NCT01777217)
Timeframe: baseline and 16 weeks
| Intervention | Scores on a scale (Median) |
|---|---|
| Solifenacin Succinate | 9.4 |
| Placebo | 6.7 |
2 reviews available for oxybutynin and Muscle Contraction
| Article | Year |
|---|---|
The puzzle of overactive bladder: controversies, inconsistencies, and insights.
Topics: Animals; Benzhydryl Compounds; Cholinergic Antagonists; Cresols; Female; Humans; Mandelic Acids; Mus | 2006 |
Uropharmacology: part VI. Parasympathetic depressants.
Topics: Acetylcholine; Atropine; Belladonna Alkaloids; Benactyzine; Cyclohexanes; Hemicholinium 3; Humans; M | 1977 |
3 trials available for oxybutynin and Muscle Contraction
| Article | Year |
|---|---|
Pelvic floor muscle training alone or in combination with oxybutynin in treatment of nonmonosymptomatic enuresis. A randomized controlled trial with 2-year follow up.
Topics: Brazil; Child; Child, Preschool; Combined Modality Therapy; Exercise Therapy; Female; Humans; Male; | 2019 |
Clinical and urodynamic efficacy of oxybutynin and verapamil in the treatment of nocturnal enuresis after formation of orthotopic ileal neobladders. A prospective, randomized, crossover study.
Topics: Adult; Calcium Channel Blockers; Cholinergic Antagonists; Colonic Pouches; Cross-Over Studies; Cyste | 2008 |
Randomized, double-blind, multicenter trial on treatment of frequency, urgency and incontinence related to detrusor hyperactivity: oxybutynin versus propantheline versus placebo.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Male; Mandelic Acid | 1991 |
65 other studies available for oxybutynin and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and antimuscarinic properties of some N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones.
Topics: Animals; Furans; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Rabbits; | 1992 |
M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland.
Topics: Animals; Benzofurans; Bradycardia; Calcium; Carbachol; Cells, Cultured; Cytosol; Dose-Response Relat | 2002 |
Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists.
Topics: Animals; Female; Models, Molecular; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Quin | 2005 |
1,4-dioxane, a suitable scaffold for the development of novel M₃ muscarinic receptor antagonists.
Topics: Animals; Blood Pressure; CHO Cells; Cricetinae; Cricetulus; Crystallography, X-Ray; Dioxanes; Guinea | 2012 |
Medications used to treat bladder disorders may alter effects of neuromodulation.
Topics: Acetanilides; Animals; Cystitis; Electric Stimulation Therapy; Female; Mandelic Acids; Muscle Contra | 2020 |
Chronic administration of anticholinergics in rats induces a shift from muscarinic to purinergic transmission in the bladder wall.
Topics: Animals; Benzhydryl Compounds; Cholinergic Agonists; Cholinergic Antagonists; Cholinergic Neurons; F | 2013 |
Gap junction expression and the effects of gap junction inhibitors in overactive bladder models: does ovariectomy have a role?
Topics: Analysis of Variance; Animals; Blotting, Western; Carbachol; Connexin 43; Disease Models, Animal; Fe | 2013 |
Effects of L-arginine, mirabegron, and oxybutynin on the primary bladder afferent nerve activities synchronized with reflexic, rhythmic bladder contractions in the rat.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Arginine; Electric Stimulation; Female; | 2015 |
Mechanisms of inhibitory action of TRK-130 (Naltalimide), a μ-opioid receptor partial agonist, on the micturition reflex.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Electric Stimulation; Guinea Pigs; Male; Mandelic Ac | 2017 |
In women with urinary incontinence how necessary is cystometry?
Topics: Adult; Aged; Female; Humans; Mandelic Acids; Middle Aged; Muscarinic Antagonists; Muscle Contraction | 2010 |
Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzofurans; Carbachol; Cresols; Diamines; Mandelic Acids; | 2011 |
Bryophyllum pinnatum inhibits detrusor contractility in porcine bladder strips--a pharmacological study towards a new treatment option of overactive bladder.
