oxotremorine has been researched along with Muscle Contraction in 111 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two subseries of nonquaternized (5a-10a) and quaternized derivatives (5b-10b) related to oxotremorine and oxotremorine-M were synthesized and tested." | 7.70 | Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. ( Ballabeni, V; Barocelli, E; Bertoni, S; Chiavarini, M; Conti, P; Dallanoce, C; De Amici, M; De Micheli, C; Impicciatore, M, 1999) |
| "The enantiomers of three 5-methyl-2-pyrrolidone analogues of the muscarinic agent oxotremorine (1) were synthesized." | 7.67 | Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogues. N-[4-(tertiary amino)-2-butynyl]-5-methyl-2-pyrrolidones. ( Amstutz, R; Jenden, DJ; Karlén, B; Ringdahl, B; Roch, M, 1985) |
| "A series of tertiary 3- and 4-haloalkylamines related to the muscarinic agent oxotremorine was synthesized." | 7.67 | Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists. ( Jenden, DJ; Ringdahl, B; Roch, M, 1988) |
| "A number of secondary and tertiary amines as well as quaternary ammonium compounds, obtained by structural modification of the amino group of oxotremorine (1) and its acetamide analogue (14), were investigated for muscarinic and antimuscarinic activity in vivo and in vitro." | 7.66 | Muscarinic activity of some secondary and tertiary amines and quaternary ammonium salts structurally related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1983) |
| "1 The enantiomers of some analogues of the central muscarinic agent, oxotremorine, were prepared and investigated for tremorogenic and tremorolytic activity in intact mice and for muscarinic and antimuscarinic activity on the isolated ileum of the guinea-pig." | 7.66 | Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1982) |
| " The influence of propranolol on the neuromuscular, tremor-producing and muscarinic effects of oxotremorine was examined." | 7.65 | Antioxotremorine action of propranolol. ( Ganguly, DK, 1976) |
| " Using the mAChR agonist Oxo M (oxotremorine M), we identified a GAR-3(mAChR)-G alpha(q) pathway that promotes protractor muscle contraction by upregulating nAChR signaling before mating." | 3.74 | G alpha(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior. ( Garcia, LR; LeBoeuf, B; Liu, Y, 2007) |
| "Two subseries of nonquaternized (5a-10a) and quaternized derivatives (5b-10b) related to oxotremorine and oxotremorine-M were synthesized and tested." | 3.70 | Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M. ( Ballabeni, V; Barocelli, E; Bertoni, S; Chiavarini, M; Conti, P; Dallanoce, C; De Amici, M; De Micheli, C; Impicciatore, M, 1999) |
| "The enantiomers of three 5-methyl-2-pyrrolidone analogues of the muscarinic agent oxotremorine (1) were synthesized." | 3.67 | Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogues. N-[4-(tertiary amino)-2-butynyl]-5-methyl-2-pyrrolidones. ( Amstutz, R; Jenden, DJ; Karlén, B; Ringdahl, B; Roch, M, 1985) |
| "A series of tertiary 3- and 4-haloalkylamines related to the muscarinic agent oxotremorine was synthesized." | 3.67 | Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists. ( Jenden, DJ; Ringdahl, B; Roch, M, 1988) |
| "The relationship between bovine tracheal muscle contraction and phosphoinositide metabolism was studied with the muscarinic agonists, methacholine, oxotremorine, and McN-A-343." | 3.67 | Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists. ( Elzinga, CR; Kauffman, HF; Meurs, H; Postema, JB; Roffel, AF; Timmermans, A; Zaagsma, J, 1988) |
| "The relationships between activation of muscarinic receptors in guinea pig bladder measured as carbachol-stimulated inositol phosphate (IP) accumulation, oxotremorine-induced adenylate cyclase (AC) inhibition and bladder detrusor smooth muscle contraction determined in vitro as well as in vivo in the slow filling cystometrogram (CMG), were analyzed from the potencies of a number of muscarinic antagonists to block these responses." | 3.67 | Muscarinic receptors: relationships among phosphoinositide breakdown, adenylate cyclase inhibition, in vitro detrusor muscle contractions and in vivo cystometrogram studies in guinea pig bladder. ( Canning, B; Costello, D; Kinnier, WJ; Lowe, V; Noronha-Blob, L; Patton, A, 1989) |
