oxonic acid has been researched along with Blood Pressure, High in 17 studies
Oxonic Acid: Antagonist of urate oxidase.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI." | 9.16 | Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer. ( Fukushima, H; Hatanaka, K; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kudo, M; Meguro, T; Miyagishima, T; Munakata, M; Nakamura, M; Nakatsumi, H; Sakata, Y; Sogabe, S; Tateyama, M; Yuki, S, 2012) |
| " We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU." | 5.34 | Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. ( Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; López-Molina, R; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007) |
| "In Japan, a study comparing the effectiveness and safety of irinotecan plus S-1 (IRIS) with those of a combination of 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) as second-line treatment in patients with advanced or recurrent colorectal cancer demonstrated that IRIS was non-inferior to FOLFIRI." | 5.16 | Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer. ( Fukushima, H; Hatanaka, K; Iwanaga, I; Kobayashi, Y; Komatsu, Y; Kudo, M; Meguro, T; Miyagishima, T; Munakata, M; Nakamura, M; Nakatsumi, H; Sakata, Y; Sogabe, S; Tateyama, M; Yuki, S, 2012) |
| "In rats with hyperuricemia induced by 2% oxonic acid and 0." | 3.74 | Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia. ( Chen, K; Cui, WY; Liu, GS; Long, CL; Pan, ZY; Qin, XC; Wang, H; Zhang, YF, 2008) |
| "Healthy virgin and breeder rats (Sprague-Dawley) with naturally occurring hypertension and arteriosclerosis were fed 5% oxonic acid and 1% uric acid added to their regular diet for 30 days." | 3.65 | Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis. ( Greenberg, BP; Wexler, BC, 1977) |
| "She was diagnosed with drug-induced thrombotic thrombocytopenic purpura (TTP)." | 1.39 | Drug-induced thrombotic thrombocytopenic purpura successfully treated with recombinant human soluble thrombomodulin. ( Fujimura, Y; Himeno, A; Hirata, H; Inoue, K; Kida, H; Kijima, T; Kumanogoh, A; Matsumoto, M; Nagatomo, I; Nishijima, Y; Otani, Y; Tachibana, I; Takahashi, R; Takeda, Y, 2013) |
| "Diabetes mellitus was diagnosed in 124 patients (50%) who had less distant metastasis and more hypertension." | 1.39 | Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer: better prognosis with statin use in diabetic patients. ( Hirano, K; Ijichi, H; Isayama, H; Kawakubo, K; Kogure, H; Koike, K; Mizuno, S; Nakai, Y; Sasahira, N; Sasaki, T; Tada, M; Tateishi, K; Yamamoto, N, 2013) |
| " Adverse events were assessed by the National Cancer Institute Common Terminology Criteria for Adverse Events." | 1.37 | Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study. ( Asaka, M; Hatanaka, K; Hosokawa, A; Iwanaga, I; Kato, T; Komatsu, Y; Kusumi, T; Miyagishima, T; Nakamura, M; Sakata, Y; Sogabe, S; Yuki, S, 2011) |
| " We therefore studied the effect of acute and chronic administration of l-arginine (a substrate for endothelial nitric oxide synthase) on the renal hemodynamic and vascular structural alterations induced by HU." | 1.34 | Effects of acute and chronic L-arginine treatment in experimental hyperuricemia. ( Avila-Casado, C; Franco, M; Herrera-Acosta, J; Johnson, RJ; López-Molina, R; Nakagawa, T; Nepomuceno, T; Sánchez-Lozada, LG; Soto, V; Tapia, E, 2007) |
