oxidopamine has been researched along with Seizures in 47 studies
Oxidopamine: A neurotransmitter analogue that depletes noradrenergic stores in nerve endings and induces a reduction of dopamine levels in the brain. Its mechanism of action is related to the production of cytolytic free-radicals.
oxidopamine : A benzenetriol that is phenethylamine in which the hydrogens at positions 2, 4, and 5 on the phenyl ring are replaced by hydroxy groups. It occurs naturally in human urine, but is also produced as a metabolite of the drug DOPA (used for the treatment of Parkinson's disease).
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Injections of 5,7-dihydroxytryptamine (5,7-DHT) in the rat ventromedial tegmentum, which depleted forebrain serotonin, and of 6-hydroxydopamine in the dorsal noradrenergic bundle, which caused a marked reduction of forebrain noradrenaline, intensified pentylenetetrazol (PTZ)-induced seizures." | 7.67 | Evidence that the dorsal raphe area is involved in the effect of clonidine against pentylenetetrazole-induced seizures in rats. ( Bendotti, C; Lazarova, M; Samanin, R, 1984) |
| "We investigated in rats whether alterations in noradrenergic function caused by 6-hydroxydopamine or alpha- and beta-adrenoceptor agonists and antagonists would modify the susceptibility of the brain to electroencephalographic seizures induced by intrahippocampal infusion of quinolinic acid." | 7.67 | Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1987) |
| " In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy." | 4.12 | Dopamine depletion in wistar rats with epilepsy. ( Becker, EL; Biase, CLCL; Carvalho, EGA; Castro, DN; Cavalcante, JBN; Costa, AF; Costa, MV; Costa, PJMS; de Melo, MR; Félix, VB; Leão, SABF; Leite, ML; Lima, JA; Lino, ATS; Moura, IMFB; Mousinho, KC; Pai, JD; Quintella, GB; Saldanha-Filho, AJM; Santos, SDBD; Silva, ATMD; Silva, JCD; Tavares, MMA; Trindade-Filho, EM; Vieira, JSS; Zambrano, LI, 2022) |
| "Injections of 5,7-dihydroxytryptamine (5,7-DHT) in the rat ventromedial tegmentum, which depleted forebrain serotonin, and of 6-hydroxydopamine in the dorsal noradrenergic bundle, which caused a marked reduction of forebrain noradrenaline, intensified pentylenetetrazol (PTZ)-induced seizures." | 3.67 | Evidence that the dorsal raphe area is involved in the effect of clonidine against pentylenetetrazole-induced seizures in rats. ( Bendotti, C; Lazarova, M; Samanin, R, 1984) |
| "The intracerebral microdialysis technique has been used to monitor extracellular levels of noradrenaline, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the rat hippocampus in vivo in response to focal and generalized seizures induced by hippocampal kindling stimulation." | 3.67 | Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study. ( Bengzon, J; Kalén, P; Kokaia, M; Lindvall, O, 1989) |
| " Severe depletion of forebrain noradrenaline (NA) with intraventricular 6-hydroxydopamine or blockade of alpha 2 adrenergic receptors with idazoxan markedly reduced the number of stimulations needed to induce the first severe limbic seizure and increased the total number of such seizures during 40 stimulations." | 3.67 | Noradrenergic mechanisms in hippocampal kindling with rapidly recurring seizures. ( Bengzon, J; Kalén, P; Kokaia, M; Lindvall, O, 1989) |
| "We investigated in rats whether alterations in noradrenergic function caused by 6-hydroxydopamine or alpha- and beta-adrenoceptor agonists and antagonists would modify the susceptibility of the brain to electroencephalographic seizures induced by intrahippocampal infusion of quinolinic acid." | 3.67 | Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1987) |
| "Chronic sound or electroshock-induced seizures caused down regulation of beta-adrenoceptors in frontal cortex and in hippocampus from GEPR-9s." | 1.31 | Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats. ( Cheong, JH; Choi, CR; Dailey, JW; Jobe, PC; Ko, KH; Reith, ME; Ryu, JR; Seo, DO; Shin, CY, 2000) |
