oxotremorine has been researched along with Tremor in 156 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied." | 7.74 | Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008) |
| " The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking alpha5 nAChR subunits (alpha5-/-) and compared with those in wild-type (WT) control mice." | 7.72 | Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor. ( Chapman, J; Korczyn, AD; Orr-Urtreger, A; Rabinowitz, R; Wang, N, 2004) |
| ") significantly enhanced harmine- but not oxotremorine-induced tremors in mice." | 7.70 | Enhancement of serotonergic neural activity contributes to cyclosporine-induced tremors in mice. ( Kanaya, A; Kataoka, Y; Matsunaga, K; Oishi, R; Shuto, H; Sueyasu, M, 1998) |
| " The present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age)." | 7.70 | Differences in central and peripheral responses to oxotremorine in young and aged rats. ( Carlini, EA; Espínola, EB; Oliveira, MG, 1999) |
| "Two subseries of nonquaternized (5a-10a) and quaternized derivatives (5b-10b) related to oxotremorine and oxotremorine-M were synthesized and tested." | 7.70 | Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. ( Ballabeni, V; Barocelli, E; Bertoni, S; Chiavarini, M; Conti, P; Dallanoce, C; De Amici, M; De Micheli, C; Impicciatore, M, 1999) |
| "Effects of beta-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets." | 7.70 | Effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets. ( Iwata, S; Mitsuda, M; Nomoto, M, 1999) |
| "To characterize the tail-tremor and locomotor hyperactivity induced by repeated nicotine administration, the effects of nicotinic, alpha-adrenergic and dopaminergic blockers were investigated in rats." | 7.69 | Characteristics of tail-tremor induced by nicotine in rats. ( Gomita, Y; Oishi, R; Suemaru, K, 1994) |
| "The effect of nipradilol, a nonselective beta-adrenergic receptor blocker with nitroglycerin-like vasodilating activity, on oxotremorine-induced tremor was studied in mice." | 7.69 | Effect of nipradilol, a beta-adrenergic blocker with vasodilating activity, on oxotremorine-induced tremor in mice. ( Fukuda, T; Iwata, S; Nomoto, M, 1996) |
| "Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens." | 7.68 | Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats. ( Almeida, OM; Santos, R, 1993) |
| "Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), were evaluated against oxotremorine-induced tremors in mice." | 7.68 | Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice. ( Ilhan, M; Sahin, I; Tuncer, M, 1990) |
| "A series of phenyl-substituted analogues of the muscarinic agent oxotremorine (1) have been prepared." | 7.68 | Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. ( Hacksell, U; Nilsson, BM; Ringdahl, B; Vargas, HM, 1992) |
| "The enantiomers of three 5-methyl-2-pyrrolidone analogues of the muscarinic agent oxotremorine (1) were synthesized." | 7.67 | Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogues. N-[4-(tertiary amino)-2-butynyl]-5-methyl-2-pyrrolidones. ( Amstutz, R; Jenden, DJ; Karlén, B; Ringdahl, B; Roch, M, 1985) |
| "A series of tertiary 3- and 4-haloalkylamines related to the muscarinic agent oxotremorine was synthesized." | 7.67 | Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists. ( Jenden, DJ; Ringdahl, B; Roch, M, 1988) |
| " Diazepam has been reported to inhibit both the tremor and mechanism of cerebellar cyclic GMP caused by harmaline by a neurotransmission in the cerebellum." | 7.67 | Ethanol effects on harmaline-induced tremor and increase of cerebellar cyclic GMP. ( Dole, VP; Gentry, RT; Rappaport, MS; Schneider, DR, 1984) |
| "Organochlorine insecticides such as DDT and chlordecone produce tremor in exposed individuals." | 7.67 | Studies on the mechanism of chlordecone-induced tremor in rats. ( Gerhart, JM; Hong, JS; Tilson, HA, 1985) |
| "The enantiomers of the oxotremorine analog N-[4-(2-chloromethylpyrrolidine)-2-butynyl]-2-pyrrolidone (BM 130) were synthesized." | 7.67 | Muscarinic actions and receptor binding of the enantiomers of BM 130, an alkylating analog of oxotremorine. ( Jenden, DJ; Katz, ED; Ringdahl, B; Roch, M, 1989) |
| "A tremor monitor was constructed and tested that quantitates soman- and oxotremorine-induced tremors." | 7.67 | Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors. ( Clement, JG; Dyck, WR, 1989) |
| "Propranolol in low doses antagonized and in higher doses facilitated oxotremorine-induced tremor (Oxo-tremor) in mice." | 7.67 | Cholinergic involvement in the modulation of oxotremorine-tremor in mice by propranolol. ( Alkondon, M; Ray, A; Sen, P, 1985) |
| "Oxotremorine-induced tremor activity in mice was suppressed by pretreatment with either L-dopa or atropine." | 7.67 | A selective potentiation by naloxone of L-dopa but not atropine suppression of oxotremorine-induced tremor in mice. ( Lucas, TS; Quock, RM, 1985) |
| "The muscarinic agonist oxotremorine was used to induce tremor in rats pretreated with methylatropine." | 7.67 | Modulation of oxotremorine-induced tremor by central beta-adrenoceptors. ( Almgren, O; Hallberg, H, 1987) |
| "Tremor induced by TRH and oxotremorine was recorded by a capacitance transducer, and its intensity and frequency were evaluated using power arrays." | 7.67 | [Power spectral analysis of tremor induced by TRH and oxotremorine in mice]. ( Fukuda, T; Izumi, K; Koja, T; Nomoto, M; Shimizu, T, 1986) |
| "The muscarinic actions of several analogs of oxotremorine were compared in the mouse." | 7.67 | Regional differences in receptor reserve for analogs of oxotremorine in vivo: implications for development of selective muscarinic agonists. ( Jenden, DJ; Ringdahl, B; Roch, M, 1987) |
| "The pharmacological effects of N-[4-(2-bromoethylmethylamino)-2-butynyl]-2-pyrrolidone (BR 401) were compared in the mouse with those of N-[4-(2-chloroethylmethylamino)-2-butynl]-2-pyrrolidone (BM 123) and oxotremorine." | 7.67 | Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse. ( Jenden, DJ; Ringdahl, B, 1987) |
| "A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation." | 7.67 | Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine. ( Boismare, F; Chadelaud, M; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1985) |
| "Cholecystokinin octapeptide (CCK-8), ceruletide (caerulein, CER) and 10 analogues of ceruletide, were studied in mice for antagonism of the tremors induced by harmine (5 mg/kg, s." | 7.66 | Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: effects on tremors induced by oxotremorine, harmine and ibogaine. A comparison with prolyl-leucylglycine amide (MIF), anti-Parkinsonian drugs and clonazepam. ( Zetler, G, 1983) |
| "Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice." | 7.66 | Potentiation by naloxone of the anti-oxotremorine effect of L-DOPA. ( Lucas, TS; Quock, RM, 1983) |
| "The efficacy of an oral treatment of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) is studied with reference to the effects on parasympathetic stimulation provoked by oxotremorine administration in mice." | 7.66 | Pharmacological study of oral CDP-choline. Interaction with oxotremorine on the parasympathetic system. ( Ortiz, JA; Sacristán, A; Tornos, ME, 1983) |
| "A number of secondary and tertiary amines as well as quaternary ammonium compounds, obtained by structural modification of the amino group of oxotremorine (1) and its acetamide analogue (14), were investigated for muscarinic and antimuscarinic activity in vivo and in vitro." | 7.66 | Muscarinic activity of some secondary and tertiary amines and quaternary ammonium salts structurally related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1983) |
| "Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse." | 7.66 | Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice. ( Fujiwara, M; Hashimoto, Y; Kataoka, Y; Kawanishi, K; Ueki, S, 1981) |
| "1 The enantiomers of some analogues of the central muscarinic agent, oxotremorine, were prepared and investigated for tremorogenic and tremorolytic activity in intact mice and for muscarinic and antimuscarinic activity on the isolated ileum of the guinea-pig." | 7.66 | Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1982) |
| "The action of the benzomorphan narcotic antagonists Mr-1452 and Mr-2266 and their respective (+) isomers Mr-1453 and Mr-2267 as well as the antimuscarinic agent atropine upon oxotremorine (OTMN)-induced analgesia, tremor, and hypothermia were investigated in mice." | 7.66 | Some observations on the effects of enantiomers of two benzomorphan narcotic antagonists and atropine on analgesia, tremor and hypothermia produced by oxotremorine. ( Ben-Sreti, MM; Sewell, RD; Upton, N, 1982) |
| "The role of peripheral catecholamines in mediating the pressor and tremorigenic effects of oxotremorine were investigated in conscious rats." | 7.66 | Peripheral catecholamines mediate certain responses to central cholinergic receptor stimulation by oxotremorine. ( Kopin, IJ; Weinstock, M; Zavadil, AP, 1980) |
| "Oxotremorine, 0." | 7.66 | The role of peripheral catecholamines in oxotremorine tremor in the rat and its antagonism by beta adrenoceptor blocking agents. ( Chiueh, CC; Kopin, IJ; Rosin, AJ; Weinstock, M; Zavadil, AP, 1978) |
| "Fourteen di- and tripeptide analogues of MIF, Pro-Leu-Gly-NH2, have been synthesized and assayed for inhibition of oxotremorine-induced tremor." | 7.66 | Tripeptide analogues of melanocyte-stimulating hormone release-inhibiting hormone (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor. ( Björkman, S; Castensson, S; Sievertsson, H, 1979) |
