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oxotremorine and Aging

oxotremorine has been researched along with Aging in 47 studies

Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" We compared the in vitro sensitivity of acetylcholinesterase, butyrylcholinesterase and [(3)H]oxotremorine-M binding to muscarinic receptors in the cortex and heart of adult (3 months) and aging (18 months) rats to chlorpyrifos, methyl parathion and their active metabolites chlorpyrifos oxon and methyl paraoxon."7.74In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. ( Mirajkar, N; Pope, CN, 2008)
" The present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age)."7.70Differences in central and peripheral responses to oxotremorine in young and aged rats. ( Carlini, EA; Espínola, EB; Oliveira, MG, 1999)
"We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats."7.67Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984)
" The results of oxotremorine treatment suggested that they undergo strong suppression of muscarinic type acetylcholine receptors (mAChRs) functions, and that the damage in the GM3-only mice is due to a mAChR receptor deficit."3.76Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. ( Egashira, N; Fujiwara, M; Fukue, Y; Furukawa, K; Iwasaki, K; Mishima, K; Ohmi, Y; Sugiura, Y; Tajima, O, 2010)
" We compared the in vitro sensitivity of acetylcholinesterase, butyrylcholinesterase and [(3)H]oxotremorine-M binding to muscarinic receptors in the cortex and heart of adult (3 months) and aging (18 months) rats to chlorpyrifos, methyl parathion and their active metabolites chlorpyrifos oxon and methyl paraoxon."3.74In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. ( Mirajkar, N; Pope, CN, 2008)
" The present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age)."3.70Differences in central and peripheral responses to oxotremorine in young and aged rats. ( Carlini, EA; Espínola, EB; Oliveira, MG, 1999)
"We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats."3.67Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984)
" However, in 22MO rats, the behavioral dose-response curve for scopolamine was shifted towards greater sensitivity."1.29Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology. ( Givens, B; Markowska, AL; Olton, DS, 1995)
"oxotremorine) were applied."1.27Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence. ( Dalton, TK; Hunt, WA; Joseph, JA, 1988)
" In young rats, parallel changes in muscarinic receptors and response were noted, but chronic administration of cholinergic drugs to senescent animals had no effect."1.27Pharmacological adaptations and muscarinic receptor plasticity in hypothalamus of senescent rats treated chronically with cholinergic drugs. ( Pedigo, NW, 1988)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199018 (38.30)18.7374
1990's18 (38.30)18.2507
2000's8 (17.02)29.6817
2010's3 (6.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Milan, L1
Courtand, G1
Cardoit, L1
Masmejean, F1
Barrière, G1
Cazalets, JR1
Garret, M1
Bertrand, SS1
Mirajkar, N1
Pope, CN1
Tajima, O1
Egashira, N1
Ohmi, Y1
Fukue, Y1
Mishima, K1
Iwasaki, K1
Fujiwara, M1
Sugiura, Y1
Furukawa, K2
McQuail, JA1
Davis, KN1
Miller, F1
Hampson, RE1
Deadwyler, SA1
Howlett, AC1
Nicolle, MM2
Birthelmer, A3
Stemmelin, J1
Jackisch, R4
Cassel, JC3
Lazaris, A2
Schweizer, T1
Zhang, HY1
Watson, ML1
Gallagher, M1
Whalley, BJ1
Constanti, A1
Karanth, S1
Liu, J1
Ray, A1
Pope, C1
Meyer, EM1
St Onge, E1
Crews, FT1
Cox, B1
Lee, TF1
Parkes, J1
Knowles, WD1
Phillips, MI1
Pedigo, NW3
Minor, LD1
Krumrei, TN1
Dam, M1
Rapoport, SI1
London, ED1
Joseph, JA9
Cao, G1
Cutler, RC1
Kelly, JF1
Denisova, NA1
Erat, S1
Mason, RP1
Roth, GS5
Markowska, AL2
Olton, DS2
Givens, B1
Pang, K1
Williams, MJ1
Hunt, WA3
Rabin, BM1
Dalton, TK3
Harris, AH1
Shibata, S1
Kodama, K1
Koga, Y1
Ueki, S1
Watanabe, S1
Frick, KM1
Gorman, LK1
Klemfuss, H1
Gillin, JC1
Overstreet, DH2
Daws, LC2
Schiller, GD2
Orbach, J2
Janowsky, DS1
Espínola, EB1
Oliveira, MG1
Carlini, EA1
Kimura, I1
Nojima, H1
Islam, MA1
Fisher, DR1
Strain, J1
DasGupta, K1
Weiler, MH1
Yamagami, K1
Feuerstein, TJ1
Lehmann, J1
Sauermann, W1
van Velthoven, V1
Kowatch, MA1
Maki, T1
Fagioli, S2
Consorti, D2
Pavone, F2
Wagster, MV1
Whitehouse, PJ1
Walker, LC1
Kellar, KJ1
Price, DL1
Kochman, K1
Ordway, GA1
Esbenshade, TA1
Kolta, MG1
Gerald, MC1
Wallace, LJ1
Consolo, S1
Wang, JX1
Fiorentini, F1
Vezzani, A1
Ladinsky, H1
Pilch, H1
Müller, WE2
Castellano, C1
Oliverio, A1
Schwab, C1
Brueckner, G1
Biesold, D1
Retz, KC1
Forster, MJ1
Frantz, N1
Lal, H1
Bering, B1
Martin, JR1
Fuchs, A1
Harting, J1
Polk, DM1