| "Amygdaloid kindled seizures in the rat induce an abrupt elevation of blood pressure accompanied by a significant decrease in heart rate." | 1.30 | Kindled seizures activate both branches of the autonomic nervous system. ( Crawford, IL; Goodman, JH; Homan, RW, 1999) |
| "In this study, audiogenic seizure severity was used as the index of seizure predisposition." | 1.29 | Noradrenergic terminal fields as determinants of seizure predisposition in GEPR-3s: a neuroanatomic assessment with intracerebral microinjections of 6-hydroxydopamine. ( Browning, RA; Dailey, JW; Jobe, PC; Mishra, PK; Wang, C, 1994) |
| "Budipine is a novel antiparkinsonian drug which is particularly beneficial in the treatment of parkinsonian tremor." | 1.29 | Effects of the antiparkinsonian drug budipine on central neurotransmitter systems. ( Klockgether, T; Löschmann, PA; Petersen, V; Steinbach, JP; Turski, L; Wüllner, U, 1996) |
| "Tonic seizures were not observed in male rats following NMDA infusions in rats with LC infusions of saline." | 1.28 | Effect of norepinephrine depletion on audiogenic-like seizures elicited by microinfusion of an excitant amino acid into the inferior colliculus of normal rats. ( Browning, RA; Faingold, CL; Wang, C, 1991) |
| "The development of seizures was significantly faster in the grafted and normal rats that had been given idazoxan than in the grafted rats that had not been subjected to alpha-2 receptor blockade." | 1.28 | Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism. ( Bengzon, J; Brundin, P; Kokaia, M; Lindvall, O, 1990) |
| "The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle." | 1.27 | Facilitation of neocortical kindling by depletion of forebrain noradrenaline. ( Altman, IM; Corcoran, ME, 1983) |
| "When the discharge became bilateral, generalized seizures were soon apparent." | 1.27 | Effect of clonidine on amygdala kindling in normal and 6-hydroxydopamine-pretreated rats. ( Giugno, L; McIntyre, DC, 1988) |
| "It appears, therefore, that the convulsions produced by nicotine are mediated through central nicotinic receptors." | 1.27 | Nicotine-induced convulsions in cats and central nicotinic receptors. ( Beleslin, DB; Krstić, SK, 1986) |
| "The nature of this NE-dependent seizure suppression mechanism and the anatomic locus or loci critical for this effect remain questions for future research." | 1.27 | Kindling antagonism: effects of norepinephrine depletion on kindled seizure suppression after concurrent, alternate stimulation in rats. ( Applegate, CD; Burchfiel, JL; Konkol, RJ, 1986) |
| "By contrast, pentylenetetrazol seizures' characteristics were significantly changed in response to the intraperitoneal administration of the norepinephrine antagonist, 6-hydroxydopamine, by abolishing the tonic and clonic phases of the seizure." | 1.27 | Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice. ( Abed, WT, 1986) |
| "The electrographic seizure produced by GBL was significantly prolonged and more severe in the 6-OHDA-treated animals." | 1.27 | Noradrenergic mechanisms in gamma-hydroxybutyrate-induced seizure activity. ( Snead, OC, 1987) |
| "The threshold of the generalized clonic convulsions induced by intravenous infusion of pentylenetetrazol (PTZ) was significantly increased by the intraperitoneal administration of noradrenaline (NA) neurotoxin, 6-hydroxydopamine, which produced no changes in the levels of catecholamines in discrete areas of rat brain, but the effect was accompanied by spinal depletion of NA." | 1.27 | A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats. ( Abed, WT, 1988) |