Topics: Animals; Carbachol; Cholinergic Agonists; Electric Stimulation; Kalanchoe; Mandelic Acids; Muscarini | 2012 |
Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Female; Mandelic Acids; Muscarinic Antag | 2012 |
Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Female; Mandelic Acids; Muscarinic Antag | 2012 |
Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Female; Mandelic Acids; Muscarinic Antag | 2012 |
Effects of mirabegron, a novel β3-adrenoceptor agonist, on primary bladder afferent activity and bladder microcontractions in rats compared with the effects of oxybutynin.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Female; Mandelic Acids; Muscarinic Antag | 2012 |
Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Carbachol; Cholinergic Agonists; Cholinergic An | 2002 |
Significance of low compliance bladder in cauda equina injury.
Topics: Administration, Intravesical; Administration, Oral; Adult; Benzilates; Cauda Equina; Compliance; Fem | 2002 |
Which stop test is best? Measuring detrusor contractility in older females.
Topics: Aged; Aged, 80 and over; Diagnostic Techniques, Urological; Female; Humans; Mandelic Acids; Middle A | 2003 |
Urodynamics in a rat neurogenic bladder model with a unilateral electrolytic lesion of the basal forebrain.
Topics: Animals; Benzilates; Brain Diseases; Cholinergic Antagonists; Disease Models, Animal; Fumarates; Mal | 2003 |
Effectiveness of vaginally administered oxybutynin on rabbit bladder function.
Topics: Acetylcholine; Administration, Intravaginal; Administration, Oral; Animals; Blood Pressure; Female; | 2003 |
Effects of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl)glycolate hydrochloride, a metabolite of oxybutynin, on bladder specimens and rhythmic bladder contraction in rats in comparison with oxybutynin.
Topics: Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Mandelic Acids; Muscle Contr | 2004 |
[Effect of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl) glycolate, metabolite of oxybutynin, on intra-artery administered acetylcholine-induced urinary bladder contraction in anesthetized dogs].
Topics: Acetylcholine; Anesthesia; Animals; Confidence Intervals; Dogs; Dose-Response Relationship, Drug; Fe | 2004 |
Effects of ryanoids on spontaneous and depolarization-evoked calcium release events in frog muscle.
Topics: Alkaloids; Animals; Calcium; Electric Stimulation; Mandelic Acids; Membrane Potentials; Microscopy, | 2004 |
Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways.
Topics: Acetylcholine; Administration, Intravesical; Afferent Pathways; Animals; Atropine; Benzhydryl Compou | 2005 |
Stoller afferent nerve stimulation in woman with therapy resistant over active bladder; a 1-year follow up.
Topics: Adult; Ankle; Electric Stimulation Therapy; Female; Follow-Up Studies; Humans; Mandelic Acids; Manom | 2006 |
Effects of Byakko-ka-ninjin-to on salivary secretion and bladder function in rats.
Topics: Animals; Drugs, Chinese Herbal; Male; Mandelic Acids; Muscle Contraction; Pilocarpine; Plant Extract | 2005 |
Propantheline and in vitro reactivity of urinary bladder smooth muscle in guinea pigs.
Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Mandelic | 2005 |
Altered neurogenic and mechanical responses to acetylcholine, ATP and substance P in detrusor from rat with outlet obstruction.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Cholinergic Agonists; Cyclooxygenase Inhib | 2006 |
Comparison of the effects of percutaneous and intraduodenal administration of oxybutynin on bladder contraction and salivation in rabbits.
Topics: Administration, Cutaneous; Animals; Duodenum; Injections; Male; Mandelic Acids; Muscle Contraction; | 2006 |
Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Benzofurans; Binding, Competitive; Carbachol; C | 2007 |
Pharmacokinetics/pharmacodynamics analysis of the relationship between the in vivo micturition pressure and receptor occupancy of (R)-oxybutynin and its metabolite in rats.
Topics: Administration, Cutaneous; Administration, Oral; Animals; Cholinergic Antagonists; In Vitro Techniqu | 2007 |
Pharmacologic evaluation of pressor and visceromotor reflex responses to bladder distension.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2008 |
Analysis of pharmacological effects of drugs used for treatment of urinary disturbance based on anticholinergic and smooth muscle-relaxing effects.
Topics: Animals; Benzilates; Butylamines; Guinea Pigs; Humans; Mandelic Acids; Muscarinic Antagonists; Muscl | 2007 |
Urodynamic findings and long-term outcome management of patients with multiple sclerosis-induced lower urinary tract dysfunction.