| "He was diagnosed with advanced gastric cancer, T2N1H0P0M0, stage II." | 1.34 | [Complete response in an elderly patient with advanced gastric cancer treated with TS-1]. ( Fujiwara, S; Harada, K; Kawahara, K; Kitano, S; Moriyama, H; Noguchi, T, 2007) |
| "Hydrochlorothiazide treatment did not prevent the hyperuricemia or arteriolopathy despite controlling blood pressure." | 1.31 | Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. ( Chen, Q; Feng, L; Gordon, KL; Han, L; Johnson, RJ; Kanellis, J; Kang, DH; Lan, HY; Mazzali, M; Nakagawa, T; Watanabe, S; Xia, YY, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, H | 1 |
| Bai, W | 1 |
| Gao, L | 1 |
| Jiang, J | 1 |
| Tang, Y | 1 |
| Niu, Y | 1 |
| Lin, H | 1 |
| Li, L | 1 |
| Nishijima, Y | 1 |
| Hirata, H | 1 |
| Himeno, A | 1 |
| Kida, H | 1 |
| Matsumoto, M | 1 |
| Takahashi, R | 1 |
| Otani, Y | 1 |
| Inoue, K | 1 |
| Nagatomo, I | 1 |
| Takeda, Y | 1 |
| Kijima, T | 1 |
| Tachibana, I | 1 |
| Fujimura, Y | 1 |
| Kumanogoh, A | 1 |
| Hou, SX | 1 |
| Zhu, WJ | 1 |
| Pang, MQ | 1 |
| Jeffry, J | 1 |
| Zhou, LL | 1 |
| Su, J | 1 |
| Wei, Y | 1 |
| Liu, M | 1 |
| Liu, T | 1 |
| Li, J | 1 |
| Ji, Y | 1 |
| Liang, J | 1 |
| Cristóbal-García, M | 1 |
| García-Arroyo, FE | 1 |
| Tapia, E | 2 |
| Osorio, H | 1 |
| Arellano-Buendía, AS | 1 |
| Madero, M | 1 |
| Rodríguez-Iturbe, B | 1 |
| Pedraza-Chaverrí, J | 1 |
| Correa, F | 1 |
| Zazueta, C | 1 |
| Johnson, RJ | 4 |
| Lozada, LG | 1 |
| Long, CL | 1 |
| Qin, XC | 1 |
| Pan, ZY | 1 |
| Chen, K | 1 |
| Zhang, YF | 1 |
| Cui, WY | 1 |
| Liu, GS | 1 |
| Wang, H | 1 |
| Hiraki, M | 1 |
| Tanaka, M | 1 |
| Sato, S | 1 |
| Kai, K | 1 |
| Morito, K | 1 |
| Kobayashi, K | 1 |
| Noshiro, H | 1 |
| Tokunaga, O | 1 |
| Miyazaki, K | 1 |
| Kihara, K | 1 |
| Kamimura, H | 1 |
| Isayama, H | 2 |
| Fujii, Y | 1 |
| Iino, Y | 1 |
| Sogabe, S | 2 |
| Komatsu, Y | 2 |
| Yuki, S | 2 |
| Kusumi, T | 1 |
| Hatanaka, K | 2 |
| Nakamura, M | 2 |
| Kato, T | 1 |
| Miyagishima, T | 2 |
| Hosokawa, A | 1 |
| Iwanaga, I | 2 |
| Sakata, Y | 2 |
| Asaka, M | 1 |
| Fukushima, H | 1 |
| Nakatsumi, H | 1 |
| Kobayashi, Y | 1 |
| Kudo, M | 1 |
| Munakata, M | 1 |
| Meguro, T | 1 |
| Tateyama, M | 1 |
| Nakai, Y | 1 |
| Sasaki, T | 1 |
| Mizuno, S | 1 |
| Sasahira, N | 1 |
| Kogure, H | 1 |
| Kawakubo, K | 1 |
| Yamamoto, N | 1 |
| Hirano, K | 1 |
| Ijichi, H | 1 |
| Tateishi, K | 1 |
| Tada, M | 1 |
| Koike, K | 1 |
| Nakagawa, T | 3 |
| Mazzali, M | 2 |
| Kang, DH | 2 |
| Sánchez-Lozada, LG | 2 |
| Herrera-Acosta, J | 2 |
| López-Molina, R | 1 |
| Nepomuceno, T | 1 |
| Soto, V | 1 |
| Avila-Casado, C | 1 |
| Franco, M | 1 |
| Harada, K | 1 |
| Noguchi, T | 1 |
| Fujiwara, S | 1 |
| Moriyama, H | 1 |
| Kitano, S | 1 |
| Kawahara, K | 1 |
| Wexler, BC | 2 |
| Kanellis, J | 1 |
| Han, L | 1 |
| Feng, L | 1 |
| Xia, YY | 1 |
| Chen, Q | 1 |
| Gordon, KL | 1 |
| Watanabe, S | 1 |
| Lan, HY | 1 |
| Greenberg, BP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Trial of Combination Therapy With Irinotecan, S-1, and Bevacizumab (IRIS/Bev) in Patients With Unresectable or Recurrent Colorectal Cancer[NCT00569790] | Phase 2 | 53 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for oxonic acid and Blood Pressure, High
| Article | Year |
|---|---|
Uric acid--a uremic toxin?