| "NA-depleted rats developed generalized seizures very rapidly by spending significantly less time than controls in the early stages of nonconvulsive or partial seizures, and they required significantly less cumulative total time in afterdischarge than controls to develop generalized seizures." | 1.27 | Characteristics of accelerated kindling after depletion of noradrenaline in adult rats. ( Corcoran, ME, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (61.70) | 18.7374 |
| 1990's | 14 (29.79) | 18.2507 |
| 2000's | 2 (4.26) | 29.6817 |
| 2010's | 1 (2.13) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Trindade-Filho, EM | 1 |
| Pai, JD | 1 |
| Castro, DN | 1 |
| Silva, ATMD | 1 |
| Costa, AF | 1 |
| Vieira, JSS | 1 |
| Santos, SDBD | 1 |
| Félix, VB | 1 |
| Leão, SABF | 1 |
| Zambrano, LI | 1 |
| Saldanha-Filho, AJM | 1 |
| Carvalho, EGA | 1 |
| Cavalcante, JBN | 1 |
| Quintella, GB | 1 |
| Lino, ATS | 1 |
| Costa, MV | 1 |
| Lima, JA | 1 |
| Tavares, MMA | 1 |
| de Melo, MR | 1 |
| Mousinho, KC | 1 |
| Biase, CLCL | 1 |
| Leite, ML | 1 |
| Costa, PJMS | 1 |
| Becker, EL | 1 |
| Moura, IMFB | 1 |
| Silva, JCD | 1 |
| Sadek, B | 1 |
| Oz, M | 1 |
| Nurulain, SM | 1 |
| Jayaprakash, P | 1 |
| Latacz, G | 1 |
| Kieć-Kononowicz, K | 1 |
| Szymańska, E | 1 |
| Henderson, JM | 1 |
| Watson, SH | 1 |
| Yue, W | 1 |
| Zhang, SS | 1 |
| Lazarova, M | 4 |
| Bendotti, C | 2 |
| Samanin, R | 3 |
| Altman, IM | 1 |
| Corcoran, ME | 3 |
| Mody, I | 1 |
| Leung, P | 1 |
| Miller, JJ | 1 |
| Waller, SB | 2 |
| Buterbaugh, GG | 3 |
| Petkov, V | 2 |
| Georgiev, V | 2 |
| Roussinov, K | 2 |
| Grigorov, I | 1 |
| Slokoska, L | 1 |
| Angelova, M | 1 |
| Getova, D | 2 |
| Todorov, S | 1 |
| Radomirov, R | 1 |
| Petkova, B | 1 |
| Shopova, S | 1 |
| Markovska, V | 1 |
| Draganova, S | 1 |
| McIntyre, DC | 4 |
| Edson, N | 3 |
| Wang, C | 2 |
| Mishra, PK | 1 |
| Dailey, JW | 2 |
| Jobe, PC | 2 |
| Browning, RA | 2 |
| Klockgether, T | 1 |
| Wüllner, U | 1 |
| Steinbach, JP | 1 |
| Petersen, V | 1 |
| Turski, L | 1 |
| Löschmann, PA | 1 |
| Shiosaki, K | 1 |
| Asin, KE | 2 |
| Britton, DR | 2 |
| Giardina, WJ | 1 |
| Bednarz, L | 2 |
| Mahan, L | 1 |
| Mikusa, J | 1 |
| Nikkel, A | 1 |
| Wismer, C | 1 |
| Knigge, KM | 1 |
| Wagner, JE | 1 |
| Goodman, JH | 1 |
| Homan, RW | 1 |
| Crawford, IL | 1 |
| Seo, DO | 1 |
| Shin, CY | 1 |
| Ryu, JR | 1 |
| Cheong, JH | 1 |
| Choi, CR | 1 |
| Reith, ME | 1 |
| Ko, KH | 1 |
| Bhat, RV | 1 |
| Worley, PF | 1 |
| Cole, AJ | 1 |
| Baraban, JM | 1 |
| DeNinno, MP | 1 |
| Schoenleber, R | 1 |
| MacKenzie, R | 1 |
| Briggs, C | 1 |
| Trugman, JM | 1 |
| Ackerman, M | 1 |
| Artman, L | 1 |
| Konkol, RJ | 3 |
| Wesselmann, U | 1 |
| Karpus, WJ | 1 |
| Leo, GL | 1 |
| Killen, JA | 1 |
| Roerig, DL | 1 |
| Faingold, CL | 1 |
| Bengzon, J | 3 |
| Kokaia, M | 4 |
| Brundin, P | 2 |
| Lindvall, O | 4 |
| N'Gouemo, P | 1 |
| Lerner-Natoli, M | 1 |
| Rondouin, G | 1 |
| Watanabe, K | 1 |
| Sandillon, F | 1 |
| Privat, A | 1 |
| Baldy-Moulinier, M | 1 |
| Holmes, GL | 1 |
| Thompson, JL | 1 |
| Depaulis, A | 1 |
| Vergnes, M | 1 |
| Liu, Z | 1 |
| Kempf, E | 1 |
| Marescaux, C | 1 |
| Weiss, GK | 1 |
| Lewis, J | 1 |
| Jimenez-Rivera, C | 1 |
| Vigil, A | 1 |
| Kalén, P | 2 |
| Barry, DI | 1 |
| Wanscher, B | 1 |
| Kragh, J | 1 |
| Bolwig, TG | 1 |
| Björklund, A | 1 |
| Garcia-Cairasco, N | 1 |
| Trivińo-Santos, HF | 1 |
| Giugno, L | 1 |
| Beleslin, DB | 1 |
| Krstić, SK | 1 |
| Wu, HQ | 1 |
| Tullii, M | 1 |
| Vezzani, A | 1 |
| Applegate, CD | 1 |
| Burchfiel, JL | 1 |
| Abed, WT | 2 |
| Snead, OC | 1 |
| Alexander, GJ | 1 |
| Kopeloff, LM | 1 |
| Chatterjie, N | 1 |
| Stockmeier, CA | 1 |
| Larsen, BR | 1 |
| Blask, DE | 1 |
| Michelson, HB | 1 |
| Danysz, W | 1 |
| Jonsson, G | 1 |
| Mohammed, AK | 1 |
| Archer, T | 1 |
| Kaijima, M | 1 |
| Le Gal La Salle, G | 1 |
| Tanaka, T | 1 |
| Yonemasu, Y | 1 |
47 other studies available for oxidopamine and Seizures
| Article | Year |
|---|---|
Dopamine depletion in wistar rats with epilepsy.
