oxotremorine has been researched along with Seizures in 28 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oxotremorine is a cholinergic agonist known to induce acute hypothermia." | 7.74 | Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats. ( Grauer, E; Levy, A, 2007) |
| "Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures." | 7.73 | Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. ( Aguiar, LM; Fonteles, MM; Freitas, RM; Nascimento, VS; Nogueira, CR; Oliveira, AA; Sousa, FC; Viana, GS, 2005) |
| "A tremor monitor was constructed and tested that quantitates soman- and oxotremorine-induced tremors." | 7.67 | Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors. ( Clement, JG; Dyck, WR, 1989) |
| " Oxotremorine is a cholinergic agonist known to induce acute hypothermia." | 3.74 | Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats. ( Grauer, E; Levy, A, 2007) |
| "Levetiracetam (LEV) is a new antiepileptic drug effective as adjunctive therapy for partial seizures." | 3.73 | Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement. ( Aguiar, LM; Fonteles, MM; Freitas, RM; Nascimento, VS; Nogueira, CR; Oliveira, AA; Sousa, FC; Viana, GS, 2005) |
| " The muscarinic agonist oxotremorine induced marked hypothermia in all the knockout mice, but the hypothermia was reduced in M2 and to a lesser extent in M3 knockout mice." | 3.72 | Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. ( Bymaster, FP; Carter, PA; Felder, CC; Gomeza, J; Hamilton, SE; McKinzie, DL; Nathanson, NM; Wess, J; Yamada, M, 2003) |
| " These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic and inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory." | 3.71 | Alteration of cardiovascular and neuronal function in M1 knockout mice. ( Anagnostaras, SG; Feigl, EO; Hamilton, SE; Hardouin, SN; Murphy, GG; Nathanson, NM; Richmond, KN; Silva, AJ, 2001) |
| ") also potentiates oxotremorine-induced tremors in mice, in a dose-dependent manner, and this effect was completely prevented by atropine." | 3.71 | Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline. ( Cunha, GM; Farias, PA; Viana, GS, 2002) |
| "A tremor monitor was constructed and tested that quantitates soman- and oxotremorine-induced tremors." | 3.67 | Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors. ( Clement, JG; Dyck, WR, 1989) |
| "The effects of nicotine for producing convulsions were modified by LiCl 2." | 1.30 | Modulation of phosphatidylinositol turnover on central nicotinic receptors. ( Lu, XQ; Wang, H; Zhang, YF, 1997) |
| "Pergolide had no effect on seizure activity as evaluated by electroshock, pentylenetetrazol (pentetrazol) or strychnine." | 1.28 | Behavioral characterization of the new potent nonselective dopamine agonist pergolide. ( Helton, DR; Modlin, DL; Williams, PD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (60.71) | 18.7374 |
| 1990's | 3 (10.71) | 18.2507 |
| 2000's | 7 (25.00) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gholami, M | 1 |
| Saboory, E | 1 |
| Zare, S | 1 |
| Roshan-Milani, S | 1 |
| Hajizadeh-Moghaddam, A | 1 |
| Bymaster, FP | 1 |
| Carter, PA | 1 |
| Yamada, M | 1 |
| Gomeza, J | 1 |
| Wess, J | 1 |
| Hamilton, SE | 2 |
| Nathanson, NM | 2 |
| McKinzie, DL | 1 |
| Felder, CC | 1 |
| Oliveira, AA | 1 |
| Nogueira, CR | 1 |
| Nascimento, VS | 1 |
| Aguiar, LM | 1 |
| Freitas, RM | 1 |
| Sousa, FC | 1 |
| Viana, GS | 2 |