| "A number of secondary and tertiary amines as well as quaternary ammonium compounds, obtained by structural modification of the amino group of oxotremorine (1) and its acetamide analogue (14), were investigated for muscarinic and antimuscarinic activity in vivo and in vitro." | 3.66 | Muscarinic activity of some secondary and tertiary amines and quaternary ammonium salts structurally related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1983) |
| "1 The enantiomers of some analogues of the central muscarinic agent, oxotremorine, were prepared and investigated for tremorogenic and tremorolytic activity in intact mice and for muscarinic and antimuscarinic activity on the isolated ileum of the guinea-pig." | 3.66 | Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine. ( Dahlbom, R; Jenden, DJ; Resul, B; Ringdahl, B, 1982) |
| "The effects of metoclopramide on smooth muscle contraction and on release of acetylcholine were studied in the guinea-pig myenteric plexus longitudinal muscle preparation." | 3.66 | The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum. ( Kilbinger, H; Kruel, R; Pfeuffer-Friederich, I; Wessler, I, 1982) |
| " Antagonism of oxotremorine induced tremors in mice by anticholinergics and neuroleptics was also significantly correlated to the corresponding data obtained in the in-vitro tests." | 3.65 | Peripheral and central muscarinic receptor affinity of psychotropic drugs. ( Christensen, AV; Fjalland, B; Hyttel, J, 1977) |
| " The influence of propranolol on the neuromuscular, tremor-producing and muscarinic effects of oxotremorine was examined." | 3.65 | Antioxotremorine action of propranolol. ( Ganguly, DK, 1976) |
| " Oxotremorine generated dose-response curves that were similar in both the circular and longitudinal vectors and intermediate to those previously reported for carbachol and aceclidine." | 1.29 | The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle. ( Gabelt, BT; Kaufman, PL; Poyer, JF, 1994) |
| " Incubation of the isolated guinea pig ileum for 30 min with BM 123 at 20 microM and 2 microM caused 94% and 48% receptor alkylation, respectively, as calculated from the shift in the agonist dose-response curve." | 1.27 | The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum. ( Dahlbom, R; Ehlert, FJ; Jenden, DJ; Resul, B; Ringdahl, B, 1984) |
| "Bisoprolol was found to be an effective beta-adrenoceptor antagonist, the pA2 values determined against isoprenaline in guinea pig atria and tracheal muscle being 7." | 1.27 | Pharmacodynamic profile of the selective beta 1-adrenoceptor antagonist bisoprolol. ( Becker, KH; Bergmann, R; Bourgois, R; Enenkel, HJ; Fuchs, A; Harting, J; Jonas, R; Lettenbaur, H; Minck, KO; Schelling, P, 1986) |
| "Pilocarpine which is a well-known partial agonist on muscarinic receptors in most smooth muscles did not cause any contraction in this tissue." | 1.27 | Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon. ( Konno, F; Takayanagi, I, 1985) |
| "Pretreatment with atropine sulphate (2." | 1.26 | Further studies on the role of cholinergic mechanisms in the development of increased naloxone potency in mice. ( Bentley, GA; Wong, CL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (57.66) | 18.7374 |
| 1990's | 30 (27.03) | 18.2507 |
| 2000's | 13 (11.71) | 29.6817 |
| 2010's | 4 (3.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valli, MJ | 1 |
| Tang, Y | 1 |
| Kosh, JW | 1 |
| Chapman, JM | 1 |
| Sowell, JW | 1 |
| Nilsson, BM | 1 |
| Vargas, HM | 1 |
| Hacksell, U | 2 |
| Amstutz, R | 2 |
| Ringdahl, B | 16 |
| Karlén, B | 1 |
| Roch, M | 2 |
| Jenden, DJ | 8 |
| Xu, R | 1 |
| Sim, MK | 1 |
| Go, ML | 1 |
| Griffin, MT | 3 |
| Matsui, M | 4 |
| Ostrom, RS | 2 |