Topics: Animals; Dopamine; Epilepsy; Male; Muscarinic Agonists; Oxidopamine; Pilocarpine; Rats; Rats, Wistar | 2022 |
Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Gly | 2017 |
Convulsive and postural effects of lesioning the mid-substantia nigra pars reticulata in naïve and 6-hydroxydopamine lesioned rats.
Topics: Animals; Apomorphine; Behavior, Animal; Cortical Synchronization; Disease Models, Animal; Dopamine A | 2003 |
[Effects of clonidine and yohimbine on semicarbazide-induced convulsion and electroconvulsive shock].
Topics: Animals; Clonidine; Electroshock; Female; Hydroxydopamines; Male; Mice; Oxidopamine; Propranolol; Re | 1984 |
The role of different types of adrenergic receptors in pentylenetetrazol-induced seizures and the effect of di-n-propylacetate in the rat.
Topics: Animals; Hydroxydopamines; Male; Oxidopamine; Pentylenetetrazole; Piperoxan; Rats; Receptors, Adrene | 1983 |
Facilitation of neocortical kindling by depletion of forebrain noradrenaline.
Topics: Animals; Brain; Cerebral Cortex; Electric Stimulation; Hydroxydopamines; Kindling, Neurologic; Male; | 1983 |
Role of norepinephrine in seizurelike activity of hippocampal pyramidal cells maintained in vitro: alteration by 6-hydroxydopamine lesions of norepinephrine-containing systems.
Topics: Animals; Evoked Potentials; Hippocampus; Hydroxydopamines; In Vitro Techniques; Male; Norepinephrine | 1983 |
Tonic convulsive thresholds and responses during the postnatal development of rats administered 6-hydroxydopamine or 5,7-dihydroxytryptamine within three days following birth.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Biogenic Amines; Brain Chemistry; Convulsants; D | 1983 |
Evidence that the dorsal raphe area is involved in the effect of clonidine against pentylenetetrazole-induced seizures in rats.
Topics: 5,7-Dihydroxytryptamine; Animals; Anticonvulsants; Brain Chemistry; Brain Stem; Clonidine; Hydroxydo | 1984 |
On the pharmacology of the ergot alkaloid elymoclavine.
Topics: Animals; Behavior, Animal; Blood Pressure; Catalepsy; Corpus Striatum; Ergolines; Exploratory Behavi | 1984 |
On some central effects of elymoclavine.
Topics: Animals; Bromocriptine; Catalepsy; Central Nervous System; Corpus Striatum; Ergolines; Exploratory B | 1984 |
Facilitation of amygdala kindling after norepinephrine depletion with 6-hydroxydopamine in rats.
Topics: Amygdala; Animals; Hydroxydopamines; Kindling, Neurologic; Male; Norepinephrine; Oxidopamine; Rats; | 1981 |
Effect of norepinephrine depletion on dorsal hippocampus kindling in rats.
Topics: Animals; Electric Stimulation; Hippocampus; Hydroxydopamines; Kindling, Neurologic; Male; Norepineph | 1982 |
Noradrenergic terminal fields as determinants of seizure predisposition in GEPR-3s: a neuroanatomic assessment with intracerebral microinjections of 6-hydroxydopamine.