| "The stereoisomers of some analogues of oxotremorine containing two chiral centres, one in the 1-position of the butynyl chas are oxotremorine antagonists." | 7.66 | Stereoselectivity of some oxotremorine antagonists containing two chiral centres. ( Dahlbom, R; Resul, B; Ringdahl, B, 1979) |
| "Meperidine (20 and 40 mg/kg, IP) did not block the cholinergic effects (tremor, salivation, and tearing) produced by oxotremorine (0." | 7.66 | Meperidine does not block the cholinergic effects of oxotremorine. ( Leander, JD, 1979) |
| "Administration of oxotremorine to mice produced centrally-mediated effects, such as catalepsy and tremor, and peripheral muscarinic actions, such as diarrhoea and lachrymation." | 7.66 | Amantadine antagonism of oxotremorine effects. ( Eshel, Y; Korczyn, AD, 1979) |
| "Tubocurarine tremor and shivering show identical topography in different muscle groups and identical frequency patterns of the EMG." | 7.66 | [Comparative characteristics of mechanisms regulating tubocurarine and cold tremor]. ( Burachevskaia, LE; Lupandin, IuV, 1978) |
| "The beta-adrenoceptor blockers propranolol, PhQA33 and LB-46 exhibited appreciable activity against tremorine-(TMN) and oxotremorine-(OTMN) induced tremor, whereas pronethalol, (+)-H56/28, (-)-H56/28, Kö-592 and L(+)-INPEA possessed weak action." | 7.65 | Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists. ( Barar, FS; Madan, BR, 1976) |
| "5-25 mg/kg) were found to restore and to intensify the oxotremorine-induced tremor in mice when injected i." | 7.65 | Thyrotropin releasing hormone (TRH): restoration of oxotremorine tremor in mice. Comparison with quipazine, a serotoninergic and dopaminergic stimulant. ( Kruse, H, 1976) |
| "Two oxotremorine antagonists have been examined using oxotremorine as the tremor salivation inducer and the ratios between the central and peripheral nervous systems determined." | 7.65 | The central and peripheral effectiveness of two oxotremorine-antagonists determined using oxotremorine-induced tremor and salivation. ( Eicholzer, A; Ogren, SO, 1977) |
| "Cyclizine was observed to induce generalized chorea in a patient with mild lingual-facial-buccal dyskinesias." | 7.65 | Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders. ( Klawans, HL; Moskovitz, C, 1977) |
| " The effect of various agents injected into the cerebral ventricles of the mouse, upon the tremor and hypothermia produced by oxotremorine (0." | 7.65 | Modification of oxotremorine tremor and hypothermia by injections of drugs into the cerebral ventricles of the mouse. ( Doggett, NS; O'Farrell, SA, 1976) |
| " The influence of propranolol on the neuromuscular, tremor-producing and muscarinic effects of oxotremorine was examined." | 7.65 | Antioxotremorine action of propranolol. ( Ganguly, DK, 1976) |
| "Oxotremorine tremor has in common with shivering its frequency range (10-28 Hz) and the co-contraction of flexors and extensors." | 5.29 | Role of the stretch reflex in oxotremorine tremor. ( Decima, EE, 1996) |
| "Tremor was evaluated using spectral analytical techniques." | 5.28 | Interactions between ethanol and pantothenic acid on tremor and behavior in squirrel monkeys. ( Newland, MC; Rivera-Calimlim, L; Weiss, B, 1992) |
| " The results of oxotremorine treatment suggested that they undergo strong suppression of muscarinic type acetylcholine receptors (mAChRs) functions, and that the damage in the GM3-only mice is due to a mAChR receptor deficit." | 3.76 | Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. ( Egashira, N; Fujiwara, M; Fukue, Y; Furukawa, K; Iwasaki, K; Mishima, K; Ohmi, Y; Sugiura, Y; Tajima, O, 2010) |
| " Variation across strains was detected in terms of acoustic startle, prepulse inhibition, and the physiologic effects of the muscarinic agonist oxotremorine." | 3.76 | Lack of association of a spontaneous mutation of the Chrm2 gene with behavioral and physiologic phenotypic differences in inbred mice. ( Arnold, J; Ding, M; Hughes, LF; Ramkumar, V; Toth, LA; Trammell, RA; Turner, J, 2010) |
| ") enhanced tremors induced by oxotremorine, a muscarinic M(1) receptor agonist." | 3.74 | Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats. ( Egashira, N; Fujiwara, M; Iwasaki, K; Kurauchi, K; Manome, N; Matsumoto, Y; Mishima, K; Shoyama, Y, 2007) |
| "Effect of zonisamide on harmaline- or oxotreorine-induced tremors, and tacrine-induced tremulous jaw movements (TJMs) was studied." | 3.74 | Effects of zonisamide on experimental tremors in rats. ( Hama, K; Kajimoto, Y; Kondo, T; Miwa, H, 2008) |
| " We investigated here muscarinic receptor reactivity in NVH lesioned animals by measuring the effects of the muscarinic receptor agonist oxotremorine on physiological responses known to be modulated by these receptors such as body temperature, salivation, tremor, pain, and prepulse inhibition of the acoustic startle (PPI)." | 3.73 | Alterations in behavioral responses to a cholinergic agonist in post-pubertal rats with neonatal ventral hippocampal lesions: relationship to changes in muscarinic receptor levels. ( Laplante, F; Nakagawasai, O; Quirion, R; Srivastava, LK, 2005) |
| "), inhibited negative inotropic (left ventricular dP/dt) effects caused by oxotremorine, a nonselective muscarinic agonist (p < 0." | 3.73 | In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine. ( Howell, G; Jenkins, C; Lineberry, B; Rockhold, R; West, L; Yokum, D, 2005) |
| " Low dose citalopram reversed both scopolamine- and THC-induced impairment of spatial memory, suppressed ECS-induced immobilization reversed the THC-induced decrease of acetylcholine (ACh) release in the dorsal hippocampus in vivo microdialysis, and enhanced tremors induced by oxotremorine, a muscarinic M1 receptor agonist." | 3.73 | Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization. ( Egashira, N; Fujioka, M; Fujiwara, M; Iwasaki, K; Matsumoto, Y; Matsushita, M; Mishima, K; Nishimura, R; Shoyama, Y, 2006) |
| " Further, the same dose of Ninjin-yoei-to enhanced oxotremorine-induced tremors in mice." | 3.72 | Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice. ( Egashira, N; Hattori, N; Ishige, A; Sakakibara, I; Yuzurihara, M, 2003) |
| "This study examined the effects of acute and chronic desipramine, 24-h total sleep deprivation (TSD) and 96-h REM sleep deprivation (REMSD) on physostigmine-induced hypothermia, analgesia and behaviour." | 3.72 | Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation. ( Murugaiah, KD; Ukponmwan, OE, 2003) |
| " The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking alpha5 nAChR subunits (alpha5-/-) and compared with those in wild-type (WT) control mice." | 3.72 | Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor. ( Chapman, J; Korczyn, AD; Orr-Urtreger, A; Rabinowitz, R; Wang, N, 2004) |
| ") also potentiates oxotremorine-induced tremors in mice, in a dose-dependent manner, and this effect was completely prevented by atropine." | 3.71 | Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline. ( Cunha, GM; Farias, PA; Viana, GS, 2002) |
| " The standard muscarinic agonists oxotremorine and pilocarpine were both active in these tests but showed little separation between efficacy and cholinergic side effects." | 3.70 | Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity. ( Bymaster, FP; Calligaro, DO; DeLapp, NW; Fink-Jensen, A; Jeppesen, L; Olesen, PH; Rasmussen, T; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Swedberg, MD; Thomsen, C; Thøgersen, H; Ward, JS, 1998) |
| ") significantly enhanced harmine- but not oxotremorine-induced tremors in mice." | 3.70 | Enhancement of serotonergic neural activity contributes to cyclosporine-induced tremors in mice. ( Kanaya, A; Kataoka, Y; Matsunaga, K; Oishi, R; Shuto, H; Sueyasu, M, 1998) |
| " The present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age)." | 3.70 | Differences in central and peripheral responses to oxotremorine in young and aged rats. ( Carlini, EA; Espínola, EB; Oliveira, MG, 1999) |
| "Two subseries of nonquaternized (5a-10a) and quaternized derivatives (5b-10b) related to oxotremorine and oxotremorine-M were synthesized and tested." | 3.70 | Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. ( Ballabeni, V; Barocelli, E; Bertoni, S; Chiavarini, M; Conti, P; Dallanoce, C; De Amici, M; De Micheli, C; Impicciatore, M, 1999) |
| "Effects of beta-blockers (propranolol, arotinolol and nipradilol) and a Ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets." | 3.70 | Effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets. ( Iwata, S; Mitsuda, M; Nomoto, M, 1999) |
| "To characterize the tail-tremor and locomotor hyperactivity induced by repeated nicotine administration, the effects of nicotinic, alpha-adrenergic and dopaminergic blockers were investigated in rats." | 3.69 | Characteristics of tail-tremor induced by nicotine in rats. ( Gomita, Y; Oishi, R; Suemaru, K, 1994) |
| "The potency of centrally administered non-selective (atropine and N-methyl scopolamine) and putatively selective muscarinic antagonists (pirenzepine, AF-DX 116 and 4-DAMP) in inhibition of oxotremorine-induced hypothermia, tremor and salivation in male mice has been compared with their potency in vitro in three functional systems, where muscarinic effects are mediated preferentially by M1 (i." | 3.69 | The involvement of muscarinic receptor subtypes in the mediation of hypothermia, tremor, and salivation in male mice. ( Lembøl, HL; Sánchez, C, 1994) |
| "The effect of nipradilol, a nonselective beta-adrenergic receptor blocker with nitroglycerin-like vasodilating activity, on oxotremorine-induced tremor was studied in mice." | 3.69 | Effect of nipradilol, a beta-adrenergic blocker with vasodilating activity, on oxotremorine-induced tremor in mice. ( Fukuda, T; Iwata, S; Nomoto, M, 1996) |