| Ehlert, FJ | 10 |
| Pak, KJ | 2 |
| Yu, Y | 1 |
| de Groat, WC | 2 |
| Xu, M | 1 |
| Zhang, Y | 1 |
| Xia, M | 1 |
| Li, XX | 1 |
| Ritter, JK | 1 |
| Zhang, F | 1 |
| Li, PL | 1 |
| Matsumoto, Y | 1 |
| Miyazato, M | 1 |
| Yokoyama, H | 1 |
| Kita, M | 1 |
| Hirao, Y | 1 |
| Chancellor, MB | 1 |
| Yoshimura, N | 1 |
| Wu, DM | 1 |
| Kawamura, H | 1 |
| Sakagami, K | 1 |
| Kobayashi, M | 1 |
| Puro, DG | 1 |
| Barocelli, E | 2 |
| Ballabeni, V | 2 |
| Bertoni, S | 2 |
| Dallanoce, C | 2 |
| De Amici, M | 2 |
| De Micheli, C | 2 |
| Impicciatore, M | 2 |
| Hsu, JC | 1 |
| Leung, K | 1 |
| Lee, AG | 1 |
| Shehnaz, D | 1 |
| Abe, DM | 1 |
| Vo, TH | 1 |
| Taketo, MM | 1 |
| Manabe, T | 1 |
| Wang, LY | 2 |
| Wang, Y | 2 |
| Zheng, JQ | 2 |
| Zhong, BH | 2 |
| Liu, H | 1 |
| Dong, SJ | 1 |
| Ruan, JX | 2 |
| Liu, KL | 1 |
| Liu, LL | 1 |
| Liu, Y | 1 |
| LeBoeuf, B | 1 |
| Garcia, LR | 1 |
| Ahn, S | 1 |
| Park, GJ | 1 |
| Sangnil, MS | 1 |
| Tran, JA | 1 |
| Ehler, FJ | 1 |
| Ueki, S | 2 |
| Okamoto, E | 2 |
| Kuwata, K | 2 |
| Toyosaka, A | 2 |
| Nagai, K | 2 |
| Uchida, S | 3 |
| Yoshida, H | 3 |
| Pong, SF | 1 |
| Pelosi, SS | 1 |
| Wessels, FL | 1 |
| Yu, CN | 1 |
| Burns, RH | 1 |
| White, RE | 1 |
| Anthony, DR | 1 |
| Ellis, KO | 1 |
| Wright, GC | 1 |
| White, RL | 1 |
| Resul, B | 5 |
| Dahlbom, R | 7 |
| Kilbinger, H | 6 |
| Halim, S | 1 |
| Lambrecht, G | 1 |
| Weiler, W | 1 |
| Wessler, I | 3 |
| Beck, D | 1 |
| Fink, K | 1 |
| Hölzl, J | 1 |
| Krieglstein, J | 1 |
| Petter, A | 1 |
| Rieger, H | 1 |
| Schönenberger, H | 1 |
| Jedrych, Z | 1 |
| Seidel, ER | 1 |
| Johnson, LR | 1 |
| Lewander, T | 1 |
| Zetterström, T | 1 |
| Kruel, R | 1 |
| Pfeuffer-Friederich, I | 1 |
| Szerb, JC | 1 |
| Chaudhuri, SK | 1 |
| Ganguly, DK | 4 |
| Watson, N | 2 |
| Reddy, H | 2 |
| Eglen, RM | 4 |
| Patel, HJ | 2 |
| Barnes, PJ | 2 |
| Takahashi, T | 1 |
| Tadjkarimi, S | 1 |
| Yacoub, MH | 1 |
| Belvisi, MG | 2 |
| Poyer, JF | 1 |
| Gabelt, BT | 1 |
| Kaufman, PL | 1 |
| Wang, P | 1 |
| Luthin, GR | 1 |
| Ruggieri, MR | 1 |
| Chrachri, A | 1 |
| Neil, DM | 1 |
| Nakagawa, T | 1 |
| Ukai, K | 1 |
| Kubo, S | 1 |
| Thomas, EA | 2 |
| Peelle, B | 1 |
| Pulido-Rios, MT | 1 |
| Leung, E | 1 |
| Tong, YC | 1 |
| Hung, YC | 1 |
| Lin, SN | 1 |
| Cheng, JT | 1 |
| Sawyer, GW | 2 |
| Giembycz, MA | 1 |
| Keeling, JE | 1 |
| Sawyer, G | 1 |
| Ehlert, F | 1 |
| von Bardeleben, RS | 1 |
| Siefken, H | 1 |
| Wolf, D | 1 |
| Karaalp, A | 1 |
| Akici, A | 1 |
| Akbulut, H | 1 |
| Ulusoy, NB | 1 |
| Oktay, S | 1 |
| Conti, P | 1 |
| Chiavarini, M | 1 |
| Mitchelson, F | 1 |
| Shen, A | 1 |
| Horio, S | 1 |
| Fukui, H | 1 |
| Ishiura, Y | 1 |
| Yoshiyama, M | 1 |
| Yokoyama, O | 1 |
| Namiki, M | 1 |
| Bymaster, FP | 1 |
| Carter, PA | 1 |
| Zhang, L | 1 |
| Falcone, JF | 1 |
| Stengel, PW | 1 |
| Cohen, ML | 1 |
| Shannon, HE | 1 |
| Gomeza, J | 1 |
| Wess, J | 1 |
| Felder, CC | 1 |
| Choppin, A | 1 |
| Goldenberg, MM | 1 |
| Bauer, R | 2 |
| Kuhn, FJ | 1 |
| Stockhaus, K | 1 |
| Wick, H | 1 |
| Nath, DN | 1 |
| Ross, HG | 1 |
| Vedasiromoni, JR | 2 |
| Wong, CL | 1 |
| Bentley, GA | 1 |
| Das, M | 1 |
| Bianchetti, A | 1 |
| Guarneri, L | 1 |
| Biraschi, LM | 1 |
| Riva, M | 1 |
| Takeyasu, K | 2 |
| Matsuda, T | 2 |
| Wada, A | 1 |
| Maruno, M | 1 |
| Lai, RT | 1 |
| Hata, F | 1 |
| Fjalland, B | 1 |
| Christensen, AV | 1 |
| Hyttel, J | 1 |
| Field, JD | 1 |
| Bowen, JM | 1 |
| Rehavi, M | 1 |
| Yaavetz, B | 1 |
| Kloog, Y | 1 |
| Maayani, S | 1 |
| Sokolovsky, M | 1 |
| Akashi, A | 1 |
| Hashizume, T | 1 |
| Tanaka, M | 1 |
| Naka, S | 1 |
| Suzuki, I | 1 |
| Svensson, U | 2 |
| Nistri, A | 1 |
| De Bellis, AM | 1 |
| Cammelli, E | 1 |
| Morrison, KJ | 1 |
| Vanhoutte, PM | 1 |
| Alves-do-Prado, W | 1 |
| Corrado, AP | 2 |
| Prado, WA | 2 |
| Haddad, EB | 1 |
| Gies, JP | 1 |
| Kadlec, O | 1 |
| Hynie, S | 1 |
| Masek, K | 1 |
| Seferna, I | 1 |
| Sevcík, J | 1 |
| Janssen, LJ | 1 |
| Daniel, EE | 1 |
| Fujimoto, S | 1 |
| Hong, SJ | 1 |