Topics: Acoustic Stimulation; Animals; Brain Chemistry; Female; Locus Coeruleus; Male; Mesencephalon; Microi | 1994 |
Effects of the antiparkinsonian drug budipine on central neurotransmitter systems.
Topics: Animals; Antiparkinson Agents; Biperiden; Central Nervous System; Dopamine; Excitatory Amino Acid An | 1996 |
Hyperactivity and behavioral seizures in rodents following treatment with the dopamine D1 receptor agonists A-86929 and ABT-431.
Topics: Animals; Behavior, Animal; Benzazepines; Dopamine Agonists; Dopamine Antagonists; Dose-Response Rela | 1996 |
Melanin-concentrating hormone (MCH) involvement in pentylenetetrazole (PTZ)-induced seizure in rat and guinea pig.
Topics: Animals; Convulsants; Female; Guinea Pigs; Hypothalamic Hormones; Male; Melanins; Neurons; Oxidopami | 1997 |
Kindled seizures activate both branches of the autonomic nervous system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonomic Nervous Syst | 1999 |
Effect of norepinephrine release on adrenoceptors in severe seizure genetically epilepsy-prone rats.
Topics: Animals; Dihydroalprenolol; Electroshock; Epilepsy; Norepinephrine; Oxidopamine; Prazosin; Rats; Rat | 2000 |
Activation of the zinc finger encoding gene krox-20 in adult rat brain: comparison with zif268.
Topics: Animals; Apomorphine; Benzazepines; Brain; DNA-Binding Proteins; Early Growth Response Protein 1; Ea | 1992 |
A68930: a potent agonist selective for the dopamine D1 receptor.
Topics: Adenylyl Cyclases; Animals; Benzazepines; Binding Sites; Carps; Chromans; Deoxyglucose; Dopamine Age | 1991 |
Suppression of clinical weakness in experimental autoimmune encephalomyelitis associated with weight changes, and post-decapitation convulsions after intracisternal-ventricular administration of 6-hydroxydopamine.
Topics: Animals; Body Weight; Brain; Catecholamines; Cerebral Ventricles; Cisterna Magna; Decerebrate State; | 1990 |
Effect of norepinephrine depletion on audiogenic-like seizures elicited by microinfusion of an excitant amino acid into the inferior colliculus of normal rats.
Topics: Acoustic Stimulation; Animals; Brain; Hydroxydopamines; Inferior Colliculi; Infusions, Parenteral; L | 1991 |
Seizure suppression in kindling epilepsy by intrahippocampal locus coeruleus grafts: evidence for an alpha-2-adrenoreceptor mediated mechanism.
Topics: Adrenergic beta-Antagonists; Animals; Dioxanes; Dopamine beta-Hydroxylase; Epilepsy; Hippocampus; Hy | 1990 |
Catecholaminergic systems and amygdala kindling development. Effects of bilateral lesions of substantia nigra dopaminergic or locus coeruleus noradrenergic neurones.
Topics: Amygdala; Animals; Dopamine; Hydroxydopamines; Immunohistochemistry; Kindling, Neurologic; Locus Coe | 1990 |
The effect of regional differences in noradrenergic neuron growth patterns on juvenile kindling.
Topics: Adrenergic Fibers; Animals; Hydroxydopamines; Kindling, Neurologic; Norepinephrine; Oxidopamine; Rat | 1990 |
Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat.
Topics: Animals; Brain; Dopamine; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Hydroxy | 1990 |
Antikindling effects of locus coeruleus stimulation: mediation by ascending noradrenergic projections.
Topics: Afferent Pathways; Animals; Electric Stimulation; Electrophysiology; Hippocampus; Hydroxydopamines; | 1990 |
Noradrenaline and 5-hydroxytryptamine release in the hippocampus during seizures induced by hippocampal kindling stimulation: an in vivo microdialysis study.
Topics: Animals; Desipramine; Hippocampus; Hydroxydopamines; Hydroxyindoleacetic Acid; Kindling, Neurologic; | 1989 |
Kindling-based status epilepticus: effect of norepinephrine depletion with 6-hydroxydopamine.
Topics: Amygdala; Animals; Cerebral Ventricles; Dopamine; Electric Stimulation; Hydroxydopamines; Injections | 1989 |
Grafts of fetal locus coeruleus neurons in rat amygdala-piriform cortex suppress seizure development in hippocampal kindling.
