oxotremorine has been researched along with Hypothermia, Accidental in 26 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oxotremorine is a cholinergic agonist known to induce acute hypothermia." | 7.74 | Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats. ( Grauer, E; Levy, A, 2007) |
| " The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking alpha5 nAChR subunits (alpha5-/-) and compared with those in wild-type (WT) control mice." | 7.72 | Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor. ( Chapman, J; Korczyn, AD; Orr-Urtreger, A; Rabinowitz, R; Wang, N, 2004) |
| "Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens." | 7.68 | Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats. ( Almeida, OM; Santos, R, 1993) |
| "The object of the study was to determine the pharmacological nature of pinacolyl methylphosphonofluoridate (soman)-induced hypothermia in mice." | 7.68 | Pharmacological nature of soman-induced hypothermia in mice. ( Clement, JG, 1993) |
| "A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation." | 7.67 | Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine. ( Boismare, F; Chadelaud, M; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1985) |
| "Pretreatment with atropine (i." | 5.26 | Apomorphine and oxotremorine hypothermia in the pigeon: dopaminergic-cholinergic interaction and the effect of paleostriatal lesions. ( Pyörnilä, A, 1980) |
| " The tests proposed here presuppose a pharmacological interaction (except the Porsolt test) but are simple enough to allow screening: included are antagonism of reserpine hypothermia, ptosis and akinesia; antagonism of effects induced by oxotremorine; antagonism of high-dose apomorphine; and potentiation of yohimbine toxicity." | 4.78 | Is it possible to predict the activity of a new antidepressant in animals with simple psychopharmacological tests? ( Bourin, M, 1990) |
| " Oxotremorine is a cholinergic agonist known to induce acute hypothermia." | 3.74 | Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats. ( Grauer, E; Levy, A, 2007) |
| " We investigated here muscarinic receptor reactivity in NVH lesioned animals by measuring the effects of the muscarinic receptor agonist oxotremorine on physiological responses known to be modulated by these receptors such as body temperature, salivation, tremor, pain, and prepulse inhibition of the acoustic startle (PPI)." | 3.73 | Alterations in behavioral responses to a cholinergic agonist in post-pubertal rats with neonatal ventral hippocampal lesions: relationship to changes in muscarinic receptor levels. ( Laplante, F; Nakagawasai, O; Quirion, R; Srivastava, LK, 2005) |
| " The muscarinic agonist oxotremorine induced marked hypothermia in all the knockout mice, but the hypothermia was reduced in M2 and to a lesser extent in M3 knockout mice." | 3.72 | Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. ( Bymaster, FP; Carter, PA; Felder, CC; Gomeza, J; Hamilton, SE; McKinzie, DL; Nathanson, NM; Wess, J; Yamada, M, 2003) |
| "This study examined the effects of acute and chronic desipramine, 24-h total sleep deprivation (TSD) and 96-h REM sleep deprivation (REMSD) on physostigmine-induced hypothermia, analgesia and behaviour." | 3.72 | Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation. ( Murugaiah, KD; Ukponmwan, OE, 2003) |
| " The effects of oxotremorine (OXO) on autonomic functions and tremor were examined in mice lacking alpha5 nAChR subunits (alpha5-/-) and compared with those in wild-type (WT) control mice." | 3.72 | Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor. ( Chapman, J; Korczyn, AD; Orr-Urtreger, A; Rabinowitz, R; Wang, N, 2004) |
| "The potency of centrally administered non-selective (atropine and N-methyl scopolamine) and putatively selective muscarinic antagonists (pirenzepine, AF-DX 116 and 4-DAMP) in inhibition of oxotremorine-induced hypothermia, tremor and salivation in male mice has been compared with their potency in vitro in three functional systems, where muscarinic effects are mediated preferentially by M1 (i." | 3.69 | The involvement of muscarinic receptor subtypes in the mediation of hypothermia, tremor, and salivation in male mice. ( Lembøl, HL; Sánchez, C, 1994) |