| Chang, CC | 1 |
| Aas, P | 1 |
| Fügner, A | 1 |
| Meurs, H | 2 |
| Roffel, AF | 1 |
| Postema, JB | 2 |
| Timmermans, A | 2 |
| Elzinga, CR | 1 |
| Kauffman, HF | 1 |
| Zaagsma, J | 2 |
| Van Amsterdam, RG | 1 |
| Brouwer, F | 1 |
| Noronha-Blob, L | 1 |
| Lowe, V | 1 |
| Patton, A | 1 |
| Canning, B | 1 |
| Costello, D | 1 |
| Kinnier, WJ | 1 |
| Lundkvist, JR | 1 |
| Rondas, AA | 1 |
| Boddeke, HW | 1 |
| Doods, HN | 1 |
| Thörig, L | 1 |
| van Haeringen, NJ | 1 |
| van Zwieten, PA | 1 |
| Wali, FA | 1 |
| Suer, AH | 1 |
| McAteer, EJ | 1 |
| Dark, CH | 1 |
| Baraban, JM | 1 |
| Gould, RJ | 1 |
| Peroutka, SJ | 1 |
| Snyder, SH | 1 |
| Harting, J | 1 |
| Becker, KH | 1 |
| Bergmann, R | 1 |
| Bourgois, R | 1 |
| Enenkel, HJ | 1 |
| Fuchs, A | 1 |
| Jonas, R | 1 |
| Lettenbaur, H | 1 |
| Minck, KO | 1 |
| Schelling, P | 1 |
| Ordway, GA | 1 |
| Esbenshade, TA | 1 |
| Kolta, MG | 1 |
| Gerald, MC | 1 |
| Wallace, LJ | 1 |
| Stein, A | 1 |
| Closse, A | 1 |
| Witkin, JM | 1 |
| Gordon, RK | 1 |
| Chiang, PK | 1 |
| Collins, SM | 1 |
| Crankshaw, DJ | 1 |
| Markowicz, ME | 1 |
| Benishin, CG | 1 |
| Pearce, LB | 1 |
| Cooper, JR | 1 |
| Nafziger, M | 1 |
| Konno, F | 1 |
| Takayanagi, I | 1 |
| Bauer, VR | 1 |
| Lindquist, A | 1 |
| Lindgren, S | 1 |
| Blair, MR | 1 |
| Brown, DM | 1 |
| Hughes, BO | 1 |
| Marsden, CD | 1 |
| Meadows, JC | 1 |
| Spicer, B | 1 |
| Phan, DV | 1 |
| György, L | 2 |
| Gellén, B | 1 |
| Dóda, M | 1 |
| Martin, YC | 1 |
| Jarboe, CH | 1 |
| Krause, RA | 1 |
| Lynn, KR | 1 |
| Dunnigan, D | 1 |
| Holland, JB | 1 |
| Cashin, CH | 1 |
| Hotten, TM | 1 |
| Szinai, SS | 1 |
1 review available for oxotremorine and Muscle Contraction
| Article | Year |
|---|---|
Functional role of M2 muscarinic receptors in the guinea pig ileum.
Topics: Animals; Colforsin; Cyclic AMP; Guinea Pigs; Heart; Histamine; Ileum; Muscarinic Antagonists; Muscle | 1995 |
1 trial available for oxotremorine and Muscle Contraction
| Article | Year |
|---|---|
Some initial animal and human pharmacological studies with benapryzine (BRL 1288).
Topics: Acetylcholine; Aged; Animals; Antiparkinson Agents; Benzilates; Clinical Trials as Topic; Dose-Respo | 1973 |
109 other studies available for oxotremorine and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.
Topics: Acetylcholine; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Synergism; Ery | 1992 |
Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Topics: Animals; Cerebral Cortex; Guinea Pigs; Ileum; Imidazoles; Molecular Structure; Muscarinic Antagonist | 1992 |
Stereoselectivity of muscarinic receptors in vivo and in vitro for oxotremorine analogues. N-[4-(tertiary amino)-2-butynyl]-5-methyl-2-pyrrolidones.
Topics: Abdominal Muscles; Animals; Atropine; Carbachol; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; | 1985 |
Tertiary 3- and 4-haloalkylamine analogues of oxotremorine as prodrugs of potent muscarinic agonists.
Topics: Analgesia; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Kinetics; Magn | 1988 |
Synthesis and pharmacological characterization of O-alkynyloximes of tropinone and N-methylpiperidinone as muscarinic agonists.
Topics: Animals; Aorta; Binding, Competitive; Drug Design; Escape Reaction; In Vitro Techniques; Male; Maze | 1998 |
The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum.
Topics: Animals; Diphenylacetic Acids; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techni | 2009 |
Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.
Topics: Animals; Colforsin; Diabetes Mellitus, Experimental; Disease Models, Animal; Male; Mice; Mice, Inbre | 2010 |
Effects of stimulation of muscarinic receptors on bladder afferent nerves in the in vitro bladder-pelvic afferent nerve preparation of the rat.
Topics: Action Potentials; Adenosine Triphosphate; Administration, Intravesical; Animals; Atropine Derivativ | 2010 |
NAD(P)H oxidase-dependent intracellular and extracellular O2•- production in coronary arterial myocytes from CD38 knockout mice.