Topics: Amygdala; Animals; Cerebral Cortex; Electric Stimulation; Hippocampus; Histocytochemistry; Hydroxydo | 1989 |
Effects of both 6-hydroxydopamine-induced and electrolytic lesion of the substantia nigra on the rotational behavior and audiogenic seizures in the rat.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Electrolysis; Functional Laterality; Hydroxydopamin | 1989 |
Noradrenergic mechanisms in hippocampal kindling with rapidly recurring seizures.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Electric Stimulation; Hippocampus; Hydroxydopamines | 1989 |
Effect of clonidine on amygdala kindling in normal and 6-hydroxydopamine-pretreated rats.
Topics: Amygdala; Animals; Brain; Clonidine; Electrophysiology; Hydroxydopamines; Kindling, Neurologic; Male | 1988 |
Nicotine-induced convulsions in cats and central nicotinic receptors.
Topics: 5,6-Dihydroxytryptamine; Animals; Brain; Cats; Dopamine Antagonists; Female; Ganglionic Blockers; He | 1986 |
Norepinephrine modulates seizures induced by quinolinic acid in rats: selective and distinct roles of alpha-adrenoceptor subtypes.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Hippocampus; Hydroxydopamines; Male; Methoxami | 1987 |
Kindling antagonism: effects of norepinephrine depletion on kindled seizure suppression after concurrent, alternate stimulation in rats.
Topics: Animals; Brain; Hydroxydopamines; Kindling, Neurologic; Male; Norepinephrine; Oxidopamine; Rats; Rat | 1986 |
Differential effects of alpha-methyl-p-tyrosine and 6-hydroxydopamine on pentylenetetrazol seizures in mice.
Topics: alpha-Methyltyrosine; Animals; Brain; Catecholamines; Dopamine; Hydroxydopamines; Male; Methyltyrosi | 1986 |
Noradrenergic mechanisms in gamma-hydroxybutyrate-induced seizure activity.
Topics: Animals; Brain Chemistry; Electroencephalography; Electrophysiology; Hydroxybutyrates; Hydroxydopami | 1987 |
A possible role for spinal noradrenaline in the mechanisms of 6-hydroxydopamine against pentylenetetrazol induced convulsions in rats.
Topics: Animals; Female; Hydroxydopamines; Male; Norepinephrine; Oxidopamine; Pentylenetetrazole; Phenobarbi | 1988 |
Characteristics of accelerated kindling after depletion of noradrenaline in adult rats.
Topics: Animals; Electric Stimulation; Hydroxydopamines; Kindling, Neurologic; Male; Norepinephrine; Oxidopa | 1988 |
Convulsive thresholds in mice: action of 6-hydroxydopamine and eboracin.
Topics: Acoustic Stimulation; Animals; Differential Threshold; Hydroxydopamines; Indenes; Male; Mice; Mice, | 1985 |
Alteration of seizures resulting from pinealectomy in the rat after neonatal treatment with 6-hydroxydopamine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain Chemistry; Desipramine; Dopamine; Female; Hydroxy | 1985 |
Convulsive thresholds and severity and the anticonvulsant effect of phenobarbital and phenytoin in adult rats administered 6-hydroxydopamine or 5,7-dihydroxytryptamine during postnatal development.
Topics: 5,7-Dihydroxytryptamine; Animals; Animals, Newborn; Anticonvulsants; Biogenic Amines; Dihydroxytrypt | 1985 |
Amygdala kindling in juvenile rats following neonatal administration of 6-hydroxydopamine.
Topics: Amygdala; Animals; Animals, Newborn; Female; Hydroxydopamines; Kindling, Neurologic; Oxidopamine; Ra | 1985 |
The hindlimb extension reflex is not a reliable marker of post-decapitation convulsions or spinal noradrenaline depletion in rats.
Topics: Animals; Animals, Newborn; Benzylamines; Brain; Hindlimb; Hydroxydopamines; Locus Coeruleus; Male; N | 1985 |
GABAergic and dopaminergic systems of the substantia nigra and amygdaloid kindling in cats.
Topics: Aminocaproates; Amygdala; Animals; Cats; Differential Threshold; Dopamine; gamma-Aminobutyric Acid; | 1985 |