Topics: Adult; Aged; Bethanechol; Bethanechol Compounds; Female; Humans; Imipramine; Male; Mandelic Acids; M | 1984 |
The uninhibited bladder in children: effect of treatment on vesicoureteral reflux resolution.
Topics: Adolescent; Anti-Infective Agents, Urinary; Child; Child, Preschool; Female; Humans; Male; Mandelic | 1984 |
Oxybutynin administration diminishes the high gastric muscular tone associated with bladder reconstruction.
Topics: Female; Humans; Infant; Linear Models; Mandelic Acids; Muscle Contraction; Muscle Tonus; Muscle, Smo | 1995 |
Agents for the treatment of overactive detrusor. VI. Synthesis and pharmacological properties of acetamide derivatives bearing cyclic amines in N-substituents.
Topics: Acetamides; Animals; In Vitro Techniques; Mandelic Acids; Muscle Contraction; Muscle, Smooth; Mydria | 1994 |
Reservoir characteristics of Mainz pouch studied in animal model. Osmolality of filling solution and effect of oxybutynin.
Topics: Animals; Cecum; Dogs; Ileum; Mandelic Acids; Models, Biological; Muscle Contraction; Muscle, Smooth; | 1993 |
Comparison of urodynamic findings and response to oxybutynin in nocturnal enuresis.
Topics: Adolescent; Child; Enuresis; Female; Humans; Male; Mandelic Acids; Muscle Contraction; Parasympathol | 1993 |
Videomicroscopic imaging of ureteral peristaltic function in rats during cystometry.
Topics: Animals; Female; Isoquinolines; Mandelic Acids; Microscopy, Video; Muscle Contraction; Muscle, Smoot | 1996 |
Comparison of oxybutynin and its active metabolite, N-desethyl-oxybutynin, in the human detrusor and parotid gland.
Topics: Adult; Aged; Atropine; Carbachol; Humans; In Vitro Techniques; Mandelic Acids; Middle Aged; Muscarin | 1997 |
Tolterodine--a new bladder-selective antimuscarinic agent.
Topics: Adult; Aged; Analgesia; Animals; Atropine; Benzhydryl Compounds; Cats; CHO Cells; Cholinergic Antago | 1997 |
Comparative analysis of bladder wall compliance based on cystometry and biosensor measurements during the micturition cycle of the rat.
Topics: Animals; Biosensing Techniques; Compliance; Female; Male; Mandelic Acids; Muscle Contraction; Rats; | 1997 |
Pharmacologic actions of temiverine (p-INN) and its active metabolite, RCC-36, on isolated human urinary bladder muscle.
Topics: Acetylcholine; Aged; Atropine; Calcium Channel Blockers; Calcium Chloride; Cholinergic Antagonists; | 1998 |
Pharmacological effects of tolterodine on human isolated urinary bladder.
Topics: Aged; Benzhydryl Compounds; Benzilates; Calcium Chloride; Carbachol; Cresols; Dose-Response Relation | 1999 |
[Effects of propiverine hydrochloride (propiverine) on isolated rat and dog urinary bladder].
Topics: Acetylcholine; Animals; Atropine; Benzilates; Butylamines; Dogs; Dose-Response Relationship, Drug; E | 1999 |
Clinical efficacy of oxybutynin on sensory urgency as compared with that on motor urgency.
Topics: Aged; Cholinergic Antagonists; Humans; Mandelic Acids; Muscle Contraction; Muscle, Smooth; Severity | 1999 |
Effects of TAK-637, a tachykinin receptor antagonist, on the micturition reflex in guinea pigs.
Topics: Animals; Benzhydryl Compounds; Benzilates; Capsaicin; Cholinergic Antagonists; Cresols; Dilatation; | 2000 |
Possible site of action of TAK-637, a tachykinin NK(1) receptor antagonist, on the micturition reflex in guinea pigs.
Topics: Animals; Atropine; Benzhydryl Compounds; Benzilates; Carbachol; Cresols; Denervation; Dose-Response | 2000 |
Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats.