Topics: ADP-ribosyl Cyclase 1; Animals; Calcium Signaling; Cells, Cultured; Coronary Vessels; Cyclic ADP-Rib | 2012 |
Role of M2 and M3 muscarinic acetylcholine receptor subtypes in activation of bladder afferent pathways in spinal cord injured rats.
Topics: Afferent Pathways; Animals; Atropine; Benzofurans; Diamines; Female; Mucous Membrane; Muscarinic Ago | 2012 |
Cholinergic regulation of pericyte-containing retinal microvessels.
Topics: Acetylcholine; Animals; Calcium; Capillaries; Carbachol; Electric Stimulation; Fluorescent Dyes; Fur | 2003 |
New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Heart Atria; Heterocyc | 2000 |
Comparison of the antimuscarinic action of p-fluorohexahydrosiladifenidol in ileal and tracheal smooth muscle.
Topics: Animals; Atropine; Cattle; Guinea Pigs; Histamine Antagonists; Hydrolysis; Ileum; In Vitro Technique | 2005 |
The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder.
Topics: Adrenergic beta-Agonists; Animals; Binding, Competitive; Colforsin; Dinoprost; Diphenylacetic Acids; | 2005 |
Pharmacological profiles of an anticholinergic agent, phencynonate hydrochloride, and its optical isomers.
Topics: Animals; Aza Compounds; Binding, Competitive; Carbachol; Cerebral Cortex; Cholinergic Antagonists; F | 2005 |
Comparative study on pharmacological effects of DM-phencynonate hydrochloride and its optical isomers.
Topics: Animals; Aza Compounds; Binding, Competitive; Carbachol; Cerebral Cortex; Female; Glycolates; Guinea | 2005 |
G alpha(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegan | 2007 |
Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Cholinergic Fibers; Dinoprost; Electric St | 2007 |
Muscarinic activity and receptor binding of the enantiomers of aceclidine and its methiodide.
Topics: Analgesics; Animals; Body Temperature; Brain; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Mice | 1982 |
Increase in muscarinic acetylcholine receptors in mouse intestine by hexamethonium treatment.
Topics: Animals; Brain; Carbachol; Female; Hexamethonium; Hexamethonium Compounds; Ileum; Intestinal Mucosa; | 1983 |
5-phenyl-2-furamidines: a new chemical class of potential antidepressants.
Topics: Acetylcholine; Amidines; Animals; Antidepressive Agents; Blepharoptosis; Brain; Furans; Guinea Pigs; | 1983 |
A comparison of the stimulant activities of oxotremorine analogues on the frog rectus abdominis and the guinea pig ileum.
Topics: Abdominal Muscles; Animals; Carbachol; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; | 1984 |
The conversion of 2-chloroalkylamine analogues of oxotremorine to aziridinium ions and their interactions with muscarinic receptors in the guinea pig ileum.
Topics: Alkylation; Animals; Aziridines; Azirines; Binding, Competitive; Carbachol; Chlorides; Guinea Pigs; | 1984 |
Comparison of affinities of muscarinic antagonists to pre- and postjunctional receptors in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Atropine Derivatives; Choline; Electric Stimulation; Guinea Pigs; Ileum; In | 1984 |
[Pharmacology of potential antidepressants of the N-L-phenylalanyl-beta-phenylalkylamine class].
Topics: Animals; Antidepressive Agents; Hexobarbital; Kidney; Male; Mice; Monoamine Oxidase Inhibitors; Moto | 1983 |
Cholinolytic activity of 3-hydroxyquinuclidyl-1-phenyl-1-cyclohexyl-1-carboxylate hydrochloride (ANC-821).
Topics: Acetylcholine; Animals; Atropine; Bronchi; Electrocardiography; In Vitro Techniques; Male; Mice; Mus | 1983 |
Muscarinic activity of some secondary and tertiary amines and quaternary ammonium salts structurally related to oxotremorine.
Topics: Amines; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle C | 1983 |
Contraction and [3H]QNB binding in collagenase isolated fundic smooth muscle cells.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Kinetics; Male; Muscle Contraction; Muscle, Smooth; O | 1983 |
Stereochemical requirements for central and peripheral muscarinic and antimuscarinic activity of some acetylenic compounds related to oxotremorine.
Topics: Acetylene; Animals; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mu | 1982 |
The pharmacological assessment of a new, potent oxotremorine analogue in mice and rats.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques | 1982 |
The effects of metoclopramide on acetylcholine release and on smooth muscle response in the isolated guinea-pig ileum.
Topics: Acetylcholine; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Metoclopramid | 1982 |
Muscarinic activity in the isolated guinea pig ileum of some carboxamides related to oxotremorine.
Topics: Animals; Dibenzylchlorethamine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; M | 1982 |
Pre- and postsynaptic effects of muscarinic agonists in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Neuromuscular J | 1980 |
Effect of low calcium and of oxotremorine on the kinetics of the evoked release of [3H]acetylcholine from the guinea-pig myenteric plexus; comparison with morphine.
Topics: Acetylcholine; Animals; Calcium; Guinea Pigs; Kinetics; Membrane Potentials; Morphine; Muscle Contra | 1980 |
Mechanism of acetylcholine release by oxotremorine.