Topics: Animals; Arteriosclerosis; Biomarkers; Enzyme Inhibitors; Humans; Hypertension; Hypertrophy; Hyperur | 2006 |
1 trial available for oxonic acid and Blood Pressure, High
| Article | Year |
|---|---|
Phase II study of combined chemotherapy with irinotecan and S-1 (IRIS) plus bevacizumab in patients with inoperable recurrent or advanced colorectal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined | 2012 |
15 other studies available for oxonic acid and Blood Pressure, High
| Article | Year |
|---|---|
Mangiferin alleviates hypertension induced by hyperuricemia via increasing nitric oxide releases.
Topics: Administration, Oral; Animals; Aorta; C-Reactive Protein; Human Umbilical Vein Endothelial Cells; Hu | 2018 |
Drug-induced thrombotic thrombocytopenic purpura successfully treated with recombinant human soluble thrombomodulin.
Topics: Acute Kidney Injury; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Antineoplastic Comb | 2013 |
Protective effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate.
Topics: Animals; Base Sequence; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; DNA Primers; Hypert | 2014 |
Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice.
Topics: Animals; Creatinine; Dioscorea; Diosgenin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; | 2014 |
Renal oxidative stress induced by long-term hyperuricemia alters mitochondrial function and maintains systemic hypertension.
Topics: Adenosine Triphosphate; Allopurinol; Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Disease | 2015 |
Activation of ATP-sensitive potassium channels protects vascular endothelial cells from hypertension and renal injury induced by hyperuricemia.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Angiotensins; Animals; Cells, Cultured; Disease Models | 2008 |
A complete response in small cell carcinoma of the esophagus treated by s-1/cisplatin combined chemotherapy and radiotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Asthma; Carcinoma, Small Cell; Cisplatin; Comb | 2010 |
[Suppression of renin-angiotensin system and cancer therapy (discussion)].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; B | 2010 |
Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study.
Topics: Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclo | 2011 |
Clinical outcomes of chemotherapy for diabetic and nondiabetic patients with pancreatic cancer: better prognosis with statin use in diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Antineoplastic Combined Chemotherapy Protoc | 2013 |
Effects of acute and chronic L-arginine treatment in experimental hyperuricemia.
Topics: Animals; Arginine; Arterioles; Endothelium, Vascular; Hypertension; Hyperuricemia; Kidney Glomerulus | 2007 |
[Complete response in an elderly patient with advanced gastric cancer treated with TS-1].
Topics: Adenocarcinoma; Aged, 80 and over; Antimetabolites, Antineoplastic; Diabetes Complications; Drug Adm | 2007 |
Allantoxanamide-induced myocardial necrosis in Sprague-Dawley vs spontaneously hypertensive rats.
Topics: Aldosterone; Animals; Blood Glucose; Blood Pressure; Blood Urea Nitrogen; Corticosterone; Female; He | 1982 |
Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism.
Topics: Administration, Oral; Allopurinol; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Con | 2002 |
Effect of increased serum urate levels on virgin rats with no arteriosclerosis versus breeder rats with preexistent arteriosclerosis.
Topics: Animals; Arteriosclerosis; Female; Hyperglycemia; Hyperlipidemias; Hypertension; Male; Oxonic Acid; | 1977 |