| " 3) The behaviorally effective doses of (+/-)-rolipram and its isomers also enhanced the oxotremorine-induced tremors in mice." | 3.69 | Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced impairments of learning and memory in rats. ( Egawa, T; Fujiwara, M; Iwasaki, K; Matsumoto, Y; Mishima, K, 1997) |
| "A series of acetylenic imidazoles related to oxotremorine (1a) were prepared and evaluated as cholinergic agents with in vitro binding assays and in vivo pharmacological tests in mice." | 3.68 | Cholinergic activity of acetylenic imidazoles and related compounds. ( Chidester, CG; Collins, RJ; Francis, JW; Heier, RF; Moon, MW; Morris, JK; Russell, RR; Sage, GP; Sethy, VH, 1991) |
| "We studied the effect of various kinds of beta-adrenergic blockers on oxotremorine-, harmaline- and thyrotropin-releasing hormone (TRH)-induced tremors in mice." | 3.68 | Effects of beta-adrenergic blockers on drug-induced tremors. ( Fukuda, T; Iwata, S; Nomoto, M, 1993) |
| "Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens." | 3.68 | Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats. ( Almeida, OM; Santos, R, 1993) |
| "Central antimuscarinic actions of dopamine receptor agonists: N,N-dipropylaminotetrain (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127), were evaluated against oxotremorine-induced tremors in mice." | 3.68 | Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice. ( Ilhan, M; Sahin, I; Tuncer, M, 1990) |
| "A series of phenyl-substituted analogues of the muscarinic agent oxotremorine (1) have been prepared." | 3.68 | Phenyl-substituted analogues of oxotremorine as muscarinic antagonists. ( Hacksell, U; Nilsson, BM; Ringdahl, B; Vargas, HM, 1992) |
| " Oxotremorine-induced tremor and salivation in mice were delayed after extremely high dosage of levocabastine; however, these were much less effective than those seen after diphenhydramine and ketotifen." | 3.68 | Central effect of the potent long-acting H1-antihistamine levocabastine. ( Aoki, I; Kamei, C; Tasaka, K; Tsujimoto, S; Yoshida, T, 1990) |
| "The enantiomers of three 5-methyl-2-pyrrolidone analogues of the muscarinic agent oxotremorine (1) were synthesized." | 3.67 | Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogues. N-[4-(tertiary amino)-2-butynyl]-5-methyl-2-pyrrolidones. ( Amstutz, R; Jenden, DJ; Karlén, B; Ringdahl, B; Roch, M, 1985) |
| "A series of tertiary 3- and 4-haloalkylamines related to the muscarinic agent oxotremorine was synthesized." | 3.67 | Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists. ( Jenden, DJ; Ringdahl, B; Roch, M, 1988) |
| " Diazepam has been reported to inhibit both the tremor and mechanism of cerebellar cyclic GMP caused by harmaline by a neurotransmission in the cerebellum." | 3.67 | Ethanol effects on harmaline-induced tremor and increase of cerebellar cyclic GMP. ( Dole, VP; Gentry, RT; Rappaport, MS; Schneider, DR, 1984) |
| "Male and female rats of two lines psychogenetically selected for bipolar extremes in shuttle box avoidance were evaluated for tremor, salivation, chromodacryoorhea, and hypothermia following treatment with the muscarinic cholinergic agonist oxotremorine." | 3.67 | Differential response to cholinergic stimulation in psychogenitically selected rat lines. ( Driscoll, P; Gentsch, C; Martin, JR, 1984) |
| " Chronic infusion resulted in mice that were supersensitive to the hypothermia and tremor produced by the muscarinic agonist, oxotremorine." | 3.67 | Chronic scopolamine treatment and brain cholinergic function. ( Artman, LD; Burch, JB; Collins, AC; Marks, MJ; O'Connor, MF, 1984) |
| "Organochlorine insecticides such as DDT and chlordecone produce tremor in exposed individuals." | 3.67 | Studies on the mechanism of chlordecone-induced tremor in rats. ( Gerhart, JM; Hong, JS; Tilson, HA, 1985) |
| " Both minaprine and SR 95070B potentiated the tremorigenic effect of oxotremorine without inducing tremor when injected alone." | 3.67 | Cholinomimetic activities of minaprine. ( Biziere, K; Kan, JP; Perio, A; Steinberg, R; Terranova, JP; Worms, P, 1989) |
| "The anticholinergic effect of atropine, imipramine, clomipramine and metapramine was evaluated on oxotremorine induced trembling in the mouse as well as on contractions of the isolated guinea pig ileum induced by electrical stimulation of the mesenteric plexus." | 3.67 | [Evaluation of the central anticholinergic activity of antidepressants. Comparison of two experimental methods]. ( Billa, JP; Dufour, P; Fabre, J; Roquebert, J, 1989) |
| "The enantiomers of the oxotremorine analog N-[4-(2-chloromethylpyrrolidine)-2-butynyl]-2-pyrrolidone (BM 130) were synthesized." | 3.67 | Muscarinic actions and receptor binding of the enantiomers of BM 130, an alkylating analog of oxotremorine. ( Jenden, DJ; Katz, ED; Ringdahl, B; Roch, M, 1989) |
| "A tremor monitor was constructed and tested that quantitates soman- and oxotremorine-induced tremors." | 3.67 | Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors. ( Clement, JG; Dyck, WR, 1989) |
| "Propranolol in low doses antagonized and in higher doses facilitated oxotremorine-induced tremor (Oxo-tremor) in mice." | 3.67 | Cholinergic involvement in the modulation of oxotremorine-tremor in mice by propranolol. ( Alkondon, M; Ray, A; Sen, P, 1985) |
| "Oxotremorine-induced tremor activity in mice was suppressed by pretreatment with either L-dopa or atropine." | 3.67 | A selective potentiation by naloxone of L-dopa but not atropine suppression of oxotremorine-induced tremor in mice. ( Lucas, TS; Quock, RM, 1985) |
| "The muscarinic agonist oxotremorine was used to induce tremor in rats pretreated with methylatropine." | 3.67 | Modulation of oxotremorine-induced tremor by central beta-adrenoceptors. ( Almgren, O; Hallberg, H, 1987) |
| " into male mice potentiated and prolonged the oxotremorine and physostigmine-induced tremor in a dose-dependent manner." | 3.67 | In vivo and in vitro studies on the potentiation of muscarinic receptor stimulation by alaproclate, a selective 5-HT uptake blocker. ( Bartfai, T; Danielsson, E; Nordström, O; Ogren, SO; Peterson, LL, 1985) |
| " Phenotypically normal rats showed tremor in response to harmaline, a drug that acts on the inferior olive to produce bursting in the climbing fiber pathway." | 3.67 | Decreased cerebellar 3',5'-cyclic guanosine monophosphate levels and insensitivity to harmaline in the genetically dystonic rat (dt). ( Beales, M; Lorden, JF; Lutes, J; McKeon, TW; Oltmans, GA, 1985) |
| "Tremor induced by TRH and oxotremorine was recorded by a capacitance transducer, and its intensity and frequency were evaluated using power arrays." | 3.67 | [Power spectral analysis of tremor induced by TRH and oxotremorine in mice]. ( Fukuda, T; Izumi, K; Koja, T; Nomoto, M; Shimizu, T, 1986) |
| "The acute and chronic effects of the centrally active oxotremorine analog, BM-5, [N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)-acetamide] were examined in rats and mice." | 3.67 | BM-5, a centrally active partial muscarinic agonist with low tremorogenic activity. In vivo and in vitro studies. ( Bartfai, T; Consolo, S; Engström, C; Ladinsky, H; Undén, A, 1987) |
| " In addition, although these mice showed no deficits in baseline rotorod performance, challenge with the cholinergic agonist oxotremorine revealed that MPP+-treated mice exhibited an increased sensitivity to the disruptive effects of the drug at each dose and time point." | 3.67 | Increased sensitivity of mice to tremorogenic agents following MPP+. ( Wagner, GC; Walsh, SL, 1987) |
| "Rolipram, in contrast to the tricyclic antidepressants amitriptyline and imipramine or the acetylcholine receptor antagonist atropine, failed to antagonize the salivation, hypothermia, or tremor caused in mice by the muscarinic receptor agonists pilocarpine or oxotremorine." | 3.67 | Absence of anticholinergic activity of rolipram, an antidepressant with a novel mechanism of action, in three different animal models in vivo. ( Löschmann, PA; Pietzuch, P; Wachtel, H, 1988) |
| "The muscarinic actions of several analogs of oxotremorine were compared in the mouse." | 3.67 | Regional differences in receptor reserve for analogs of oxotremorine in vivo: implications for development of selective muscarinic agonists. ( Jenden, DJ; Ringdahl, B; Roch, M, 1987) |
| "The pharmacological effects of N-[4-(2-bromoethylmethylamino)-2-butynyl]-2-pyrrolidone (BR 401) were compared in the mouse with those of N-[4-(2-chloroethylmethylamino)-2-butynl]-2-pyrrolidone (BM 123) and oxotremorine." | 3.67 | Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse. ( Jenden, DJ; Ringdahl, B, 1987) |
| "The dose-effect of oxotremorine upon the onset, duration and magnitude of tremor and salivation was studied in both mice and rats." | 3.67 | Serotonergic potentiation of muscarinic agonist evoked tremor and salivation in rat and mouse. ( Bartfai, T; Carlsson, S; Ogren, SO, 1985) |
| "A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation." | 3.67 | Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine. ( Boismare, F; Chadelaud, M; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1985) |
| "Cholecystokinin octapeptide (CCK-8), ceruletide (caerulein, CER) and 10 analogues of ceruletide, were studied in mice for antagonism of the tremors induced by harmine (5 mg/kg, s." | 3.66 | Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: effects on tremors induced by oxotremorine, harmine and ibogaine. A comparison with prolyl-leucylglycine amide (MIF), anti-Parkinsonian drugs and clonazepam. ( Zetler, G, 1983) |