Topics: Acetylcholine; Animals; Azides; Muscle Contraction; Neuromuscular Junction; Ouabain; Oxotremorine; R | 1980 |
Role of muscarinic M2 and M3 receptors in guinea-pig trachea: effects of receptor alkylation.
Topics: Alkylation; Animals; Diamines; Dioxolanes; Diphenylacetic Acids; Drug Interactions; Guinea Pigs; His | 1995 |
Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea.
Topics: Acetylcholine; Adolescent; Adult; Animals; Autoreceptors; Child; Dose-Response Relationship, Drug; E | 1995 |
The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle.
Topics: Animals; Carbachol; Ciliary Body; Dose-Response Relationship, Drug; In Vitro Techniques; Macaca mula | 1994 |
Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins.
Topics: Animals; GTP-Binding Proteins; Humans; Muscarinic Agonists; Muscle Contraction; N-Methylscopolamine; | 1995 |
Interaction and synchronization between two abdominal motor systems in crayfish.
Topics: Abdominal Muscles; Acetylcholine; Animals; Astacoidea; Central Nervous System; Dose-Response Relatio | 1993 |
Antidepressive effects of the stereoisomer cis-dosulepin hydrochloride.
Topics: Acetylcholine; Animals; Antidepressive Agents; Apomorphine; Blepharoptosis; Body Temperature; Brain | 1993 |
Involvement of the M2 muscarinic receptor in contractions of the guinea pig trachea, guinea pig esophagus, and rat fundus.
Topics: Adrenergic beta-Agonists; Animals; Colforsin; Cyclic AMP; Esophagus; Gastric Fundus; Guinea Pigs; Hi | 1996 |
Functional interactions between muscarinic M2 receptors and 5-hydroxytryptamine (5-HT)4 receptors and beta 3-adrenoceptors in isolated oesophageal muscularis mucosae of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Atropine; Dose-Response | 1996 |
Pharmacological characterization of the muscarinic receptors mediating contraction of canine saphenous vein.
Topics: Animals; Dioxolanes; Dogs; Female; In Vitro Techniques; Muscarinic Agonists; Muscle Contraction; Mus | 1995 |
Pharmacological characterization of the muscarinic receptor subtypes responsible for the contractile response in the rat urinary bladder.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Analysis of Var | 1997 |
Contractile roles of the M2 and M3 muscarinic receptors in the guinea pig colon.
Topics: Animals; Colforsin; Colon; Cyclic AMP; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; M | 1998 |
Inhibition of cholinergic neurotransmission in guinea pig trachea by NS1619, a putative activator of large-conductance, calcium-activated potassium channels.
Topics: Acetylcholine; Animals; Benzimidazoles; Calcium; Cholinergic Agonists; Depression, Chemical; Dogs; E | 1998 |
Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Histamine; | 1999 |
Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon: evidence for M2/M3 receptor interactions.
Topics: Animals; Colon; Diphenylacetic Acids; Guinea Pigs; Hydrolysis; In Vitro Techniques; Male; Models, Bi | 1999 |
Prejunctional muscarinic receptors regulating neurotransmitter release in airways.
Topics: Acetylcholine; Animals; Choline; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques | 1995 |
Distinct functional muscarinic receptors in guinea-pig gallbladder, ileum and atria.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Carbachol; Electric S | 1999 |
Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.
Topics: Animals; Atrial Function; Cholinergic Agents; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; | 1999 |
Studies on muscarinic M2 receptors in smooth muscle.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cecum; Guinea Pigs; Histamine; In Vi | 1999 |
Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Animals; Calcium; Enzyme Inhibitors; G | 2001 |
Central muscarinic mechanisms regulating voiding in rats.
Topics: Animals; Atropine; Brain; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Injecti | 2001 |
Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.
Topics: Animals; Carbachol; Cerebral Cortex; Heart; Heart Rate; Humans; Hypothermia; Male; Mice; Mice, Knock | 2001 |
Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle.
Topics: Acetylcholine; Animals; Carbachol; Diamines; Dioxolanes; Dose-Response Relationship, Drug; In Vitro | 2001 |
Some aspects in the pharmacology of diclonium bromide (2-(3,2-dichloroanilino)quinolizinium bromide). Part I: Antispasmodic action.
Topics: Acetylcholine; Animals; Colon; Dogs; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guin | 1976 |
[General pharmacology and secretion inhibitory action of (8r)-3alpha-hydroxy-8-isopropyl-1alphaH,5alphaH-tropanium bromide-(+/-)-tropate (ipratropiumbromide) (author's transl)].
Topics: Animals; Atropine Derivatives; Blood Pressure; Brain; Cats; Dogs; Ganglia, Autonomic; Gastric Juice; | 1976 |
Rat isolated phrenic nerve-diaphragm preparation for pharmacological study of muscle spindle afferent activity: effect of oxotremorine.
Topics: Animals; Diaphragm; In Vitro Techniques; Muscle Contraction; Muscle Spindles; Neuromuscular Junction | 1978 |
Further studies on the role of cholinergic mechanisms in the development of increased naloxone potency in mice.
Topics: Abdominal Muscles; Animals; Atropine; Drug Synergism; Humans; Male; Mice; Morphine; Motor Activity; | 1979 |
Enhancement by oxotremorine of acetylcholine release from the rat phrenic nerve.