Other Studies

47 other studies available for oxotremorine and Aging

ArticleYear
Age-Related Changes in Pre- and Postsynaptic Partners of the Cholinergic C-Boutons in Wild-Type and SOD1G93A Lumbar Motoneurons.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Aging; Animals; Animals, Newborn; Cholinergic Neurons; Immunohistochemistry; Interneurons; Lumbar Ve

2015
In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases.
    Biochemical pharmacology, 2008, Oct-15, Volume: 76, Issue:8

    Topics: Acetylcholinesterase; Aging; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibit

2008
Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice.
    Behavioural brain research, 2010, Jan-05, Volume: 206, Issue:1

    Topics: Age Factors; Aging; Animals; Body Weight; Brain; Maze Learning; Mice; Mice, Knockout; Motor Skills;

2010
Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.
    Neuropharmacology, 2013, Volume: 70

    Topics: Aging; Animals; Baclofen; CA1 Region, Hippocampal; Calcium; Excitatory Amino Acid Agonists; GABA-B R

2013
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
    Brain research bulletin, 2003, May-15, Volume: 60, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging;

2003
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate

2003
Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats.
    Neurobiology of aging, 2007, Volume: 28, Issue:4

    Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Cell Membrane; Dose-Response Re

2007
Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: relevance to epileptiform bursting susceptibility.
    Neuroscience, 2006, Jul-07, Volume: 140, Issue:3

    Topics: Action Potentials; Aging; Animals; Animals, Newborn; Causality; Epilepsy; Excitatory Postsynaptic Po

2006
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices.
    Neurobiology of aging, 2007, Volume: 28, Issue:8

    Topics: Acetylcholine; Age Factors; Aging; Animals; Behavior, Animal; Cholinesterase Inhibitors; Corpus Stri

2007
Comparative in vivo effects of parathion on striatal acetylcholine accumulation in adult and aged rats.
    Toxicology, 2007, Oct-08, Volume: 239, Issue:3

    Topics: Acetylcholine; Aging; Animals; Binding, Competitive; Cholinesterase Inhibitors; Corpus Striatum; Def

2007
Effects of aging on rat cortical presynaptic cholinergic processes.
    Neurobiology of aging, 1984,Winter, Volume: 5, Issue:4

    Topics: Acetylcholine; Aging; Animals; Atropine; Cerebral Cortex; Choline; Culture Techniques; Dose-Response

1984
Decreased ability to cope with heat and cold linked to a dysfunction in a central dopaminergic pathway in elderly rats.
    Life sciences, 1981, May-04, Volume: 28, Issue:18

    Topics: Age Factors; Aging; Amphetamines; Animals; Apomorphine; Body Temperature Regulation; Dopamine; Male;

1981
Neurophysiological and behavioral maturation of cerebellar function studied with tremorogenic drugs.
    Neuropharmacology, 1980, Volume: 19, Issue:8

    Topics: Action Potentials; Aging; Alkaloids; Animals; Animals, Newborn; Cerebellum; Harmaline; Nerve Fibers;

1980
Cholinergic drug effects and brain muscarinic receptor binding in aged rats.
    Neurobiology of aging, 1984,Fall, Volume: 5, Issue:3