| "Pretreatment with the catecholamine precursor L-DOPA but not the narcotic antagonist naloxone suppressed the tremorigenic effect of oxotremorine in mice." | 3.66 | Potentiation by naloxone of the anti-oxotremorine effect of L-DOPA. ( Lucas, TS; Quock, RM, 1983) |
| "The efficacy of an oral treatment of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) is studied with reference to the effects on parasympathetic stimulation provoked by oxotremorine administration in mice." | 3.66 | Pharmacological study of oral CDP-choline. Interaction with oxotremorine on the parasympathetic system. ( Ortiz, JA; Sacristán, A; Tornos, ME, 1983) |
| "A number of secondary and tertiary amines as well as quaternary ammonium compounds, obtained by structural modification of the amino group of oxotremorine (1) and its acetamide analogue (14), were investigated for muscarinic and antimuscarinic activity in vivo and in vitro." | 3.66 | Muscarinic activity of some secondary and tertiary amines and quaternary ammonium salts structurally related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1983) |
| " Finally, minaprine does not antagonize either oxotremorine-induced tremors or physiostigmine-induced lethality." | 3.66 | Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug. ( Bizière, K; Kan, JP; Muyard, JP; Roncucci, R; Souilhac, J, 1982) |
| "Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse." | 3.66 | Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice. ( Fujiwara, M; Hashimoto, Y; Kataoka, Y; Kawanishi, K; Ueki, S, 1981) |
| "1 The enantiomers of some analogues of the central muscarinic agent, oxotremorine, were prepared and investigated for tremorogenic and tremorolytic activity in intact mice and for muscarinic and antimuscarinic activity on the isolated ileum of the guinea-pig." | 3.66 | Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1982) |
| "The action of the benzomorphan narcotic antagonists Mr-1452 and Mr-2266 and their respective (+) isomers Mr-1453 and Mr-2267 as well as the antimuscarinic agent atropine upon oxotremorine (OTMN)-induced analgesia, tremor, and hypothermia were investigated in mice." | 3.66 | Some observations on the effects of enantiomers of two benzomorphan narcotic antagonists and atropine on analgesia, tremor and hypothermia produced by oxotremorine. ( Ben-Sreti, MM; Sewell, RD; Upton, N, 1982) |
| "The role of peripheral catecholamines in mediating the pressor and tremorigenic effects of oxotremorine were investigated in conscious rats." | 3.66 | Peripheral catecholamines mediate certain responses to central cholinergic receptor stimulation by oxotremorine. ( Kopin, IJ; Weinstock, M; Zavadil, AP, 1980) |
| "In experiments on cats cold tremor and tremor induced by oxotremorine injection into the caudate nucleus (caudate tremor) were compared." | 3.66 | [Comparative neurophysiologic characteristics of cold and caudate tremor]. ( Lupandin, IuV, 1981) |
| "Oxotremorine, 0." | 3.66 | The role of peripheral catecholamines in oxotremorine tremor in the rat and its antagonism by beta adrenoceptor blocking agents. ( Chiueh, CC; Kopin, IJ; Rosin, AJ; Weinstock, M; Zavadil, AP, 1978) |
| "Fourteen di- and tripeptide analogues of MIF, Pro-Leu-Gly-NH2, have been synthesized and assayed for inhibition of oxotremorine-induced tremor." | 3.66 | Tripeptide analogues of melanocyte-stimulating hormone release-inhibiting hormone (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor. ( Björkman, S; Castensson, S; Sievertsson, H, 1979) |
| "The stereoisomers of some analogues of oxotremorine containing two chiral centres, one in the 1-position of the butynyl chas are oxotremorine antagonists." | 3.66 | Stereoselectivity of some oxotremorine antagonists containing two chiral centres. ( Dahlbom, R; Resul, B; Ringdahl, B, 1979) |
| " The tremorigenic effect of oxotremorine was also measured in mice treated with 10 mg/kg of AT for 1 month." | 3.66 | Central cholinergic receptor supersensitivity after long-term atropine administration. ( Herman, ZS; Słominska-Zurek, J, 1979) |
| "Meperidine (20 and 40 mg/kg, IP) did not block the cholinergic effects (tremor, salivation, and tearing) produced by oxotremorine (0." | 3.66 | Meperidine does not block the cholinergic effects of oxotremorine. ( Leander, JD, 1979) |
| "Oxotremorine, a specific stimulant of central muscarinic acetylcholine receptors, inhibited lateral hypothalamic self-stimulation at a dose-level less than one-tenth of that necessary to produce body tremor." | 3.66 | Central cholinergic mechanisms in electrical self-stimulation and in drug-induced tremor in rats. ( Herberg, LJ; Wishart, TB, 1979) |
| "Administration of oxotremorine to mice produced centrally-mediated effects, such as catalepsy and tremor, and peripheral muscarinic actions, such as diarrhoea and lachrymation." | 3.66 | Amantadine antagonism of oxotremorine effects. ( Eshel, Y; Korczyn, AD, 1979) |
| "Tubocurarine tremor and shivering show identical topography in different muscle groups and identical frequency patterns of the EMG." | 3.66 | [Comparative characteristics of mechanisms regulating tubocurarine and cold tremor]. ( Burachevskaia, LE; Lupandin, IuV, 1978) |
| "The beta-adrenoceptor blockers propranolol, PhQA33 and LB-46 exhibited appreciable activity against tremorine-(TMN) and oxotremorine-(OTMN) induced tremor, whereas pronethalol, (+)-H56/28, (-)-H56/28, Kö-592 and L(+)-INPEA possessed weak action." | 3.65 | Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists. ( Barar, FS; Madan, BR, 1976) |
| "5-25 mg/kg) were found to restore and to intensify the oxotremorine-induced tremor in mice when injected i." | 3.65 | Thyrotropin releasing hormone (TRH): restoration of oxotremorine tremor in mice. Comparison with quipazine, a serotoninergic and dopaminergic stimulant. ( Kruse, H, 1976) |
| "Pro-Leu-Gly-NH2 (MIF) inhibits the tremor induced by oxotremorine." | 3.65 | On the optimal dosage of Pro-Leu-Gly-NH2 (MIF) in neuropharmacological tests and clinical use. ( Björkman, S; Sievertsson, H, 1977) |
| "Two oxotremorine antagonists have been examined using oxotremorine as the tremor salivation inducer and the ratios between the central and peripheral nervous systems determined." | 3.65 | The central and peripheral effectiveness of two oxotremorine-antagonists determined using oxotremorine-induced tremor and salivation. ( Eicholzer, A; Ogren, SO, 1977) |
| "Oxotremorine did not alter the level of 5-HT and 5-hydroxyindoleacetic acid in different brain regions." | 3.65 | Serotonin content in the central nervous system of rats and cholinergic tremor. ( Funk, KF; Oelszner, W; Staib, AH; Westermann, KH, 1975) |
| "Cyclic GMP levels were dose-dependently increased by excitatory drugs such as picrotoxin, pentetrazol, oxotremorine and harmaline in mouse cerebellum and medial forebrain (parts of the cortex, hippocampus, hypothalamus, thalamus, striatum and midbrain) in vivo." | 3.65 | Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain. ( Dinnedahl, V; Gumulka, SW; Opmeer, FA; Schönhöfer, PS, 1976) |
| "N-carbamoyl-2-(2,6-dichlorophenyl) acetamidine hydrochloride (LON 954) causes a reproducible rest tremor in mice, of rapid onset and short duration with no associated rigidity or akinesia and in the absence of any marked changes in body temperature or accompanying peripheral parasympathomimetic effects." | 3.65 | The production of an alternative laboratory model of the Parkinson syndrome using a new benzylimidoylurea derivative LON 954. ( Coward, DM; Doggett, NS, 1977) |
| "The tremorogenic properties of a series of benzylimidoylurea derivatives are described." | 3.65 | The pharmacology of N-carbamoyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride (LON-954) a new tremorogenic agent. ( Coward, DM; Doggett, NS; Sayers, AC, 1977) |
| " Antagonism of oxotremorine induced tremors in mice by anticholinergics and neuroleptics was also significantly correlated to the corresponding data obtained in the in-vitro tests." | 3.65 | Peripheral and central muscarinic receptor affinity of psychotropic drugs. ( Christensen, AV; Fjalland, B; Hyttel, J, 1977) |
| "Cyclizine was observed to induce generalized chorea in a patient with mild lingual-facial-buccal dyskinesias." | 3.65 | Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders. ( Klawans, HL; Moskovitz, C, 1977) |
| " The effect of various agents injected into the cerebral ventricles of the mouse, upon the tremor and hypothermia produced by oxotremorine (0." | 3.65 | Modification of oxotremorine tremor and hypothermia by injections of drugs into the cerebral ventricles of the mouse. ( Doggett, NS; O'Farrell, SA, 1976) |
| "Glycine and GABA administered intraventricularly and intrastriatally were found to inhibit the oxotremorin tremor in rats." | 3.65 | [Effect of various amino acids and their antagonists on the cholinergic tremor and acetylcholine release in the CNS of the rat]. ( Oelszner, W; Scherber, A; Staib, AH, 1975) |
| " The influence of propranolol on the neuromuscular, tremor-producing and muscarinic effects of oxotremorine was examined." | 3.65 | Antioxotremorine action of propranolol. ( Ganguly, DK, 1976) |
| "Oxotremorine tremor has in common with shivering its frequency range (10-28 Hz) and the co-contraction of flexors and extensors." | 1.29 | Role of the stretch reflex in oxotremorine tremor. ( Decima, EE, 1996) |
| "Tremor was evaluated using spectral analytical techniques." | 1.28 | Interactions between ethanol and pantothenic acid on tremor and behavior in squirrel monkeys. ( Newland, MC; Rivera-Calimlim, L; Weiss, B, 1992) |
| "Tremor was assessed by visual observation and by an objective method based on accelerometry." | 1.27 | Beta-adrenoceptor agonists do not cause tremor in the conscious rat. ( Almgren, O; Hallberg, H, 1985) |