| "Hypothermia and tremor responses of oxotremorine and eserine were studied in rats after several T3 treatment regimens." | 3.68 | Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats. ( Almeida, OM; Santos, R, 1993) |
| "The object of the study was to determine the pharmacological nature of pinacolyl methylphosphonofluoridate (soman)-induced hypothermia in mice." | 3.68 | Pharmacological nature of soman-induced hypothermia in mice. ( Clement, JG, 1993) |
| "5-32 mg kg-1, ip) fully prevented apomorphine (16 mg kg-1, sc)- and partly reversed reserpine- and oxotremorine-induced hypothermia." | 3.68 | Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice. ( Assous, E; Duteil, J; Mangiameli, P; Pointeau, AM; Rambert, FA, 1991) |
| " This effect is especially studied by using antagonism of apomorphine, reserpine, oxotremorine-induced hypothermia." | 3.67 | Psychopharmacological profile of salsolinol. ( Bulach, C; Chermat, R; Dordain, G; Simon, P, 1986) |
| "A peripheral and cerebral cholinergic syndrome was induced in mice by oxotremorine administration; pretreatment orally with cytidine diphosphocholine (CDP-choline) does not potentiate this syndrome and even antagonizes oxotremorine-induced salivation." | 3.67 | Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine. ( Boismare, F; Chadelaud, M; Chretien, P; Daoust, M; Moore, N; Saligaut, C, 1985) |
| "Pretreatment with atropine (i." | 1.26 | Apomorphine and oxotremorine hypothermia in the pigeon: dopaminergic-cholinergic interaction and the effect of paleostriatal lesions. ( Pyörnilä, A, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (34.62) | 18.7374 |
| 1990's | 10 (38.46) | 18.2507 |
| 2000's | 7 (26.92) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bymaster, FP | 2 |
| Carter, PA | 2 |
| Yamada, M | 1 |
| Gomeza, J | 3 |
| Wess, J | 3 |
| Hamilton, SE | 1 |
| Nathanson, NM | 1 |
| McKinzie, DL | 1 |
| Felder, CC | 2 |
| Murugaiah, KD | 1 |
| Ukponmwan, OE | 1 |
| Wang, N | 1 |
| Orr-Urtreger, A | 1 |
| Chapman, J | 1 |
| Rabinowitz, R | 1 |
| Korczyn, AD | 1 |
| Laplante, F | 1 |
| Nakagawasai, O | 1 |
| Srivastava, LK | 1 |
| Quirion, R | 1 |
| Padley, JR | 1 |
| Overstreet, DH | 2 |
| Pilowsky, PM | 1 |
| Goodchild, AK | 1 |
| Grauer, E | 1 |
| Levy, A | 1 |
| Resul, B | 1 |
| Lewander, T | 1 |
| Zetterström, T | 1 |
| Ringdahl, B | 1 |
| Muhi-Eldeen, Z | 1 |
| Dahlbom, R | 1 |
| Pyörnilä, A | 1 |
| Francès, H | 1 |
| Lecrubier, Y | 1 |
| Simon, P | 2 |
| Salmi, P | 1 |
| Karlsson, T | 1 |
| Ahlenius, S | 1 |
| Janowsky, DS | 1 |
| Pucilowski, O | 1 |
| Rezvani, AH | 1 |
| Sánchez, C | 1 |
| Lembøl, HL | 1 |
| Clement, JG | 2 |
| Almeida, OM | 1 |
| Santos, R | 1 |
| Zhang, L | 2 |
| Kostenis, E | 1 |
| Felder, C | 1 |
| Bymaster, F | 1 |
| Brodkin, J | 1 |
| Shannon, H | 1 |
| Xia, B | 1 |
| Deng, C | 1 |
| Falcone, JF | 1 |
| Stengel, PW | 1 |
| Cohen, ML | 1 |
| Shannon, HE | 1 |
| Duteil, J | 1 |
| Rambert, FA | 1 |
| Pointeau, AM | 1 |
| Mangiameli, P | 1 |
| Assous, E | 1 |
| Bourin, M | 1 |
| Nakahara, N | 1 |
| Fujise, N | 1 |
| Kawanishi, G | 1 |
| Mizobe, F | 1 |
| Bulach, C | 1 |
| Dordain, G | 1 |
| Chermat, R | 1 |
| Saligaut, C | 1 |
| Daoust, M | 1 |
| Chadelaud, M | 1 |
| Moore, N | 1 |
| Chretien, P | 1 |
| Boismare, F | 1 |
| Martin, JR | 1 |
| Fuchs, A | 1 |
| Harting, J | 1 |
| Leslie, GB | 1 |
| Hayman, DG | 1 |
| Ireson, JD | 1 |
| Smith, S | 1 |
| Brossi, A | 1 |
| Pool, W | 1 |
| Sheppard, H | 1 |
| Burns, JJ | 1 |
| Kaiser, A | 1 |
| Bigler, R | 1 |
| Bartholini, G | 1 |
| Pletscher, A | 1 |
| Lapin, IP | 1 |
1 review available for oxotremorine and Hypothermia, Accidental
| Article | Year |
|---|---|
Is it possible to predict the activity of a new antidepressant in animals with simple psychopharmacological tests?
Topics: Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Hypothermia; Motor Activity; Oxotremo | 1990 |
25 other studies available for oxotremorine and Hypothermia, Accidental
| Article | Year |
|---|---|
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity.
Topics: Animals; Apomorphine; Body Temperature; Cerebral Cortex; Dopamine Agonists; Dose-Response Relationsh | 2003 |
Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation.
Topics: Adrenergic Uptake Inhibitors; Analgesia; Animals; Body Temperature; Central Nervous System; Desipram | 2003 |
Nicotinic acetylcholine receptor alpha5 subunits modulate oxotremorine-induced salivation and tremor.