    Topics: Aging; Animals; Male; Motor Activity; Oxotremorine; Pain; Quinuclidinyl Benzilate; Rats; Rats, Inbre

1984
Aging and cholinergic system: a 2-deoxyglucose study in the rat brain.
    Monographs in neural sciences, 1984, Volume: 11

    Topics: Aging; Animals; Autoradiography; Blood Glucose; Brain; Deoxyglucose; Energy Metabolism; Male; Oxotre

1984
In vivo or in vitro administration of the nitrone spin-trapping compound, n-tert-butyl-alpha-phenylnitrone, (PBN) reduces age-related deficits in striatal muscarinic receptor sensitivity.
    Brain research, 1995, Feb-06, Volume: 671, Issue:1

    Topics: Aging; Animals; Cyclic N-Oxides; Dopamine; Muscarinic Agonists; Neostriatum; Nitrogen Oxides; Oxidat

1995
Dissociation of striatal GTPase and dopamine release responses to muscarinic cholinergic agonists in F344 rats: influence of age and dietary manipulation.
    Journal of neurochemistry, 1995, Volume: 64, Issue:6

    Topics: Aging; Animals; Carbachol; Cholesterol; Cholinergic Agents; Corpus Striatum; Diet; Dopamine; GTP Pho

1995
Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:3 Pt 1

    Topics: Aging; Animals; Cholinergic Agonists; Cholinergic Antagonists; Electrophysiology; Evoked Potentials;

1995
Activation of the medial septal area attenuates LTP of the lateral perforant path and enhances heterosynaptic LTD of the medial perforant path in aged rats.
    Brain research, 1993, Dec-31, Volume: 632, Issue:1-2

    Topics: Aging; Animals; Electric Stimulation; Evoked Potentials; Female; Frontal Lobe; Hippocampus; Infusion

1993
Deficits in the sensitivity of striatal muscarinic receptors induced by 56Fe heavy-particle irradiation: further "age-radiation" parallels.
    Radiation research, 1993, Volume: 135, Issue:2

    Topics: Aging; Animals; Calcimycin; Calcium; Corpus Striatum; Dopamine; Inositol 1,4,5-Trisphosphate; Iron R

1993
Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats.
    Brain research, 1993, Feb-19, Volume: 603, Issue:2

    Topics: Acetylcholine; Aging; Animals; Aziridines; Cerebral Cortex; Cerebral Ventricles; Choline; Deoxygluco

1993
Oxotremorine infusions into the medial septal area of middle-aged rats affect spatial reference memory and ChAT activity.
    Behavioural brain research, 1996, Volume: 80, Issue:1-2

    Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Cholinergic Agonists; Discrimination, Psychologi

1996
Neonatal scopolamine or antidepressant treatment: effect on development of hamster circadian rhythms.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents; Circadian Rhythm; Cricetinae; Female; Male;

1998
Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Body Temperature Regulation; Depressive Diso

1998
Differences in central and peripheral responses to oxotremorine in young and aged rats.
    Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:3

    Topics: Aging; Animals; Central Nervous System; Corpus Striatum; Dacryocystitis; Muscarinic Agonists; Oxotre

1999
[The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentia

1998
Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells.
    Free radical biology & medicine, 2002, Jan-15, Volume: 32, Issue:2

    Topics: Aging; Animals; Antioxidants; Calcium; Calcium Channel Blockers; Cell Survival; Chlorocebus aethiops

2002
Age-related differences in the phosphoinositide system in rat neostriatum.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:2

    Topics: Aging; Animals; Corpus Striatum; In Vitro Techniques; Inositol; Lithium; Male; Oxotremorine; Phospha

1992
Decrement of muscarinic receptor-stimulated low-KM GTPase in striatum and hippocampus from the aged rat.
    Brain research, 1992, Apr-03, Volume: 576, Issue:2

    Topics: Aging; Animals; Blotting, Western; Carbachol; Cell Membrane; Corpus Striatum; GTP Phosphohydrolases;

1992
The autoinhibitory feedback control of acetylcholine release in human neocortex tissue.
    Brain research, 1992, Feb-14, Volume: 572, Issue:1-2

    Topics: Acetylcholine; Aging; Atropine; Cerebral Cortex; Electric Stimulation; Feedback; Humans; In Vitro Te

