oxotremorine has been researched along with Aging in 47 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We compared the in vitro sensitivity of acetylcholinesterase, butyrylcholinesterase and [(3)H]oxotremorine-M binding to muscarinic receptors in the cortex and heart of adult (3 months) and aging (18 months) rats to chlorpyrifos, methyl parathion and their active metabolites chlorpyrifos oxon and methyl paraoxon." | 7.74 | In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. ( Mirajkar, N; Pope, CN, 2008) |
| " The present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age)." | 7.70 | Differences in central and peripheral responses to oxotremorine in young and aged rats. ( Carlini, EA; Espínola, EB; Oliveira, MG, 1999) |
| "We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats." | 7.67 | Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984) |
| " The results of oxotremorine treatment suggested that they undergo strong suppression of muscarinic type acetylcholine receptors (mAChRs) functions, and that the damage in the GM3-only mice is due to a mAChR receptor deficit." | 3.76 | Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. ( Egashira, N; Fujiwara, M; Fukue, Y; Furukawa, K; Iwasaki, K; Mishima, K; Ohmi, Y; Sugiura, Y; Tajima, O, 2010) |
| " We compared the in vitro sensitivity of acetylcholinesterase, butyrylcholinesterase and [(3)H]oxotremorine-M binding to muscarinic receptors in the cortex and heart of adult (3 months) and aging (18 months) rats to chlorpyrifos, methyl parathion and their active metabolites chlorpyrifos oxon and methyl paraoxon." | 3.74 | In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. ( Mirajkar, N; Pope, CN, 2008) |
| " The present article investigated central responses (tremor) and peripheral responses (chromodacryorrhea) subsequent to the administration of oxotremorine to young (3-6 months of age) and aged rats (24-30 months of age)." | 3.70 | Differences in central and peripheral responses to oxotremorine in young and aged rats. ( Carlini, EA; Espínola, EB; Oliveira, MG, 1999) |
| "We studied the effects of aging on the [3H]-choline uptake, acetylation, [3H]-ACh release and muscarinic modulation of [3H]-ACh release in cortical synaptosomes prepared from Fischer 344 male rats." | 3.67 | Effects of aging on rat cortical presynaptic cholinergic processes. ( Crews, FT; Meyer, EM; St Onge, E, 1984) |
| " However, in 22MO rats, the behavioral dose-response curve for scopolamine was shifted towards greater sensitivity." | 1.29 | Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology. ( Givens, B; Markowska, AL; Olton, DS, 1995) |
| "oxotremorine) were applied." | 1.27 | Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence. ( Dalton, TK; Hunt, WA; Joseph, JA, 1988) |
| " In young rats, parallel changes in muscarinic receptors and response were noted, but chronic administration of cholinergic drugs to senescent animals had no effect." | 1.27 | Pharmacological adaptations and muscarinic receptor plasticity in hypothalamus of senescent rats treated chronically with cholinergic drugs. ( Pedigo, NW, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (38.30) | 18.7374 |
| 1990's | 18 (38.30) | 18.2507 |
| 2000's | 8 (17.02) | 29.6817 |
| 2010's | 3 (6.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Milan, L | 1 |
| Courtand, G | 1 |
| Cardoit, L | 1 |
| Masmejean, F | 1 |
| Barrière, G | 1 |
| Cazalets, JR | 1 |
| Garret, M | 1 |
| Bertrand, SS | 1 |
| Mirajkar, N | 1 |
| Pope, CN | 1 |
| Tajima, O | 1 |
| Egashira, N | 1 |
| Ohmi, Y | 1 |
| Fukue, Y | 1 |
| Mishima, K | 1 |
| Iwasaki, K | 1 |
| Fujiwara, M | 1 |
| Sugiura, Y | 1 |
| Furukawa, K | 2 |
| McQuail, JA | 1 |
| Davis, KN | 1 |