| Fonteles, MM | 1 |
| Hegab, MI | 1 |
| Abdulla, MM | 1 |
| Grauer, E | 1 |
| Levy, A | 1 |
| Pong, SF | 1 |
| Pelosi, SS | 1 |
| Wessels, FL | 1 |
| Yu, CN | 1 |
| Burns, RH | 1 |
| White, RE | 1 |
| Anthony, DR | 1 |
| Ellis, KO | 1 |
| Wright, GC | 1 |
| White, RL | 1 |
| Georgiev, VP | 1 |
| Lambadjieva, ND | 1 |
| Gulati, A | 1 |
| Nath, C | 1 |
| Dhawan, KN | 1 |
| Bhargava, KP | 1 |
| Agarwal, AK | 1 |
| Seth, PK | 1 |
| Olney, JW | 1 |
| Collins, JF | 1 |
| De Gubareff, T | 1 |
| Abood, LG | 1 |
| Saraswati, M | 1 |
| Lerner-Marmarosh, N | 1 |
| Hashmi, M | 1 |
| Wang, H | 1 |
| Lu, XQ | 1 |
| Zhang, YF | 1 |
| Abrahám, G | 1 |
| Sólyom, S | 1 |
| Csuzdi, E | 1 |
| Berzsenyi, P | 1 |
| Ling, I | 1 |
| Tarnawa, I | 1 |
| Hámori, T | 1 |
| Pallagi, I | 1 |
| Horváth, K | 1 |
| Andrási, F | 1 |
| Kapus, G | 1 |
| Hársing, LG | 1 |
| Király, I | 1 |
| Patthy, M | 1 |
| Horváth, G | 1 |
| Hardouin, SN | 1 |
| Anagnostaras, SG | 1 |
| Murphy, GG | 1 |
| Richmond, KN | 1 |
| Silva, AJ | 1 |
| Feigl, EO | 1 |
| Cunha, GM | 1 |
| Farias, PA | 1 |
| Rubin, EH | 1 |
| Ferrendelli, JA | 1 |
| Kruse, H | 1 |
| Hoffmann, I | 1 |
| Gerhards, HJ | 1 |
| Leven, M | 1 |
| Schacht, U | 1 |
| Plotnikoff, NP | 3 |
| Kastin, AJ | 3 |
| White, WF | 1 |
| Schally, AV | 1 |
| Helton, DR | 1 |
| Modlin, DL | 1 |
| Williams, PD | 1 |
| Clement, JG | 1 |
| Dyck, WR | 1 |
| Witkin, JM | 1 |
| Alvarado-Garcia, R | 1 |
| Lee, MA | 1 |
| Witkin, KM | 1 |
| Inch, TD | 1 |
| Green, DM | 1 |
| Thompson, PB | 1 |
| Phan, DV | 2 |
| Bite, A | 2 |
| György, L | 3 |
| Döda, M | 2 |
| Spilker, BA | 1 |
| Dhasmana, KM | 1 |
| Davies, JE | 1 |
| Claassen, V | 1 |
| Ursillo, RC | 1 |
| McCulloch, JA | 1 |
28 other studies available for oxotremorine and Seizures
| Article | Year |
|---|---|
The effect of dorsal hippocampal administration of nicotinic and muscarinic cholinergic ligands on pentylenetetrazol-induced generalized seizures in rats.
Topics: Animals; Atropine; Hippocampus; Male; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotin | 2012 |
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
Topics: Animals; Apomorphine; Body Temperature; Cerebral Cortex; Dopamine Agonists; Dose-Response Relationsh | 2003 |
Evaluation of levetiracetam effects on pilocarpine-induced seizures: cholinergic muscarinic system involvement.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocampus; Levetiracetam; Male; Mic | 2005 |
4-Chloro-2,2-disubstituted chromen-3-carboxaldehyde: synthesis of some fused polycyclic heterocycles as anti-inflammatory, analgesic, anticonvulsant, and antiparkinsonian agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antiparkinson Agents; Benzopyrans; C | 2006 |
Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats.
Topics: Aldicarb; Animals; Body Temperature; Carbamates; Central Nervous System; Cholinesterase Inhibitors; | 2007 |
5-phenyl-2-furamidines: a new chemical class of potential antidepressants.
Topics: Acetylcholine; Amidines; Animals; Antidepressive Agents; Blepharoptosis; Brain; Furans; Guinea Pigs; | 1983 |
Interactions between cholinergic drugs, gamma-aminobutyric acid and cyclic guanosine monophosphate on picrotoxin-induced convulsive-seizure threshold.
Topics: Animals; Cyclic GMP; Dibutyryl Cyclic GMP; Drug Interactions; gamma-Aminobutyric Acid; Mice; Oxotrem | 1981 |
Effect of electroconvulsive shock on central cholinergic (muscarinic) receptors.