1992
Selective cross-activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata.
    Brain research, 1990, Dec-24, Volume: 537, Issue:1-2

    Topics: Aging; Animals; Arachidonic Acid; Arachidonic Acids; Biotransformation; Carbachol; Corpus Striatum;

1990
Early development of muscarinic supersensitivity in a genetic animal model of depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1991, Volume: 4, Issue:3

    Topics: Aging; Animals; Atropine Derivatives; Body Temperature; Body Weight; Brain; Depression; Disease Mode

1991
Age-related cholinergic drug effects on analgesia in two inbred strains of mice.
    Brain research, 1990, Feb-26, Volume: 510, Issue:1

    Topics: Aging; Analgesia; Animals; Cholinergic Fibers; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oxo

1990
Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:9

    Topics: Aging; Animals; Autoradiography; Macaca mulatta; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rec

1990
Reduction of motor behavioural deficits in senescence via chronic prolactin or estrogen administration: time course and putative mechanisms of action.
    Brain research, 1989, Dec-29, Volume: 505, Issue:2

    Topics: Aging; Animals; Corpus Striatum; Dopamine; Estrogens; Female; Male; Motor Activity; Oxotremorine; Pr

1989
Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice.
    Brain research. Developmental brain research, 1989, Sep-01, Volume: 49, Issue:1

    Topics: Aging; Analgesia; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, I

1989
Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder.
    The Journal of urology, 1986, Volume: 136, Issue:2

    Topics: Acetylcholine; Aging; Animals; Atropine; Bethanechol; Bethanechol Compounds; Male; Muscle Contractio

1986
Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence.
    Brain research, 1988, Jun-28, Volume: 454, Issue:1-2

    Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Cholinergic Fibers; Corpus Striatum;

1988
In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats.
    Brain research, 1986, May-28, Volume: 374, Issue:2

    Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Cholinergic Fibers; Corpus S

1986
Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice.
    Psychopharmacology, 1988, Volume: 94, Issue:1

    Topics: Aging; Animals; Atropine; Cerebral Cortex; Female; Male; Mice; Oxotremorine; Piracetam; Pyrrolidinon

1988
Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand-muscarinic receptor interface?
    Brain research, 1988, Jun-28, Volume: 454, Issue:1-2

    Topics: Aging; Animals; Calcimycin; Corpus Striatum; Dopamine; In Vitro Techniques; Inositol 1,4,5-Trisphosp

1988
Pharmacological adaptations and muscarinic receptor plasticity in hypothalamus of senescent rats treated chronically with cholinergic drugs.
    Psychopharmacology, 1988, Volume: 95, Issue:4

    Topics: Adaptation, Psychological; Aging; Animals; Atropine Derivatives; Hypothalamus; Male; Oxotremorine; P

1988
Age-dependent differences in cholinergic drug response in two strains of mice.
    Neuroscience letters, 1988, Feb-03, Volume: 84, Issue:3

    Topics: Aging; Animals; Brain; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Nicotine; Oxotrem

1988
Differences in behavioral responses to oxotremorine and physostigmine in New Zealand black (NZB/BlNJ) and C57BL/6 mice.
    Neuropharmacology, 1987, Volume: 26, Issue:5

    Topics: Aging; Animals; Autonomic Nervous System; Body Temperature; Brain; Cholinergic Fibers; Male; Mice; M

1987
Stereospecific 3H-QNB binding to human erythrocyte membranes associated with muscarinic cholinergic receptors.
    Journal of neural transmission, 1987, Volume: 68, Issue:1-2

    Topics: Adult; Aging; Animals; Atropine; Brain; Carbachol; Erythrocyte Membrane; Female; Guanylyl Imidodipho

1987
Drug induced hypothermia in adult and senescent rats.
    Neurobiology of aging, 1985,Summer, Volume: 6, Issue:2

    Topics: Aging; Animals; Apomorphine; Body Temperature; Female; Hypothermia; Oxotremorine; Rats; Rats, Inbred

1985
Reduced muscarinic receptor plasticity in frontal cortex of aged rats after chronic administration of cholinergic drugs.
    Life sciences, 1985, Oct-14, Volume: 37, Issue:15

    Topics: Adaptation, Physiological; Aging; Animals; Atropine Derivatives; Cerebral Cortex; Male; Oxotremorine

1985