oxybutynin has been researched along with Hot Flashes in 6 studies
oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.
Hot Flashes: A sudden, temporary sensation of heat predominantly experienced by some women during MENOPAUSE. (Random House Unabridged Dictionary, 2d ed)
Excerpt | Relevance | Reference |
---|---|---|
"Oxybutynin is an effective, nonhormonal therapy for moderate-to-severe vasomotor symptoms in postmenopausal women." | 2.82 | Extended-release oxybutynin therapy for vasomotor symptoms in women: a randomized clinical trial. ( Gaines, T; LaGuardia, KD; Simon, JA, 2016) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 6 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Smith, TJ | 1 |
Loprinzi, CL | 1 |
Deville, C | 1 |
Simon, JA | 1 |
Gaines, T | 1 |
LaGuardia, KD | 1 |
Guttuso, T | 1 |
Bezwada, P | 1 |
Shaikh, A | 1 |
Misra, D | 1 |
Schmidt, PJ | 1 |
Ben Dor, R | 1 |
Martinez, PE | 1 |
Guerrieri, GM | 1 |
Harsh, VL | 1 |
Thompson, K | 1 |
Koziol, DE | 1 |
Nieman, LK | 1 |
Rubinow, DR | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis[NCT05282277] | Phase 4 | 103 participants (Anticipated) | Interventional | 2022-04-20 | Recruiting | ||
The Effects of Acute Withdrawal of Estradiol on Mood Symptoms in Women With Perimenopausal Depression[NCT00060736] | 60 participants (Actual) | Observational | 2003-05-05 | Completed | |||
Effects of a Tissue Selective Estrogen Complex (TESC) on Depression and the Neural Reward System in the Perimenopause[NCT03740009] | Phase 4 | 20 participants (Actual) | Interventional | 2019-01-02 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"The primary outcome measure is functional magnetic resonance imaging (fMRI) data collected during a Monetary Incentive Delay (MID) Task. All participants will complete the fMRI Monetary Incentive Delay (MID) task at baseline and at 3 weeks. During the task, participants need to select the correct response during win and lose conditions by pressing a button on a button box in the MRI. Participant's blood-oxygen-level dependent (BOLD) activation response (A measurement of oxygen level that is released to neurons since areas of the brain that are thought to be more active or involved in certain tasks require more oxygen to perform the tasks.) is measured while they performed the task in MRI scanner." (NCT03740009)
Timeframe: Baseline to 3 weeks
Intervention | percent signal change (Mean) | |||||
---|---|---|---|---|---|---|
Caudate Baseline | Caudate Posttreatment | Nucleus Accumbens Baseline | Nucleus Accumbens Posttreatment | Putamen Baseline | Putamen Posttreatment | |
Perimenopausal Women, Depressed | .0704 | .0475 | .0623 | .0280 | .0399 | .0408 |
The second primary outcome measure uses the Mood and Anxiety Symptoms Questionnaire - Anhedonic Depression Scale (MASQ-AD) to examine symptom change. All participants will complete the MASQ-AD at each study visit, which measures their current symptoms of depression and anxiety. Scores range from 22 to 110 with lower scores reflecting a better outcome. (NCT03740009)
Timeframe: Baseline, week 2, week 3, week 4 (post treatment)
Intervention | score on a scale (Mean) | |||
---|---|---|---|---|
Baseline Week 1 | Week 2 | Week 3 | Post Treatment Week 4 | |
Perimenopausal Women, Depressed | 72.1 | 62.4 | 57.2 | 54.5 |
2 reviews available for oxybutynin and Hot Flashes
Article | Year |
---|---|
Effective and clinically meaningful non-hormonal hot flash therapies.
Topics: Actaea; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Cyclohexanols; Desvenlafaxine Succinat | 2012 |
The Effect of Transdermal Estrogen Patch Use on Cardiovascular Outcomes: A Systematic Review.
Topics: Administration, Cutaneous; Cardiovascular Diseases; Estrogen Replacement Therapy; Estrogens; Female; | 2017 |
2 trials available for oxybutynin and Hot Flashes
Article | Year |
---|---|
Extended-release oxybutynin therapy for vasomotor symptoms in women: a randomized clinical trial.
Topics: Adult; Aged; Delayed-Action Preparations; Double-Blind Method; Female; Hot Flashes; Humans; Mandelic | 2016 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
Effects of Estradiol Withdrawal on Mood in Women With Past Perimenopausal Depression: A Randomized Clinical Trial.
Topics: Aged; Cross-Over Studies; Depression; Depressive Disorder; Double-Blind Method; Estradiol; Estrogen | 2015 |
2 other studies available for oxybutynin and Hot Flashes
Article | Year |
---|---|
Oxybutynin for Hot Flashes Due to Androgen Deprivation in Men.
Topics: Aged; Androgen Antagonists; Anilides; Hot Flashes; Humans; Leuprolide; Male; Mandelic Acids; Muscari | 2018 |
Oxybutynin for hot flashes in women with breast cancer.
Topics: Breast Neoplasms; Delayed-Action Preparations; Drug Interactions; Female; Hot Flashes; Humans; Mande | 2019 |