oxotremorine has been researched along with Astrocytoma in 4 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of muscarinic cholinergic receptors on 1321N1 human astrocytoma cells results in a 40-70% inhibition of isoproterenol- or prostaglandin E1 (PGE1)-stimulated accumulation of cyclic AMP." | 3.66 | Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation. ( Harden, TK; Meeker, RB, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lazarewicz, JW | 1 |
| Kanje, M | 1 |
| Meeker, RB | 2 |
| Harden, TK | 3 |
| Heng, MM | 1 |
| Brown, JH | 1 |
4 other studies available for oxotremorine and Astrocytoma
| Article | Year |
|---|---|
Effects of neurotransmitters on calcium efflux from cultured glioma cells.
Topics: Astrocytoma; Atropine; Calcium; Calcium Radioisotopes; Carbachol; Cells, Cultured; Cyclic AMP; Cycli | 1981 |
Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Astro | 1982 |
Muscarinic cholinergic receptor-mediated control of cyclic AMP metabolism. Agonist-induced changes in nucleotide synthesis and degradation.
Topics: Alprostadil; Astrocytoma; Carbachol; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Humans | 1983 |
Receptor reserve in the calcium-dependent cyclic AMP response of astrocytoma cells to muscarinic receptor stimulation: demonstration by agonist-induced desensitization, receptor inactivation, and phorbol ester treatment.
Topics: Astrocytoma; Calcium; Carbachol; Cells, Cultured; Cyclic AMP; Inositol Phosphates; Isoproterenol; Ox | 1986 |