| " In dose-response studies, a slight decrease in exploratory activity and initiation of low-level tremors was observed after 0." | 1.27 | A new method for quantification of tremors in mice. ( Isom, GE; Johnson, JD; Meisenheimer, TL, 1986) |
| "Imipramine methiodide is a quaternary derivative of imipramine which does not cross the blood-brain barrier easily." | 1.27 | Comparison of imipramine-imipraminium in mice. To elucidate central or peripheral origin of effects of imipramine. ( Frances, H; Simon, P, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 116 (74.36) | 18.7374 |
| 1990's | 25 (16.03) | 18.2507 |
| 2000's | 13 (8.33) | 29.6817 |
| 2010's | 2 (1.28) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moon, MW | 1 |
| Chidester, CG | 1 |
| Heier, RF | 1 |
| Morris, JK | 1 |
| Collins, RJ | 1 |
| Russell, RR | 1 |
| Francis, JW | 1 |
| Sage, GP | 1 |
| Sethy, VH | 2 |
| Amstutz, R | 1 |
| Ringdahl, B | 13 |
| Karlén, B | 4 |
| Roch, M | 4 |
| Jenden, DJ | 8 |
| Bromidge, SM | 1 |
| Brown, F | 1 |
| Cassidy, F | 1 |
| Clark, MS | 1 |
| Dabbs, S | 1 |
| Hadley, MS | 1 |
| Hawkins, J | 1 |
| Loudon, JM | 1 |
| Naylor, CB | 1 |
| Orlek, BS | 1 |
| Riley, GJ | 1 |
| Sauerberg, P | 1 |
| Jeppesen, L | 1 |
| Olesen, PH | 1 |
| Rasmussen, T | 1 |
| Swedberg, MD | 1 |
| Sheardown, MJ | 1 |
| Fink-Jensen, A | 1 |
| Thomsen, C | 1 |
| Thøgersen, H | 1 |
| Rimvall, K | 1 |
| Ward, JS | 1 |
| Calligaro, DO | 1 |
| DeLapp, NW | 1 |
| Bymaster, FP | 3 |
| Shannon, HE | 2 |
| Tajima, O | 1 |
| Egashira, N | 4 |
| Ohmi, Y | 1 |
| Fukue, Y | 1 |
| Mishima, K | 4 |
| Iwasaki, K | 5 |
| Fujiwara, M | 5 |
| Sugiura, Y | 1 |
| Furukawa, K | 2 |
| Ding, M | 1 |
| Arnold, J | 1 |
| Turner, J | 1 |
| Ramkumar, V | 1 |
| Hughes, LF | 1 |
| Trammell, RA | 1 |
| Toth, LA | 1 |
| Yuzurihara, M | 1 |
| Hattori, N | 1 |
| Sakakibara, I | 1 |
| Ishige, A | 1 |
| Murugaiah, KD | 1 |
| Ukponmwan, OE | 1 |
| DECIMA, EE | 3 |
| HASLETT, WL | 1 |
| ARCHIBALD, JL | 1 |
| BEBBINGTON, A | 1 |
| SHAKESHAFT, D | 1 |
| RAND, RW | 1 |
| Wang, N | 1 |
| Orr-Urtreger, A | 1 |
| Chapman, J | 1 |
| Rabinowitz, R | 1 |
| Korczyn, AD | 3 |
| Laplante, F | 1 |
| Nakagawasai, O | 1 |
| Srivastava, LK | 1 |
| Quirion, R | 1 |
| Howell, G | 1 |
| West, L | 1 |
| Jenkins, C | 1 |
| Lineberry, B | 1 |
| Yokum, D | 1 |
| Rockhold, R | 1 |
| Matsumoto, Y | 3 |
| Fujioka, M | 1 |
| Matsushita, M | 1 |
| Shoyama, Y | 2 |
| Nishimura, R | 1 |
| Manome, N | 1 |
| Kurauchi, K | 1 |
| Nannan, G | 1 |
| Runmei, Y | 1 |
| Fusheng, L | 1 |
| Shoulan, Z | 1 |
| Guangqing, L | 1 |
| Miwa, H | 2 |
| Hama, K | 1 |
| Kajimoto, Y | 1 |
| Kondo, T | 1 |
| Björkman, S | 4 |
| Lewander, T | 2 |
| Zetterström, T | 2 |
| Resul, B | 6 |
| Muhi-Eldeen, Z | 2 |
| Dahlbom, R | 9 |
| Frances, H | 2 |
| Chermat, R | 1 |
| Simon, P | 2 |
| Pong, SF | 1 |
| Pelosi, SS | 1 |
| Wessels, FL | 1 |
| Yu, CN | 1 |
| Burns, RH | 1 |
| White, RE | 1 |
| Anthony, DR | 1 |
| Ellis, KO | 1 |
| Wright, GC | 1 |
| White, RL | 1 |
| Alkondon, M | 2 |
| Ray, A | 2 |
| Sen, P | 2 |
| Knowles, WD | 1 |
| Phillips, MI | 1 |
| Zetler, G | 1 |
| Rappaport, MS | 1 |
| Gentry, RT | 1 |
| Schneider, DR | 1 |
| Dole, VP | 1 |
| Martin, JR | 1 |
| Driscoll, P | 1 |
| Gentsch, C | 1 |
| Shinozaki, H | 2 |
| Hirate, K | 1 |
| Ishida, M | 1 |
| Quock, RM | 2 |
| Lucas, TS | 2 |
| Tornos, ME | 1 |
| Sacristán, A | 1 |
| Ortiz, JA | 1 |
| Marks, MJ | 1 |
| O'Connor, MF | 1 |
| Artman, LD | 1 |
| Burch, JB | 1 |
| Collins, AC | 1 |
| Bizière, K | 2 |
| Kan, JP | 2 |
| Souilhac, J | 1 |
| Muyard, JP | 1 |
| Roncucci, R | 1 |
| Kawanishi, K | 1 |
| Hashimoto, Y | 1 |
| Kataoka, Y | 2 |
| Ueki, S | 1 |
| Ben-Sreti, MM | 1 |
| Sewell, RD | 1 |
| Upton, N | 1 |
| Weinstock, M | 3 |
| Zavadil, AP | 2 |
| Kopin, IJ | 2 |
| Lupandin, IuV | 2 |
| Bohman, B | 1 |
| Halaris, A | 1 |
| Karbowski, M | 1 |
| Suemaru, K | 1 |
| Oishi, R | 2 |
| Gomita, Y | 1 |
| Iwata, S | 3 |
| Nomoto, M | 4 |
| Fukuda, T | 3 |
| Sánchez, C | 1 |
| Lembøl, HL | 1 |
| Almeida, OM | 1 |
| Santos, R | 1 |
| Yeşilada, A | 1 |
| Gökhan, N | 1 |
| Ozer, I | 1 |
| Vural, K | 1 |
| Erol, K | 1 |
| Takeuchi, H | 1 |
| Yatsugi, S | 1 |
| Hatanaka, K | 1 |
| Nakato, K | 1 |
| Hattori, H | 1 |
| Sonoda, R | 1 |
| Koshiya, K | 1 |
| Fujii, M | 1 |
| Yamaguchi, T | 1 |
| Nickel, B | 1 |
| Kolasiewicz, W | 1 |
| Szelenyi, I | 1 |
| Egawa, T | 1 |
| Shuto, H | 1 |
| Kanaya, A | 1 |
| Matsunaga, K | 1 |
| Sueyasu, M | 1 |
| Welsh, JP | 1 |
| Gomeza, J | 3 |
| Shannon, H | 2 |
| Kostenis, E | 2 |
| Felder, C | 2 |
| Zhang, L | 3 |
| Brodkin, J | 2 |
| Grinberg, A | 1 |
| Sheng, H | 1 |
| Wess, J | 4 |
| Espínola, EB | 1 |
| Oliveira, MG | 1 |
| Carlini, EA | 1 |
| Bymaster, F | 1 |
| Xia, B | 1 |
| Deng, C | 1 |
| Dallanoce, C | 1 |
| Conti, P | 1 |
| De Amici, M | 1 |
| De Micheli, C | 1 |
| Barocelli, E | 1 |
| Chiavarini, M | 1 |
| Ballabeni, V | 1 |
| Bertoni, S | 1 |
| Impicciatore, M | 1 |
| Mitsuda, M | 1 |
| Nishi, K | 1 |
| Fuwa, T | 1 |
| Mizuno, Y | 1 |
| Carter, PA | 1 |
| Falcone, JF | 1 |
| Stengel, PW | 1 |
| Cohen, ML | 1 |
| Felder, CC | 2 |
| Yamada, M | 1 |
| Lamping, KG | 1 |
| Duttaroy, A | 1 |
| Zhang, W | 1 |
| Cui, Y | 1 |
| McKinzie, DL | 1 |
| Deng, CX | 1 |
| Faraci, FM | 1 |
| Cunha, GM | 1 |
| Farias, PA | 1 |
| Viana, GS | 1 |
| Barar, FS | 1 |
| Madan, BR | 1 |
| Castensson, S | 3 |
| Lindeke, B | 4 |
| Sievertsson, H | 4 |
| Kruse, H | 1 |
| Eicholzer, A | 1 |
| Ogren, SO | 3 |
| Rosin, AJ | 1 |
| Chiueh, CC | 1 |
| Leinot, M | 1 |
| Benoit, J | 1 |
| Basiez, M | 1 |
| Meunier, A | 1 |
| Labrid, C | 1 |
| Herman, ZS | 1 |
| Słominska-Zurek, J | 1 |
| Oelszner, W | 4 |
| Funk, KF | 1 |
| Staib, AH | 4 |
| Westermann, KH | 2 |
| Bauer, R | 1 |
| Kuhn, FJ | 1 |
| Stockhaus, K | 1 |
| Wick, H | 1 |
| Simantov, R | 1 |
| Snyder, SH | 1 |
| Oster-Granite, ML | 1 |
| Silvestrini, B | 1 |
| Lisciani, R | 1 |
| Mao, CC | 1 |
| Guidotti, A | 2 |
| Costa, E | 2 |
| Biggio, G | 1 |
| Opmeer, FA | 1 |
| Gumulka, SW | 1 |
| Dinnedahl, V | 1 |
| Schönhöfer, PS | 1 |
| Coward, DM | 2 |
| Doggett, NS | 3 |
| Ljunggren, C | 1 |
| Leander, JD | 1 |
| Wishart, TB | 1 |
| Herberg, LJ | 1 |
| Eshel, Y | 2 |
| David, J | 1 |
| Kaul, CL | 1 |
| Grewal, RS | 1 |
| Sayers, AC | 1 |
| Fjalland, B | 1 |
| Christensen, AV | 1 |
| Hyttel, J | 1 |
| Svensson, U | 1 |
| Hacksell, U | 3 |
| Burachevskaia, LE | 1 |
| Klawans, HL | 1 |
| Moskovitz, C | 1 |
| Maayani, S | 1 |
| Egozi, Y | 1 |
| Pinchasi, I | 1 |
| Sokolovsky, M | 1 |
| Fisher, A | 1 |
| Gitter, S | 1 |
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| O'Farrell, SA | 1 |
| Scherber, A | 2 |
| Ganguly, DK | 1 |
| Newland, MC | 1 |
| Rivera-Calimlim, L | 1 |
| Weiss, B | 1 |
| Sahin, I | 1 |
| Tuncer, M | 1 |
| Ilhan, M | 1 |
| Nilsson, BM | 1 |
| Vargas, HM | 1 |
| István, G | 1 |
| Gyertyán, I | 1 |
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| Petöcz, L | 1 |
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| Tsujimoto, S | 1 |
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| Aoki, I | 1 |
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| Lorden, JF | 1 |
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| Szporny, L | 1 |
156 other studies available for oxotremorine and Tremor
| Article | Year |
|---|---|
Cholinergic activity of acetylenic imidazoles and related compounds.
Topics: Acetylene; Animals; Brain; Imidazoles; Mice; Molecular Structure; Muscarinic Antagonists; Oxotremori | 1991 |
Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogues. N-[4-(tertiary amino)-2-butynyl]-5-methyl-2-pyrrolidones.
Topics: Abdominal Muscles; Animals; Atropine; Carbachol; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; | 1985 |
Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists.
Topics: Analgesia; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Kinetics; Magn | 1988 |
Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.
Topics: Alzheimer Disease; Animals; Binding Sites; Blood Pressure; Brain; CHO Cells; Cricetinae; Electroence | 1997 |
Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Brain; Dopamine Antagonists; Drug Evaluation, Pre | 1998 |
Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice.
Topics: Age Factors; Aging; Animals; Body Weight; Brain; Maze Learning; Mice; Mice, Knockout; Motor Skills; | 2010 |
Lack of association of a spontaneous mutation of the Chrm2 gene with behavioral and physiologic phenotypic differences in inbred mice.
Topics: Alleles; Amino Acid Sequence; Analysis of Variance; Animals; Base Sequence; Behavior, Animal; Bindin | 2010 |
Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice.
Topics: Administration, Oral; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drugs, Chinese He | 2003 |
Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation.
Topics: Adrenergic Uptake Inhibitors; Analgesia; Animals; Body Temperature; Central Nervous System; Desipram | 2003 |
EFFECTS OF OXOTREMORINE ON GAMMA FIBER ACTIVITY.
Topics: Cats; Central Nervous System; Chlorpromazine; Decerebrate State; Muscles; Neurophysiology; Oxotremor | 1964 |
IMPROVED SYNTHESIS OF OXOTREMORINE.
Topics: Chemistry, Pharmaceutical; Oxotremorine; Parasympatholytics; Parkinsonian Disorders; Pyrroles; Resea | 1965 |
AN IMPROVED SYNTHESIS OF OXOTREMORINE.
Topics: Chemistry, Pharmaceutical; Oxotremorine; Pyrroles; Pyrrolidinones; Research; Tremor | 1965 |
OXOTREMORINE INDUCED TREMOR IN THE DECORTICATED CAT.
Topics: Atropine; Cats; Cerebral Decortication; Drug Tolerance; Electromyography; Heterocyclic Compounds; Ox | 1965 |
Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor.
