oxotremorine has been researched along with Acute Confusional Senile Dementia in 25 studies
Oxotremorine: A non-hydrolyzed muscarinic agonist used as a research tool.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Current treatment of Alzheimer's Disease (AD) requires acetylcholinesterase inhibition to increase acetylcholine (ACh) concentrations in the synaptic cleft." | 1.31 | Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788. ( Billard, W; Binch, H; Clader, J; Coffin, V; Cohen-Williams, M; Crosby, G; Duffy, RA; Kozlowski, J; Lachowicz, JE; Ruperto, V; Strader, CD; Zhou, G, 2001) |
| " Nicotine enhanced release, with a bell-shaped dose-response curve." | 1.29 | Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function. ( Potter, PE; Thorne, B, 1995) |
| "In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effects on cognitive function." | 1.27 | Induction of depression with oxotremorine in patients with Alzheimer's disease. ( Davidson, M; Davis, BM; Davis, KL; Hollander, E; Horvath, TB; Mohs, RC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 14 (56.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jenkins, SM | 1 |
| Wadsworth, HJ | 1 |
| Bromidge, S | 1 |
| Orlek, BS | 2 |
| Wyman, PA | 1 |
| Riley, GJ | 2 |
| Hawkins, J | 2 |
| Klein, JT | 2 |
| Davis, L | 2 |
| Olsen, GE | 2 |
| Wong, GS | 1 |
| Huger, FP | 2 |
| Smith, CP | 2 |
| Petko, WW | 2 |
| Cornfeldt, M | 2 |
| Wilker, JC | 1 |
| Blitzer, RD | 1 |
| Landau, E | 1 |
| Haroutunian, V | 2 |
| Martin, LL | 1 |
| Effland, RC | 2 |
| Kapples, KJ | 1 |
| Bromidge, SM | 1 |
| Brown, F | 1 |
| Cassidy, F | 1 |
| Clark, MS | 1 |
| Dabbs, S | 1 |
| Hadley, MS | 1 |
| Loudon, JM | 1 |
| Naylor, CB | 1 |
| Overk, CR | 1 |
| Felder, CC | 3 |
| Tu, Y | 1 |
| Schober, DA | 1 |
| Bales, KR | 1 |
| Wuu, J | 1 |
| Mufson, EJ | 1 |
| Joseph, JA | 1 |
| Fisher, DR | 1 |
| Carey, AN | 1 |
| Greenwald, BS | 1 |
| Davis, KL | 3 |
| Wood, PL | 1 |
| Etienne, P | 1 |
| Lal, S | 1 |
| Nair, NP | 1 |
| Finlayson, MH | 1 |
| Gauthier, S | 1 |
| Palo, J | 1 |
| Haltia, M | 1 |
| Paetau, A | 1 |
| Bird, ED | 1 |
| London, ED | 1 |
| McKinney, M | 1 |
| Dam, M | 1 |
| Ellis, A | 1 |
| Coyle, JT | 1 |
| Thorne, B | 1 |
| Potter, PE | 1 |
| Ferrari-DiLeo, G | 1 |
| Mash, DC | 2 |
| Flynn, DD | 2 |
| Hérnandez-Hérnandez, A | 1 |
| Adem, A | 1 |
| Ravid, R | 2 |
| Cowburn, RF | 2 |
| Wiehager, B | 1 |
| Winblad, B | 1 |
| Plate, R | 1 |
| Plaum, MJ | 1 |
| de Boer, T | 1 |
| Andrews, JS | 1 |
| Rae, DR | 1 |
| Gibson, S | 1 |
| Lachowicz, JE | 2 |
| Lowe, D | 1 |
| Duffy, RA | 2 |
| Ruperto, V | 2 |
| Taylor, LA | 1 |
| Guzik, H | 1 |
| Brown, J | 1 |
| Berger, JG | 1 |
| Tice, M | 1 |
| McQuade, R | 1 |
| Kozlowski, J | 2 |
| Clader, J | 2 |
| Strader, CD | 2 |
| Murgolo, N | 1 |
| Ladner, CJ | 1 |
| Lee, JM | 1 |
| Albrecht, C | 1 |
| Bloss, HG | 1 |
| Jackisch, R | 1 |
| Feuerstein, TJ | 1 |
| Zhou, G | 1 |
| Billard, W | 1 |
| Binch, H | 1 |
| Crosby, G | 1 |
| Cohen-Williams, M | 1 |
| Coffin, V | 1 |
| Porter, AC | 1 |
| Skillman, TL | 1 |
| Zhang, L | 1 |
| Bymaster, FP | 2 |
| Nathanson, NM | 1 |
| Hamilton, SE | 1 |
| Gomeza, J | 1 |
| Wess, J | 1 |
| McKinzie, DL | 1 |
| Carter, PA | 1 |
| DeLapp, NW | 1 |
| Calligaro, DO | 1 |
| Pearce, BD | 1 |
| Potter, LT | 2 |
| Santucci, AC | 1 |
| Drukarch, B | 1 |
| Kits, KS | 1 |
| Van der Meer, EG | 1 |
| Lodder, JC | 1 |
| Stoof, JC | 1 |
| Hollander, E | 1 |
| Davidson, M | 1 |
| Davis, BM | 1 |
| Mohs, RC | 1 |
| Horvath, TB | 1 |
1 review available for oxotremorine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Experimental pharmacology of Alzheimer disease.