Topics: Acetylcholine; Animals; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; | 1978 |
Pharmacological properties of n1-piperonyl-n4-3,7,11-trimethyl-2,6,10-dodecatrienyl-piperazine, a new non-anticholinergic gastric antisecretory agent.
Topics: Animals; Carbachol; Central Nervous System; Depression, Chemical; Dogs; Feeding Behavior; Female; Ga | 1975 |
Changes in muscarinic acetylcholine receptors of mice by chronic administrations of diisopropylfluorophosphate and papaverine.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Intestine, Small; Isoflurophate; Kinetics; Male; M | 1979 |
Experimental evidence and dynamic aspects of spare receptor.
Topics: Animals; Bethanechol Compounds; Binding Sites; Dibenzylchlorethamine; Guinea Pigs; Ileum; In Vitro T | 1979 |
Peripheral and central muscarinic receptor affinity of psychotropic drugs.
Topics: Acetylcholine; Animals; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle C | 1977 |
Oxotremorine neuromuscular blockade: effects of calcium and neostigmine and interactions with D-tubocurarine and decamethonium.
Topics: Animals; Calcium; Decamethonium Compounds; Diaphragm; Drug Interactions; Electric Stimulation; In Vi | 1978 |
In vivo and in vitro studies on the antimuscarinic activity of some amino esters of benzilic acid.
Topics: Acetylcholine; Animals; Benzilates; Body Temperature; Brain; Guinea Pigs; In Vitro Techniques; Kinet | 1978 |
[Pharmacological properties of lopramine].
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Blood Pressure; Body Temperature; Cardiac Out | 1976 |
Acetylene compounds of potential pharmacological value. XIX. N-(dialkylaminoalkynyl)-substituted succinimides and 2-pyrrolidones as partial cholinergic agonists.
Topics: Alkynes; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Muscle Contraction; Mydriatics; Oxo | 1975 |
Drug-induced changes in behaviour and ganglionic acetylcholine concentration of the leech.
Topics: Acetylcholine; Animals; Behavior, Animal; Ethanol; Ether; Ganglia; In Vitro Techniques; Leeches; Mus | 1975 |
Antioxotremorine action of propranolol.
Topics: Animals; Blood Pressure; Diaphragm; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction | 1976 |
Characterization of muscarinic receptors that mediate contraction of guinea-pig isolated trachea to choline esters: effect of removing epithelium.
Topics: Acetylcholine; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Dose-Response Relationship, D | 1992 |
Effects of atropine, pirenzepine, imipramine and phenothiazines on the mammalian neuromuscular junction.
Topics: Acetylcholine; Animals; Atropine; Diaphragm; Electric Stimulation; Female; Imipramine; Male; Muscle | 1992 |
Neuraminidase reduces the number of super-high-affinity [3H]oxotremorine-M binding sites in lung.
Topics: Animals; Carbachol; Clostridium perfringens; Guinea Pigs; In Vitro Techniques; Kinetics; Lung; Male; | 1992 |
Non-synaptic cholinergic modulation of neurogenic twitches of the guinea-pig ileum.
Topics: Acetylcholine; Action Potentials; Adenylyl Cyclases; Animals; Atropine; Calcium; Guinea Pigs; Ileum; | 1991 |
Pre- and postjunctional muscarinic receptors in canine bronchi.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bethanechol Compounds | 1990 |
M3 cholinoceptors and P2y purinoceptors mediating relaxation of arteries in spontaneously hypertensive rats at prehypertensive stages.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Arteries; Carbachol; Cholinergic Antagonists; Endoth | 1991 |
Nicotinic actions of oxotremorine on murine skeletal muscle. Evidence against muscarinic modulation of acetylcholine release.
Topics: Acetylcholine; Action Potentials; Animals; Arecoline; Calcium; Diaphragm; Evoked Potentials; In Vitr | 1990 |
Prejunctional control of cholinergic nerves in airway smooth muscle exerted by muscarinic, purinergic and glutamergic receptors.
Topics: Acetylcholine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aspartic Acid; Bronchi; Diamin | 1990 |
Pharmacology of the anticholinergic bronchospasmolytic agent flutropium bromide.
Topics: Animals; Atropine Derivatives; Blood Pressure; Bronchodilator Agents; Dogs; Female; Gastric Acid; Gu | 1986 |
Evidence for a direct relationship between phosphoinositide metabolism and airway smooth muscle contraction induced by muscarinic agonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Cattle; Inositol Phos | 1988 |
Role of phosphoinositide metabolism in functional antagonism of airway smooth muscle contraction by beta-adrenoceptor agonists.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Adrenergic beta-Agonists; Anim | 1989 |
Muscarinic receptors: relationships among phosphoinositide breakdown, adenylate cyclase inhibition, in vitro detrusor muscle contractions and in vivo cystometrogram studies in guinea pig bladder.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Female; Guinea Pigs; Hydrolysis; In Vitro T | 1989 |
Conformationally restricted analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Topics: Animals; Biological Assay; Cerebral Cortex; Chemical Phenomena; Chemistry; Guinea Pigs; Ileum; Mice; | 1989 |
Cholinergic receptors in the extraocular rectus muscle of the rabbit.