Topics: Anesthesia; Animals; Cholinergic Antagonists; Dose-Response Relationship, Drug; Female; Fumarates; H | 2001 |
Modern pharmacotherapy of urge urinary incontinence in the USA: tolterodine and oxybutynin.
Topics: Aged; Behavior Therapy; Benzhydryl Compounds; Combined Modality Therapy; Cresols; Female; Humans; Ma | 2000 |
[Effects of tiropramide hydrochloride on the isolated detrusor and intravesical pressure of the bladder in situ in rats].
Topics: Animals; Butylamines; Dose-Response Relationship, Drug; Flavoxate; In Vitro Techniques; Male; Mandel | 1992 |
Inhibitory effect of inaperisone hydrochloride (inaperisone), a new centrally acting muscle relaxant, on the micturition reflex.
Topics: Anesthesia; Animals; Atropine; Baclofen; Brain; Male; Mandelic Acids; Muscle Contraction; Muscle Rel | 1992 |
Effects of the anticholinergic drug prifinium bromide on urinary bladder contractions in rat in vivo and in guinea-pig in vitro.
Topics: Animals; Atropine; Barium; Barium Compounds; Butylamines; Calcium Channel Blockers; Chlorides; Elect | 1991 |
The effect of oxyphenonium bromide and oxybutynin hydrochloride on detrusor contractility and reflux in children with vesicoureteral reflux and detrusor instability.
Topics: Child; Child, Preschool; Female; Humans; Male; Mandelic Acids; Muscle Contraction; Oxyphenonium; Par | 1991 |
Analogues of oxybutynin. Synthesis and antimuscarinic and bladder activity of some substituted 7-amino-1-hydroxy-5-heptyn-2-ones and related compounds.
Topics: Alkynes; Amines; Animals; Carbachol; Cyclobutanes; Female; Guinea Pigs; Mandelic Acids; Muscarinic A | 1991 |
Enantiomers of oxybutynin: in vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs.
Topics: Animals; Female; Guinea Pigs; In Vitro Techniques; Male; Mandelic Acids; Mice; Muscle Contraction; P | 1991 |
Antispasmodic effects of flavoxate, MFCA, and REC 15/2053 on smooth muscle of human prostate and urinary bladder.
Topics: Adenoma; Dose-Response Relationship, Drug; Flavoxate; Humans; Male; Mandelic Acids; Muscle Contracti | 1991 |
Urethral pressure changes in women with detrusor instability. Bladder or urethral pathologic process?
Topics: Adult; Aged; Female; Humans; Mandelic Acids; Middle Aged; Muscle Contraction; Muscle, Smooth; Parasy | 1991 |
Ambulant monitoring to assess the efficacy of oxybutynin chloride in patients with mixed incontinence.
Topics: Adult; Female; Humans; Male; Mandelic Acids; Monitoring, Physiologic; Muscle Contraction; Parasympat | 1990 |
In vitro intravesical instillation of anticholinergic, antispasmodic and calcium blocking agents (rabbit whole bladder model).
Topics: Administration, Intravesical; Animals; Atropine; Bethanechol; Bethanechol Compounds; Calcium Channel | 1989 |
Pharmacological properties of tiropramide, an antispasmodic drug.
Topics: Animals; Calcium; Cecum; Female; Flavoxate; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; | 1989 |
R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Guinea Pigs | 1988 |
Depressant action of oxybutynin on the contractility of intestinal and urinary tract smooth muscle.
Topics: Acetylcholine; Animals; Calcium Chloride; Depression, Chemical; Dose-Response Relationship, Drug; El | 1987 |
Analysis of the in vitro pharmacologic response of renal pelvis and detrusor smooth muscle to thiphenamil, oxybutynin and verapamil.
Topics: Animals; Diphenylacetic Acids; In Vitro Techniques; Kidney Pelvis; Male; Mandelic Acids; Muscle Cont | 1988 |
[Effect of terodiline hydrochloride in isolated rabbit detrusor].
Topics: Animals; Butylamines; Calcium Channel Blockers; Depression, Chemical; Dose-Response Relationship, Dr | 1987 |
[Effect of oxybutynin hydrochloride on isolated smooth muscles (ileum, urinary bladder and urethra)].
Topics: Acetylcholine; Animals; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Ma | 1986 |