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oxidopamine and Tremor

oxidopamine has been researched along with Tremor in 17 studies

Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).

Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.

Research Excerpts

ExcerptRelevanceReference
"The aim of the present study was to examine the influence of a unilateral 6-hydroxydopamine (6-OHDA)-induced partial lesion of both the substantia nigra pars compacta (SNc, A9) and retrorubral field (RRF, A8) on the tremor evoked by harmaline."7.786-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats. ( Berghauzen, K; Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Schulze, G, 2012)
"Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway has been suggested to be crucial for the harmaline-induced tremor."7.77Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. ( Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Pastuszka, A, 2011)
"The effect of 6-hydroxydopamine on repeated nicotine-induced tail-tremor was investigated in rats."7.70Involvement of the central catecholaminergic system in nicotine-induced tail-tremor in rats. ( Araki, H; Gomita, Y; Kawakami, Y; Suemaru, K; Tanizaki, Y, 1998)
"The effects of nicotinic and beta-adrenergic receptor antagonists on tail-tremor induced by repeated nicotine administration were investigated in rats."7.69Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. ( Gomita, Y; Kawasaki, H; Oishi, R; Suemaru, K; Tanizaki, Y, 1997)
"It has previously been reported that intracerebroventricular administration of neurotensin (30 micrograms) reduced muscular rigidity and tremors, induced by a neurochemical lesion with 6-hydroxydopamine in the posterolateral hypothalamus of rats."7.68Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat. ( Jolicoeur, FB; Rivest, R; St-Pierre, S, 1991)
" Intact male GPR88 KO mice showed diminished tacrine-induced PD-like tremor and spontaneous hyperlocomotion."3.96Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. ( Mannoury-la-Cour, C; Mantas, I; Millan, MJ; Svenningsson, P; Yang, Y; Zhang, X, 2020)
"The aim of the present study was to examine the influence of a unilateral 6-hydroxydopamine (6-OHDA)-induced partial lesion of both the substantia nigra pars compacta (SNc, A9) and retrorubral field (RRF, A8) on the tremor evoked by harmaline."3.786-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats. ( Berghauzen, K; Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Schulze, G, 2012)
"Abnormal synchronous activation of the glutamatergic olivo-cerebellar pathway has been suggested to be crucial for the harmaline-induced tremor."3.77Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats. ( Kolasiewicz, W; Kuter, K; Nowak, P; Ossowska, K; Pastuszka, A, 2011)
") proved capable of reducing jaw tremors in tacrine model of Parkinson's disease tremor."3.74Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats. ( Borsini, F; Carminati, P; Frau, L; Morelli, M; Schintu, N; Simola, N; Tronci, E, 2007)
" When an animal moves on the plate, its movements are sensed by the transducers whose signals are processed by computer to yield measurements of a wide range of behaviors or behavioral attributes, such as locomotor activity, rotation around the center, whole-body tremor, and amphetamine-induced stereotypies."3.71A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. ( Birkestrand, BR; Chen, R; Fowler, SC; Moss, SJ; Vorontsova, E; Wang, G; Zarcone, TJ, 2001)
"The effect of 6-hydroxydopamine on repeated nicotine-induced tail-tremor was investigated in rats."3.70Involvement of the central catecholaminergic system in nicotine-induced tail-tremor in rats. ( Araki, H; Gomita, Y; Kawakami, Y; Suemaru, K; Tanizaki, Y, 1998)
" Because prenylated proteins are avid methyl acceptors at the terminal carboxylic acid groups, 1 micromol S-farnesylcysteine (FC) analogs blocked the SAM-induced tremors in the experimental rats."3.70Farnesyl-L-cysteine analogs block SAM-induced Parkinson's disease-like symptoms in rats. ( Charlton, CG; Lamango, NS, 2000)
"The effects of nicotinic and beta-adrenergic receptor antagonists on tail-tremor induced by repeated nicotine administration were investigated in rats."3.69Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. ( Gomita, Y; Kawasaki, H; Oishi, R; Suemaru, K; Tanizaki, Y, 1997)
"It has previously been reported that intracerebroventricular administration of neurotensin (30 micrograms) reduced muscular rigidity and tremors, induced by a neurochemical lesion with 6-hydroxydopamine in the posterolateral hypothalamus of rats."3.68Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat. ( Jolicoeur, FB; Rivest, R; St-Pierre, S, 1991)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's5 (29.41)18.2507
2000's5 (29.41)29.6817
2010's5 (29.41)24.3611
2020's1 (5.88)2.80