Topics: Acetylcholine; Animals; Bradycardia; Defecation; Dose-Response Relationship, Drug; Female; Ganglia, | 2004 |
Alterations in behavioral responses to a cholinergic agonist in post-pubertal rats with neonatal ventral hippocampal lesions: relationship to changes in muscarinic receptor levels.
Topics: Analgesics; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Body Temperature; Female; | 2005 |
In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine.
Topics: Animals; Cardiovascular System; Cholinergic Antagonists; Diamines; Histamine H1 Antagonists; Loratad | 2005 |
Low dose citalopram reverses memory impairment and electroconvulsive shock-induced immobilization.
Topics: Animals; Brain Chemistry; Citalopram; Dronabinol; Electroshock; Hallucinogens; Male; Memory Disorder | 2006 |
Kamikihi-to, a Kampo medicine, ameliorates impairment of spatial memory in rats.
Topics: Animals; Dronabinol; Drugs, Chinese Herbal; Male; Maze Learning; Medicine, Kampo; Memory; Memory Dis | 2007 |
Effects of AIT-082, a purine derivative, on tremor induced by arecoline or oxotremorine in mice.
Topics: Aminobenzoates; Animals; Arecoline; Dose-Response Relationship, Drug; Hypoxanthines; Male; Mice; Mic | 2007 |
Effects of zonisamide on experimental tremors in rats.
Topics: Animals; Anticonvulsants; Central Nervous System Stimulants; Cholinesterase Inhibitors; Harmaline; I | 2008 |
MIF (Pro-Leu-Gly-NH2): failure to affect oxotremorine effects in mice and rats as well as fluphenazine catalepsy or amphetamine hyperactivity in rats.
Topics: Amphetamine; Animals; Catalepsy; Fluphenazine; Humans; Male; Mice; Motor Activity; MSH Release-Inhib | 1980 |
Synthesis and pharmacological properties of N-[4-(1-azetidinyl)-2-butynyl]-2-pyrrolidone, a highly potent oxotremorine-like agent.
Topics: Animals; Central Nervous System; Hypothermia; Male; Mice; Oxotremorine; Peripheral Nerves; Tremor | 1980 |
Oxotremorine behavioural effects as a screening test in mice.
Topics: Animals; Behavior, Animal; Body Temperature; Drug Evaluation, Preclinical; Drug Interactions; Male; | 1980 |
5-phenyl-2-furamidines: a new chemical class of potential antidepressants.
Topics: Acetylcholine; Amidines; Animals; Antidepressive Agents; Blepharoptosis; Brain; Furans; Guinea Pigs; | 1983 |
Effect of beta-adrenergic blocking agents, with differing ancillary properties on oxotremorine induced tremor in mice.
Topics: Adrenergic beta-Antagonists; Animals; Female; Male; Mice; Oxotremorine; Tremor | 1984 |
Neurophysiological and behavioral maturation of cerebellar function studied with tremorogenic drugs.
Topics: Action Potentials; Aging; Alkaloids; Animals; Animals, Newborn; Cerebellum; Harmaline; Nerve Fibers; | 1980 |
Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: effects on tremors induced by oxotremorine, harmine and ibogaine. A comparison with prolyl-leucylglycine amide (MIF), anti-Parkinsonian drugs and clonazepam.
Topics: Alkaloids; Animals; Antiparkinson Agents; Benzodiazepinones; Ceruletide; Cholecystokinin; Clonazepam | 1983 |
Ethanol effects on harmaline-induced tremor and increase of cerebellar cyclic GMP.
Topics: Alkaloids; Animals; Cerebellum; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Ethanol; Har | 1984 |
Differential response to cholinergic stimulation in psychogenitically selected rat lines.
Topics: Animals; Body Temperature; Female; Male; N-Methylscopolamine; Oxotremorine; Parasympathetic Nervous | 1984 |
[A quantitative analyzing method for drug-induced tremor].
Topics: Animals; Ethology; Harmaline; Magnetics; Mice; Monitoring, Physiologic; Motor Activity; Oxotremorine | 1984 |
Quantitative analysis of drug-induced tremor in mice.
Topics: Alkaloids; Animals; Harmaline; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Oxotremorine; Spe | 1984 |
Potentiation by naloxone of the anti-oxotremorine effect of L-DOPA.
Topics: Animals; Carbidopa; Dose-Response Relationship, Drug; Drug Synergism; Levodopa; Male; Mice; Mice, In | 1983 |
Pharmacological study of oral CDP-choline. Interaction with oxotremorine on the parasympathetic system.
Topics: Animals; Body Temperature; Choline; Cytidine Diphosphate Choline; Diarrhea; Drug Interactions; Femal | 1983 |
Chronic scopolamine treatment and brain cholinergic function.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain Chemistry; Choline O-Acetyltransferase; Female; | 1984 |
Muscarinic activity of some secondary and tertiary amines and quaternary ammonium salts structurally related to oxotremorine.
Topics: Amines; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle C | 1983 |
Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Catalepsy; Dextroamphetamine; Drug Evaluation; Dru | 1982 |
Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice.
Topics: 5-Hydroxytryptophan; Alkaloids; Animals; Antidepressive Agents; Behavior, Animal; Diazepam; Disease | 1981 |
Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine.
Topics: Acetylene; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mu | 1982 |
Some observations on the effects of enantiomers of two benzomorphan narcotic antagonists and atropine on analgesia, tremor and hypothermia produced by oxotremorine.
Topics: Animals; Atropine; Benzomorphans; Body Temperature; Drug Interactions; Male; Mice; Morphinans; Narco | 1982 |
Peripheral catecholamines mediate certain responses to central cholinergic receptor stimulation by oxotremorine.
Topics: Adrenal Medulla; Animals; Blood Pressure; Catecholamines; Epinephrine; Hydroxydopamines; Male; Norep | 1980 |
[Comparative neurophysiologic characteristics of cold and caudate tremor].
Topics: Animals; Cats; Caudate Nucleus; Cold Temperature; Disease Models, Animal; Motor Neurons; Oxotremorin | 1981 |
Effects of tricyclic antidepressants on muscarinic cholinergic receptor binding in mouse brain.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Male; Mice; Oxotremorine; Quinuclidinyl Benzilate; | 1981 |
Characteristics of tail-tremor induced by nicotine in rats.
Topics: Animals; Haloperidol; Hexamethonium; Male; Mecamylamine; Motor Activity; Nicotine; Oxotremorine; Rat | 1994 |
Effects of beta-adrenergic blockers on drug-induced tremors.
Topics: Adrenergic beta-Antagonists; Animals; Fourier Analysis; Harmaline; Male; Mice; Mice, Inbred Strains; | 1993 |
The involvement of muscarinic receptor subtypes in the mediation of hypothermia, tremor, and salivation in male mice.
Topics: Animals; Female; Guinea Pigs; Hypothermia; Male; Mice; Mice, Inbred Strains; Muscarinic Antagonists; | 1994 |
Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats.
Topics: Acetylcholinesterase; Animals; Brain; Hyperthyroidism; Hypothermia; Male; Oxotremorine; Parasympatho | 1993 |
Role of the stretch reflex in oxotremorine tremor.
Topics: Animals; Cats; Denervation; Electromyography; Female; Male; Muscles; Neurons, Afferent; Oxotremorine | 1996 |
Effect of nipradilol, a beta-adrenergic blocker with vasodilating activity, on oxotremorine-induced tremor in mice.
Topics: Adrenergic beta-Agonists; Animals; Male; Mice; Oxotremorine; Propanolamines; Tremor; Vasodilator Age | 1996 |
5-methyl-8-N-substituted-thiocarbamoyl-7,8-diazabicyclo[4.3.0] non-6-enes: evaluation as BSAO inhibitors and pharmacological activity screening.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antiparkinson Agents; Cattle; Female; Imidazole | 1996 |
Pharmacological studies on YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT2A receptor antagonistic activity.
Topics: Animals; Citalopram; Fluoxetine; Learning; Mice; Mice, Inbred ICR; Morpholines; Olfactory Bulb; Oxot | 1997 |
Quantification of rigidity and tremor activity in rats by using a new device and its validation by different classes of drugs.
Topics: Analgesics, Opioid; Animals; Antiparkinson Agents; Central Nervous System Depressants; Male; Muscari | 1997 |
Rolipram and its optical isomers, phosphodiesterase 4 inhibitors, attenuated the scopolamine-induced impairments of learning and memory in rats.
Topics: Animals; Avoidance Learning; Dose-Response Relationship, Drug; Isomerism; Learning; Male; Maze Learn | 1997 |
Enhancement of serotonergic neural activity contributes to cyclosporine-induced tremors in mice.
Topics: Animals; Biogenic Monoamines; Brain; Cyclosporine; Hallucinogens; Harmine; Immunosuppressive Agents; | 1998 |
Systemic harmaline blocks associative and motor learning by the actions of the inferior olive.
Topics: Animals; Association Learning; Conditioning, Classical; Female; Harmaline; Learning; Male; Memory; M | 1998 |
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.
Topics: Analgesia; Animals; Brain; Embryo, Mammalian; Female; Gene Expression; Genomic Library; Homozygote; | 1999 |
Differences in central and peripheral responses to oxotremorine in young and aged rats.
Topics: Aging; Animals; Central Nervous System; Corpus Striatum; Dacryocystitis; Muscarinic Agonists; Oxotre | 1999 |
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesia; Animals; Apomorphine; Brain; | 1999 |
Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.
Topics: Animals; Atrial Function; Cholinergic Agents; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; | 1999 |
Effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Callithrix; Flunarizine; Injections, | 1999 |
Differential expression of c-fos following administration of two tremorgenic agents: harmaline and oxotremorine.
Topics: Animals; Brain; Cell Count; Dose-Response Relationship, Drug; Harmaline; Male; Neural Pathways; Neur | 2000 |
Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.
Topics: Animals; Carbachol; Cerebral Cortex; Heart; Heart Rate; Humans; Hypothermia; Male; Mice; Mice, Knock | 2001 |
Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice.
Topics: Acetylcholine; Animals; Arteries; Body Temperature; Brain; Cerebral Arteries; Corpus Striatum; Dopam | 2001 |
Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline.
Topics: Acetylcholinesterase; Animals; Anxiety; Avoidance Learning; Hippocampus; Learning Disabilities; Male | 2002 |
Tremorine-oxotremorine-induced tremor, hypothermia and analgesia, and physostigmine toxicity, in mice after pretreatment with beta-adrenoceptor antagonists.
Topics: Adrenergic beta-Antagonists; Analgesics; Animals; Body Temperature; Depression, Chemical; Male; Mice | 1976 |
Peptides related to melanostatin (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor.