| Miller, F | 1 |
| Hampson, RE | 1 |
| Deadwyler, SA | 1 |
| Howlett, AC | 1 |
| Nicolle, MM | 2 |
| Birthelmer, A | 3 |
| Stemmelin, J | 1 |
| Jackisch, R | 4 |
| Cassel, JC | 3 |
| Lazaris, A | 2 |
| Schweizer, T | 1 |
| Zhang, HY | 1 |
| Watson, ML | 1 |
| Gallagher, M | 1 |
| Whalley, BJ | 1 |
| Constanti, A | 1 |
| Karanth, S | 1 |
| Liu, J | 1 |
| Ray, A | 1 |
| Pope, C | 1 |
| Meyer, EM | 1 |
| St Onge, E | 1 |
| Crews, FT | 1 |
| Cox, B | 1 |
| Lee, TF | 1 |
| Parkes, J | 1 |
| Knowles, WD | 1 |
| Phillips, MI | 1 |
| Pedigo, NW | 3 |
| Minor, LD | 1 |
| Krumrei, TN | 1 |
| Dam, M | 1 |
| Rapoport, SI | 1 |
| London, ED | 1 |
| Joseph, JA | 9 |
| Cao, G | 1 |
| Cutler, RC | 1 |
| Kelly, JF | 1 |
| Denisova, NA | 1 |
| Erat, S | 1 |
| Mason, RP | 1 |
| Roth, GS | 5 |
| Markowska, AL | 2 |
| Olton, DS | 2 |
| Givens, B | 1 |
| Pang, K | 1 |
| Williams, MJ | 1 |
| Hunt, WA | 3 |
| Rabin, BM | 1 |
| Dalton, TK | 3 |
| Harris, AH | 1 |
| Shibata, S | 1 |
| Kodama, K | 1 |
| Koga, Y | 1 |
| Ueki, S | 1 |
| Watanabe, S | 1 |
| Frick, KM | 1 |
| Gorman, LK | 1 |
| Klemfuss, H | 1 |
| Gillin, JC | 1 |
| Overstreet, DH | 2 |
| Daws, LC | 2 |
| Schiller, GD | 2 |
| Orbach, J | 2 |
| Janowsky, DS | 1 |
| Espínola, EB | 1 |
| Oliveira, MG | 1 |
| Carlini, EA | 1 |
| Kimura, I | 1 |
| Nojima, H | 1 |
| Islam, MA | 1 |
| Fisher, DR | 1 |
| Strain, J | 1 |
| DasGupta, K | 1 |
| Weiler, MH | 1 |
| Yamagami, K | 1 |
| Feuerstein, TJ | 1 |
| Lehmann, J | 1 |
| Sauermann, W | 1 |
| van Velthoven, V | 1 |
| Kowatch, MA | 1 |
| Maki, T | 1 |
| Fagioli, S | 2 |
| Consorti, D | 2 |
| Pavone, F | 2 |
| Wagster, MV | 1 |
| Whitehouse, PJ | 1 |
| Walker, LC | 1 |
| Kellar, KJ | 1 |
| Price, DL | 1 |
| Kochman, K | 1 |
| Ordway, GA | 1 |
| Esbenshade, TA | 1 |
| Kolta, MG | 1 |
| Gerald, MC | 1 |
| Wallace, LJ | 1 |
| Consolo, S | 1 |
| Wang, JX | 1 |
| Fiorentini, F | 1 |
| Vezzani, A | 1 |
| Ladinsky, H | 1 |
| Pilch, H | 1 |
| Müller, WE | 2 |
| Castellano, C | 1 |
| Oliverio, A | 1 |
| Schwab, C | 1 |
| Brueckner, G | 1 |
| Biesold, D | 1 |
| Retz, KC | 1 |
| Forster, MJ | 1 |
| Frantz, N | 1 |
| Lal, H | 1 |
| Bering, B | 1 |
| Martin, JR | 1 |
| Fuchs, A | 1 |
| Harting, J | 1 |
| Polk, DM | 1 |
47 other studies available for oxotremorine and Aging
| Article | Year |
|---|---|
Age-Related Changes in Pre- and Postsynaptic Partners of the Cholinergic C-Boutons in Wild-Type and SOD1G93A Lumbar Motoneurons.
Topics: Aging; Animals; Animals, Newborn; Cholinergic Neurons; Immunohistochemistry; Interneurons; Lumbar Ve | 2015 |
In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases.
Topics: Acetylcholinesterase; Aging; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibit | 2008 |
Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice.
Topics: Age Factors; Aging; Animals; Body Weight; Brain; Maze Learning; Mice; Mice, Knockout; Motor Skills; | 2010 |
Hippocampal Gαq/₁₁ but not Gαo-coupled receptors are altered in aging.
Topics: Aging; Animals; Baclofen; CA1 Region, Hippocampal; Calcium; Excitatory Amino Acid Agonists; GABA-B R | 2013 |
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; | 2003 |
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate | 2003 |
Muscarinic receptor-mediated GTP-Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Cell Membrane; Dose-Response Re | 2007 |
Developmental changes in presynaptic muscarinic modulation of excitatory and inhibitory neurotransmission in rat piriform cortex in vitro: relevance to epileptiform bursting susceptibility.
Topics: Action Potentials; Aging; Animals; Animals, Newborn; Causality; Epilepsy; Excitatory Postsynaptic Po | 2006 |
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices.
