Page last updated: 2024-11-02

oxybutynin and Hot Flashes

oxybutynin has been researched along with Hot Flashes in 6 studies

oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.

Hot Flashes: A sudden, temporary sensation of heat predominantly experienced by some women during MENOPAUSE. (Random House Unabridged Dictionary, 2d ed)

Research Excerpts

ExcerptRelevanceReference
"Oxybutynin is an effective, nonhormonal therapy for moderate-to-severe vasomotor symptoms in postmenopausal women."2.82Extended-release oxybutynin therapy for vasomotor symptoms in women: a randomized clinical trial. ( Gaines, T; LaGuardia, KD; Simon, JA, 2016)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, TJ1
Loprinzi, CL1
Deville, C1
Simon, JA1
Gaines, T1
LaGuardia, KD1
Guttuso, T1
Bezwada, P1
Shaikh, A1
Misra, D1
Schmidt, PJ1
Ben Dor, R1
Martinez, PE1
Guerrieri, GM1
Harsh, VL1
Thompson, K1
Koziol, DE1
Nieman, LK1
Rubinow, DR1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis[NCT05282277]Phase 4103 participants (Anticipated)Interventional2022-04-20Recruiting
The Effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women With Perimenopausal Depression[NCT00060736]60 participants (Actual)Observational2003-05-05Completed
Effects of a Tissue Selective Estrogen Complex (TESC) on Depression and the Neural Reward System in the Perimenopause[NCT03740009]Phase 420 participants (Actual)Interventional2019-01-02Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in Frontostriatal Reactivity to Reward During MID fMRI Task

"The primary outcome measure is functional magnetic resonance imaging (fMRI) data collected during a Monetary Incentive Delay (MID) Task. All participants will complete the fMRI Monetary Incentive Delay (MID) task at baseline and at 3 weeks. During the task, participants need to select the correct response during win and lose conditions by pressing a button on a button box in the MRI. Participant's blood-oxygen-level dependent (BOLD) activation response (A measurement of oxygen level that is released to neurons since areas of the brain that are thought to be more active or involved in certain tasks require more oxygen to perform the tasks.) is measured while they performed the task in MRI scanner." (NCT03740009)
Timeframe: Baseline to 3 weeks

Interventionpercent signal change (Mean)
Caudate BaselineCaudate PosttreatmentNucleus Accumbens BaselineNucleus Accumbens PosttreatmentPutamen BaselinePutamen Posttreatment
Perimenopausal Women, Depressed.0704.0475.0623.0280.0399.0408

Depressive Symptoms as Measured by the MASQ-AD

The second primary outcome measure uses the Mood and Anxiety Symptoms Questionnaire - Anhedonic Depression Scale (MASQ-AD) to examine symptom change. All participants will complete the MASQ-AD at each study visit, which measures their current symptoms of depression and anxiety. Scores range from 22 to 110 with lower scores reflecting a better outcome. (NCT03740009)
Timeframe: Baseline, week 2, week 3, week 4 (post treatment)

Interventionscore on a scale (Mean)
Baseline Week 1Week 2Week 3Post Treatment Week 4
Perimenopausal Women, Depressed72.162.457.254.5

Reviews

2 reviews available for oxybutynin and Hot Flashes

ArticleYear
Effective and clinically meaningful non-hormonal hot flash therapies.
    Maturitas, 2012, Volume: 72, Issue:1

    Topics: Actaea; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanols; Desvenlafaxine Succinat

2012
The Effect of Transdermal Estrogen Patch Use on Cardiovascular Outcomes: A Systematic Review.
    Journal of women's health (2002), 2017, Volume: 26, Issue:12

    Topics: Administration, Cutaneous; Cardiovascular Diseases; Estrogen Replacement Therapy; Estrogens; Female;

2017

Trials

2 trials available for oxybutynin and Hot Flashes

ArticleYear
Extended-release oxybutynin therapy for vasomotor symptoms in women: a randomized clinical trial.
    Menopause (New York, N.Y.), 2016, Volume: 23, Issue:11

    Topics: Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Female; Hot Flashes; Humans; Mandelic

2016
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
    JAMA psychiatry, 2015, Volume: 72, Issue:7

    Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen

2015

Other Studies

2 other studies available for oxybutynin and Hot Flashes

ArticleYear
Oxybutynin for Hot Flashes Due to Androgen Deprivation in Men.
    The New England journal of medicine, 2018, 05-03, Volume: 378, Issue:18

    Topics: Aged; Androgen Antagonists; Anilides; Hot Flashes; Humans; Leuprolide; Male; Mandelic Acids; Muscari

2018
Oxybutynin for hot flashes in women with breast cancer.
    The Medical letter on drugs and therapeutics, 2019, Feb-25, Volume: 61, Issue:1566

    Topics: Breast Neoplasms; Delayed-Action Preparations; Drug Interactions; Female; Hot Flashes; Humans; Mande

2019