Topics: Animals; Glycine; Leucine; Male; Mice; MSH Release-Inhibiting Hormone; Oxotremorine; Peptides; Proli | 1976 |
Thyrotropin releasing hormone (TRH): restoration of oxotremorine tremor in mice. Comparison with quipazine, a serotoninergic and dopaminergic stimulant.
Topics: Animals; Autonomic Agents; Body Temperature; Dopamine; Male; Mice; Neurotransmitter Agents; Oxotremo | 1976 |
On the optimal dosage of Pro-Leu-Gly-NH2 (MIF) in neuropharmacological tests and clinical use.
Topics: Animals; Dose-Response Relationship, Drug; Male; Mice; MSH Release-Inhibiting Hormone; Oxotremorine; | 1977 |
The central and peripheral effectiveness of two oxotremorine-antagonists determined using oxotremorine-induced tremor and salivation.
Topics: Alkynes; Animals; Arecoline; Male; Mice; Oxotremorine; Pyrrolidinones; Salivation; Time Factors; Tre | 1977 |
The role of peripheral catecholamines in oxotremorine tremor in the rat and its antagonism by beta adrenoceptor blocking agents.
Topics: Adrenal Medulla; Adrenergic beta-Antagonists; Animals; Catecholamines; Epinephrine; Hydroxydopamines | 1978 |
Tripeptide analogues of melanocyte-stimulating hormone release-inhibiting hormone (Pro-Leu-Gly-NH2) as inhibitors of oxotremorine-induced tremor.
Topics: Animals; Catalepsy; Chemical Phenomena; Chemistry; Fluphenazine; Humans; Male; Mice; Molecular Confo | 1979 |
Stereoselectivity of some oxotremorine antagonists containing two chiral centres.
Topics: Animals; Atropine; Male; Mice; Molecular Conformation; Mydriatics; Oxotremorine; Stereoisomerism; Tr | 1979 |
[Comparaison, in the mouse, of two treatments for alcohol withdrawal syndrome. Inhibition of oxo tremorine-induced tremor, sedative and motor effects (author's transl)].
Topics: Alcoholism; Animals; Antipsychotic Agents; Barbiturates; Benzamides; Carbamates; Dyskinesia, Drug-In | 1979 |
Central cholinergic receptor supersensitivity after long-term atropine administration.
Topics: Acetylcholine; Animals; Atropine; Behavior, Animal; Dose-Response Relationship, Drug; Male; Motor Ac | 1979 |
Serotonin content in the central nervous system of rats and cholinergic tremor.
Topics: Animals; Brain; Brain Chemistry; Female; Fenclonine; Hydroxyindoleacetic Acid; Oxotremorine; Parasym | 1975 |
[General pharmacology and secretion inhibitory action of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropanium bromide-(+/-)-tropate (ipratropiumbromide) (author's transl)].
Topics: Animals; Atropine Derivatives; Blood Pressure; Brain; Cats; Dogs; Ganglia, Autonomic; Gastric Juice; | 1976 |
Harmaline-induced tremor in the rat: abolition by 3-acetylpyridine destruction of cerebellar climbing fibers.
Topics: Alkaloids; Animals; Cerebellar Cortex; Harmaline; Male; Niacinamide; Nicotinic Acids; Oxotremorine; | 1976 |
Experimental data suggesting an adrenergic mechanism in the production of parkinsonian symptoms.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Clonidine; Female; Fenclonine; Imipramine; Male; Mice; Mice, | 1976 |
Inhibition by diazepam of the tremor and the increase of cerebellar cGMD content elicited by harmaline.
Topics: Alkaloids; Animals; Binding Sites; Cerebellum; Cyclic GMP; Diazepam; Dose-Response Relationship, Dru | 1975 |
3-Acetylpyridine: a tool to inhibit the tremor and the increase of cGMP content in cerebellar cortex elicited by harmaline.
Topics: Alkaloids; Animals; Brain Chemistry; Cerebellar Cortex; Cyclic GMP; Glutamates; Harmaline; Male; Oxo | 1975 |
Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
Topics: Animals; Atropine; Brain; Brain Chemistry; Convulsants; Cyclic AMP; Cyclic GMP; Diazepam; Drug Inter | 1976 |
The production of an alternative laboratory model of the Parkinson syndrome using a new benzylimidoylurea derivative LON 954.
Topics: Animals; Antiparkinson Agents; Benzimidazoles; Disease Models, Animal; Drug Evaluation, Preclinical; | 1977 |
Acetylene compounds of potential pharmacological value. XXVIII. Oxotremorine analogues substituted with a methyl group in the lactam ring.
Topics: Acetylene; Animals; Chemical Phenomena; Chemistry; Lactams; Mice; Oxotremorine; Tremor | 1979 |
Meperidine does not block the cholinergic effects of oxotremorine.
Topics: Animals; Atropine; Female; Meperidine; Oxotremorine; Parasympatholytics; Rats; Salivation; Tears; Tr | 1979 |
Acetylene compounds of potential pharmacological value. XXX. Synthesis and pharmacological properties of N-(4-pyrrolidino-2-pentynyl)-substituted 2-pyrrolidone and succinimide.
Topics: Acetylene; Animals; Chemical Phenomena; Chemistry; Mice; Oxotremorine; Pyrrolidinones; Succinimides; | 1979 |
Central cholinergic mechanisms in electrical self-stimulation and in drug-induced tremor in rats.
Topics: Animals; Apomorphine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Hyp | 1979 |
Abolition of oxotremorine effects by L-DOPA pretreatment.
Topics: Animals; Catalepsy; Diarrhea; Dose-Response Relationship, Drug; Drug Interactions; Humans; Levodopa; | 1979 |
Amantadine antagonism of oxotremorine effects.
Topics: Amantadine; Animals; Catalepsy; Diarrhea; Drug Antagonism; Humans; Male; Mice; Oxotremorine; Tears; | 1979 |
Pharmacological & biochemical characterization of antiparkinson drugs in reserpinized mice.
Topics: Animals; Antiparkinson Agents; Ataxia; Blepharoptosis; Catatonia; Disease Models, Animal; Humans; Ma | 1979 |
The pharmacology of N-carbamoyl-2-(2,6-dichlorophenyl)acetamidine hydrochloride (LON-954) a new tremorogenic agent.
Topics: Analgesics; Animals; Cats; Decerebrate State; Dogs; Drug Interactions; Drug Tolerance; Female; Levod | 1977 |
Peripheral and central muscarinic receptor affinity of psychotropic drugs.
Topics: Acetylcholine; Animals; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle C | 1977 |
Acetylene compounds of potential pharmacological value. XXV. N-(4-pyrrolidino-2-butynyl)-N-alkylcarboxamides.
Topics: Alkynes; Animals; Drug Evaluation, Preclinical; Mice; Oxotremorine; Parasympathomimetics; Tremor | 1978 |
[Comparative characteristics of mechanisms regulating tubocurarine and cold tremor].
Topics: Animals; Body Temperature; Cats; Electric Stimulation; Electromyography; Injections, Intraventricula | 1978 |
Cyclizine-induced chorea. Observations on the influence of cyclizine on dopamine-related movement disorders.
Topics: Aged; Amphetamine; Animals; Apomorphine; Behavior, Animal; Chorea; Cyclizine; Dyskinesia, Drug-Induc | 1977 |
On the interaction of drugs with the cholinergic nervous system--IV. Tolerance to oxotremorine in mice: in vivo and in vitro studies.
Topics: Animals; Body Temperature; Brain; Drug Tolerance; Female; In Vitro Techniques; Male; Mice; Mice, Inb | 1977 |
A new probe for heterogeneity in muscarinic receptors: 2-methyl-spiro-(1, 3-dioxolane-4, 3')-quinuclidine.
Topics: Animals; Blood Pressure; Cricetinae; Depression, Chemical; Ganglia, Spinal; Guinea Pigs; Ileum; In V | 1976 |
Modification of oxotremorine tremor and hypothermia by injections of drugs into the cerebral ventricles of the mouse.
Topics: Acetylcholine; Animals; Apomorphine; Atropine; Body Temperature; Dopamine; Drug Interactions; Female | 1976 |
[Effect of various amino acids and their antagonists on the cholinergic tremor and acetylcholine release in the CNS of the rat].
Topics: Acetylcholine; Aminobutyrates; Animals; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; | 1975 |
Antioxotremorine action of propranolol.
Topics: Animals; Blood Pressure; Diaphragm; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction | 1976 |
Interactions between ethanol and pantothenic acid on tremor and behavior in squirrel monkeys.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Female; Nervous System; Oxotremorine; Pantotheni | 1992 |
Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice.
Topics: Animals; Atropine; Dopamine Agents; Indans; Indenes; Male; Mice; Naphthalenes; Oxotremorine; Parasym | 1990 |
Phenyl-substituted analogues of oxotremorine as muscarinic antagonists.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Guinea Pigs; In Vitro Techniques; Magnetic Resonance | 1992 |
Possible involvement of the antiserotoninergic and antihistaminergic activity in the anticataleptogenic effect of EGYT-2509.
Topics: Animals; Antipsychotic Agents; Catalepsy; Dibenzoxazepines; Histamine Antagonists; Oxotremorine; Rat | 1990 |
Central effect of the potent long-acting H1-antihistamine levocabastine.
Topics: Acetates; Animals; Avoidance Learning; Central Nervous System; Electroencephalography; Histamine H1 | 1990 |
Studies on the mechanism of chlordecone-induced tremor in rats.
Topics: Animals; Apomorphine; Ataxia; Chlordecone; Dose-Response Relationship, Drug; Harmine; Insecticides; | 1985 |
Cholinomimetic activities of minaprine.
Topics: Animals; Atropine; Avoidance Learning; Behavior, Animal; Female; Guinea Pigs; In Vitro Techniques; M | 1989 |
[Evaluation of the central anticholinergic activity of antidepressants. Comparison of two experimental methods].
Topics: Animals; Antidepressive Agents, Tricyclic; Atropine; Clomipramine; Dibenzazepines; Female; Guinea Pi | 1989 |
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Topics: Animals; Biological Assay; Cerebral Cortex; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Mice; | 1989 |
Muscarinic actions and receptor binding of the enantiomers of BM 130, an alkylating analog of oxotremorine.
Topics: Alkylation; Animals; Body Temperature; Cerebral Cortex; Guinea Pigs; Lethal Dose 50; Male; Mice; Oxo | 1989 |
Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Isometric Contraction; Male; Mice; Oxotremorine | 1989 |
Beta-adrenoceptor agonists do not cause tremor in the conscious rat.