Topics: Acetylcholine; Age Factors; Aging; Animals; Behavior, Animal; Cholinesterase Inhibitors; Corpus Stri | 2007 |
Comparative in vivo effects of parathion on striatal acetylcholine accumulation in adult and aged rats.
Topics: Acetylcholine; Aging; Animals; Binding, Competitive; Cholinesterase Inhibitors; Corpus Striatum; Def | 2007 |
Effects of aging on rat cortical presynaptic cholinergic processes.
Topics: Acetylcholine; Aging; Animals; Atropine; Cerebral Cortex; Choline; Culture Techniques; Dose-Response | 1984 |
Decreased ability to cope with heat and cold linked to a dysfunction in a central dopaminergic pathway in elderly rats.
Topics: Age Factors; Aging; Amphetamines; Animals; Apomorphine; Body Temperature Regulation; Dopamine; Male; | 1981 |
Neurophysiological and behavioral maturation of cerebellar function studied with tremorogenic drugs.
Topics: Action Potentials; Aging; Alkaloids; Animals; Animals, Newborn; Cerebellum; Harmaline; Nerve Fibers; | 1980 |
Cholinergic drug effects and brain muscarinic receptor binding in aged rats.
Topics: Aging; Animals; Male; Motor Activity; Oxotremorine; Pain; Quinuclidinyl Benzilate; Rats; Rats, Inbre | 1984 |
Aging and cholinergic system: a 2-deoxyglucose study in the rat brain.
Topics: Aging; Animals; Autoradiography; Blood Glucose; Brain; Deoxyglucose; Energy Metabolism; Male; Oxotre | 1984 |
In vivo or in vitro administration of the nitrone spin-trapping compound, n-tert-butyl-alpha-phenylnitrone, (PBN) reduces age-related deficits in striatal muscarinic receptor sensitivity.
Topics: Aging; Animals; Cyclic N-Oxides; Dopamine; Muscarinic Agonists; Neostriatum; Nitrogen Oxides; Oxidat | 1995 |
Dissociation of striatal GTPase and dopamine release responses to muscarinic cholinergic agonists in F344 rats: influence of age and dietary manipulation.
Topics: Aging; Animals; Carbachol; Cholesterol; Cholinergic Agents; Corpus Striatum; Diet; Dopamine; GTP Pho | 1995 |
Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology.
Topics: Aging; Animals; Cholinergic Agonists; Cholinergic Antagonists; Electrophysiology; Evoked Potentials; | 1995 |
Activation of the medial septal area attenuates LTP of the lateral perforant path and enhances heterosynaptic LTD of the medial perforant path in aged rats.
Topics: Aging; Animals; Electric Stimulation; Evoked Potentials; Female; Frontal Lobe; Hippocampus; Infusion | 1993 |
Deficits in the sensitivity of striatal muscarinic receptors induced by 56Fe heavy-particle irradiation: further "age-radiation" parallels.
Topics: Aging; Animals; Calcimycin; Calcium; Corpus Striatum; Dopamine; Inositol 1,4,5-Trisphosphate; Iron R | 1993 |
Improving effect of acetylcholine receptor agonists on a deficit of 2-deoxyglucose uptake in cerebral cortical and hippocampal slices in aged and AF64A-treated rats.
Topics: Acetylcholine; Aging; Animals; Aziridines; Cerebral Cortex; Cerebral Ventricles; Choline; Deoxygluco | 1993 |
Oxotremorine infusions into the medial septal area of middle-aged rats affect spatial reference memory and ChAT activity.
Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Cholinergic Agonists; Discrimination, Psychologi | 1996 |
Neonatal scopolamine or antidepressant treatment: effect on development of hamster circadian rhythms.
Topics: Aging; Animals; Animals, Newborn; Antidepressive Agents; Circadian Rhythm; Cricetinae; Female; Male; | 1998 |
Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Body Temperature Regulation; Depressive Diso | 1998 |
Differences in central and peripheral responses to oxotremorine in young and aged rats.
Topics: Aging; Animals; Central Nervous System; Corpus Striatum; Dacryocystitis; Muscarinic Agonists; Oxotre | 1999 |
[The involvement of muscarinic M1 receptor in the regulation of action potentials in mouse isolated right atria].
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Acetylcholine; Action Potentia | 1998 |
Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells.
Topics: Aging; Animals; Antioxidants; Calcium; Calcium Channel Blockers; Cell Survival; Chlorocebus aethiops | 2002 |
Age-related differences in the phosphoinositide system in rat neostriatum.