Authors

AuthorsStudies
Mantas, I1
Yang, Y1
Mannoury-la-Cour, C1
Millan, MJ1
Zhang, X1
Svenningsson, P1
Pinna, A1
Bonaventura, J1
Farré, D1
Sánchez, M1
Simola, N2
Mallol, J1
Lluís, C1
Costa, G1
Baqi, Y1
Müller, CE1
Cortés, A1
McCormick, P1
Canela, EI1
Martínez-Pinilla, E1
Lanciego, JL1
Casadó, V1
Armentero, MT1
Franco, R1
Mu, X1
Yuan, X1
Du, LD1
He, GR1
Du, GH1
Kolasiewicz, W2
Kuter, K2
Nowak, P2
Pastuszka, A1
Ossowska, K2
Bethel-Brown, CS1
Morris, JK1
Stanford, JA1
Berghauzen, K1
Schulze, G1
Aubin, N1
Barneoud, P1
Carter, C1
Caille, D1
Sontag, N1
Marc, C1
Lolivier, J1
Gardes, A1
Perron, C1
Le Kim, A1
Charieras, T1
Pandini, M1
Burnier, P1
Puech, F1
Jegham, S1
George, P1
Scatton, B1
Curet, O1
Tronci, E1
Borsini, F1
Schintu, N1
Frau, L1
Carminati, P1
Morelli, M1
Suemaru, K2
Kawasaki, H1
Oishi, R1
Gomita, Y2
Tanizaki, Y2
Kawakami, Y1
Araki, H1
Lindner, MD1
Cain, CK1
Plone, MA1
Frydel, BR1
Blaney, TJ1
Emerich, DF1
Hoane, MR1
Fukuzaki, K1
Kamenosono, T1
Nagata, R1
Lamango, NS1
Charlton, CG1
Fowler, SC1
Birkestrand, BR1
Chen, R1
Moss, SJ1
Vorontsova, E1
Wang, G1
Zarcone, TJ1
Jolicoeur, FB2
Rivest, R2
Drumheller, A1
St-Pierre, S1
Buonamici, M1
Maj, R1
Pagani, F1
Rossi, AC1
Khazan, N1

Other Studies

17 other studies available for oxidopamine and Tremor

ArticleYear
Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia.
    Neuropharmacology, 2020, 01-01, Volume: 162

    Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Corpus Striatum; Dopami

2020
L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies.
    Experimental neurology, 2014, Volume: 253

    Topics: Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Cannabinoid Receptor Antagonists;

2014
Antagonism of quercetin against tremor induced by unilateral striatal lesion of 6-OHDA in rats.
    Journal of Asian natural products research, 2016, Volume: 18, Issue:1

    Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Male; Molecular Structure; Neuroprote

2016
Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats.
    Cerebellum (London, England), 2011, Volume: 10, Issue:2

    Topics: Adrenergic Agents; Animals; Brain Chemistry; Central Nervous System Stimulants; Cerebellum; Chromato

2011
Young and middle-aged rats exhibit isometric forelimb force control deficits in a model of early-stage Parkinson's disease.
    Behavioural brain research, 2011, Nov-20, Volume: 225, Issue:1

    Topics: Adrenergic Agents; Aging; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Forelimb; Male

2011
6-OHDA injections into A8-A9 dopaminergic neurons modelling early stages of Parkinson's disease increase the harmaline-induced tremor in rats.
    Brain research, 2012, Oct-05, Volume: 1477

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Animals; Central Nervous System Stimulants; Cereb

2012
SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzophenones; Brain; Corpus Striatum; Disease Models, Anim

2004
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
    European journal of pharmacology, 2007, Jul-02, Volume: 566, Issue:1-3

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavi

2007
Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5

    Topics: Adrenergic Agents; Adrenergic beta-Antagonists; Animals; Carteolol; Dimethylphenylpiperazinium Iodid

1997
Involvement of the central catecholaminergic system in nicotine-induced tail-tremor in rats.
    Acta medica Okayama, 1998, Volume: 52, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Catecholamines; Drug Administration Schedule; Injections, Intraperi

1998
Incomplete nigrostriatal dopaminergic cell loss and partial reductions in striatal dopamine produce akinesia, rigidity, tremor and cognitive deficits in middle-aged rats.
    Behavioural brain research, 1999, Volume: 102, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Brain Mapping; Corpus Striatum; Dementia; Dopa

1999
Effects of ropinirole on various parkinsonian models in mice, rats, and cynomolgus monkeys.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:3

    Topics: Animals; Antiparkinson Agents; Bromocriptine; Catalepsy; Dopamine Agonists; Indoles; Macaca fascicul

2000
Farnesyl-L-cysteine analogs block SAM-induced Parkinson's disease-like symptoms in rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 66, Issue:4

    Topics: Amphetamine; Animals; Central Nervous System Stimulants; Chromatography, Gel; Cysteine; Freeze Dryin

2000
A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor.
    Journal of neuroscience methods, 2001, May-30, Volume: 107, Issue:1-2

    Topics: Amphetamine; Animals; Behavior, Animal; Biomechanical Phenomena; Central Nervous System; Dopamine Up

2001
Hypokinesia, rigidity, and tremor induced by hypothalamic 6-OHDA lesions in the rat.
    Brain research bulletin, 1991, Volume: 26, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Dopamine; Dyskinesia, Drug-Induced; Homovanillic Aci

1991
Structure-activity studies of neurotensin on muscular rigidity and tremors induced by 6-hydroxydopamine lesions in the posterolateral hypothalamus of the rat.
    Neuropharmacology, 1991, Volume: 30, Issue:1

    Topics: Animals; Cerebral Ventricles; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxydopam

1991
Tremor at rest episodes in unilaterally 6-OHDA-induced substantia nigra lesioned rats: EEG-EMG and behavior.
    Neuropharmacology, 1986, Volume: 25, Issue:3

    Topics: Animals; Apomorphine; Behavior, Animal; Electroencephalography; Electromyography; Hydroxydopamines;

1986