Topics: Adrenergic beta-Agonists; Animals; Isoproterenol; Male; Oxotremorine; Rats; Rats, Inbred Strains; Re | 1985 |
Cholinergic involvement in the modulation of oxotremorine-tremor in mice by propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Atropine; Brain; Cholinesterase Inhibitors; Dose-Response Rela | 1985 |
A selective potentiation by naloxone of L-dopa but not atropine suppression of oxotremorine-induced tremor in mice.
Topics: Animals; Atropine; Drug Synergism; Levodopa; Male; Mice; Mice, Inbred ICR; Naloxone; Oxotremorine; T | 1985 |
Modulation of oxotremorine-induced tremor by central beta-adrenoceptors.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood-Brain Barrier; Epinephrine; Ma | 1987 |
In vivo and in vitro studies on the potentiation of muscarinic receptor stimulation by alaproclate, a selective 5-HT uptake blocker.
Topics: Alanine; Animals; Brain; Cyclic GMP; Drug Synergism; Hippocampus; Male; Mice; Oxotremorine; Physosti | 1985 |
Decreased cerebellar 3',5'-cyclic guanosine monophosphate levels and insensitivity to harmaline in the genetically dystonic rat (dt).
Topics: Alkaloids; Animals; Behavior, Animal; Cerebellum; Cyclic GMP; Drug Resistance; Dystonia; Harmaline; | 1985 |
[Power spectral analysis of tremor induced by TRH and oxotremorine in mice].
Topics: Animals; Atropine; Haloperidol; Male; Mice; Oxotremorine; Propranolol; Reaction Time; Thyrotropin-Re | 1986 |
BM-5, a centrally active partial muscarinic agonist with low tremorogenic activity. In vivo and in vitro studies.
Topics: Acetylcholine; Animals; Body Temperature; Brain; Choline; Dose-Response Relationship, Drug; In Vitro | 1987 |
Increased sensitivity of mice to tremorogenic agents following MPP+.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Conditioning, Operant; Corpus Striatum; Drug Synergism; Male; | 1987 |
Absence of anticholinergic activity of rolipram, an antidepressant with a novel mechanism of action, in three different animal models in vivo.
Topics: Animals; Antidepressive Agents; Body Temperature; Female; Mice; Oxotremorine; Parasympatholytics; Pi | 1988 |
Regional differences in receptor reserve for analogs of oxotremorine in vivo: implications for development of selective muscarinic agonists.
Topics: Analgesia; Animals; Body Temperature; Guinea Pigs; Male; Mice; Mice, Inbred Strains; Muscarine; Oxot | 1987 |
Stress-induced immobility in rats with cholinergic supersensitivity.
Topics: Amitriptyline; Animals; Arousal; Hippocampus; Kinetics; Male; Motor Activity; Oxotremorine; Quinucli | 1986 |
A new method for quantification of tremors in mice.
Topics: Animals; Computers; Electric Conductivity; Male; Mice; Oxotremorine; Tremor | 1986 |
Muscarinic actions of an N-methyl-N-2-bromoethylamino analog of oxotremorine (BR 401) in the mouse.
Topics: Analgesics; Animals; Atropine; Body Temperature Regulation; Male; Mice; Oxotremorine; Parasympathomi | 1987 |
Serotonergic potentiation of muscarinic agonist evoked tremor and salivation in rat and mouse.
Topics: Alanine; Animals; Arecoline; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Oxo | 1985 |
Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine.
Topics: Administration, Oral; Animals; Choline; Cytidine Diphosphate Choline; Diarrhea; Female; Hypothermia; | 1985 |
Comparison of imipramine-imipraminium in mice. To elucidate central or peripheral origin of effects of imipramine.
Topics: Animals; Apomorphine; Body Temperature; Drug Synergism; Imipramine; Male; Mice; Motor Activity; Oxot | 1985 |
The influence of synthetic "substance P" on tremor caused by LSD in mice.
Topics: Acetylcholine; Amphetamine; Animals; Atropine; Behavior, Animal; Brain Chemistry; Drug Synergism; Fe | 1973 |
Interactions between oxotremorine and inhibitors of cholinesterase enzymes.
Topics: Animals; Atropine; Body Temperature; Brain; Cholinesterase Inhibitors; Drug Synergism; Female; Isofl | 1973 |
[Tremor and motility following oxotremorine and harmine in rats with lesions of the nigro-striatal system].
Topics: Alkaloids; Animals; Caudate Nucleus; Corpus Striatum; Dopamine; Female; Globus Pallidus; Heterocycli | 1974 |
Studies on the inhibition of oxotremorine induced tremor by a melanocyte-stimulating hormone release-inhibiting factor, thyrotropin releasing hormone and related peptides.
Topics: Animals; Chromatography, Thin Layer; Dose-Response Relationship, Drug; Glutamates; Glycine; Histidin | 1974 |
Role of 5-HT in the action of some drugs affecting extrapyramidal system.
Topics: Amphetamine; Animals; Brain; Catalepsy; Chlorpromazine; Electrodes; Extrapyramidal Tracts; Female; F | 1973 |
Effect of L-5HTP on tremorine- or oxotremorine-induced tremor in mice and rats.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Drug Synergism; Fenclonine; Male; Mice; Oxotremorine; Rats; | 1973 |
Proceedings: On the action of oxotremorine on the cholinergic system of rat brain.
Topics: Acetylcholine; Acetyltransferases; Animals; Brain; Brain Stem; Cerebral Cortex; Choline; Cholinester | 1974 |
Interaction of oxotremorine with atropine, chlorpromazine, cyproheptadine, imipramine and phenoxybenzamine on the flexor reflex of the chronic spinal dog.
Topics: Animals; Atropine; Chlorpromazine; Cyproheptadine; Dogs; Drug Interactions; Imipramine; Oxotremorine | 1973 |
Synthesis and pharmacology of 1-(2-thioxopyrrolidino)-4-pyrrolidino-2-butyne, the thiolactam analogue of oxotremorine.
Topics: Acetylcholine; Alkynes; Animals; Chromatography, Gas; Chromatography, Thin Layer; Guinea Pigs; Ileum | 1972 |
The effects of some beta adrenergic blocking agents on the central and peripheral actions of tremorine and oxotremorine.
Topics: Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Animals; Atropine; Central Nervous System; | 1972 |
[Motor reactions of chronic spinal rats after administration of oxotremorine].
Topics: Animals; Behavior, Animal; Decerebrate State; Forelimb; Motor Activity; Oxotremorine; Rats; Spine; T | 1974 |
Effect of 6-hydroxydopamine on some actions of tremorine and oxotremorine.
Topics: Amines; Animals; Body Temperature; Brain Chemistry; Catecholamines; Dopamine; Dose-Response Relation | 1974 |
[Pharmacological study of ethyl gamma hydroxybutyrate glycolate].
Topics: Animals; Cerebral Cortex; Dopamine; Glycolates; Hydroxybutyrates; Hypnotics and Sedatives; Male; Mic | 1974 |
Activity in the olivo-cerebello-bulbar system of the cat during ibogaline- and oxotremorine-induced tremor.
Topics: Animals; Brain Stem; Cats; Cerebellar Nuclei; Electroencephalography; Indole Alkaloids; Indoles; Liv | 1974 |
L-DOPA: chemical modifications and biological evaluation.
Topics: Animals; Antiparkinson Agents; Blepharoptosis; Catatonia; Disease Models, Animal; Humans; Hypothermi | 1974 |
Antagonism of tremorine-induced tremor by serotoninergic agents in mice. Interactions with levodopa.
Topics: 5-Hydroxytryptophan; Animals; Atropine; Benztropine; Dihydroxyphenylalanine; Dose-Response Relations | 1972 |
[Inhibition by (intraventricular) glycine of the tremorigenic activity of oxotremorine in the rabbit].
Topics: Animals; Brain; Caudate Nucleus; Cerebral Ventricles; Corpus Striatum; Glycine; Injections; Male; Ox | 1974 |
Interaction of kynurenine and its metabolites with tryptamine, serotonin and its precursors and oxotremorine.
Topics: Animals; Behavior, Animal; Diarrhea; Drug Antagonism; Drug Interactions; Female; Humans; Hypothermia | 1972 |
Synthesis and pharmacology of centrally acting dopamine derivatives qnd analogs in relation to parkinson's disease.
Topics: Acetylation; Alkylation; Animals; Body Temperature; Chemical Phenomena; Chemistry; Dopamine; Hydroly | 1973 |
Correlation between brain dopamine levels and 1-dopa activity in anti-Parkinson tests.
Topics: Animals; Antiparkinson Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Blepharoptosis; Brain; | 1973 |
Postnatal development of central effects of atropine and oxotremorine in dogs in relation to brain development.
Topics: Acetyltransferases; Age Factors; Animals; Atropine; Behavior, Animal; Brain; Brain Chemistry; Cholin | 1973 |
Antimuscarinic drugs--effect on brain acetylcholine and tremors in rats.
Topics: Acetylcholine; Animals; Atropine; Benztropine; Brain Chemistry; Depression, Chemical; Drug Interacti | 1973 |
[Tremorine as test for evaluating antitremor agents (a review of the literature)].
Topics: Animals; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Guinea P | 1973 |
Alpha-methyldopamine derivatives. Synthesis and pharmacology.
Topics: Animals; Apomorphine; Blepharoptosis; Body Temperature; Depression, Chemical; Dihydroxyphenylalanine | 1974 |
[Pharmacological study of amantadine, a new antiparkinson drug].
Topics: Amantadine; Amines; Animals; Antiparkinson Agents; Avoidance Learning; Brain; Catatonia; Dopamine; D | 1974 |
Acetylene compounds of potential pharmacological value. XVI. N-(perhydroazepinoalkynyl)- and N-(perhydroazocinoalkynyl)succinimides.
Topics: Acetylcholine; Animals; Crystallization; Eye; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Oxotrem | 1972 |
The effect of elantrine, a new anti-Parkinsonism agent, on drug-induced tremor in mice.
Topics: Alkaloids; Animals; Antiparkinson Agents; Atropine; Benztropine; Body Temperature; Central Nervous S | 1972 |
Depression by amantadine of drug-induced rigidity in the rat.
Topics: Amantadine; Animals; Depression, Chemical; Electrodes, Implanted; Electromyography; Motor Activity; | 1972 |
Oxotremorine antagonism by a hypothalamic hormone, melanocyte-stimulating hormone release-inhibiting factor (MIF).
Topics: Acetylcholine; Animals; Ataxia; Diarrhea; Dihydroxyphenylalanine; Drug Antagonism; Guinea Pigs; Huma | 1972 |
Effect of gamma-hydroxybutyric acid on tremor induced oxotremorin.
Topics: Animals; Atropine; Brain Chemistry; Disease Models, Animal; Drug Antagonism; Drug Synergism; Female; | 1972 |