Topics: Animals; Cerebral Cortex; Electroshock; Female; Male; Oxotremorine; Quinuclidinyl Benzilate; Rats; R | 1982 |
Dipiperidinoethane neurotoxicity clarified.
Topics: Amygdala; Animals; Biotransformation; Convulsants; Kainic Acid; Oxotremorine; Piperidines; Rats; Rec | 1982 |
Affinity ligands and related agents for brain muscarinic and nicotinic cholinergic receptors.
Topics: Affinity Labels; Animals; Brain; Carbachol; Choline; Kinetics; Ligands; Mice; Naloxone; Nicotine; Ox | 1993 |
Modulation of phosphatidylinositol turnover on central nicotinic receptors.
Topics: Animals; Brain; Lithium Chloride; Male; Mice; Muscarinic Agonists; Nicotine; Oxotremorine; Phosphati | 1997 |
New non competitive AMPA antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsa | 2000 |
Alteration of cardiovascular and neuronal function in M1 knockout mice.
Topics: Animals; Calcium Channels; Cells, Cultured; Electrophysiology; Gene Targeting; GTP-Binding Proteins; | 2001 |
Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline.
Topics: Acetylcholinesterase; Animals; Anxiety; Avoidance Learning; Hippocampus; Learning Disabilities; Male | 2002 |
Distribution and regulation of cyclic nucleotide levels in cerebellum, in vivo.
Topics: Amphetamine; Animals; Atropine; Cerebellum; Cyclic AMP; Cyclic GMP; Diazepam; Female; Harmaline; In | 1977 |
Pharmacological and biochemical studies with three metabolites of nomifensine.
Topics: Animals; Antidepressive Agents; Body Temperature; Brain; Catalepsy; Dopamine; Drug Interactions; Ele | 1977 |
Neuropharmacological review of hypothalamic releasing factors.
Topics: Animals; Apomorphine; Behavior, Animal; Central Nervous System; Dihydroxyphenylalanine; Electroencep | 1977 |
Neuropharmacological tests with alpha-melanocyte stimulating hormone.
Topics: Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Synergism; Electroshock; Male; Melanocyte-St | 1976 |
Gonadotropin releasing hormone (GnRH): neuropharmacological studies.
Topics: Animals; Behavior, Animal; Dihydroxyphenylalanine; Drug Synergism; Gonadotropin-Releasing Hormone; M | 1975 |
Behavioral characterization of the new potent nonselective dopamine agonist pergolide.
Topics: Analgesics; Animals; Avoidance Learning; Behavior, Animal; Body Temperature; Bromocriptine; Dogs; Fe | 1992 |
Device for quantitating tremor activity in mice: antitremor activity of atropine versus soman- and oxotremorine-induced tremors.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Isometric Contraction; Male; Mice; Oxotremorine | 1989 |
Nonmuscarinic neurotoxicity of oxotremorine.
Topics: Animals; Arecoline; Atropine; Atropine Derivatives; Benactyzine; Benztropine; Crying; Diazepam; Dose | 1987 |
The central and peripheral activities of anti-acetylcholine drugs. Some concepts of practical relevance.
Topics: Acetylcholine; Animals; Atropine; Central Nervous System; Decerebrate State; Electroencephalography; | 1973 |
Effect of oxotremorine on behaviour and EEG of reserpine-pretreated rats.
Topics: Animals; Atropine; Atropine Derivatives; Brain; Electroencephalography; Female; Male; Mecamylamine; | 1974 |
Effect of cholinesterase inhibitors on the susceptibility to pentetrazole of the mouse.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; F | 1974 |
Differentiation between effects of nicotine and DMPP by amantadine.
Topics: Acetylcholine; Amantadine; Animals; Blood Pressure; Cats; Drug Antagonism; Drug Interactions; Drug S | 1973 |
Antin ociceptive activity of nicotine.
Topics: Acetates; Analgesia; Animals; Dimethylphenylpiperazinium Iodide; Drug Tolerance; Injections, Intrape | 1973 |
The effect of elantrine, a new anti-Parkinsonism agent, on drug-induced tremor in mice.
Topics: Alkaloids; Animals; Antiparkinson Agents; Atropine; Benztropine; Body Temperature; Central Nervous S | 1972 |