Topics: Acetylcholine; Animals; Carbachol; Dimethylphenylpiperazinium Iodide; Female; Hexamethonium Compound | 1989 |
Comparative effects of atropine and oxotremorine on neuromuscular transmission at the rat hemidiaphragm preparation.
Topics: Animals; Atropine; Diaphragm; Electric Stimulation; Feedback; In Vitro Techniques; Male; Muscle Cont | 1987 |
Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle.
Topics: Animals; Atropine; Bradykinin; Calcium; Dogs; Female; Guinea Pigs; Histamine; Ileum; Male; Muscle Co | 1985 |
Pharmacodynamic profile of the selective beta 1-adrenoceptor antagonist bisoprolol.
Topics: Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 1986 |
Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder.
Topics: Acetylcholine; Aging; Animals; Atropine; Bethanechol; Bethanechol Compounds; Male; Muscle Contractio | 1986 |
Dicyclomine discriminates between M1- and M2-muscarinic receptors in the guinea-pig ileum.
Topics: Animals; Cyclohexanecarboxylic Acids; Dicyclomine; Electric Stimulation; Guinea Pigs; Ileum; In Vitr | 1988 |
Antimuscarinic oxotremorine analogs distinguish high and low affinity agonist states of muscarinic receptors.
Topics: Animals; Binding, Competitive; Carbachol; Cerebral Cortex; Guinea Pigs; Ileum; In Vitro Techniques; | 1988 |
Dimethylsulfonium and thiolanium analogues of the muscarinic agent oxotremorine.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Muscle Contraction; Onium | 1988 |
Comparison of in vitro actions with behavioral effects of antimuscarinic agents.
Topics: alpha-Amylases; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro T | 1987 |
Dissociation of contraction and muscarinic receptor binding to isolated smooth muscle cells.
Topics: Animals; Atropine; Binding, Competitive; Carbachol; Dogs; Kinetics; Methacholine Chloride; Methachol | 1986 |
Cholinergic agonist and antagonist interactions on motor nerve endings of the rat--evidence for the involvement of presynaptic receptors in the regulation of acetylcholine release.
Topics: Acetylcholine; Animals; Atropine; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Male | 1987 |
Muscarinic and antimuscarinic activity of acetamides related to oxotremorine in the guinea pig urinary bladder.
Topics: Acetamides; Animals; Carbachol; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction | 1987 |
Kinetics of solvolysis and muscarinic actions of an N-methyl-N-(2-bromoethyl)amino analogue of oxotremorine.
Topics: Animals; Anura; Cyclization; Guinea Pigs; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Muscle C | 1987 |
Structural requirements for affinity and efficacy of N-(4-amino-2-butynyl)succinimides at muscarinic receptors in the guinea-pig ileum and urinary bladder.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Oxot | 1987 |
Isolation of a factor (substance B) that antagonizes presynaptic modulation: pharmacological properties.
Topics: 2-Chloroadenosine; Acetylcholine; Adenosine; Animals; Brain Chemistry; Clonidine; Guinea Pigs; Hexam | 1986 |
Two types of neuronal muscarine receptors modulating acetylcholine release from guinea-pig myenteric plexus.
Topics: Acetylcholine; Animals; Benzodiazepinones; Guinea Pigs; Ileum; In Vitro Techniques; Muscarine; Muscl | 1985 |
Qualitative and quantitative analysis of muscarinic acetylcholine receptors in the piebald lethal mouse model of Hirschsprung's disease.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Colon; Disease Models, Animal; Female; Hirschsprung Di | 1985 |
Muscarinic acetylcholine receptors in the rabbit ciliary body smooth muscle: spare receptors and threshold phenomenon.
Topics: Animals; Arecoline; Atropine; Carbachol; Ciliary Body; In Vitro Techniques; Male; Muscle Contraction | 1985 |
[Pharmacology of the bronchospasmolytic oxitropium bromide].
Topics: Acetylcholine; Animals; Blood Pressure; Bronchial Spasm; Dogs; Electrocardiography; Female; Gastric | 1985 |
Stereospecificity of oxotremorine antagonists.
Topics: Acetylcholine; Alkynes; Animals; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Mice; Muscle | 1974 |
Effect of oxotremorine and arecoline on the inferior eyelid of the rat.
Topics: Adrenal Glands; Adrenalectomy; Animals; Arecoline; Atropine; Eyelids; Female; Guanethidine; Hyperten | 1972 |
Influence of the surgical isolation of the hypothalamus on oxotremorine-induced rage reaction and sympathetic response in the cat.
Topics: Anger; Animals; Arecoline; Behavior, Animal; Cats; Female; Gallamine Triethiodide; Hypothalamus; Mal | 1972 |
Potential anti-Parkinson drugs designed by receptor mapping.
Topics: Analgesics; Animals; Antiparkinson Agents; Binding Sites; Dopamine; Indenes; Mice; Models, Biologica | 1973 |
Synthesis and anticholinergic properties of 1-Adamant-1-yl-1-phenyl-3-N-pyrrolidino-1-propanol hydrochloride.
Topics: 1-Propanol; Animals; Bridged-Ring Compounds; Cycloparaffins; Guinea Pigs; Ileum; In Vitro Techniques | 1972 |