Topics: Acetylcholine; Animals; Bradycardia; Defecation; Dose-Response Relationship, Drug; Female; Ganglia, | 2004 |
Alterations in behavioral responses to a cholinergic agonist in post-pubertal rats with neonatal ventral hippocampal lesions: relationship to changes in muscarinic receptor levels.
Topics: Analgesics; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Body Temperature; Female; | 2005 |
Impaired cardiac and sympathetic autonomic control in rats differing in acetylcholine receptor sensitivity.
Topics: Algorithms; Animals; Atropine Derivatives; Baroreflex; Blood Pressure; Electrophysiology; Heart; Hea | 2005 |
Oxotremorine-induced hypothermia as a method for evaluating long-term neuronal changes following poisoning by cholinesterase inhibitors in rats.
Topics: Aldicarb; Animals; Body Temperature; Carbamates; Central Nervous System; Cholinesterase Inhibitors; | 2007 |
Synthesis and pharmacological properties of N-[4-(1-azetidinyl)-2-butynyl]-2-pyrrolidone, a highly potent oxotremorine-like agent.
Topics: Animals; Central Nervous System; Hypothermia; Male; Mice; Oxotremorine; Peripheral Nerves; Tremor | 1980 |
Apomorphine and oxotremorine hypothermia in the pigeon: dopaminergic-cholinergic interaction and the effect of paleostriatal lesions.
Topics: Animals; Apomorphine; Atropine; Body Temperature; Choline; Columbidae; Dopamine; Drug Interactions; | 1980 |
Isolation increases the responses to beta-adrenergic stimulation in mice.
Topics: Albuterol; Animals; Apomorphine; Hypothermia; Male; Mice; Mice, Inbred Strains; Oxotremorine; Social | 1980 |
Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat.
Topics: Amphetamines; Animals; Benzazepines; Body Temperature; Body Temperature Regulation; Chromans; Clonid | 1994 |
Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Depressive Disorder; Disease | 1994 |
The involvement of muscarinic receptor subtypes in the mediation of hypothermia, tremor, and salivation in male mice.
Topics: Animals; Female; Guinea Pigs; Hypothermia; Male; Mice; Mice, Inbred Strains; Muscarinic Antagonists; | 1994 |
Experimentally induced mortality following repeated measurement of rectal temperature in mice.
Topics: Animals; Atropine; Body Temperature; Hypothermia; Male; Mice; Oxotremorine; Receptors, Muscarinic; R | 1993 |
Triiodothyronine (T3) modifies cholinergic-induced hypothermia and tremor in rats.
Topics: Acetylcholinesterase; Animals; Brain; Hyperthyroidism; Hypothermia; Male; Oxotremorine; Parasympatho | 1993 |
Pharmacological nature of soman-induced hypothermia in mice.
Topics: Acetylcholinesterase; Animals; Atropine; Body Temperature; Cholinesterase Inhibitors; Cholinesterase | 1993 |
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesia; Animals; Apomorphine; Brain; | 1999 |
Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice.
Topics: Animals; Carbachol; Cerebral Cortex; Heart; Heart Rate; Humans; Hypothermia; Male; Mice; Mice, Knock | 2001 |
Flerobuterol: a potential antidepressant drug related to beta-adrenergic agonists. Experimental profile in mice.
Topics: Adrenergic beta-Agonists; Albuterol; Analysis of Variance; Animals; Antidepressive Agents; Apomorphi | 1991 |
Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.
Topics: Animals; Avoidance Learning; Hypothermia; Male; Memory; Mice; Oxotremorine; Quinuclidines; Receptors | 1990 |
Psychopharmacological profile of salsolinol.
Topics: Animals; Apomorphine; Behavior, Animal; Hypothermia; Isoquinolines; Male; Mice; Mice, Inbred Strains | 1986 |
Oxotremorine-induced cholinergic syndrome: modifications by levodopa and/or oral cytidine diphosphocholine.
Topics: Administration, Oral; Animals; Choline; Cytidine Diphosphate Choline; Diarrhea; Female; Hypothermia; | 1985 |
Drug induced hypothermia in adult and senescent rats.
Topics: Aging; Animals; Apomorphine; Body Temperature; Female; Hypothermia; Oxotremorine; Rats; Rats, Inbred | 1985 |
The effects of some beta adrenergic blocking agents on the central and peripheral actions of tremorine and oxotremorine.
Topics: Adrenergic beta-Antagonists; Alprenolol; Amino Alcohols; Animals; Atropine; Central Nervous System; | 1972 |
L-DOPA: chemical modifications and biological evaluation.
Topics: Animals; Antiparkinson Agents; Blepharoptosis; Catatonia; Disease Models, Animal; Humans; Hypothermi | 1974 |
Interaction of kynurenine and its metabolites with tryptamine, serotonin and its precursors and oxotremorine.
Topics: Animals; Behavior, Animal; Diarrhea; Drug Antagonism; Drug Interactions; Female; Humans; Hypothermia | 1972 |