oxybutynin has been researched along with Aggression in 1 studies
oxybutynin: RN given refers to parent cpd
oxybutynin : A racemate comprising equimolar amounts of (R)-oxybutynin and esoxybutynin. An antispasmodic used for the treatment of overactive bladder.
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lewis, AS | 1 |
| van Schalkwyk, GI | 1 |
| Lopez, MO | 1 |
| Volkmar, FR | 1 |
| Picciotto, MR | 1 |
| Sukhodolsky, DG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Transdermal Nicotine on Response Inhibition to Emotional Cues in Schizophrenia[NCT03838484] | 18 participants (Actual) | Interventional | 2019-05-10 | Terminated (stopped due to Recruitment challenges due to Covid19.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Participants will be shown fearful, sad, angry, and disgust faces (negative valence) and neutral faces performed in 5 blocks (3 emotional blocks with angry/fearful/sad/disgust faces and 2 non-emotional blocks). In each block the subject is instructed on the go/no-go targets and will press a key (Go) or withhold pressing a key (NoGo). The False Alarm Error Rate will be measured by the proportion of incorrect responses." (NCT03838484)
Timeframe: Week 1
| Intervention | Proportion of incorrect responses (Mean) |
|---|---|
| Healthy: Placebo | 0.20 |
| Healthy: Nicotine | 0.15 |
| SCZ: Placebo | 0.11 |
| SCZ: Nicotine | 0.19 |
"Participants will be shown fearful, sad, angry, and disgust faces (negative valence) and neutral faces performed in 5 blocks (3 emotional blocks with angry/fearful/sad/disgust faces and 2 non-emotional blocks). In each block the subject is instructed on the go/no-go targets and will press a key (Go) or withhold pressing a key (NoGo). The False Alarm Error Rate will be measured by the proportion of incorrect responses." (NCT03838484)
Timeframe: Week 2
| Intervention | Proportion of incorrect responses (Mean) |
|---|---|
| Healthy: Nicotine | 0.18 |
| Healthy: Placebo | 0.13 |
| SCZ: Nicotine | 0.15 |
| SCZ: Placebo | 0.23 |
"Participants will be shown fearful, sad, angry, and disgust faces (negative valence) and neutral faces performed in 5 blocks (3 emotional blocks with angry/fearful/sad/disgust faces and 2 non-emotional blocks). In each block the subject is instructed on the go/no-go targets and will press a key (Go) or withhold pressing a key (NoGo). The Omission Error Rate will be measured by the proportion of questions asked with a failure to respond." (NCT03838484)
Timeframe: Week 1
| Intervention | Proportion of omitted responses (Mean) |
|---|---|
| Healthy: Placebo | 0.24 |
| Healthy: Nicotine | 0.29 |
| SCZ: Placebo | 0.44 |
| SCZ: Nicotine | 0.27 |
"Participants will be shown fearful, sad, angry, and disgust faces (negative valence) and neutral faces performed in 5 blocks (3 emotional blocks with angry/fearful/sad/disgust faces and 2 non-emotional blocks). In each block the subject is instructed on the go/no-go targets and will press a key (Go) or withhold pressing a key (NoGo). The Omission Error Rate will be measured by the proportion of questions asked with a failure to respond." (NCT03838484)
Timeframe: Week 2
| Intervention | Proportion of omitted responses (Mean) |
|---|---|
| Healthy: Nicotine | 0.29 |
| Healthy: Placebo | 0.23 |
| SCZ: Nicotine | 0.38 |
| SCZ: Placebo | 0.30 |
Time taken from stimulus presentation to button push during Go trials (NCT03838484)
Timeframe: Week 1
| Intervention | Milliseconds (Mean) |
|---|---|
| Healthy: Placebo | 485.09 |
| Healthy: Nicotine | 491.05 |
| SCZ: Placebo | 468.96 |
| SCZ: Nicotine | 517.05 |
Time taken from stimulus presentation to button push during Go trials (NCT03838484)
Timeframe: Week 2
| Intervention | Milliseconds (Mean) |
|---|---|
| Healthy: Nicotine | 477.54 |
| Healthy: Placebo | 511.10 |
| SCZ: Nicotine | 478.99 |
| SCZ: Placebo | 490.67 |
Time taken from stimulus presentation to button push during NoGo trials (NCT03838484)
Timeframe: Week 1
| Intervention | Milliseconds (Mean) |
|---|---|
| Healthy: Placebo | 718.89 |
| Healthy: Nicotine | 658.20 |
| SCZ: Placebo | 813.00 |
| SCZ: Nicotine | 692.95 |
Time taken from stimulus presentation to button push during NoGo trials (NCT03838484)
Timeframe: Week 2
| Intervention | Milliseconds (Mean) |
|---|---|
| Healthy: Nicotine | 727.30 |
| Healthy: Placebo | 758.12 |
| SCZ: Nicotine | 769.95 |
| SCZ: Placebo | 703.99 |
1 trial available for oxybutynin and Aggression
| Article | Year |
|---|---|
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder.
Topics: Adolescent; Adult; Aggression; Autism Spectrum Disorder; Double-Blind Method; Female; Humans; Irrita | 2018 |