Topics: Acetylcholine; Adult; Aged; Alzheimer Disease; Dementia; Dopamine; gamma-Aminobutyric Acid; Humans; | 1983 |
24 other studies available for oxotremorine and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Ligands; Radioligand Assay; Rats; Receptors, Muscarinic | 1992 |
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biogenic Amines; Brain; In Vitro Techniques; Indoles; Magnetic Resonance | 1996 |
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biogenic Amines; In Vitro Techniques; Mice; Pyridines; Quinuclidinyl Ben | 1996 |
Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.
Topics: Alzheimer Disease; Animals; Binding Sites; Blood Pressure; Brain; CHO Cells; Cricetinae; Electroence | 1997 |
Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease.
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Binding, Competitive; Biomarkers; Cerebra | 2010 |
Fruit extracts antagonize Abeta- or DA-induced deficits in Ca2+ flux in M1-transfected COS-7 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blueberry Plants; Calcium; COS Cell | 2004 |
A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease.
Topics: Adult; Aged; Alzheimer Disease; Cerebral Cortex; Choline O-Acetyltransferase; Dementia; Female; Huma | 1983 |
Decreased cortical glucose utilization after ibotenate lesion of the rat ventromedial globus pallidus.
Topics: Alzheimer Disease; Animals; Autoradiography; Brain Diseases; Cerebral Cortex; Globus Pallidus; Gluco | 1984 |
Lesion with the neurotoxin AF64A alters hippocampal cholinergic receptor function.
Topics: Acetylcholine; Alzheimer Disease; Animals; Aziridines; Choline; Disease Models, Animal; Electric Sti | 1995 |
Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbachol; Cerebral Cortex; Choline O-Acetyltransferase; | 1995 |
Preservation of acetylcholine muscarinic M2 receptor G-protein interactions in the neocortex of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Female; GTP-Binding Proteins; Guanylyl Imidodiphosphate; H | 1995 |
Acetylcholine muscarinic M2 receptor stimulated [35S]GTP gamma S binding shows regional selective changes in Alzheimer's disease postmortem brain.
Topics: Age Factors; Aged; Alzheimer Disease; Autopsy; Brain; Cell Membrane; Dentate Gyrus; Frontal Lobe; GT | 1996 |
Synthesis and muscarinic activities of 3-(pyrazolyl)-1,2,5,6-tetrahydropyridine derivatives.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Alzheimer Disease; Analysis of Variance; Animals; Bind | 1996 |
SCH 57790: a novel M2 receptor selective antagonist.
Topics: Acetylcholine; Adenylyl Cyclases; Alzheimer Disease; Animals; Binding Sites; CHO Cells; Colforsin; C | 1999 |
Reduced high-affinity agonist binding at the M(1) muscarinic receptor in Alzheimer's disease brain: differential sensitivity to agonists and divalent cations.
Topics: Acetylcholine; Aged; Alzheimer Disease; Brain; Carbachol; Cations, Divalent; Chlorides; Edetic Acid; | 1999 |
Evaluation of autoreceptor-mediated control of [(3)H]acetylcholine release in rat and human neocortex.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Atropine; Carrier Proteins; Electric Stimulation; F | 1999 |
Facilitation of acetylcholine release and improvement in cognition by a selective M2 muscarinic antagonist, SCH 72788.
Topics: Acetylcholine; Adenylyl Cyclases; Alzheimer Disease; Animals; CHO Cells; Cricetinae; Dose-Response R | 2001 |
Elucidating the role of muscarinic receptors in psychosis.
Topics: Alzheimer Disease; Animals; Cell Fractionation; Cell Line; Cell Membrane; Cerebral Cortex; Disease M | 2001 |
Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo.
Topics: Acetylcholine; Alzheimer Disease; Animals; Cholinergic Fibers; Dioxolanes; Dose-Response Relationshi | 2001 |
Coupling of m1 muscarinic receptors to G protein in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Binding, Competitive; Cerebral Cortex; Choline O-Acetylt | 1991 |
Pharmacological alleviation of combined cholinergic/noradrenergic lesion-induced memory deficits in rats.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Benzylamines; Cholinergic Agents; Cholinergic Fibers | 1991 |
9-Amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease, inhibits acetylcholinesterase activity and slow outward K+ current.
Topics: Alzheimer Disease; Aminoacridines; Animals; Atropine; Cerebral Cortex; Cholinesterase Inhibitors; Co | 1987 |
Induction of depression with oxotremorine in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blood Pressure; Cognition; Depressive Disorder; Female; Humans; Male; Memor | 1987 |
Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.
Topics: Aged; Alzheimer Disease; Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; | 1985 |