Topics: Aging; Animals; Corpus Striatum; In Vitro Techniques; Inositol; Lithium; Male; Oxotremorine; Phospha | 1992 |
Decrement of muscarinic receptor-stimulated low-KM GTPase in striatum and hippocampus from the aged rat.
Topics: Aging; Animals; Blotting, Western; Carbachol; Cell Membrane; Corpus Striatum; GTP Phosphohydrolases; | 1992 |
The autoinhibitory feedback control of acetylcholine release in human neocortex tissue.
Topics: Acetylcholine; Aging; Atropine; Cerebral Cortex; Electric Stimulation; Feedback; Humans; In Vitro Te | 1992 |
Selective cross-activation/inhibition of second messenger systems and the reduction of age-related deficits in the muscarinic control of dopamine release from perifused rat striata.
Topics: Aging; Animals; Arachidonic Acid; Arachidonic Acids; Biotransformation; Carbachol; Corpus Striatum; | 1990 |
Early development of muscarinic supersensitivity in a genetic animal model of depression.
Topics: Aging; Animals; Atropine Derivatives; Body Temperature; Body Weight; Brain; Depression; Disease Mode | 1991 |
Age-related cholinergic drug effects on analgesia in two inbred strains of mice.
Topics: Aging; Analgesia; Animals; Cholinergic Fibers; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oxo | 1990 |
Laminar organization and age-related loss of cholinergic receptors in temporal neocortex of rhesus monkey.
Topics: Aging; Animals; Autoradiography; Macaca mulatta; N-Methylscopolamine; Oxotremorine; Pirenzepine; Rec | 1990 |
Reduction of motor behavioural deficits in senescence via chronic prolactin or estrogen administration: time course and putative mechanisms of action.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Estrogens; Female; Male; Motor Activity; Oxotremorine; Pr | 1989 |
Developmental differences of antinociceptive effects of oxotremorine in two inbred strains of mice.
Topics: Aging; Analgesia; Animals; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Mice, I | 1989 |
Effect of age on cholinergic muscarinic responsiveness and receptors in the rat urinary bladder.
Topics: Acetylcholine; Aging; Animals; Atropine; Bethanechol; Bethanechol Compounds; Male; Muscle Contractio | 1986 |
Age-related decrements in the muscarinic enhancement of K+-evoked release of endogenous striatal dopamine: an indicator of altered cholinergic-dopaminergic reciprocal inhibitory control in senescence.
Topics: Aging; Animals; Bethanechol; Bethanechol Compounds; Carbachol; Cholinergic Fibers; Corpus Striatum; | 1988 |
In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats.
Topics: Acetylcholine; Aging; Animals; Brain; Brain Chemistry; Cerebral Cortex; Cholinergic Fibers; Corpus S | 1986 |
Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice.
Topics: Aging; Animals; Atropine; Cerebral Cortex; Female; Male; Mice; Oxotremorine; Piracetam; Pyrrolidinon | 1988 |
Alterations in muscarinic control of striatal dopamine autoreceptors in senescence: a deficit at the ligand-muscarinic receptor interface?
Topics: Aging; Animals; Calcimycin; Corpus Striatum; Dopamine; In Vitro Techniques; Inositol 1,4,5-Trisphosp | 1988 |
Pharmacological adaptations and muscarinic receptor plasticity in hypothalamus of senescent rats treated chronically with cholinergic drugs.
Topics: Adaptation, Psychological; Aging; Animals; Atropine Derivatives; Hypothalamus; Male; Oxotremorine; P | 1988 |
Age-dependent differences in cholinergic drug response in two strains of mice.
Topics: Aging; Animals; Brain; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Nicotine; Oxotrem | 1988 |
Differences in behavioral responses to oxotremorine and physostigmine in New Zealand black (NZB/BlNJ) and C57BL/6 mice.
Topics: Aging; Animals; Autonomic Nervous System; Body Temperature; Brain; Cholinergic Fibers; Male; Mice; M | 1987 |
Stereospecific 3H-QNB binding to human erythrocyte membranes associated with muscarinic cholinergic receptors.
Topics: Adult; Aging; Animals; Atropine; Brain; Carbachol; Erythrocyte Membrane; Female; Guanylyl Imidodipho | 1987 |
Drug induced hypothermia in adult and senescent rats.
Topics: Aging; Animals; Apomorphine; Body Temperature; Female; Hypothermia; Oxotremorine; Rats; Rats, Inbred | 1985 |
Reduced muscarinic receptor plasticity in frontal cortex of aged rats after chronic administration of cholinergic drugs.
Topics: Adaptation, Physiological; Aging; Animals; Atropine Derivatives; Cerebral Cortex; Male; Oxotremorine | 1985 |